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Volumn 133, Issue 12, 2010, Pages 3724-3733

The decrease of β-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies

Author keywords

Dementia with lewy bodies; Differential isoform expression; mRNA expression; synuclein; synuclein

Indexed keywords

ALPHA SYNUCLEIN; ALPHA SYNUCLEIN TRANSCRIPT SNCA140; BETA SYNUCLEIN; BETA SYNUCLEIN TRANSCRIPT VARIANT 1; BETA SYNUCLEIN TRANSCRIPT VARIANT 2; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 79951936156     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awq275     Document Type: Article
Times cited : (38)

References (41)
  • 1
    • 0037335814 scopus 로고    scopus 로고
    • Prevalence and characteristics of dementia in Parkinson disease: An 8-year prospective study
    • DOI 10.1001/archneur.60.3.387
    • Aarsland D, Andersen K, Larsen JP, Lolk A, Kragh-Sorensen P. Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study. Arch Neurol 2003; 60: 387-92. (Pubitemid 36314364)
    • (2003) Archives of Neurology , vol.60 , Issue.3 , pp. 387-392
    • Aarsland, D.1    Andersen, K.2    Larsen, J.P.3    Lolk, A.4    Kragh-Sorensen, P.5
  • 2
    • 46149119425 scopus 로고    scopus 로고
    • Differential expression of alpha-synucleln, parkin, and synphllln-1 isoforms in Lewy body disease
    • Beyer K, Domingo-Sàbat M, Humbert J, Carrato C, Ferrer I, Ariza A. Differential expression of alpha-synucleln, parkin, and synphllln-1 isoforms In Lewy body disease. Neurogenetics 2008a; 9: 163-72.
    • (2008) Neurogenetics , vol.9 , pp. 163-172
    • Beyer, K.1    Domingo-Sàbat, M.2    Humbert, J.3    Carrato, C.4    Ferrer, I.5    Ariza, A.6
  • 3
    • 38649119157 scopus 로고    scopus 로고
    • Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases
    • DOI 10.1007/s10048-007-0106-0
    • Beyer K, Domingo-Sábat M, Lao JI, Carrato C, Ferrer I, Ariza A. Identification and characterization of a new alpha-synucleln isoform and its role in Lewy body diseases. Neurogenetics 2008b; 9: 15-23. (Pubitemid 351170166)
    • (2008) Neurogenetics , vol.9 , Issue.1 , pp. 15-23
    • Beyer, K.1    Domingo-Sabat, M.2    Lao, J.I.3    Carrato, C.4    Ferrer, I.5    Ariza, A.6
  • 4
    • 33747778534 scopus 로고    scopus 로고
    • Low alpha-synuclein 126 mRNA levels in dementia with Lewy bodies and Alzheimer disease
    • DOI 10.1097/01.wnr.0000224773.66904.e7, PII 0000175620060821000020
    • Beyer K, Humbert J, Ferrer A, Lao JI, Carrato C, López D, et al. Low alpha-synuclein 126 mRNA levels In dementia with Lewy bodies and Alzheimer disease. Neuroreport 2006; 17: 1327-30. (Pubitemid 44337076)
    • (2006) NeuroReport , vol.17 , Issue.12 , pp. 1327-1330
    • Beyer, K.1    Humbert, J.2    Ferrer, A.3    Lao, J.I.4    Carrato, C.5    Lopez, D.6    Ferrer, I.7    Ariza, A.8
  • 6
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • DOI 10.1016/S0197-4580(02)00065-9, PII S0197458002000659
    • Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003; 24: 197-211. (Pubitemid 36007810)
    • (2003) Neurobiology of Aging , vol.24 , Issue.2 , pp. 197-211
    • Braak, H.1    Del Tredici, K.2    Rub, U.3    De Vos, R.A.4    Jansen Steur, E.N.5    Braak, E.6
  • 7
    • 0025863618 scopus 로고
    • Neuropathological staging of Alzheimer-related changes
    • Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 1991; 82: 239-59.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 8
    • 0030668423 scopus 로고    scopus 로고
    • Diagnostic criteria for neuropathologic assessment of Alzheimer's disease
