Accelerated formation of α-synuclein oligomers by concerted action of the 20s proteasome and familial parkinson mutations

Journal of Bioenergetics and Biomembranes

Volumn 42, Issue 1, 2010, Pages 85-95

  Lewis, Karen A ^a,b   Yaeger, Arynn ^a   Demartino, George N ^a   Thomas, Philip J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Synuclein; 20S proteasome; Amyloid; Cytotoxicity; Endoproteolysis; Liposomes; Parkinson disease; Soluble oligomers

Indexed keywords

ALANINE; ALPHA SYNUCLEIN; GLUTAMIC ACID; LIPOSOME; LYSINE; OLIGOMER; PROLINE; PROTEASOME; THREONINE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; IN VITRO STUDY; NEUROPATHOLOGY; NONHUMAN; PARKINSON DISEASE; POINT MUTATION; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DEFECT; PROTEIN DEGRADATION; PROTEIN METABOLISM; WILD TYPE;

ALPHA-SYNUCLEIN; AMYLOID; ANIMALS; CATTLE; HUMANS; KINETICS; LEWY BODIES; LIPOSOMES; MODELS, NEUROLOGICAL; PARKINSON DISEASE; PEPTIDE FRAGMENTS; POINT MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN MULTIMERIZATION;

EID: 77950021983     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-009-9258-y     Document Type: Article

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