메뉴 건너뛰기




Volumn 32, Issue 1, 2013, Pages 97-105

CXCL13 activation of c-Myc induces RANK ligand expression in stromal/preosteoblast cells in the oral squamous cell carcinoma tumor-bone microenvironment

Author keywords

c Myc; CXCL13; oral squamous cell carcinoma; osteoblast; RANK ligand

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CXCR5; CXCL13 CHEMOKINE; MITOGEN ACTIVATED PROTEIN KINASE 3; OSTEOCLAST DIFFERENTIATION FACTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NFAT3;

EID: 84871952717     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.24     Document Type: Article
Times cited : (56)

References (44)
  • 2
    • 0036152352 scopus 로고    scopus 로고
    • Presentation, treatment, and outcome of oral cavity cancer: A National Cancer Data Base report
    • Funk GF, Karnell LH, Robinson RA, Zhen WK, Trask DK, Hoffman HT. Presentation, treatment, and outcome of oral cavity cancer: A National Cancer Data Base report. Head Neck 2002; 24: 165-180.
    • (2002) Head Neck , vol.24 , pp. 165-180
    • Funk, G.F.1    Karnell, L.H.2    Robinson, R.A.3    Zhen, W.K.4    Trask, D.K.5    Hoffman, H.T.6
  • 3
    • 38149007268 scopus 로고    scopus 로고
    • Molecular pathogenesis of oral squamous cell carcinoma: Implications for therapy
    • Choi S, Myers JN. Molecular pathogenesis of oral squamous cell carcinoma: Implications for therapy. J Dent Res 2008; 87: 14-32.
    • (2008) J Dent Res , vol.87 , pp. 14-32
    • Choi, S.1    Myers, J.N.2
  • 4
    • 33846858391 scopus 로고    scopus 로고
    • Establishment of a murine model of bone invasion by oral squamous cell carcinoma
    • Nomura T, Shibahara T, Katakura A, Matsubara S, Takano N. Establishment of a murine model of bone invasion by oral squamous cell carcinoma. Oral Oncol 2007; 43: 257-262.
    • (2007) Oral Oncol , vol.43 , pp. 257-262
    • Nomura, T.1    Shibahara, T.2    Katakura, A.3    Matsubara, S.4    Takano, N.5
  • 5
    • 33751585152 scopus 로고    scopus 로고
    • Differential expression and activation of NF-kappaB family proteins during oral carcinogenesis: Role of high risk human papillomavirus infection
    • Mishra A, Bharti AC, Varghese P, Saluja D, Das BC. Differential expression and activation of NF-kappaB family proteins during oral carcinogenesis: Role of high risk human papillomavirus infection. Int J Cancer 2006; 119: 2840-2850.
    • (2006) Int J Cancer , vol.119 , pp. 2840-2850
    • Mishra, A.1    Bharti, A.C.2    Varghese, P.3    Saluja, D.4    Das, B.C.5
  • 6
    • 0035882576 scopus 로고    scopus 로고
    • Role of HGF/c-met system in invasion and metastasis of oral squamous cell carcinoma cells in vitro and its clinical significance
    • Uchida D, Kawamata H, Omotehara F, Nakashiro K, Kimura-Yanagawa T, Hino S et al. Role of HGF/c-met system in invasion and metastasis of oral squamous cell carcinoma cells in vitro and its clinical significance. Int J Cancer 2001; 93: 489-496.
    • (2001) Int J Cancer , vol.93 , pp. 489-496
    • Uchida, D.1    Kawamata, H.2    Omotehara, F.3    Nakashiro, K.4    Kimura-Yanagawa, T.5    Hino, S.6
  • 7
    • 13044316551 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    • Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E et al. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 1999; 96: 3540-3545.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3540-3545
    • Hsu, H.1    Lacey, D.L.2    Dunstan, C.R.3    Solovyev, I.4    Colombero, A.5    Timms, E.6
  • 9
    • 21144438505 scopus 로고    scopus 로고
    • MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL
    • Lynch CC, Hikosaka A, Acuff HB, Martin MD, Kawai N, Singh RK et al. MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell 2005; 7: 485-496.