    • DOI 10.1016/S0197-4580(97)00062-6, PII S0197458097000626
    • Braak H, Braak E. Diagnostic criteria for neuropathological assessment of Alzheimer's disease. Neurobiol Aging 1997; 18: S85-S88. (Pubitemid 27454703)
    • (1997) Neurobiology of Aging , vol.18 , Issue.4 SUPPL.
    • Braak, H.1    Braak, E.2
  • 9
    • 36248933671 scopus 로고    scopus 로고
    • Cognitive dysfunction and dementia in Parkinson disease
    • DOI 10.1002/mds.21677
    • Caballol N, Martí MJ, Tolosa E. Cognitive dysfunction and dementia In Parkinson disease. Mov Disord 2007; 22: S358-S366. (Pubitemid 350134189)
    • (2007) Movement Disorders , vol.22 , Issue.SUPPL. 17
    • Caballol, N.1    Marti, M.J.2    Tolosa, E.3
  • 10
    • 0141844595 scopus 로고    scopus 로고
    • β-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: Cross-talk with α-synuclein and implication for Parkinson's disease
    • DOI 10.1074/jbc.M306083200
    • da Costa CA, Masliah E, Checler F. Beta-synucleln displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-lnduced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease. J Biol Chem 2003; 278: 37330-5. (Pubitemid 37175250)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.39 , pp. 37330-37335
    • Da Costa, C.A.1    Masliah, E.2    Checler, F.3
  • 11
    • 69149089854 scopus 로고    scopus 로고
    • Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
    • Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, et al. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci USA 2009; 106: 13010-15.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 13010-13015
    • Desplats, P.1    Lee, H.J.2    Bae, E.J.3    Patrick, C.4    Rockenstein, E.5    Crews, L.6
  • 13
    • 0042970162 scopus 로고    scopus 로고
    • Dementia associated with Parkinson's disease
    • DOI 10.1016/S1474-4422(03)00351-X
    • Emre M. Dementia associated with Parkinson's disease. Lancet Neurol 2003; 2: 229-37. (Pubitemid 37443310)
    • (2003) Lancet Neurology , vol.2 , Issue.4 , pp. 229-237
    • Emre, M.1
  • 14
    • 34447307401 scopus 로고    scopus 로고
    • Dementia with lewy bodies
    • DOI 10.1016/j.ncl.2007.03.001, PII S0733861907000473, Dementia
    • Ferman TJ, Boeve BF. Dementia with Lewy bodies. Neurol Clin 2007; 25: 741-60. (Pubitemid 47058869)
    • (2007) Neurologic Clinics , vol.25 , Issue.3 , pp. 741-760
    • Ferman, T.J.1    Boeve, B.F.2
  • 16
    • 58349114729 scopus 로고    scopus 로고
    • Differences in clinical course between dementia with Lewy bodies and Alzheimer's disease
    • Hanyu H, Sato T, Hirao K, Kanetaka H, Sakurai H, Iwamoto T. Differences in clinical course between dementia with Lewy bodies and Alzheimer's disease. Eur J Neurol 2009; 16: 212-17.
    • (2009) Eur J Neurol , vol.16 , pp. 212-217
    • Hanyu, H.1    Sato, T.2    Hirao, K.3    Kanetaka, H.4    Sakurai, H.5    Iwamoto, T.6
  • 17
    • 2542499831 scopus 로고    scopus 로고
    • β-synuclein regulates Akt activity in neuronal cells: A possible mechanism for neuroprotection in Parkinson's disease
    • DOI 10.1074/jbc.M313784200
    • Hashimoto M, Bar-On P, Ho G, Takenouchi T, Rockenstein E, Crews L, et al. Beta-synuclein regulates Akt activity In neuronal cells. A possible mechanism for neuroprotection In Parkinson's disease. J Biol Chem 2004; 279: 23622-9. (Pubitemid 38685677)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.22 , pp. 23622-23629
    • Hashimoto, M.1    Bar-On, P.2    Ho, G.3    Takenouchi, T.4    Rockenstein, E.5    Crews, L.6    Masliah, E.7
