-
1
-
-
81055144784
-
Autophagy: renovation of cells and tissues
-
Mizushima N., Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011, 147:728-741.
-
(2011)
Cell
, vol.147
, pp. 728-741
-
-
Mizushima, N.1
Komatsu, M.2
-
2
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B., Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132:27-42.
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
3
-
-
84866122688
-
Autophagy modulation as a potential therapeutic target for diverse diseases
-
Rubinsztein D.C., et al. Autophagy modulation as a potential therapeutic target for diverse diseases. Nat. Rev. Drug Discov. 2012, 11:709-730.
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 709-730
-
-
Rubinsztein, D.C.1
-
4
-
-
33745713171
-
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
-
Degenhardt K., et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006, 10:51-64.
-
(2006)
Cancer Cell
, vol.10
, pp. 51-64
-
-
Degenhardt, K.1
-
5
-
-
66449099090
-
Autophagy suppresses tumorigenesis through elimination of p62
-
Mathew R., et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009, 137:1062-1075.
-
(2009)
Cell
, vol.137
, pp. 1062-1075
-
-
Mathew, R.1
-
6
-
-
84865147552
-
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments
-
Wojtkowiak J.W., et al. Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Cancer Res. 2012, 72:3938-3947.
-
(2012)
Cancer Res.
, vol.72
, pp. 3938-3947
-
-
Wojtkowiak, J.W.1
-
7
-
-
79951847989
-
Principles and current strategies for targeting autophagy for cancer treatment
-
Amaravadi R.K., et al. Principles and current strategies for targeting autophagy for cancer treatment. Clin. Cancer Res. 2011, 17:654-666.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 654-666
-
-
Amaravadi, R.K.1
-
8
-
-
78751556979
-
Autophagy as a therapeutic target in cancer
-
Chen N., Karantza V. Autophagy as a therapeutic target in cancer. Cancer Biol. Ther. 2011, 11:157-168.
-
(2011)
Cancer Biol. Ther.
, vol.11
, pp. 157-168
-
-
Chen, N.1
Karantza, V.2
-
9
-
-
84864805916
-
Autophagy and cancer - issues we need to digest
-
Liu E.Y., Ryan K.M. Autophagy and cancer - issues we need to digest. J. Cell Sci. 2012, 125:2349-2358.
-
(2012)
J. Cell Sci.
, vol.125
, pp. 2349-2358
-
-
Liu, E.Y.1
Ryan, K.M.2
-
10
-
-
84861526009
-
Deconvoluting the context-dependent role for autophagy in cancer
-
White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat. Rev. Cancer 2012, 12:401-410.
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 401-410
-
-
White, E.1
-
11
-
-
79251577061
-
The regulation of autophagy - unanswered questions
-
Chen Y., Klionsky D.J. The regulation of autophagy - unanswered questions. J. Cell Sci. 2011, 124:161-170.
-
(2011)
J. Cell Sci.
, vol.124
, pp. 161-170
-
-
Chen, Y.1
Klionsky, D.J.2
-
12
-
-
84855500993
-
Autophagy: for better or for worse
-
Wirawan E., et al. Autophagy: for better or for worse. Cell Res. 2012, 22:43-61.
-
(2012)
Cell Res.
, vol.22
, pp. 43-61
-
-
Wirawan, E.1
-
13
-
-
33947250696
-
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
-
Liang J., et al. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat. Cell Biol. 2007, 9:218-224.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 218-224
-
-
Liang, J.1
-
14
-
-
47249157360
-
Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum
-
Sakaki K., et al. Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum. J. Biol. Chem. 2008, 283:15370-15380.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 15370-15380
-
-
Sakaki, K.1
-
15
-
-
43649104579
-
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
-
Zhang H., et al. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J. Biol. Chem. 2008, 283:10892-10903.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 10892-10903
-
-
Zhang, H.1
-
16
-
-
77953699711
-
Termination of autophagy and reformation of lysosomes regulated by mTOR
-
Yu L., et al. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 2010, 465:942-946.
-
(2010)
Nature
, vol.465
, pp. 942-946
-
-
Yu, L.1
-
17
-
-
9144240441
-
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
-
Qu X., et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest. 2003, 112:1809-1820.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1809-1820
-
-
Qu, X.1
-
18
-
-
33745751085
-
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
-
Liang C., et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat. Cell Biol. 2006, 8:688-699.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 688-699
-
-
Liang, C.1
-
19
-
-
34848899280
-
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
-
Takahashi Y., et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat. Cell Biol. 2007, 9:1142-1151.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 1142-1151
-
-
Takahashi, Y.1
-
20
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
Yue Z., et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:15077-15082.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 15077-15082
-
-
Yue, Z.1
-
21
-
-
79955377420
-
Autophagy-deficient mice develop multiple liver tumors
-
Takamura A., et al. Autophagy-deficient mice develop multiple liver tumors. Genes Dev. 2011, 25:795-800.
-
(2011)
Genes Dev.
, vol.25
, pp. 795-800
-
-
Takamura, A.1
-
22
-
-
0026709013
-
Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms
-
Futreal P.A., et al. Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms. Cancer Res. 1992, 52:2624-2627.
-
(1992)
Cancer Res.
, vol.52
, pp. 2624-2627
-
-
Futreal, P.A.1
-
23
-
-
0030008911
-
Frequent microsatellite instability in epithelial borderline ovarian tumors
-
Tangir J., et al. Frequent microsatellite instability in epithelial borderline ovarian tumors. Cancer Res. 1996, 56:2501-2505.
-
(1996)
Cancer Res.
