P62: A versatile multitasker takes on cancer

Trends in Biochemical Sciences

Volumn 37, Issue 6, 2012, Pages 230-236

  Moscat, Jorge ^a   Diaz Meco, Maria T ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Atypical PKCs; Autophagy; Cancer; MTORC1; NF B; NRF2; P62; Sequestosome1

Indexed keywords

CYCLIN DEPENDENT KINASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN KINASE C; PROTEIN P62; REGULATOR PROTEIN; TRANSCRIPTION FACTOR NRF2; TUBERIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

APOPTOSIS; AUTOPHAGY; CANCER CONTROL; CELL DIVISION; CELL FUNCTION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; GENOMIC INSTABILITY; GROWTH REGULATION; HUMAN; MALIGNANT NEOPLASTIC DISEASE; MALIGNANT TRANSFORMATION; METABOLIC REGULATION; NONHUMAN; NUTRIENT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ADIPOGENESIS; AUTOPHAGY; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; GENOMIC INSTABILITY; HUMANS; MITOSIS; NF-KAPPA B; OXIDATIVE STRESS; PROTEINS; REACTIVE OXYGEN SPECIES; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6;

EID: 84861939463     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2012.02.008     Document Type: Review

References (71)

1. Sanchez P., et al. Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol. Cell. Biol. 1998, 18:3069-3080.
2. Puls A., et al. Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:6191-6196.
3. Moscat J., et al. Cell signaling and function organized by PB1 domain interactions. Mol. Cell 2006, 23:631-640.
4. Sumimoto H., et al. Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and plants. Sci. STKE 2007, 2007:re6.
5. Ohno S. Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity. Curr. Opin. Cell Biol. 2001, 13:641-648.
6. Macara I.G. Par proteins: partners in polarization. Curr. Biol. 2004, 14:R160-R162.
7. Moscat J., Diaz-Meco M.T. p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 2009, 137:1001-1004.
8. DeBerardinis R.J., et al. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008, 7:11-20.
9. Jorgensen P., Tyers M. How cells coordinate growth and division. Curr. Biol. 2004, 14:R1014-R1027.
10. Negrini S., et al. Genomic instability-an evolving hallmark of cancer. Nat. Rev. Mol. Cell Biol. 2010, 11:220-228.
11. Duran A., et al. The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev. Cell 2004, 6:303-309.
12. Rodriguez A., et al. Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab. 2006, 3:211-222.
13. Duran A., et al. p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Mol. Cell 2011, 44:134-146.
14. Kim D.H., et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002, 110:163-175.
15. Wullschleger S., et al. TOR signaling in growth and metabolism. Cell 2006, 124:471-484.
16. Huang J., et al. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol. Cell. Biol. 2008, 28:4104-4115.
17. Kim E., et al. Regulation of TORC1 by Rag GTPases in nutrient response. Nat. Cell Biol. 2008, 10:935-945.
18. Sancak Y., et al. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 2008, 320:1496-1501.
19. Kim J., Guan K.L. Amino acid signaling in TOR activation. Annu. Rev. Biochem. 2011, 80:1001-1032.
20. Bjorkoy G., et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 2005, 171:603-614.
21. Moscat J., Diaz-Meco M.T. Feedback on fat: p62-mTORC1-autophagy connections. Cell 2011, 147:724-727.
22. Macgurn J.A., et al. TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor. Cell 2011, 147:1104-1117.
23. Sancak Y., et al. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010, 141:290-303.
24. Zoncu R., et al. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H-ATPase. Science 2011, 334:678-683.
25. Maehama T., et al. RalA functions as an indispensable signal mediator for the nutrient-sensing system. J. Biol. Chem. 2008, 283:35053-35059.
26. Flinn R.J., et al. The late endosome is essential for mTORC1 signaling. Mol. Biol. Cell 2010, 21:833-841.
27. Li L., et al. Regulation of mTORC1 by the Rab and Arf GTPases. J. Biol. Chem. 2010, 285:19705-19709.
28. Sanz L., et al. The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J. 2000, 19:1576-1586.
29. Takamura A., et al. Autophagy-deficient mice develop multiple liver tumors. Genes Dev. 2011, 25:795-800.
30. Inami Y., et al. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J. Cell Biol. 2011, 193:275-284.
31. Komatsu M., et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007, 131:1149-1163.
