메뉴 건너뛰기




Volumn 9, Issue 1, 2008, Pages 15-23

Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases

Author keywords

Alpha synuclein; Alzheimer disease; Dementia with Lewy bodies; Differential isoform expression; mRNA expression

Indexed keywords

ALPHA SYNUCLEIN; ALPHA SYNUCLEIN 98; UNCLASSIFIED DRUG;

EID: 38649119157     PISSN: 13646745     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10048-007-0106-0     Document Type: Article
Times cited : (70)

References (44)
  • 1
    • 4644336256 scopus 로고    scopus 로고
    • Tissue transglutaminase catalyzes the formation of alpha-synuclein crosslinks in Parkinson's disease
    • Andringa G, Lam KY, Chegary M, Wang X, Chase TN, Bennett MC (2004) Tissue transglutaminase catalyzes the formation of alpha-synuclein crosslinks in Parkinson's disease. FASEB J 18:932-934
    • (2004) FASEB J , vol.18 , pp. 932-934
    • Andringa, G.1    Lam, K.Y.2    Chegary, M.3    Wang, X.4    Chase, T.N.5    Bennett, M.C.6
  • 2
    • 33747769942 scopus 로고    scopus 로고
    • Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers
    • Beyer K (2006) Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers. Acta Neuropathol (Berl) 112:237-251
    • (2006) Acta Neuropathol (Berl) , vol.112 , pp. 237-251
    • Beyer, K.1
  • 8
    • 2342457804 scopus 로고    scopus 로고
    • Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease
    • Dalfo E, Barrachina M, Rosa JL, Ambrosio S, Ferrer I (2004) Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease. Neurobiol Dis 16:92-97
    • (2004) Neurobiol Dis , vol.16 , pp. 92-97
    • Dalfo, E.1    Barrachina, M.2    Rosa, J.L.3    Ambrosio, S.4    Ferrer, I.5
  • 9
    • 0032540327 scopus 로고    scopus 로고
    • Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes
    • Davidson WS, Jonas A, Clayton DF, George JM (1998) Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J Biol Chem 273:9443-9449
    • (1998) J Biol Chem , vol.273 , pp. 9443-9449
    • Davidson, W.S.1    Jonas, A.2    Clayton, D.F.3    George, J.M.4
  • 10
    • 25844458239 scopus 로고    scopus 로고
    • Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies
    • Ferrer I, Gomez-Isla T, Puig B, Freixes M, Ribe E, Dalfo E, Avila J (2005) Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies. Curr Alzheimer Res 2:3-18
    • (2005) Curr Alzheimer Res , vol.2
    • Ferrer, I.1    Gomez-Isla, T.2    Puig, B.3    Freixes, M.4    Ribe, E.5    Dalfo, E.6    Avila, J.7
  • 12
    • 0029981526 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease
    • Forno LS (1996) Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol 55:259-272
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 259-272
    • Forno, L.S.1
  • 13
    • 0033978622 scopus 로고    scopus 로고
    • Complex regulation of tau exon 10, whose missplicing causes frontotemporal dementia
    • Gao QS, Memmott J, Lafyatis R, Stamm S, Screaton G, Andreadis A (2000) Complex regulation of tau exon 10, whose missplicing causes frontotemporal dementia. J Neurochem 74:490-500
    • (2000) J Neurochem , vol.74 , pp. 490-500
    • Gao, Q.S.1    Memmott, J.2    Lafyatis, R.3    Stamm, S.4    Screaton, G.5    Andreadis, A.6
  • 15
    • 0028985267 scopus 로고
    • The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
    • Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, de Silva HA, Kittel A, Saitoh T (1995) The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14:467-475
    • (1995) Neuron , vol.14 , pp. 467-475