  • 18
    • 0035950270 scopus 로고    scopus 로고
    • β-synuclein inhibits α-synuclein aggregation: A possible role as an anti-Parkinsonian factor
    • DOI 10.1016/S0896-6273(01)00462-7
    • Hashimoto M, Rockenstein E, Mante M, Mallory M, Masliah E. beta-synuclein inhibits alpha-synuclein aggregation: a possible role as an antiparkinsonian factor. Neuron 2001; 32: 213-23. (Pubitemid 33030190)
    • (2001) Neuron , vol.32 , Issue.2 , pp. 213-223
    • Hashimoto, M.1    Rockenstein, E.2    Mante, M.3    Mallory, M.4    Masliah, E.5
  • 19
    • 57549098245 scopus 로고    scopus 로고
    • Beta-synuclein occurs in vivo in lipid-associated oligomers and forms hetero-oligomers with alpha-synuclein
    • Israeli E, Sharon R. Beta-synuclein occurs in vivo In lipid-associated oligomers and forms hetero-oligomers with alpha-synuclein. J Neurochem 2009; 108: 465-74.
    • (2009) J Neurochem , vol.108 , pp. 465-474
    • Israeli, E.1    Sharon, R.2
  • 20
    • 45749155306 scopus 로고    scopus 로고
    • A critical reappraisal of current staging of Lewy-related pathology in human brain
    • Jellinger KA. A critical reappraisal of current staging of Lewy-related pathology in human brain. Acta Neuropathol 2008a; 116: 1-16.
    • (2008) Acta Neuropathol , vol.116 , pp. 1-16
    • Jellinger, K.A.1
  • 21
    • 43249110159 scopus 로고    scopus 로고
    • Striatal beta-amyloid deposition in Parkinson disease with dementia
    • Jellinger KA. Striatal beta-amyloid deposition in Parkinson disease with dementia. J Neuropathol Exp Neurol 2008b; 67: 484-5.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 484-485
    • Jellinger, K.A.1
  • 22
    • 68749116710 scopus 로고    scopus 로고
    • A critical evaluation of current staging of alpha-synucleln pathology in Lewy body disorders
    • Jellinger KA. A critical evaluation of current staging of alpha-synucleln pathology in Lewy body disorders. Biochim Biophys Acta 2009; 1792: 730-40.
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 730-740
    • Jellinger, K.A.1
  • 23
    • 33747762262 scopus 로고    scopus 로고
    • Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies?
    • Jellinger KA, Attems J. Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies? Acta Neuropathol 2006; 112: 253-60.
    • (2006) Acta Neuropathol , vol.112 , pp. 253-260
    • Jellinger, K.A.1    Attems, J.2
  • 25
    • 33846997878 scopus 로고    scopus 로고
    • Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
    • Kramer ML, Schulz-Schaeffer WJ. Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J Neurosci 2007; 27: 1405-10.
    • (2007) J Neurosci , vol.27 , pp. 1405-1410
    • Kramer, M.L.1    Schulz-Schaeffer, W.J.2
  • 26
    • 0035710746 scopus 로고    scopus 로고
    • -ΔΔCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmlttgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-8. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 27
    • 0023722437 scopus 로고
    • Synuclein: A neuron-specific protein localized to the nucleus and presynaptic nerve terminal
    • Maroteaux L, Campanelli JT, Serieller RH. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci 1988; 8: 2804-15.
    • (1988) J Neurosci , vol.8 , pp. 2804-2815
    • Maroteaux, L.1    Campanelli, J.T.2    Serieller, R.H.3
  • 30
    • 65249162241 scopus 로고    scopus 로고
    • Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies
    • Paleologou KE, Kragh CL, Mann DM, Salem SA, Al-Shaml R, Allsop D, et al. Detection of elevated levels of soluble alpha-synuclein oligomers In post-mortem brain extracts from patients with dementia with Lewy bodies. Brain 2009; 132: 1093-101.