, vol.56
, pp. 2501-2505
-
-
Tangir, J.1
-
24
-
-
0028911287
-
Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q in human prostate cancer
-
Gao X., et al. Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q in human prostate cancer. Cancer Res. 1995, 55:1002-1005.
-
(1995)
Cancer Res.
, vol.55
, pp. 1002-1005
-
-
Gao, X.1
-
25
-
-
80053501671
-
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13
-
Liu J., et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 2011, 147:223-234.
-
(2011)
Cell
, vol.147
, pp. 223-234
-
-
Liu, J.1
-
26
-
-
84865626729
-
The effects of Nrf2 on tumor angiogenesis: a review of the possible mechanisms of action
-
Zhou S., et al. The effects of Nrf2 on tumor angiogenesis: a review of the possible mechanisms of action. Crit. Rev. Eukaryot. Gene Expr. 2012, 22:149-160.
-
(2012)
Crit. Rev. Eukaryot. Gene Expr.
, vol.22
, pp. 149-160
-
-
Zhou, S.1
-
27
-
-
84866932320
-
ER stress-induced inflammation: does it aid or impede disease progression?
-
Garg A.D., et al. ER stress-induced inflammation: does it aid or impede disease progression?. Trends Mol. Med. 2012, 18:589-598.
-
(2012)
Trends Mol. Med.
, vol.18
, pp. 589-598
-
-
Garg, A.D.1
-
28
-
-
84868567192
-
When autophagy meets cancer through p62/SQSTM1
-
Puissant A., et al. When autophagy meets cancer through p62/SQSTM1. Am. J. Cancer Res. 2012, 2:397-413.
-
(2012)
Am. J. Cancer Res.
, vol.2
, pp. 397-413
-
-
Puissant, A.1
-
29
-
-
84861939463
-
P62: a versatile multitasker takes on cancer
-
Moscat J., Diaz-Meco M.T. p62: a versatile multitasker takes on cancer. Trends Biochem. Sci. 2012, 37:230-236.
-
(2012)
Trends Biochem. Sci.
, vol.37
, pp. 230-236
-
-
Moscat, J.1
Diaz-Meco, M.T.2
-
30
-
-
41249084239
-
The signaling adaptor p62 is an important NF-κB mediator in tumorigenesis
-
Duran A., et al. The signaling adaptor p62 is an important NF-κB mediator in tumorigenesis. Cancer Cell 2008, 13:343-354.
-
(2008)
Cancer Cell
, vol.13
, pp. 343-354
-
-
Duran, A.1
-
31
-
-
84870546460
-
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth
-
Hart L.S., et al. ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J. Clin. Invest. 2012, 122:4621-4634.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 4621-4634
-
-
Hart, L.S.1
-
32
-
-
64349123107
-
Autophagy mediates the mitotic senescence transition
-
Young A.R., et al. Autophagy mediates the mitotic senescence transition. Genes Dev. 2009, 23:798-803.
-
(2009)
Genes Dev.
, vol.23
, pp. 798-803
-
-
Young, A.R.1
-
33
-
-
12944303650
-
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
-
Lum J.J., et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 2005, 120:237-248.
-
(2005)
Cell
, vol.120
, pp. 237-248
-
-
Lum, J.J.1
-
34
-
-
79952229430
-
Pancreatic cancers require autophagy for tumor growth
-
Yang S., et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011, 25:717-729.
-
(2011)
Genes Dev.
, vol.25
, pp. 717-729
-
-
Yang, S.1
-
35
-
-
79952228407
-
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
-
Guo J.Y., et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 2011, 25:460-470.
-
(2011)
Genes Dev.
, vol.25
, pp. 460-470
-
-
Guo, J.Y.1
-
36
-
-
78751511180
-
Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
-
Lock R., et al. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol. Biol. Cell 2011, 22:165-178.
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 165-178
-
-
Lock, R.1
-
37
-
-
84855439046
-
Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation
-
Wu S.Y., et al. Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation. Neoplasia 2011, 13:1171-1182.
-
(2011)
Neoplasia
, vol.13
, pp. 1171-1182
-
-
Wu, S.Y.1
-
38
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones S., et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008, 321:1801-1806.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
-
39
-
-
80054686286
-
Tumor metastasis: molecular insights and evolving paradigms
-
Valastyan S., Weinberg R.A. Tumor metastasis: molecular insights and evolving paradigms. Cell 2011, 147:275-292.
-
(2011)
Cell
, vol.147
, pp. 275-292
-
-
Valastyan, S.1
Weinberg, R.A.2
-
40
-
-
81855169964
-
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
-
Kang T.W., et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 2011, 479:547-551.
-
(2011)
Nature
, vol.479
, pp. 547-551
-
-
Kang, T.W.1
-
41
-
-
41449109334
-
Induction of autophagy during extracellular matrix detachment promotes cell survival
-
Fung C., et al. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol. Biol. Cell 2008, 19:797-806.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 797-806
-
-
Fung, C.1
-
42
-
-
79956003662
-
Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma
-
Ma X.H., et al. Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma. Clin. Cancer Res. 2011, 17:3478-3489.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 3478-3489
-
-
Ma, X.H.1
-
43
-
-
84856003912
-
Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome
-
Lazova R., et al. Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome. Clin. Cancer Res. 2012, 18:370-379.
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 370-379
-
-
Lazova, R.1
-
44
-
-
84863578884
-
DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer
-
Lv Q., et al. DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer. Cancer Res. 2012, 72:3238-3250.
-
(2012)
Cancer Res.
, vol.72
, pp. 3238-3250
-
-
Lv, Q.1
-
45
-
-
57449121645
-
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
-
Lu Z., et al. The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. J. Clin. Invest. 2008, 118:3917-3929.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3917-3929
-
-
Lu, Z.1
-
46
-
-
79953306808
-
Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival
-
Elgendy M., et al. Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol. Cell 2011, 42:23-35.