    • Iwai, A.1    Masliah, E.2    Yoshimoto, M.3    Ge, N.4    Flanagan, L.5    De Silva, H.A.6    Kittel, A.7    Saitoh, T.8
  • 16
    • 2942555022 scopus 로고    scopus 로고
    • Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling
    • Jao CC, Der-Sarkissian A, Chen J, Langen R (2004) Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling. Proc Natl Acad Sci U S A 101:8331-8336
    • (2004) Proc Natl Acad Sci U S a , vol.101 , pp. 8331-8336
    • Jao, C.C.1    Der-Sarkissian, A.2    Chen, J.3    Langen, R.4
  • 18
    • 0018145267 scopus 로고
    • Lewy bodies in cerebral cortex, report of three cases
    • Kosaka K (1978) Lewy bodies in cerebral cortex, report of three cases. Acta Neuropathol (Berl) 42:127-134
    • (1978) Acta Neuropathol (Berl) , vol.42 , pp. 127-134
    • Kosaka, K.1
  • 19
    • 0344305371 scopus 로고    scopus 로고
    • Morphogenesis of Lewy bodies: Dissimilar incorporation of alpha-synuclein, ubiquitin, and p62
    • Kuusisto E, Parkkinen L, Alafuzoff I (2003) Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62. J Neuropathol Exp Neurol 62:1241-1253
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 1241-1253
    • Kuusisto, E.1    Parkkinen, L.2    Alafuzoff, I.3
  • 20
    • 0037016741 scopus 로고    scopus 로고
    • Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form
    • Lee HJ, Choi C, Lee SJ (2002) Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. J Biol Chem 277:671-678
    • (2002) J Biol Chem , vol.277 , pp. 671-678
    • Lee, H.J.1    Choi, C.2    Lee, S.J.3
  • 22
    • 3142695169 scopus 로고    scopus 로고
    • Tau isoforms which contain the domain encoded by exon 6 and their role in neurite elongation
    • Luo MH, Leski ML, Andreadis A (2004) Tau isoforms which contain the domain encoded by exon 6 and their role in neurite elongation. J Cell Biochem 91:880-895
    • (2004) J Cell Biochem , vol.91 , pp. 880-895
    • Luo, M.H.1    Leski, M.L.2    Andreadis, A.3
  • 23
    • 3142704290 scopus 로고    scopus 로고
    • Novel isoforms of tau that lack the microtubule-binding domain
    • Luo MH, Tse SW, Memmott J, Andreadis A (2004) Novel isoforms of tau that lack the microtubule-binding domain. J Neurochem 90:340-351
    • (2004) J Neurochem , vol.90 , pp. 340-351
    • Luo, M.H.1    Tse, S.W.2    Memmott, J.3    Andreadis, A.4
  • 24
    • 33751552347 scopus 로고    scopus 로고
    • Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: Implications for fibrillation
    • Marsh JA, Singh VK, Jia Z, Forman-Kay JD (2006) Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation. Protein Sci 15:2795-2804
    • (2006) Protein Sci , vol.15 , pp. 2795-2804
    • Marsh, J.A.1    Singh, V.K.2    Jia, Z.3    Forman-Kay, J.D.4
  • 25
    • 31544457062 scopus 로고    scopus 로고
    • Pathophysiology of synuclein aggregation in Lewy body disease
    • Mukaetova-Ladinska EB, McKeith IG (2006) Pathophysiology of synuclein aggregation in Lewy body disease. Mech Ageing Dev 127:188-202
    • (2006) Mech Ageing Dev , vol.127 , pp. 188-202
    • Mukaetova-Ladinska, E.B.1    McKeith, I.G.2
  • 26
    • 0034193399 scopus 로고    scopus 로고
    • Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
    • Murphy DD, Rueter SM, Trojanowski JQ, Lee VM (2000) Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J Neurosci 20:3214-3220
    • (2000) J Neurosci , vol.20 , pp. 3214-3220
    • Murphy, D.D.1    Rueter, S.M.2    Trojanowski, J.Q.3    Lee, V.M.4
  • 27
    • 2642514788 scopus 로고    scopus 로고
    • Alpha-synuclein: Normal function and role in neurodegenerative diseases