32. Hippert M.M., et al. Autophagy in cancer: good, bad, or both?. Cancer Res. 2006, 66:9349-9351.
33. Mathew R., White E. Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night. Curr. Opin. Genet. Dev. 2011, 21:113-119.
34. Yue Z., et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:15077-15082.
35. Inoki K., et al. Dysregulation of the TSC-mTOR pathway in human disease. Nat. Genet. 2005, 37:19-24.
36. Taguchi K., et al. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 2011, 16:123-140.
37. Komatsu M., et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat. Cell Biol. 2010, 12:213-223.
38. Lau A., et al. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol. Cell. Biol. 2010, 30:3275-3285.
39. Copple I.M., et al. Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway. J. Biol. Chem. 2010, 285:16782-16788.
40. Jain A., et al. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J. Biol. Chem. 2010, 285:22576-22591.
41. Guo J.Y., et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 2011, 25:460-470.
42. Geisler S., et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat. Cell Biol. 2010, 12:119-131.
43. Geisler S., et al. The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. Autophagy 2010, 6:871-878.
44. Okatsu K., et al. p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells 2010, 15:887-900.
45. Narendra D., et al. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 2010, 6:1090-1106.
46. Duran A., et al. The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. Cancer Cell 2008, 13:343-354.
47. Ling J., et al. Kras(G12D)-Induced IKK2/beta/NF-kappaB activation by IL-1alpha and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer cell 2012, 21:105-120.
48. Wooten M.W., et al. The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. J. Biol. Chem. 2005, 280:35625-35629.
49. Laurin N., et al. Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone. Am. J. Hum. Genet. 2002, 70:1582-1588.
50. Roodman G.D. Insights into the pathogenesis of Paget's disease. Ann. N. Y. Acad. Sci. 2010, 1192:176-180.
51. Daroszewska A., et al. A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice. Hum. Mol. Genet. 2011, 20:2734-2744.
52. Kurihara N., et al. Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease. Cell Metab. 2011, 13:23-34.
53. Benhar M., et al. ROS, stress-activated kinases and stress signaling in cancer. EMBO Rep. 2002, 3:420-425.
54. Starczynowski D.T., et al. TRAF6 is an amplified oncogene bridging the RAS and NF-kappaB pathways in human lung cancer. J. Clin. Invest. 2011, 121:4095-4105.
55. Mathew R., et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009, 137:1062-1075.
56. Gao C., et al. Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat. Cell Biol. 2010, 12:781-790.
57. Hussain S., et al. Nephrin deficiency activates NF-kappaB and promotes glomerular injury. J. Am. Soc. Nephrol. 2009, 20:1733-1743.
58. Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
59. Holland A.J., Cleveland D.W. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat. Rev. Mol. Cell Biol. 2009, 10:478-487.
60. Kastan M.B., Bartek J. Cell-cycle checkpoints and cancer. Nature 2004, 432:316-323.
61. Kops G.J., et al. ZW10 links mitotic checkpoint signaling to the structural kinetochore. J. Cell Biol. 2005, 169:49-60.
62. Vecchione A., et al. Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer cell 2007, 11:275-289.
63. Nigg E.A. Mitotic kinases as regulators of cell division and its checkpoints. Nat. Rev. Mol. Cell Biol. 2001, 2:21-32.
64. Malumbres M., Barbacid M. Mammalian cyclin-dependent kinases. Trends Biochem. Sci. 2005, 30:630-641.
65. Linares J.F., et al. Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation. Mol. Cell. Biol. 2011, 31:105-117.
66. Pankiv S., et al. Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies. J. Biol. Chem. 2010, 285:5941-5953.
67. Salomoni P., Pandolfi P.P. The role of PML in tumor suppression. Cell 2002, 108:165-170.
68. Pohl C., Jentsch S. Midbody ring disposal by autophagy is a post-abscission event of cytokinesis. Nat. Cell Biol. 2009, 11:65-70.
69. Kuo T.C., et al. Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat. Cell Biol. 2011, 13:1467.
70. Rello-Varona S., et al. Autophagic removal of micronuclei. Cell cycle 2012, 11:170-176.
71. Zhang Y., et al. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:19860-19865.