    • (2005) Cancer Cell , vol.7 , pp. 485-496
    • Lynch, C.C.1    Hikosaka, A.2    Acuff, H.B.3    Martin, M.D.4    Kawai, N.5    Singh, R.K.6
  • 10
    • 79957939457 scopus 로고    scopus 로고
    • The cellular and molecular mechanisms of bone invasion by oral squamous cell carcinoma
    • Jimi E, Furuta H, Matsuo K, Tominaga K, Takahashi T, Nakanishi O. The cellular and molecular mechanisms of bone invasion by oral squamous cell carcinoma. Oral Dis 2011; 17: 462-468.
    • (2011) Oral Dis , vol.17 , pp. 462-468
    • Jimi, E.1    Furuta, H.2    Matsuo, K.3    Tominaga, K.4    Takahashi, T.5    Nakanishi, O.6
  • 11
    • 0034144269 scopus 로고    scopus 로고
    • Chemokines: A new classification system and their role in immunity
    • Zlotnik A, Yoshie O. Chemokines: A new classification system and their role in immunity. Immunity 2000; 12: 121-127.
    • (2000) Immunity , vol.12 , pp. 121-127
    • Zlotnik, A.1    Yoshie, O.2
  • 13
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001; 410: 50-56.
    • (2001) Nature , vol.410 , pp. 50-56
    • Muller, A.1    Homey, B.2    Soto, H.3    Ge, N.4    Catron, D.5    Buchanan, M.E.6
  • 14
    • 0032536373 scopus 로고    scopus 로고
    • B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
    • Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med 1998; 187: 655-660.
    • (1998) J Exp Med , vol.187 , pp. 655-660
    • Legler, D.F.1    Loetscher, M.2    Roos, R.S.3    Clark-Lewis, I.4    Baggiolini, M.5    Moser, B.6
  • 15
    • 1642462940 scopus 로고    scopus 로고
    • IL1beta and TNFalpha differently modulate CXCL13 chemokine in stromal cells and osteoblasts isolated from osteoarthritis patients: Evidence of changes associated to cell maturation
    • Lisignoli G, Cristino S, Toneguzzi S, Grassi F, Piacentini A, Cavallo C et al. IL1beta and TNFalpha differently modulate CXCL13 chemokine in stromal cells and osteoblasts isolated from osteoarthritis patients: Evidence of changes associated to cell maturation. Exp Gerontol 2004; 39: 659-665.
    • (2004) Exp Gerontol , vol.39 , pp. 659-665
    • Lisignoli, G.1    Cristino, S.2    Toneguzzi, S.3    Grassi, F.4    Piacentini, A.5    Cavallo, C.6
  • 16
    • 67650429727 scopus 로고    scopus 로고
    • Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion
    • Singh S, Singh R, Sharma PK, Singh UP, Rai SN, Chung LW et al. Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion. Cancer Lett 2009; 283: 29-35.
    • (2009) Cancer Lett , vol.283 , pp. 29-35
    • Singh, S.1    Singh, R.2    Sharma, P.K.3    Singh, U.P.4    Rai, S.N.5    Chung, L.W.6
  • 17
    • 33645668431 scopus 로고    scopus 로고
    • Chemokine receptors in head and neck cancer: Association with metastatic spread and regulation during chemotherapy
    • Muller A, Sonkoly E, Eulert C, Gerber PA, Kubitza R, Schirlau K et al. Chemokine receptors in head and neck cancer: Association with metastatic spread and regulation during chemotherapy. Int J Cancer 2006; 118: 2147-2157.
    • (2006) Int J Cancer , vol.118 , pp. 2147-2157
    • Muller, A.1    Sonkoly, E.2    Eulert, C.3    Gerber, P.A.4    Kubitza, R.5    Schirlau, K.6
  • 18
    • 33750704289 scopus 로고    scopus 로고
    • Identification of a gene signature for rapid screening of oral squamous cell carcinoma
    • Ziober AF, Patel KR, Alawi F, Gimotty P, Weber RS, Feldman MM et al. Identification of a gene signature for rapid screening of oral squamous cell carcinoma. Clin Cancer Res 2006; 12: 5960-5971.
    • (2006) Clin Cancer Res , vol.12 , pp. 5960-5971
    • Ziober, A.F.1    Patel, K.R.2    Alawi, F.3    Gimotty, P.4    Weber, R.S.5    Feldman, M.M.6
  • 19
    • 34249807326 scopus 로고    scopus 로고
    • A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma
    • Vachani A, Nebozhyn M, Singhal S, Alila L, Wakeam E, Muschel R et al. A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma. Clin Cancer Res 2007; 13: 2905-2915.