    • (2009) Brain , vol.132 , pp. 1093-1101
    • Paleologou, K.E.1    Kragh, C.L.2    Mann, D.M.3    Salem, S.A.4    Al-Shaml, R.5    Allsop, D.6
  • 31
    • 0037426346 scopus 로고    scopus 로고
    • Beta-synuclein Inhibits formation of alpha-synuclein protofibrils: A possible therapeutic strategy against Parkinson's disease
    • Park JY, Lansbury PT Jr. Beta-synuclein Inhibits formation of alpha-synuclein protofibrils: a possible therapeutic strategy against Parkinson's disease. Biochemistry 2003; 42: 3696-700.
    • (2003) Biochemistry , vol.42 , pp. 3696-3700
    • Park, J.Y.1    Lansbury Jr., P.T.2
  • 32
    • 41049086156 scopus 로고    scopus 로고
    • Effect of RNA quality on transcript intensity levels in microarray analysis of human post-mortem brain tissues
    • Popova T, Mennerich D, Weith A, Quast K. Effect of RNA quality on transcript intensity levels In microarray analysis of human post-mortem brain tissues. BMC Genomics 2008; 9: 91.
    • (2008) BMC Genomics , vol.9 , pp. 91
    • Popova, T.1    Mennerich, D.2    Weith, A.3    Quast, K.4
  • 33
    • 4444337502 scopus 로고    scopus 로고
    • Mathematics of quantitative kinetic PCR and the application of standard curves
    • Rutledge RG, Côté C. Mathematics of quantitative kinetic PCR and the application of standard curves. Nucleic Acids Res 2003; 31: e93.
    • (2003) Nucleic Acids Res , vol.31
    • Rutledge, R.G.1    Côté, C.2
  • 34
    • 33750475626 scopus 로고    scopus 로고
    • Quantitative real-time RT-PCR data analysis: Current concepts and the novel gene expression's C T difference formula
    • Schefe JH, Lehmann KE, Buschmann IR, Unger T, Funke-Kaiser H. Quantitative real-time RT-PCR data analysis: current concepts and the novel "gene expression's C T difference" formula. J Mol Med 2006; 84: 901-10.
    • (2006) J Mol Med , vol.84 , pp. 901-910
    • Schefe, J.H.1    Lehmann, K.E.2    Buschmann, I.R.3    Unger, T.4    Funke-Kaiser, H.5
  • 35
    • 44949231424 scopus 로고    scopus 로고
    • T method
    • DOI 10.1038/nprot.2008.73, PII NPROT.2008.73
    • Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008; 3: 1101-8. (Pubitemid 351818697)
    • (2008) Nature Protocols , vol.3 , Issue.6 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 39
    • 34548184125 scopus 로고    scopus 로고
    • Residual Structure, Backbone Dynamics, and Interactions within the Synuclein Family
    • DOI 10.1016/j.jmb.2007.07.008, PII S0022283607009229
    • Sung YH, Eliezer D. Residual structure, backbone dynamics, and interactions within the synuclein family. J Mol Biol 2007; 372: 689-707. (Pubitemid 47313488)
    • (2007) Journal of Molecular Biology , vol.372 , Issue.3 , pp. 689-707
    • Sung, Y.-H.1    Eliezer, D.2
  • 41
    • 0037023699 scopus 로고    scopus 로고
    • Biophysical properties of the synucleins and their propensities to fibrillate: Inhibition of α-synuclein assembly by β- And γ-synucleins
    • DOI 10.1074/jbc.M109541200
    • Uversky VN, Li J, Souillac P, Millett IS, Doniach S, Jakes R, et al. Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synuclein. J Biol Chem 2002; 277: 11970-8. (Pubitemid 34952757)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.14 , pp. 11970-11978
    • Uversky, V.N.1    Li, J.2    Souillac, P.3    Millett, I.S.4    Doniach, S.5    Jakes, R.6    Goedert, M.7    Fink, A.L.8


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