Inhibition of α-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region

PLoS ONE

Volumn 3, Issue 10, 2008, Pages

  Herrera, Fernando E ^a,b   Chesi, Alessandra ^b,c   Paleologou, Katerina E ^d   Schmid, Adrian ^d   Munoz, Adriana ^a,b,c   Vendruscolo, Michele ^e   Gustincich, Stefano ^b,c   Lashuel, Hilal A ^d   Carloni, Paolo ^a,b  

^a DEMOCRITOS NATIONAL SIMULATION CENTER   (Italy)

^b ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^c SISSA   (Italy)

^d EPFL   (Switzerland)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ALPHA SYNUCLEIN; DOPAMINE; GLUTAMIC ACID; AMINO ACID; MULTIPROTEIN COMPLEX; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; AQUEOUS SOLUTION; ARTICLE; BINDING KINETICS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HYPOTHESIS; IN VITRO STUDY; MOLECULAR DYNAMICS; MOLECULAR MODEL; MUTANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARKINSON DISEASE; PATHOGENESIS; POINT MUTATION; PROTEIN AGGREGATION; PROTEIN STRUCTURE; BINDING SITE; CHEMICAL STRUCTURE; COMPUTER SIMULATION; DRUG ANTAGONISM; GENETICS; HUMAN; METABOLISM; PROTEIN BINDING;

ALPHA-SYNUCLEIN; AMINO ACIDS; BINDING SITES; COMPUTER SIMULATION; DOPAMINE; HUMANS; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; MUTANT PROTEINS; PARKINSON DISEASE; POINT MUTATION; PROTEIN BINDING;

EID: 54849423681     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003394     Document Type: Article

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