    • (2007) Clin Cancer Res , vol.13 , pp. 2905-2915
    • Vachani, A.1    Nebozhyn, M.2    Singhal, S.3    Alila, L.4    Wakeam, E.5    Muschel, R.6
  • 20
    • 69449094082 scopus 로고    scopus 로고
    • A novel function of CXCL13 to stimulate RANK ligand expression in oral squamous cell carcinoma cells
    • Yuvaraj S, Griffin AC, Sundaram K, Kirkwood KL, Norris JS, Reddy SV. A novel function of CXCL13 to stimulate RANK ligand expression in oral squamous cell carcinoma cells. Mol Cancer Res 2009; 7: 1399-1407.
    • (2009) Mol Cancer Res , vol.7 , pp. 1399-1407
    • Yuvaraj, S.1    Griffin, A.C.2    Sundaram, K.3    Kirkwood, K.L.4    Norris, J.S.5    Reddy, S.V.6
  • 21
    • 77951249158 scopus 로고    scopus 로고
    • Role of CXC chemokine ligand 13 in oral squamous cell carcinoma associated osteolysis in athymic mice
    • Pandruvada SN, Yuvaraj S, Liu X, Sundaram K, Shanmugarajan S, Ries WL et al. Role of CXC chemokine ligand 13 in oral squamous cell carcinoma associated osteolysis in athymic mice. Int J Cancer 2010; 126: 2319-2329.
    • (2010) Int J Cancer , vol.126 , pp. 2319-2329
    • Pandruvada, S.N.1    Yuvaraj, S.2    Liu, X.3    Sundaram, K.4    Shanmugarajan, S.5    Ries, W.L.6
  • 22
    • 0036198604 scopus 로고    scopus 로고
    • SV40T antigen and telomerase are required to obtain immortalized human adult bone cells without loss of the differentiated phenotype
    • Darimont C, Avanti O, Tromvoukis Y, Vautravers-Leone P, Kurihara N, Roodman GD et al. SV40T antigen and telomerase are required to obtain immortalized human adult bone cells without loss of the differentiated phenotype. Cell Growth Differ 2002; 13: 59-67.
    • (2002) Cell Growth Differ , vol.13 , pp. 59-67
    • Darimont, C.1    Avanti, O.2    Tromvoukis, Y.3    Vautravers-Leone, P.4    Kurihara, N.5    Roodman, G.D.6
  • 23
    • 1642410788 scopus 로고    scopus 로고
    • Functional role for heat shock factors in the transcriptional regulation of human RANK ligand gene expression in stromal/osteoblast cells
    • Roccisana JL, Kawanabe N, Kajiya H, Koide M, Roodman GD, Reddy SV. Functional role for heat shock factors in the transcriptional regulation of human RANK ligand gene expression in stromal/osteoblast cells. J Biol Chem 2004; 279: 10500-10507.
    • (2004) J Biol Chem , vol.279 , pp. 10500-10507
    • Roccisana, J.L.1    Kawanabe, N.2    Kajiya, H.3    Koide, M.4    Roodman, G.D.5    Reddy, S.V.6
  • 24
    • 33745821237 scopus 로고    scopus 로고
    • Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation
    • Chen G, Sircar K, Aprikian A, Potti A, Goltzman D, Rabbani SA. Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation. Cancer 2006; 107: 289-298.
    • (2006) Cancer , vol.107 , pp. 289-298
    • Chen, G.1    Sircar, K.2    Aprikian, A.3    Potti, A.4    Goltzman, D.5    Rabbani, S.A.6
  • 25
    • 67650924224 scopus 로고    scopus 로고
    • Increased RANKL expression is related to tumour migration and metastasis of renal cell carcinomas
    • Mikami S, Katsube K, Oya M, Ishida M, Kosaka T, Mizuno R et al. Increased RANKL expression is related to tumour migration and metastasis of renal cell carcinomas. J Pathol 2009; 218: 530-539.
    • (2009) J Pathol , vol.218 , pp. 530-539
    • Mikami, S.1    Katsube, K.2    Oya, M.3    Ishida, M.4    Kosaka, T.5    Mizuno, R.6
  • 26
    • 79952193038 scopus 로고    scopus 로고
    • Tumourinfiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling
    • Tan W, Zhang W, Strasner A, Grivennikov S, Cheng JQ, Hoffman RM et al. Tumourinfiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature 2011; 470: 548-553.
