Dementia with Lewy Bodies

Neurologic Clinics

Volumn 25, Issue 3, 2007, Pages 741-760

  Ferman, Tanis J ^a   Boeve, Bradley F ^b  

^a MAYO CLINIC   (United States)

^b Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBIDOPA; CLONAZEPAM; DONEPEZIL; LEVODOPA; NEUROLEPTIC AGENT; OLANZAPINE;

ALZHEIMER DISEASE; BEHAVIOR THERAPY; DAYTIME SOMNOLENCE; DEMENTIA; DISEASE SEVERITY; DRUG TOLERABILITY; DYSAUTONOMIA; EXTRAPYRAMIDAL SYNDROME; HUMAN; LEWY BODY; LOW DRUG DOSE; MOTOR PERFORMANCE; NEUROPSYCHOLOGY; PARKINSONISM; PRIORITY JOURNAL; REM SLEEP; REVIEW; SLEEP DISORDER; VISUAL HALLUCINATION;

DIAGNOSIS, DIFFERENTIAL; HUMANS; LEWY BODY DISEASE; PRACTICE GUIDELINES;

EID: 34447307401     PISSN: 07338619     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ncl.2007.03.001     Document Type: Review

References (191)

1. Galasko D., Hansen L.A., Katzman R., et al. Clinical-neuropathological correlations in Alzheimer's disease and related dementias. Arch Neurol 51 (1994) 888-895
2. Joachim C.L., Morris J.H., and Selkoe D.J. Clinically diagnosed Alzheimer's disease: autopsy results in 150 cases. Ann Neurol 24 (1988) 50-56
3. Hansen L., Salmon D., Galasko D., et al. The Lewy body variant of Alzheimer's disease: a clinical and pathologic entity. Neurology 40 (1990) 1-8
4. Hulette C., Mirra S., Wilkinson W., et al. The consortium to establish a registry for Alzheimer's Disease (CERAD). Part IX. A prospective cliniconeuropathologic study of Parkinson's features in Alzheimer's disease. Neurology 45 (1995) 1991-1995
5. Perry E.K., Marshall E., Perry R.H., et al. Cholinergic and dopaminergic activities in senile dementia of Lewy body type. Alzheimer Dis Assoc Disord 4 (1990) 87-95
6. Lennox G., Lowe J., Landon M., et al. Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry. J Neurol Neurosurg Psychiatry 52 (1989) 1236-1247
7. McKeith I.G., Galasko D., Kosaka K., et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 47 (1996) 1113-1124
8. McKeith I.G., Ballard C.G., Perry R.H., et al. Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies. Neurology 54 (2000) 1050-1058
9. Lopez O.L., Becker J.T., Kaufer D.I., et al. Research evaluation and prospective diagnosis of dementia with Lewy bodies. Arch Neurol 59 (2002) 43-46
10. Verghese J., Crystal H.A., Dickson D.W., et al. Validity of clinical criteria for the diagnosis of dementia with Lewy bodies. Neurology 53 (1999) 1974-1982
11. Litvan I., MacIntyre A., Goetz C.G., et al. Accuracy of the clinical diagnoses of Lewy body disease, Parkinson disease, and dementia with Lewy bodies: a clinicopathologic study. Arch Neurol 55 (1998) 969-978
12. Mega M.S., Masterman D.L., Benson D.F., et al. Dementia with Lewy bodies: reliability and validity of clinical and pathologic criteria. Neurology 47 (1996) 1403-1409
13. Lippa C.F., Smith T.W., and Swearer J.M. Alzheimer's disease and Lewy body disease: a comparative clinicopathological study. Ann Neurol 35 (1994) 81-88
14. Kuzuhara S., and Yoshimura M. Clinical and neuropathological aspects of diffuse Lewy body disease in the elderly. Adv Neurol 60 (1993) 464-469
15. Klatka L.A., Louis E.D., and Schiffer R.B. Psychiatric features in diffuse Lewy body disease: a clinicopathologic study using Alzheimer's disease and Parkinson's disease comparison groups. Neurology 47 (1996) 1148-1152