-
(2011)
Mol. Cell
, vol.42
, pp. 23-35
-
-
Elgendy, M.1
-
47
-
-
77952568396
-
Hallmarks of cancer: interactions with the tumor stroma
-
Pietras K., Ostman A. Hallmarks of cancer: interactions with the tumor stroma. Exp. Cell Res. 2010, 316:1324-1331.
-
(2010)
Exp. Cell Res.
, vol.316
, pp. 1324-1331
-
-
Pietras, K.1
Ostman, A.2
-
48
-
-
83755181759
-
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice
-
Michaud M., et al. Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science 2011, 334:1573-1577.
-
(2011)
Science
, vol.334
, pp. 1573-1577
-
-
Michaud, M.1
-
49
-
-
75349083568
-
Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation
-
Garg A.D., et al. Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation. Biochim. Biophys. Acta 2010, 1805:53-71.
-
(2010)
Biochim. Biophys. Acta
, vol.1805
, pp. 53-71
-
-
Garg, A.D.1
-
50
-
-
82455210868
-
Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β
-
Dupont N., et al. Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β. EMBO J. 2011, 30:4701-4711.
-
(2011)
EMBO J.
, vol.30
, pp. 4701-4711
-
-
Dupont, N.1
-
51
-
-
84865293299
-
Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity
-
Townsend K.N., et al. Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity. Immunol. Rev. 2012, 249:176-194.
-
(2012)
Immunol. Rev.
, vol.249
, pp. 176-194
-
-
Townsend, K.N.1
-
52
-
-
84859386792
-
Autophagy and the immune system
-
Kuballa P., et al. Autophagy and the immune system. Annu. Rev. Immunol. 2012, 30:611-646.
-
(2012)
Annu. Rev. Immunol.
, vol.30
, pp. 611-646
-
-
Kuballa, P.1
-
53
-
-
78751672975
-
Autophagy in immunity and inflammation
-
Levine B., et al. Autophagy in immunity and inflammation. Nature 2011, 469:323-335.
-
(2011)
Nature
, vol.469
, pp. 323-335
-
-
Levine, B.1
-
54
-
-
79951642032
-
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
-
Nakahira K., et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 2011, 12:222-230.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 222-230
-
-
Nakahira, K.1
-
55
-
-
84855465222
-
Role of autophagy in angiogenesis in aortic endothelial cells
-
Du J., et al. Role of autophagy in angiogenesis in aortic endothelial cells. Am. J. Physiol. Cell Physiol. 2012, 302:C383-C391.
-
(2012)
Am. J. Physiol. Cell Physiol.
, vol.302
-
-
Du, J.1
-
56
-
-
83955162908
-
High mobility group box 1 promotes endothelial cell angiogenic behavior in vitro and improves muscle perfusion in vivo in response to ischemic injury
-
Sachdev U., et al. High mobility group box 1 promotes endothelial cell angiogenic behavior in vitro and improves muscle perfusion in vivo in response to ischemic injury. J. Vasc. Surg. 2012, 55:180-191.
-
(2012)
J. Vasc. Surg.
, vol.55
, pp. 180-191
-
-
Sachdev, U.1
-
57
-
-
78649242978
-
HMGB1: a novel Beclin 1-binding protein active in autophagy
-
Kang R., et al. HMGB1: a novel Beclin 1-binding protein active in autophagy. Autophagy 2010, 6:1209-1211.
-
(2010)
Autophagy
, vol.6
, pp. 1209-1211
-
-
Kang, R.1
-
58
-
-
77949542302
-
The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival
-
Kang R., et al. The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival. Cell Death Differ. 2010, 17:666-676.
-
(2010)
Cell Death Differ.
, vol.17
, pp. 666-676
-
-
Kang, R.1
-
59
-
-
79961102995
-
Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis
-
Lee S.J., et al. Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis. Autophagy 2011, 7:829-839.
-
(2011)
Autophagy
, vol.7
, pp. 829-839
-
-
Lee, S.J.1
-
60
-
-
79953151458
-
Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
-
Schreiber R.D., et al. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 2011, 331:1565-1570.
-
(2011)
Science
, vol.331
, pp. 1565-1570
-
-
Schreiber, R.D.1
-
61
-
-
79956325949
-
Spatial coupling of mTOR and autophagy augments secretory phenotypes
-
Narita M., et al. Spatial coupling of mTOR and autophagy augments secretory phenotypes. Science 2011, 332:966-970.
-
(2011)
Science
, vol.332
, pp. 966-970
-
-
Narita, M.1
-
62
-
-
79960113933
-
A downside to apoptosis in cancer therapy?
-
Connell P.P., Weichselbaum R.R. A downside to apoptosis in cancer therapy?. Nat. Med. 2011, 17:780-782.
-
(2011)
Nat. Med.
, vol.17
, pp. 780-782
-
-
Connell, P.P.1
Weichselbaum, R.R.2
-
63
-
-
80052806536
-
Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression
-
Noman M.Z., et al. Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression. Cancer Res. 2011, 71:5976-5986.
-
(2011)
Cancer Res.
, vol.71
, pp. 5976-5986
-
-
Noman, M.Z.1
-
64
-
-
84879783969
-
ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death
-
( press)
-
Garg A.D., et al. ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death. Autophagy 2013, (in press).
-
(2013)
Autophagy
-
-
Garg, A.D.1
-
65
-
-
84866754237
-
An immunosurveillance mechanism controls cancer cell ploidy
-
Senovilla L., et al. An immunosurveillance mechanism controls cancer cell ploidy. Science 2012, 337:1678-1684.