    • (2011) Nature , vol.470 , pp. 548-553
    • Tan, W.1    Zhang, W.2    Strasner, A.3    Grivennikov, S.4    Cheng, J.Q.5    Hoffman, R.M.6
  • 27
    • 0037211817 scopus 로고    scopus 로고
    • Human osteoblasts express functional CXC chemokine receptors 3 and 5: Activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release
    • Lisignoli G, Toneguzzi S, Piacentini A, Cattini L, Lenti A, Tschon M et al. Human osteoblasts express functional CXC chemokine receptors 3 and 5: Activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release. J Cell Physiol 2003; 194: 71-79.
    • (2003) J Cell Physiol , vol.194 , pp. 71-79
    • Lisignoli, G.1    Toneguzzi, S.2    Piacentini, A.3    Cattini, L.4    Lenti, A.5    Tschon, M.6
  • 28
    • 79959765107 scopus 로고    scopus 로고
    • CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation
    • El-Haibi CP, Singh R, Sharma PK, Singh S, Lillard Jr. JW. CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation. Cell Prolif 2011; 44: 311-319.
    • (2011) Cell Prolif , vol.44 , pp. 311-319
    • El-Haibi, C.P.1    Singh, R.2    Sharma, P.K.3    Singh, S.4    Lillard Jr., J.W.5
  • 30
    • 33748757159 scopus 로고    scopus 로고
    • Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors
    • Marampon F, Ciccarelli C, Zani BM. Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors. Mol Cancer 2006; 5: 31.
    • (2006) Mol Cancer , vol.5 , pp. 31
    • Marampon, F.1    Ciccarelli, C.2    Zani, B.M.3
  • 31
    • 0034937704 scopus 로고    scopus 로고
    • Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology
    • Hofbauer LC, Heufelder AE. Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology. J Mol Med 2001; 79: 243-253.
    • (2001) J Mol Med , vol.79 , pp. 243-253
    • Hofbauer, L.C.1    Heufelder, A.E.2
  • 32
    • 0036721615 scopus 로고    scopus 로고
    • 25(OH)2 vitamin D3-stimulated osteoclast formation in spleen-osteoblast cocultures is mediated in part by enhanced IL-1 alpha and receptor activator of NF-kappa B ligand production in osteoblasts
    • Lee SK, Kalinowski J, Jastrzebski S, Lorenzo JA. 1,25(OH)2 vitamin D3-stimulated osteoclast formation in spleen-osteoblast cocultures is mediated in part by enhanced IL-1 alpha and receptor activator of NF-kappa B ligand production in osteoblasts. J Immunol 2002; 169: 2374-2380.
    • (2002) J Immunol , vol.1 , Issue.169 , pp. 2374-2380
    • Lee, S.K.1    Kalinowski, J.2    Jastrzebski, S.3    Lorenzo, J.A.4
  • 33
    • 0034618580 scopus 로고    scopus 로고
    • Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: Modulation of the expression by osteotropic factors and cytokines
    • Nakashima T, Kobayashi Y, Yamasaki S, Kawakami A, Eguchi K, Sasaki H et al. Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: Modulation of the expression by osteotropic factors and cytokines. Biochem Biophys Res Commun 2000; 275: 768-775.
    • (2000) Biochem Biophys Res Commun , vol.275 , pp. 768-775
    • Nakashima, T.1    Kobayashi, Y.2    Yamasaki, S.3    Kawakami, A.4    Eguchi, K.5    Sasaki, H.6
  • 34
    • 76149087471 scopus 로고    scopus 로고
    • Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: Significance of interleukin-6 synthesized by stromal cells in response to cancer cells
    • Kayamori K, Sakamoto K, Nakashima T, Takayanagi H, Morita K, Omura K et al. Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells. Am J Pathol 2010; 176: 968-980.
    • (2010) Am J Pathol , vol.176 , pp. 968-980
    • Kayamori, K.1    Sakamoto, K.2    Nakashima, T.3    Takayanagi, H.4    Morita, K.5    Omura, K.6
  • 35
    • 2342631887 scopus 로고    scopus 로고
    • The high rate of bone resorption in multiple myeloma is due to RANK (receptor activator of nuclear factor-kappaB) and RANK ligand expression
    • Roux S, Mariette X. The high rate of bone resorption in multiple myeloma is due to RANK (receptor activator of nuclear factor-kappaB) and RANK ligand expression. Leuk Lymphoma 2004; 45: 1111-1118.