16. Walker M.P., Ayre G.A., Cummings J.L., et al. The clinician assessment of fluctuation and the one day fluctuation assessment scale. Two methods to assess fluctuating confusion in dementia. Br J Psychiatry 177 (2000) 252-256
17. McKeith I.G., Dickson D.W., Lowe J., et al., for the consortium on DLB. Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology 65 (2005) 1863-1872
18. Salmon D.P., Galasko D., Hansen L.A., et al. Neuropsychological deficits associated with diffuse Lewy body disease. Brain Cogn 31 (1996) 148-165
19. Ferman T.J., Boeve B.F., Smith G.E., et al. Dementia with Lewy bodies may present as dementia and REM sleep behavior disorder without parkinsonism or hallucinations. J Int Neuropsychol Soc 8 (2002) 907-914
20. Ferman T.J., Boeve B.F., Smith G.E., et al. REM sleep behavior disorder and dementia: cognitive differences when compared with AD. Neurology 52 (1999) 951-957
21. Ferman T.J., Smith G.E., Boeve B.F., et al. Neuropsychological differentiation of dementia with Lewy bodies from normal aging and Alzheimer's disease. Clin Neuropsychol 20 (2006) 623-636
22. Boeve B.F., Silber M.H., Ferman T.J., et al. REM sleep behavior disorder and degenerative dementia: an association likely reflecting Lewy body disease. Neurology 51 (1998) 363-370
23. Calderon J., Perry R.J., Erzinclioglu S.W., et al. Perception, attention, and working memory are disproportionately impaired in dementia with Lewy bodies compared with Alzheimer's disease. J Neurol Neurosurg Psychiatry 70 (2001) 157-164
24. Ballard C., Holmes C., McKeith I., et al. Psychiatric morbidity in dementia with Lewy bodies: a prospective clinical and neuropathological comparative study with Alzheimer's disease. Am J Psychiatry 156 (1999) 1039-1045
25. Shimomura T., Mori E., Yamashita H., et al. Cognitive loss in dementia with Lewy bodies and Alzheimer disease. Arch Neurol 55 (1998) 1547-1552
26. Connor D.J., Salmon D.P., Sandy T.J., et al. Cognitive profiles of autopsy-confirmed Lewy body variant vs pure Alzheimer disease. Arch Neurol 55 (1998) 994-1000
27. Simard M., van Reekum R., and Myran D. Visuospatial impairment in dementia with Lewy bodies and Alzheimer's disease: a process analysis approach. Int J Geriatr Psychiatry 18 (2003) 387-391
28. Forstl H., Burns A., Luthert P., et al. The Lewy-body variant of Alzheimer's disease. Clinical and pathological findings. Br J Psychiatry 162 (1993) 385-392
29. Gnanalingham K.K., Byrne E.J., Thornton A., et al. Motor and cognitive function in Lewy body dementia: comparison with Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry 62 (1997) 243-252
30. Mori E., Shimomura T., Fujimori M., et al. Visuoperceptual impairment in dementia with L'wy bodies. Arch Neurol 57 (2000) 489-493
31. Mosimann U.P., Mather G., Wesnes K.A., et al. Visual perception in Parkinson disease dementia and dementia with Lewy bodies. Neurology 63 (2004) 2091-2096
32. Mosimann U.P., Muri R.M., Burn D.J., et al. Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies. Brain 128 (2005) 1267-1276
33. Mito Y., Yoshida K., Yabe I., et al. Brain 3-D-SSP SPECT analysis in dementia with Lewy bodies, Parkinson's disease with and without dementia and Alzheimer's disease. Clinical Neurology and Neurosurgery 107 (2005) 396-403
34. Shimuzu S., Hanyu H., Kanetaka H., et al. Differentiation of dementia with Lewy bodies from Alzheimer's disease using brain SPECT. Dementia and Geriatric Cognitive Disorders 20 (2005) 25-30