-
(2012)
Science
, vol.337
, pp. 1678-1684
-
-
Senovilla, L.1
-
66
-
-
84876098009
-
Targeting ER stress induced apoptosis and inflammation in cancer
-
Verfaillie T., et al. Targeting ER stress induced apoptosis and inflammation in cancer. Cancer Lett. 2013, 332:249-264.
-
(2013)
Cancer Lett.
, vol.332
, pp. 249-264
-
-
Verfaillie, T.1
-
67
-
-
79959944026
-
Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?
-
De Bock K., et al. Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?. Nat. Rev. Clin. Oncol. 2011, 8:393-404.
-
(2011)
Nat. Rev. Clin. Oncol.
, vol.8
, pp. 393-404
-
-
De Bock, K.1
-
68
-
-
79961101955
-
Cancer cells metabolically 'fertilize' the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors
-
Martinez-Outschoorn U.E., et al. Cancer cells metabolically 'fertilize' the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors. Cell Cycle 2011, 10:2504-2520.
-
(2011)
Cell Cycle
, vol.10
, pp. 2504-2520
-
-
Martinez-Outschoorn, U.E.1
-
69
-
-
84862886876
-
Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production
-
Capparelli C., et al. Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Cell Cycle 2012, 11:2285-2302.
-
(2012)
Cell Cycle
, vol.11
, pp. 2285-2302
-
-
Capparelli, C.1
-
70
-
-
79954504372
-
Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment
-
Martinez-Outschoorn U.E., et al. Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment. Int. J. Biochem. Cell Biol. 2011, 43:1045-1051.
-
(2011)
Int. J. Biochem. Cell Biol.
, vol.43
, pp. 1045-1051
-
-
Martinez-Outschoorn, U.E.1
-
71
-
-
84865800743
-
Autophagy is a protective mechanism for human melanoma cells under acidic stress
-
Marino M.L., et al. Autophagy is a protective mechanism for human melanoma cells under acidic stress. J. Biol. Chem. 2012, 287:30664-30676.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 30664-30676
-
-
Marino, M.L.1
-
72
-
-
80053417028
-
Metformin inhibits melanoma development through autophagy and apoptosis mechanisms
-
Tomic T., et al. Metformin inhibits melanoma development through autophagy and apoptosis mechanisms. Cell Death Dis. 2011, 2:e199.
-
(2011)
Cell Death Dis.
, vol.2
-
-
Tomic, T.1
-
73
-
-
84859360525
-
Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
-
Shi W.Y., et al. Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy. Cell Death Dis. 2012, 3:e275.
-
(2012)
Cell Death Dis.
, vol.3
-
-
Shi, W.Y.1
-
74
-
-
50849110457
-
Prevention of cancer by inhibiting aging
-
Blagosklonny M.V. Prevention of cancer by inhibiting aging. Cancer Biol. Ther. 2008, 7:1520-1524.
-
(2008)
Cancer Biol. Ther.
, vol.7
, pp. 1520-1524
-
-
Blagosklonny, M.V.1
-
75
-
-
53549098864
-
Diet, autophagy, and cancer: a review
-
Singletary K., Milner J. Diet, autophagy, and cancer: a review. Cancer Epidemiol. Biomarkers Prev. 2008, 17:1596-1610.
-
(2008)
Cancer Epidemiol. Biomarkers Prev.
, vol.17
, pp. 1596-1610
-
-
Singletary, K.1
Milner, J.2
-
76
-
-
78650448754
-
Chemical modulators of autophagy as biological probes and potential therapeutics
-
Fleming A., et al. Chemical modulators of autophagy as biological probes and potential therapeutics. Nat. Chem. Biol. 2011, 7:9-17.
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 9-17
-
-
Fleming, A.1
-
77
-
-
77951233877
-
Targeting the autophagy pathway for cancer chemoprevention
-
Steeves M.A., et al. Targeting the autophagy pathway for cancer chemoprevention. Curr. Opin. Cell Biol. 2010, 22:218-225.
-
(2010)
Curr. Opin. Cell Biol.
, vol.22
, pp. 218-225
-
-
Steeves, M.A.1
-
78
-
-
84894656668
-
Moderate calorie restriction activates autophagy during tumor growth suppression
-
Dunlap S.M., et al. Moderate calorie restriction activates autophagy during tumor growth suppression. Cancer Res. 2012, 72:4104.
-
(2012)
Cancer Res.
, vol.72
, pp. 4104
-
-
Dunlap, S.M.1
-
79
-
-
80755132255
-
Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study
-
Shen S., et al. Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study. Oncogene 2011, 30:4544-4556.
-
(2011)
Oncogene
, vol.30
, pp. 4544-4556
-
-
Shen, S.1
-
80
-
-
67650745428
-
PUMA- and Bax-induced autophagy contributes to apoptosis
-
Yee K.S., et al. PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death Differ. 2009, 16:1135-1145.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 1135-1145
-
-
Yee, K.S.1
-
81
-
-
78649636176
-
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
-
Wirawan E., et al. Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis. 2010, 1:e18.
-
(2010)
Cell Death Dis.
, vol.1
-
-
Wirawan, E.1
-
82
-
-
84455172960
-
Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage
-
Lepine S., et al. Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage. J. Biol. Chem. 2011, 286:44380-44390.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 44380-44390
-
-
Lepine, S.1
-
83
-
-
84865155931
-
Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response
-
Pagliarini V., et al. Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response. Cell Death Differ. 2012, 19:1495-1504.
-
(2012)
Cell Death Differ.
