Oxidative stress-induced phosphorylation, degradation and aggregation of α-synuclein are linked to upregulated CK2 and cathepsin D

European Journal of Neuroscience

Volumn 26, Issue 4, 2007, Pages 863-874

  Takahashi, Makio ^a   Ko, Li Wen ^a   Kulathingal, Jayanarayan ^a   Jiang, Peizhou ^a   Sevlever, Daniel ^a   Yen, Shu Hui C ^a  

^a MAYO CLINIC   (United States)

Author keywords

synuclein ( Syn); Casein kinase 2 (CK2); Cathepsin D (CatD); Oxidative stress; Phosphorylation

Indexed keywords

5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE; 5,6,7 TETRABROMOBENZOTRIAZOLE; ALPHA SYNUCLEIN; ASCORBIC ACID; CASEIN KINASE II; CASEIN KINASE INHIBITOR; CATHEPSIN D; ENZYME INHIBITOR; FERROUS CHLORIDE; G PROTEIN COUPLED RECEPTOR KINASE 2; GENE PRODUCT; OLIGOMER; PEPSTATIN; S129 PROTEIN; TETRACYCLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LINEAGE; CONTROLLED STUDY; DRUG MECHANISM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MOUSE; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; UPREGULATION; WILD TYPE;

ALPHA-SYNUCLEIN; BETA-ADRENERGIC RECEPTOR KINASE; BLOTTING, WESTERN; CASEIN KINASE II; CATHEPSIN D; CELLS, CULTURED; FERROUS COMPOUNDS; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC VECTORS; HUMANS; INCLUSION BODIES; LYSOSOMES; NEURONS; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TETRACYCLINE; TRANSFECTION; UP-REGULATION;

EID: 34547975971     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2007.05736.x     Document Type: Article

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