35. Lobotesis K., Fenwick J.D., Phipps A., et al. Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD. Neurology 56 (2001) 643-649
36. Imamura T., Ishii K., Hirono N., et al. Occipital glucose metabolism in dementia with lewy bodies with and without Parkinsonism: a study using positron emission tomography. Dement Geriatr Cogn Disord 12 (2001) 194-197
37. Dickson D.W., Ruan D., Crystal H., et al. Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease: light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD. Neurology 41 (1991) 1402-1409
38. Dickson D.W., Schmidt M.L., Lee V.M., et al. Immunoreactivity profile of hippocampal CA2/3 neurites in diffuse Lewy body disease. Acta Neuropathol (Berl) 87 (1994) 269-276
39. Barber R., Gholkar A., Scheltens P., et al. Medial temporal lobe atrophy on MRI in dementia with Lewy bodies. Neurology 52 (1999) 1153-1158
40. Johnson D.K., Morris J.C., and Galvin J.E. Verbal and visuospatial deficits in dementia with Lewy bodies. Neurology 65 (2005) 1232-1238
41. Huber S.J., Paulson G.W., and Shuttleworth E.C. Relationship of motor symptoms, intellectual impairment, and depression in Parkinson's disease. J Neurol Neurosurg Psychiatry 51 (1988) 855-858
42. Richards M., Stern Y., Marder K., et al. Relationships between extrapyramidal signs and cognitive function in a community-dwelling cohort of patients with Parkinson's disease and normal elderly individuals. Ann Neurol 33 (1993) 267-274
43. Pearce J. The extrapyramidal disorder of Alzheimer's disease. Eur Neurol 12 (1974) 94-103
44. Molsa P.K., Marttila R.J., and Rinne U.K. Extrapyramidal signs in Alzheimer's disease. Neurology 34 (1984) 1114-1116
45. Rinne U.K., Laakso K., and Molsa P.K. Relationship between Parkinson's and Alzheimer's diseases. Involvement of extrapyramidal, dopaminergic, cholinergic, and somatostatin mechanisms in relation to dementia. Acta Neurol Scand 69 (1984) 59-60
46. Mayeux R., Stern Y., and Spanton S. Heterogeneity in dementia of the Alzheimer type: evidence of subgroups. Neurology 35 (1985) 453-461
47. Crystal H.A., Dickson D.W., Lizardi J.E., et al. Antemortem diagnosis of diffuse Lewy body disease. Neurology 40 (1990) 1523-1528
48. Byrne E.J., Lennox G., Lowe J., et al. Diffuse Lewy body disease: clinical features in 15 cases. J Neurol Neurosurg Psychiatry 52 (1989) 709-717
49. Galasko D., Katzman R., Salmon D.P., et al. Clinical and neuropathological findings in Lewy body dementias. Brain Cogn 31 (1996) 166-175
50. Gibb W.R., Esiri M.M., and Lees A.J. Clinical and pathological features of diffuse cortical Lewy body disease (Lewy body dementia). Brain 110 Pt 5 (1987) 1131-1153
51. McKeith I., Mintzer J., Aarsland D., et al., on behalf of the International Psychogeriatric Association Expert Meeting on DLB. Dementia with Lewy bodies. Lancet Neurol 3 (2004) 19-28
52. Molloy S., McKeith I.G., O'Brien J.T., et al. The role of levodopa in the management of dementia with Lewy bodies. J of Neurol, Neurosurg and Psychiatry 76 (2005) 1200-1203
53. McKeith I.G., Fairbairn A.F., Perry R.H., et al. The clinical diagnosis and misdiagnosis of senile dementia of Lewy body type (SDLT). Br J Psychiatry 165 (1994) 324-332
54. Ferman T.J., Boeve B.F., Silber M.H., et al. Hallucinations and delusions associated with the REM sleep behavior disorder/dementia syndrome. J Neuropsychiatry Clin Neurosci 9 (1997) 692