, vol.19
, pp. 1495-1504
-
-
Pagliarini, V.1
-
84
-
-
84865128914
-
Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death
-
Oral O., et al. Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death. Apoptosis 2012, 17:810-820.
-
(2012)
Apoptosis
, vol.17
, pp. 810-820
-
-
Oral, O.1
-
85
-
-
69649090647
-
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis
-
Betin V.M., Lane J.D. Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. J. Cell Sci. 2009, 122:2554-2566.
-
(2009)
J. Cell Sci.
, vol.122
, pp. 2554-2566
-
-
Betin, V.M.1
Lane, J.D.2
-
86
-
-
79953652969
-
The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans
-
Ruck A., et al. The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans. Autophagy 2011, 7:386-400.
-
(2011)
Autophagy
, vol.7
, pp. 386-400
-
-
Ruck, A.1
-
87
-
-
80053392926
-
A critical role for UVRAG in apoptosis
-
Yin X., et al. A critical role for UVRAG in apoptosis. Autophagy 2011, 7:1242-1244.
-
(2011)
Autophagy
, vol.7
, pp. 1242-1244
-
-
Yin, X.1
-
88
-
-
84862295360
-
Guidelines for the use and interpretation of assays for monitoring autophagy
-
Klionsky D.J., et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012, 8:445-544.
-
(2012)
Autophagy
, vol.8
, pp. 445-544
-
-
Klionsky, D.J.1
-
89
-
-
33846794896
-
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
-
Amaravadi R.K., et al. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J. Clin. Invest. 2007, 117:326-336.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 326-336
-
-
Amaravadi, R.K.1
-
90
-
-
38149141767
-
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
-
Maclean K.H., et al. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J. Clin. Invest. 2008, 118:79-88.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 79-88
-
-
Maclean, K.H.1
-
91
-
-
78049260915
-
Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer
-
Jiang P.D., et al. Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. Biomed. Pharmacother. 2010, 64:609-614.
-
(2010)
Biomed. Pharmacother.
, vol.64
, pp. 609-614
-
-
Jiang, P.D.1
-
92
-
-
79956224883
-
Targeting autophagy during cancer therapy to improve clinical outcomes
-
Levy J.M., Thorburn A. Targeting autophagy during cancer therapy to improve clinical outcomes. Pharmacol. Ther. 2011, 131:130-141.
-
(2011)
Pharmacol. Ther.
, vol.131
, pp. 130-141
-
-
Levy, J.M.1
Thorburn, A.2
-
93
-
-
33847685719
-
Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme
-
Briceno E., et al. Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme. Surg. Neurol. 2007, 67:388-391.
-
(2007)
Surg. Neurol.
, vol.67
, pp. 388-391
-
-
Briceno, E.1
-
94
-
-
83755169511
-
Cancer. Autophagy in tumor immunity
-
Amaravadi R.K. Cancer. Autophagy in tumor immunity. Science 2011, 334:1501-1502.
-
(2011)
Science
, vol.334
, pp. 1501-1502
-
-
Amaravadi, R.K.1
-
95
-
-
84857267849
-
Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy
-
Maycotte P., et al. Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Autophagy 2012, 8:200-212.
-
(2012)
Autophagy
, vol.8
, pp. 200-212
-
-
Maycotte, P.1
-
96
-
-
79952217657
-
Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension
-
Lee S.J., et al. Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension. Am. J. Respir. Crit. Care Med. 2011, 183:649-658.
-
(2011)
Am. J. Respir. Crit. Care Med.
, vol.183
, pp. 649-658
-
-
Lee, S.J.1
-
97
-
-
0034650742
-
Vascular protection by chloroquine during brain tumor therapy with Tf-CRM107
-
Hagihara N., et al. Vascular protection by chloroquine during brain tumor therapy with Tf-CRM107. Cancer Res. 2000, 60:230-234.
-
(2000)
Cancer Res.
, vol.60
, pp. 230-234
-
-
Hagihara, N.1
-
98
-
-
74949118681
-
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
-
Rouschop K.M., et al. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J. Clin. Invest. 2010, 120:127-141.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 127-141
-
-
Rouschop, K.M.1
-
99
-
-
84861893781
-
Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression
-
Liang X., et al. Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression. Cancer Res. 2012, 72:2791-2801.
-
(2012)
Cancer Res.
, vol.72
, pp. 2791-2801
-
-
Liang, X.1
-
100
-
-
84870239310
-
Immunogenic cell death and DAMPs in cancer therapy
-
Krysko D.V., et al. Immunogenic cell death and DAMPs in cancer therapy. Nat. Rev. Cancer 2012, 12:860-875.
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 860-875
-
-
Krysko, D.V.1
-
101
-
-
84858000639
-
Enlightening the impact of immunogenic cell death in photodynamic cancer therapy
-
Galluzzi L., et al. Enlightening the impact of immunogenic cell death in photodynamic cancer therapy. EMBO J. 2012, 31:1055-1057.
-
(2012)
EMBO J.
, vol.31
, pp. 1055-1057
-
-
Galluzzi, L.1
-
102
-
-
84866904950
-
The emergence of phox-ER stress induced immunogenic apoptosis
-
Garg A.D., et al. The emergence of phox-ER stress induced immunogenic apoptosis. Oncoimmunology 2012, 1:786-788.
-
(2012)
Oncoimmunology
, vol.1
, pp. 786-788
-
-
Garg, A.D.1
-
103
-
-
84883785740
-
Inducers of immunogenic cancer cell death
-
Dudek A.M., et al. Inducers of immunogenic cancer cell death. Cytokine Growth Factor Rev. 2013, 10.1016/j.cytogfr.2013.01.005.
-
(2013)
Cytokine Growth Factor Rev.