    • Norris EH, Giasson BI, Lee VM (2004) Alpha-synuclein: normal function and role in neurodegenerative diseases. Curr Top Dev Biol 60:17-54
    • (2004) Curr Top Dev Biol , vol.60 , pp. 17-54
    • Norris, E.H.1    Giasson, B.I.2    Lee, V.M.3
  • 30
    • 12944325313 scopus 로고    scopus 로고
    • Alternative splicing in the N-terminus of Alzheimer's presenilin 1
    • Scheper W, Zwart R, Baas F (2004) Alternative splicing in the N-terminus of Alzheimer's presenilin 1. Neurogenetics 5:223-227
    • (2004) Neurogenetics , vol.5 , pp. 223-227
    • Scheper, W.1    Zwart, R.2    Baas, F.3
  • 33
    • 33846465955 scopus 로고    scopus 로고
    • Effect of reparation of repeat sequences in the human alpha-synuclein on fibrillation ability
    • Sode K, Ochiai S, Kobayashi N, Usuzaka E (2007) Effect of reparation of repeat sequences in the human alpha-synuclein on fibrillation ability. Int J Biol Sci 3:1-7
    • (2007) Int J Biol Sci , vol.3 , pp. 1-7
    • Sode, K.1    Ochiai, S.2    Kobayashi, N.3    Usuzaka, E.4
  • 34
    • 0032568534 scopus 로고    scopus 로고
    • Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
    • Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M (1998) alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc Natl Acad Sci U S A 95:6469-6473
    • (1998) Proc Natl Acad Sci U S a , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 38
    • 0028618190 scopus 로고
    • Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A beta component of Alzheimer's disease amyloid
    • Ueda K, Saitoh T, Mori H (1994) Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A beta component of Alzheimer's disease amyloid. Biochem Biophys Res Commun 205:1366-1372
    • (1994) Biochem Biophys Res Commun , vol.205 , pp. 1366-1372
    • Ueda, K.1    Saitoh, T.2    Mori, H.3
  • 41
    • 0029904487 scopus 로고    scopus 로고
    • NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
    • Weinreb PH, Zhen W, Poon AW, Conway KA, Lansbury PT, Jr. (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35:13709-13715
    • (1996) Biochemistry , vol.35 , pp. 13709-13715
    • Weinreb, P.H.1    Zhen, W.2    Poon, A.W.3    Conway, K.A.4    Lansbury Jr., P.T.5
  • 42
    • 0036712421 scopus 로고    scopus 로고
    • Genome-wide detection of tissue-specific alternative splicing in the human transcriptome
    • Xu Q, Modrek B, Lee C (2002) Genome-wide detection of tissue-specific alternative splicing in the human transcriptome. Nucleic Acids Res 30:3754-3766
    • (2002) Nucleic Acids Res , vol.30 , pp. 3754-3766
    • Xu, Q.1    Modrek, B.2    Lee, C.3
  • 43
    • 0038349624 scopus 로고    scopus 로고
    • Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome
    • Zavolan M, Kondo S, Schonbach C, Adachi J, Hume DA, Hayashizaki Y, Gaasterland T (2003) Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome. Genome Res 13:1290-1300
    • (2003) Genome Res , vol.13 , pp. 1290-1300
    • Zavolan, M.1    Kondo, S.2    Schonbach, C.3    Adachi, J.4    Hume, D.A.5    Hayashizaki, Y.6    Gaasterland, T.7
  • 44
    • 0141891097 scopus 로고    scopus 로고
    • The association of alpha-synuclein with membranes affects bilayer structure, stability, and fibril formation
    • Zhu M, Li J, Fink AL (2003) The association of alpha-synuclein with membranes affects bilayer structure, stability, and fibril formation. J Biol Chem 278:40186-40197
    • (2003) J Biol Chem , vol.278 , pp. 40186-40197
    • Zhu, M.1    Li, J.2    Fink, A.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.