55. Ferman T.J., Boeve B.F., Smith G.E., et al. The phenomenology of psychotic features in Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Neurology 64 (2005) A257
56. Cercy S.P., and Bylsma F.W. Lewy bodies and progressive dementia: a critical review and meta-analysis. J Int Neuropsychol Soc 3 (1997) 179-194
57. Sanchez-Ramos J.R., Ortoll R., and Paulson G.W. Visual hallucinations associated with Parkinson disease. Arch Neurol 53 (1996) 1265-1268
58. Harding A.J., Broe G.A., and Halliday G.M. Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe. Brain 125 (2002) 391-403
59. McKeith I., Fairbairn A., Perry R., et al. Neuroleptic sensitivity in patients with senile dementia of Lewy body type. BMJ 305 (1992) 673-678
60. Rockwell E., Choure J., Galasko D., et al. Psychopathology at initial diagnosis in dementia with Lewy bodies versus Alzheimer disease: comparison of matched groups with autopsy-confirmed diagnoses. Int J Geriatr Psychiatry 15 (2000) 819-823
61. Ala T.A., Yang K.H., Sung J.H., et al. Hallucinations and signs of parkinsonism help distinguish patients with dementia and cortical Lewy bodies from patients with Alzheimer's disease at presentation: a clinicopathological study. J Neurol Neurosurg Psychiatry 62 (1997) 16-21
62. Hope T., Keene J., Fairburn C.G., et al. Natural history of behavioural changes and psychiatric symptoms in Alzheimer's disease. A longitudinal study. Br J Psychiatry 174 (1999) 39-44
63. Ferman T.J., Dickson D.W., Graff-Radford N., et al. Early onset of visual hallucinations in dementia distinguishes pathologically-confirmed Lewy body disease from AD. Neurology 60 5 (2003) A264
64. Salmon D.P., Kwo-on-Yuen P.F., Heindel W.C., et al. Differentiation of Alzheimer's disease and Huntington's disease with the Dementia Rating Scale. Arch Neurol 46 (1989) 1204-1208
65. Ballard C., Bannister C., Graham C., et al. Associations of psychotic symptoms in dementia sufferers. Br J Psychiatry 167 (1995) 537-540
66. Klein C., Kompf D., Pulkowski U., et al. A study of visual hallucinations in patients with Parkinson's disease. J Neurol 244 (1997) 371-377
67. Lopez O.L., Becker J.T., Brenner R.P., et al. Alzheimer's disease with delusions and hallucinations: neuropsychological and electroencephalographic correlates. Neurology 41 (1991) 906-912
68. Lopez O.L., Brenner R.P., Becker J.T., et al. EEG spectral abnormalities and psychosis as predictors of cognitive and functional decline in probable Alzheimer's disease. Neurology 48 (1997) 1521-1525
69. Boeve B., Silber M., and Ferman T. REM sleep behavior disorder in Parkinson's disease and dementia with Lewy bodies. J Geriatr Psychiatry Neurol 17 (2004) 146-157
70. Boeve B.F., Silber M.H., Parisi J.E., et al. Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. Neurology 61 (2003) 40-45
71. Lopez O.L., Hamilton R.L., Becker J.T., et al. Severity of cognitive impairment and the clinical diagnosis of AD with Lewy bodies. Neurology 54 (2000) 1780-1787
72. Hohl U., Tiraboschi P., Hansen L.A., et al. Diagnostic accuracy of dementia with Lewy bodies. Arch Neurol 57 (2000) 347-351
73. Walker M.P., Ayre G.A., Perry E.K., et al. Quantification and characterization of fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease. Dement Geriatr Cogn Disord 11 (2000) 327-335