-
-
Dudek, A.M.1
-
104
-
-
33846057130
-
Calreticulin exposure dictates the immunogenicity of cancer cell death
-
Obeid M., et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat. Med. 2007, 13:54-61.
-
(2007)
Nat. Med.
, vol.13
, pp. 54-61
-
-
Obeid, M.1
-
105
-
-
84857997683
-
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death
-
Garg A.D., et al. A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death. EMBO J. 2012, 31:1062-1079.
-
(2012)
EMBO J.
, vol.31
, pp. 1062-1079
-
-
Garg, A.D.1
-
106
-
-
84856696459
-
Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin
-
Garg A.D., et al. Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin. Cancer Immunol. Immunother. 2012, 61:215-221.
-
(2012)
Cancer Immunol. Immunother.
, vol.61
, pp. 215-221
-
-
Garg, A.D.1
-
107
-
-
70350569295
-
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β-dependent adaptive immunity against tumors
-
Ghiringhelli F., et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β-dependent adaptive immunity against tumors. Nat. Med. 2009, 15:1170-1178.
-
(2009)
Nat. Med.
, vol.15
, pp. 1170-1178
-
-
Ghiringhelli, F.1
-
108
-
-
34948820602
-
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
-
Apetoh L., et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat. Med. 2007, 13:1050-1059.
-
(2007)
Nat. Med.
, vol.13
, pp. 1050-1059
-
-
Apetoh, L.1
-
109
-
-
57649217868
-
Autophagy regulates selective HMGB1 release in tumor cells that are destined to die
-
Thorburn J., et al. Autophagy regulates selective HMGB1 release in tumor cells that are destined to die. Cell Death Differ. 2009, 16:175-183.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 175-183
-
-
Thorburn, J.1
-
110
-
-
77955038334
-
The epidermal growth factor receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1α and Bcl-2 and activating the beclin 1/hVps34 complex
-
Li X., Fan Z. The epidermal growth factor receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1α and Bcl-2 and activating the beclin 1/hVps34 complex. Cancer Res. 2010, 70:5942-5952.
-
(2010)
Cancer Res.
, vol.70
, pp. 5942-5952
-
-
Li, X.1
Fan, Z.2
-
111
-
-
84870701628
-
EGFR tyrosine kinase inhibition induces autophagy in cancer cells
-
Fung C., et al. EGFR tyrosine kinase inhibition induces autophagy in cancer cells. Cancer Biol. Ther. 2012, 13:1417-1424.
-
(2012)
Cancer Biol. Ther.
, vol.13
, pp. 1417-1424
-
-
Fung, C.1
-
112
-
-
34548190981
-
T cells are crucial for the anti-metastatic effect of anti-epidermal growth factor receptor antibodies
-
Garrido G., et al. T cells are crucial for the anti-metastatic effect of anti-epidermal growth factor receptor antibodies. Cancer Immunol. Immunother. 2007, 56:1701-1710.
-
(2007)
Cancer Immunol. Immunother.
, vol.56
, pp. 1701-1710
-
-
Garrido, G.1
-
113
-
-
84864128654
-
Cardiac glycosides exert anticancer effects by inducing immunogenic cell death
-
143ra199
-
Menger L., et al. Cardiac glycosides exert anticancer effects by inducing immunogenic cell death. Sci. Transl. Med. 2012, 4:143ra199.
-
(2012)
Sci. Transl. Med.
, vol.4
-
-
Menger, L.1
-
114
-
-
84860862890
-
Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1)
-
Yang H., et al. Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1). Mol. Med. 2012, 18:250-259.
-
(2012)
Mol. Med.
, vol.18
, pp. 250-259
-
-
Yang, H.1
-
115
-
-
84870858655
-
ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner
-
Fader C.M., et al. ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner. Autophagy 2012, 8:1741-1756.
-
(2012)
Autophagy
, vol.8
, pp. 1741-1756
-
-
Fader, C.M.1
-
116
-
-
52049102433
-
Efficient cross-presentation depends on autophagy in tumor cells
-
Li Y., et al. Efficient cross-presentation depends on autophagy in tumor cells. Cancer Res. 2008, 68:6889-6895.
-
(2008)
Cancer Res.
, vol.68
, pp. 6889-6895
-
-
Li, Y.1
-
118
-
-
84864318195
-
Chaperone-mediated autophagy: a unique way to enter the lysosome world
-
Kaushik S., Cuervo A.M. Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol. 2012, 22:407-417.
-
(2012)
Trends Cell Biol.
, vol.22
, pp. 407-417
-
-
Kaushik, S.1
Cuervo, A.M.2
-
119
-
-
79952355107
-
Selective autophagy mediated by autophagic adapter proteins
-
Johansen T., Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011, 7:279-296.
-
(2011)
Autophagy
, vol.7
, pp. 279-296
-
-
Johansen, T.1
Lamark, T.2
-
120
-
-
84871005673
-
The pathways of mitophagy for quality control and clearance of mitochondria
-
Ashrafi G., Schwarz T.L. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ. 2013, 20:31-42.
-
(2013)
Cell Death Differ.
, vol.20
, pp. 31-42
-
-
Ashrafi, G.1
Schwarz, T.L.2
-
121
-
-
84859161154
-
Microautophagy: lesser-known self-eating
-
Li W.W., et al. Microautophagy: lesser-known self-eating. Cell. Mol. Life Sci. 2012, 69:1125-1136.
-
(2012)
Cell. Mol. Life Sci.
, vol.69
, pp. 1125-1136
-
-
Li, W.W.1
-
122
-
-
40449086885
-
Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
-
Apel A., et al. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res. 2008, 68:1485-1494.