    • (2004) Leuk Lymphoma , vol.45 , pp. 1111-1118
    • Roux, S.1    Mariette, X.2
  • 36
    • 49149106876 scopus 로고    scopus 로고
    • Significance of the fibrous stroma in bone invasion by human gingival squamous cell carcinomas
    • Ishikuro M, Sakamoto K, Kayamori K, Akashi T, Kanda H, Izumo T et al. Significance of the fibrous stroma in bone invasion by human gingival squamous cell carcinomas. Bone 2008; 43: 621-627.
    • (2008) Bone , vol.43 , pp. 621-627
    • Ishikuro, M.1    Sakamoto, K.2    Kayamori, K.3    Akashi, T.4    Kanda, H.5    Izumo, T.6
  • 37
    • 69249094919 scopus 로고    scopus 로고
    • Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase- 9, contributes to tumor-induced osteolysis
    • Thiolloy S, Halpern J, Holt GE, Schwartz HS, Mundy GR, Matrisian LM et al. Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase- 9, contributes to tumor-induced osteolysis. Cancer Res 2009; 69: 6747-6755.
    • (2009) Cancer Res , vol.69 , pp. 6747-6755
    • Thiolloy, S.1    Halpern, J.2    Holt, G.E.3    Schwartz, H.S.4    Mundy, G.R.5    Matrisian, L.M.6
  • 38
    • 48649097728 scopus 로고    scopus 로고
    • Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand
    • Wilson TJ, Nannuru KC, Futakuchi M, Sadanandam A, Singh RK. Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand. Cancer Res 2008; 68: 5803-5811.
    • (2008) Cancer Res , vol.68 , pp. 5803-5811
    • Wilson, T.J.1    Nannuru, K.C.2    Futakuchi, M.3    Sadanandam, A.4    Singh, R.K.5
  • 40
    • 33747616250 scopus 로고    scopus 로고
    • Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway
    • Buchholz M, Schatz A, Wagner M, Michl P, Linhart T, Adler G et al. Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. EMBO J 2006; 25: 3714-3724.
    • (2006) EMBO J , vol.25 , pp. 3714-3724
    • Buchholz, M.1    Schatz, A.2    Wagner, M.3    Michl, P.4    Linhart, T.5    Adler, G.6
  • 41
    • 36349002340 scopus 로고    scopus 로고
    • Myc stimulates B lymphocyte differentiation and amplifies calcium signaling
    • Habib T, Park H, Tsang M, de Alboran IM, Nicks A, Wilson L et al. Myc stimulates B lymphocyte differentiation and amplifies calcium signaling. J Cell Biol 2007; 179: 717-731.
    • (2007) J Cell Biol , vol.179 , pp. 717-731
    • Habib, T.1    Park, H.2    Tsang, M.3    De Alboran, I.M.4    Nicks, A.5    Wilson, L.6
  • 42
    • 77956258205 scopus 로고    scopus 로고
    • Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation
    • Singh G, Singh SK, Konig A, Reutlinger K, Nye MD, Adhikary T et al. Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation. J Biol Chem 2010; 285: 27241-27250.
    • (2010) J Biol Chem , vol.285 , pp. 27241-27250
    • Singh, G.1    Singh, S.K.2    Konig, A.3    Reutlinger, K.4    Nye, M.D.5    Adhikary, T.6
  • 44
    • 34548820978 scopus 로고    scopus 로고
    • Dissecting the Akt/mammalian target of rapamycin signaling network: Emerging results from the head and neck cancer tissue array initiative
    • Molinolo AA, Hewitt SM, Amornphimoltham P, Keelawat S, Rangdaeng S, Meneses Garcia A et al. Dissecting the Akt/mammalian target of rapamycin signaling network: Emerging results from the head and neck cancer tissue array initiative. Clin Cancer Res 2007; 13: 4964-4973.
    • (2007) Clin Cancer Res , vol.13 , pp. 4964-4973
    • Molinolo, A.A.1    Hewitt, S.M.2    Amornphimoltham, P.3    Keelawat, S.4    Rangdaeng, S.5    Meneses Garcia, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.