74. Ballard C.G., Aarsland D., McKeith I., et al. Fluctuations in attention: PD dementia vs DLB with parkinsonism. Neurology 59 (2002) 1714-1720
75. Ballard C., Walker M., O'Brien J., et al. The characterisation and impact of 'fluctuating' cognition in dementia with Lewy bodies and Alzheimer's disease. Int J Geriatr Psychiatry 16 (2001) 494-498
76. Ballard C., O'Brien J., Gray A., et al. Attention and fluctuating attention in patients with dementia with Lewy bodies and Alzheimer disease. Arch Neurol 58 (2001) 977-982
77. Ferman T.J., Smith G.E., Boeve B.F., et al. DLB fluctuations: specific features that reliably differentiate DLB from AD and normal aging. Neurology 62 (2004) 181-187
78. Ferman T.J., Boeve B.F., Silber M.H., et al. Is fluctuating cognition in dementia with sleep. Sleep 24 (2001) 374
79. Boeve B.F., Ferman T.J., Silber M.H., et al. Sleep disturbances in dementia with Lewy bodies involve more than REM sleep behavior disorder. Neurology 60 5 (2003) A79
80. Kales A., Ansel R.D., Markham C.H., et al. Sleep in patients with Parkinson's disease and normal subjects prior to and following levodopa administration. Clin Pharmacol Ther 12 (1971) 397-406
81. Wetter T.C., Collado-Seidel V., Pollmacher T., et al. Sleep and periodic leg movement patterns in drug-free patients with Parkinson's disease and multiple system atrophy. Sleep 23 (2000) 361-367
82. Bliwise D.L. Sleep in normal aging and dementia. Sleep 16 (1993) 40-81
83. American Sleep Disorders Association. The international classification of sleep disorders diagnostic and coding manual (1997), American Sleep Disorders Association, Rochester (MN)
84. Jouvet M., and Delorme F. [Locus coeruleus et sommeil paradoxal]. C R Seances Soc Biol Fil 159 (1965) 895-899
85. Lai Y.Y., and Siegel J.M. Physiological and anatomical link between Parkinson-like disease and REM sleep behavior disorder. Mol Neurobiol 27 (2003) 137-152
86. Hendricks J.C., Morrison A.R., and Mann G.L. Different behaviors during paradoxical sleep without atonia depend on pontine lesion site. Brain Res 239 (1982) 81-105
87. Lu J., Sherman D., Devor M., et al. A putative flip-flop switch for control of REM sleep. Nature 441 (2006) 589-594
88. Plazzi G., Corsini R., Provini F., et al. REM sleep behavior disorders in multiple system atrophy. Neurology 48 (1997) 1094-1097
89. Gagnon J.F., Bedard M.A., Fantini M.L., et al. REM sleep behavior disorder and REM sleep without atonia in Parkinson's disease. Neurology 59 (2002) 585-589
90. Schenck C.H., Bundlie S.R., and Mahowald M.W. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology 46 (1996) 388-393
91. Turner R.S., Chervin R.D., Frey K.A., et al. Probable diffuse Lewy body disease presenting as REM sleep behavior disorder. Neurology 49 (1997) 523-527
92. Boeve B.F., Silber M.H., Ferman T.J., et al. Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy. Mov Disord 16 (2001) 622-630
93. Uchiyama M., Isse K., Tanaka K., et al. Incidental Lewy body disease in a patient with REM sleep behavior disorder. Neurology 45 (1995) 709-712
94. Boeve B.F., Dickson D.W., Olson E.J., et al. Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Sleep Med 8 (2007) 60-64
95. Boeve BF, Silber MH, Saper CB, et al. Pathophysiology of REM sleep behavior disorder and relevance to neurodegenerative disease. Brain, in press.