-
(2008)
Cancer Res.
, vol.68
, pp. 1485-1494
-
-
Apel, A.1
-
123
-
-
67650095390
-
The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells
-
Lomonaco S.L., et al. The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells. Int. J. Cancer 2009, 125:717-722.
-
(2009)
Int. J. Cancer
, vol.125
, pp. 717-722
-
-
Lomonaco, S.L.1
-
124
-
-
1842865745
-
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
-
Kanzawa T., et al. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ. 2004, 11:448-457.
-
(2004)
Cell Death Differ.
, vol.11
, pp. 448-457
-
-
Kanzawa, T.1
-
125
-
-
77955714496
-
Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma
-
Claerhout S., et al. Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma. Int. J. Cancer 2010, 127:2790-2803.
-
(2010)
Int. J. Cancer
, vol.127
, pp. 2790-2803
-
-
Claerhout, S.1
-
126
-
-
79952244140
-
Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells
-
Liu D., et al. Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells. Med. Oncol. 2011, 28:105-111.
-
(2011)
Med. Oncol.
, vol.28
, pp. 105-111
-
-
Liu, D.1
-
127
-
-
84866552377
-
Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species
-
Rubio N., et al. Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species. Autophagy 2012, 8:1312-1324.
-
(2012)
Autophagy
, vol.8
, pp. 1312-1324
-
-
Rubio, N.1
-
128
-
-
79957634644
-
Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage
-
Dewaele M., et al. Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage. J. Cell. Mol. Med. 2011, 15:1402-1414.
-
(2011)
J. Cell. Mol. Med.
, vol.15
, pp. 1402-1414
-
-
Dewaele, M.1
-
129
-
-
84866552686
-
ATG7 deficiency suppresses apoptosis and cell death induced by lysosomal photodamage
-
Kessel D.H., et al. ATG7 deficiency suppresses apoptosis and cell death induced by lysosomal photodamage. Autophagy 2012, 8:1333-1341.
-
(2012)
Autophagy
, vol.8
, pp. 1333-1341
-
-
Kessel, D.H.1
-
130
-
-
37349067228
-
Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells
-
Chen Y., et al. Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ. 2008, 15:171-182.
-
(2008)
Cell Death Differ.
, vol.15
, pp. 171-182
-
-
Chen, Y.1
-
131
-
-
54049151248
-
A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance
-
Samaddar J.S., et al. A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance. Mol. Cancer Ther. 2008, 7:2977-2987.
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 2977-2987
-
-
Samaddar, J.S.1
-
132
-
-
38049020942
-
Autophagy protects LNCaP cells under androgen deprivation conditions
-
Li M., et al. Autophagy protects LNCaP cells under androgen deprivation conditions. Autophagy 2008, 4:54-60.
-
(2008)
Autophagy
, vol.4
, pp. 54-60
-
-
Li, M.1
-
133
-
-
58749088233
-
Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells
-
Shingu T., et al. Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells. Int. J. Cancer 2009, 124:1060-1071.
-
(2009)
Int. J. Cancer
, vol.124
, pp. 1060-1071
-
-
Shingu, T.1
-
134
-
-
66449122303
-
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
-
Bellodi C., et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J. Clin. Invest. 2009, 119:1109-1123.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1109-1123
-
-
Bellodi, C.1
-
135
-
-
78650380694
-
Autophagy induction by Bcr-Abl-expressing cells facilitates their recovery from a targeted or nontargeted treatment
-
Crowley L.C., et al. Autophagy induction by Bcr-Abl-expressing cells facilitates their recovery from a targeted or nontargeted treatment. Am. J. Hematol. 2011, 86:38-47.
-
(2011)
Am. J. Hematol.
, vol.86
, pp. 38-47
-
-
Crowley, L.C.1
-
136
-
-
77956282607
-
Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST)
-
Gupta A., et al. Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST). Proc. Natl. Acad. Sci. U.S.A. 2010, 107:14333-14338.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 14333-14338
-
-
Gupta, A.1
-
137
-
-
77953383616
-
Autophagy blockade sensitizes prostate cancer cells towards Src family kinase inhibitors
-
Wu Z., et al. Autophagy blockade sensitizes prostate cancer cells towards Src family kinase inhibitors. Genes Cancer 2010, 1:40-49.
-
(2010)
Genes Cancer
, vol.1
, pp. 40-49
-
-
Wu, Z.1
-
138
-
-
80052380331
-
Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling
-
Wang K., et al. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy 2011, 7:966-978.
-
(2011)
Autophagy
, vol.7
, pp. 966-978
-
-
Wang, K.1
-
139
-
-
66249085237
-
The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib
-
Milani M., et al. The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib. Cancer Res. 2009, 69:4415-4423.
-
(2009)
Cancer Res.
, vol.69
, pp. 4415-4423
-
-
Milani, M.1
-
140
-
-
79952016563
-
Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagy-lysosome and ER stress
-
Kawaguchi T., et al. Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagy-lysosome and ER stress. Int. J. Oncol. 2011, 38:643-654.
-
(2011)
Int. J. Oncol.
, vol.38
, pp. 643-654
-
-
Kawaguchi, T.1
-
141
-
-
33947495259
-
Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells
-
Iwamaru A., et al. Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells. Oncogene 2007, 26:1840-1851.
-
(2007)
Oncogene
, vol.26
, pp. 1840-1851
-
-
Iwamaru, A.1
-
142
-
-
67650885510
-
Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab
-
Vazquez-Martin A., et al. Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PLoS ONE 2009, 4:e6251.
-
(2009)
PLoS ONE
, vol.4
-
-
Vazquez-Martin, A.1
-
143
-
-
34347394714
-
Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance
-
Carew J.S., et al. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood 2007, 110:313-322.
