PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase

Clinical Cancer Research

Volumn 17, Issue 16, 2011, Pages 5353-5366

  Ling, Yi He ^a   Aracil, Miguel ^c   Zou, Yiyu ^a   Yuan, Ziqiang ^a   Lu, Bo ^b   Jimeno, Jośe ^c,d   Cuervo, Ana Maria ^a   Perez Soler, Roman ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c Phamamar R and D   (Spain)

^d Pangaea Biotech   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; CASPASE; DEATH ASSOCIATED PROTEIN KINASE; ELISIDEPSIN; GREEN FLUORESCENT PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SMALL INTERFERING RNA; WORTMANNIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL ORGANELLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG SMALL CELL CANCER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ADENINE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CARCINOMA, NON-SMALL-CELL LUNG; CASPASES; CELL LINE, TUMOR; DEPSIPEPTIDES; ENZYME ACTIVATION; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOBLOTTING; LUNG NEOPLASMS; MICE; MICE, NUDE; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80051691846     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-1948     Document Type: Article

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