-
(2007)
Blood
, vol.110
, pp. 313-322
-
-
Carew, J.S.1
-
144
-
-
77953289524
-
Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model
-
Li J., et al. Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. Eur. J. Cancer 2010, 46:1900-1909.
-
(2010)
Eur. J. Cancer
, vol.46
, pp. 1900-1909
-
-
Li, J.1
-
145
-
-
40949107961
-
Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells
-
Tiwari M., et al. Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells. Carcinogenesis 2008, 29:600-609.
-
(2008)
Carcinogenesis
, vol.29
, pp. 600-609
-
-
Tiwari, M.1
-
146
-
-
77958609008
-
Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells
-
Kanematsu S., et al. Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells. Anticancer Res. 2010, 30:3381-3390.
-
(2010)
Anticancer Res.
, vol.30
, pp. 3381-3390
-
-
Kanematsu, S.1
-
147
-
-
77149128638
-
Inhibition of autophagy potentiates sulforaphane-induced apoptosis in human colon cancer cells
-
Nishikawa T., et al. Inhibition of autophagy potentiates sulforaphane-induced apoptosis in human colon cancer cells. Ann. Surg. Oncol. 2010, 17:592-602.
-
(2010)
Ann. Surg. Oncol.
, vol.17
, pp. 592-602
-
-
Nishikawa, T.1
-
148
-
-
67651152483
-
Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells
-
Tormo D., et al. Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells. Cancer Cell 2009, 16:103-114.
-
(2009)
Cancer Cell
, vol.16
, pp. 103-114
-
-
Tormo, D.1
-
149
-
-
58349098150
-
Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis
-
Kim R.H., et al. Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis. Cancer Res. 2009, 69:700-708.
-
(2009)
Cancer Res.
, vol.69
, pp. 700-708
-
-
Kim, R.H.1
-
150
-
-
65949086045
-
Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells
-
Bommareddy A., et al. Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. Cancer Res. 2009, 69:3704-3712.
-
(2009)
Cancer Res.
, vol.69
, pp. 3704-3712
-
-
Bommareddy, A.1
-
151
-
-
77955355798
-
Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells
-
Suh Y., et al. Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells. Carcinogenesis 2010, 31:1424-1433.
-
(2010)
Carcinogenesis
, vol.31
, pp. 1424-1433
-
-
Suh, Y.1
-
152
-
-
76249124608
-
Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation
-
Puissant A., et al. Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Cancer Res. 2010, 70:1042-1052.
-
(2010)
Cancer Res.
, vol.70
, pp. 1042-1052
-
-
Puissant, A.1
-
153
-
-
34447132925
-
Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells
-
Kim E.H., et al. Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res. 2007, 67:6314-6324.
-
(2007)
Cancer Res.
, vol.67
, pp. 6314-6324
-
-
Kim, E.H.1
-
154
-
-
34347238938
-
Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways
-
Aoki H., et al. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol. Pharmacol. 2007, 72:29-39.
-
(2007)
Mol. Pharmacol.
, vol.72
, pp. 29-39
-
-
Aoki, H.1
-
155
-
-
27144503701
-
Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death
-
Hoyer-Hansen M., et al. Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ. 2005, 12:1297-1309.
-
(2005)
Cell Death Differ.
, vol.12
, pp. 1297-1309
-
-
Hoyer-Hansen, M.1
-
156
-
-
66449115318
-
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
-
Salazar M., et al. Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J. Clin. Invest. 2009, 119:1359-1372.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1359-1372
-
-
Salazar, M.1
-
157
-
-
79251605988
-
β-Lapachone-induced reactive oxygen species (ROS) generation mediates autophagic cell death in glioma U87 MG cells
-
Park E.J., et al. β-Lapachone-induced reactive oxygen species (ROS) generation mediates autophagic cell death in glioma U87 MG cells. Chem. Biol. Interact. 2011, 189:37-44.
-
(2011)
Chem. Biol. Interact.
, vol.189
, pp. 37-44
-
-
Park, E.J.1
-
158
-
-
80051691846
-
PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase
-
Ling Y.H., et al. PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase. Clin. Cancer Res. 2011, 17:5353-5366.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 5353-5366
-
-
Ling, Y.H.1
-
159
-
-
0027674545
-
Antimelanoma activity of chloroquine, an antimalarial agent with high affinity for melanin
-
Inoue S., et al. Antimelanoma activity of chloroquine, an antimalarial agent with high affinity for melanin. Pigment Cell Res. 1993, 6:354-358.
-
(1993)
Pigment Cell Res.
, vol.6
, pp. 354-358
-
-
Inoue, S.1
-
160
-
-
31544473720
-
Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study
-
Bettuzzi S., et al. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res. 2006, 66:1234-1240.
-
(2006)
Cancer Res.
, vol.66
, pp. 1234-1240
-
-
Bettuzzi, S.1
-
161
-
-
79551639050
-
Curcumin: a review of anticancer properties and therapeutic activity in head and neck squamous cell carcinoma
-
Wilken R., et al. Curcumin: a review of anticancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol. Cancer 2011, 10:12.
-
(2011)
Mol. Cancer
, vol.10
, pp. 12
-
-
Wilken, R.1
-
162
-
-
84860847973
-
New strategies in cancer chemoprevention by phytochemicals
-
Singh M., et al. New strategies in cancer chemoprevention by phytochemicals. Front. Biosci. (Elite Ed.) 2012, 4:426-452.
-
(2012)
Front. Biosci. (Elite Ed.)
, vol.4
, pp. 426-452
-
-
Singh, M.1
|