96. Thaisetthawatkul P., Boeve B.F., Benarroch E.E., et al. Autonomic dysfunction in dementia with Lewy bodies. Neurology 62 (2004) 1804-1809
97. Stern Y., Albert M., Brandt J., et al. Utility of extrapyramidal signs and psychosis as predictors of cognitive and functional decline, nursing home admission, and death in Alzheimer's disease: prospective analyses from the Predictors Study. Neurology 44 (1994) 2300-2307
98. Armstrong T.P., Hansen L.A., Salmon D.P., et al. Rapidly progressive dementia in a patient with the Lewy body variant of Alzheimer's disease. Neurology 41 (1991) 1178-1180
99. Olichney J.M., Galasko D., Salmon D.P., et al. Cognitive decline is faster in Lewy body variant than in Alzheimer's disease. Neurology 51 (1998) 351-357
100. Ballard C., Patel A., Oyebode F., et al. Cognitive decline in patients with Alzheimer's disease, vascular dementia and senile dementia of Lewy body type. Age Ageing 25 (1996) 209-213
101. Ballard C., O'Brien J., Morris C.M., et al. The progression of cognitive impairment in dementia with Lewy bodies, vascular dementia and Alzheimer's disease. Int J Geriatr Psychiatry 16 (2001) 499-503
102. Helmes E., Bowler J.V., Merskey H., et al. Rates of cognitive decline in Alzheimer's disease and dementia with Lewy bodies. Dement Geriatr Cogn Disord 15 (2003) 67-71
103. Williams M.M., Xiong C., Morris J.C., et al. Survival and mortality differences between dementia with Lewy bodies vs. Alzheimer's disease. Neurology 67 (2006) 1935-1941
104. Dickson D.W. Dementia with Lewy bodies: neuropathology. J Geriatr Psychiatry Neurol 15 (2002) 210-216
105. Pollanen M.S., Dickson D.W., and Bergeron C. Pathology and biology of the Lewy body. J Neuropathol Exp Neurol 52 (1993) 183-191
106. Dickson D.W., Davies P., Mayeux R., et al. Diffuse Lewy body disease. Neuropathological and biochemical studies of six patients. Acta Neuropathol (Berl) 75 (1987) 8-15
107. Dickson D.W., Feany M.B., Yen S.H., et al. Cytoskeletal pathology in non-Alzheimer degenerative dementia: new lesions in diffuse Lewy body disease, Pick's disease, and corticobasal degeneration. J Neural Transm Suppl 47 (1996) 31-46
108. Kosaka K., Yoshimura M., Ikeda K., et al. Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree-a new disease?. Clin Neuropathol 3 (1984) 185-192
109. Braak H., and Braak E. Pathoanatomy of Parkinson's disease. J Neurol 247 Suppl 2 (2000) :II3-10
110. Braak H., Del Tredici K., Rub U., et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24 (2003) 197-211
111. Kosaka K. Diffuse Lewy body disease in Japan. J Neurol 237 (1990) 197-204
112. Whitwell JL, Jack CR, Parisi JE, et al. Rates of cerebral atrophy differ in different degenerative pathologies. Brain 2007;130:1148-58.
113. Whitwell JL, Weigand SD, Josephs KA, et al. Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's disease. Brain 2007;130:708-19.
114. Dickson D.W. Neuropathological diagnosis of Alzheimer's disease: a perspective from longitudinal clinicopathological studies. Neurobiol Aging 18 (1997) S21-S26
115. Lippa C.F., Smith T.W., and Perry E. Dementia with Lewy bodies: choline acetyltransferase parallels nucleus basalis pathology. J Neural Transm 106 (1999) 525-535
116. Dickson D.W., Crystal H., Mattiace L.A., et al. Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques. Acta Neuropathol (Berl) 78 (1989) 572-584
117. Dickson D.W. The pathogenesis of senile plaques. J Neuropathol Exp Neurol 56 (1997) 321-339
118. Armstrong R.A., Cairns N.J., and Lantos P.L. Beta-amyloid deposition in the temporal lobe of patients with dementia with Lewy bodies: comparison with non-demented cases and Alzheimer's disease. Dement Geriatr Cogn Disord 11 (2000) 187-192
119. Jellinger K.A. Morphological substrates of mental dysfunction in Lewy body disease: an update. J Neural Transm Suppl 59 (2000) 185-212
120. Katzman R., Brown T., Thal L.J., et al. Comparison of rate of annual change of mental status score in four independent studies of patients with Alzheimer's disease. Ann Neurol 24 (1988) 384-389
121. Dickson D.W., Crystal H.A., Mattiace L.A., et al. Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiol Aging 13 (1992) 179-189
122. Hansen L.A., Masliah E., Galasko D., et al. Plaque-only Alzheimer disease is usually the lewy body variant, and vice versa. J Neuropathol Exp Neurol 52 (1993) 648-654
123. Samuel W., Galasko D., Masliah E., et al. Neocortical lewy body counts correlate with dementia in the Lewy body variant of Alzheimer's disease. J Neuropathol Exp Neurol 55 (1996) 44-52
124. Braak H., and Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 82 (1991) 239-259
125. Samuel W., Alford M., Hofstetter C.R., et al. Dementia with Lewy bodies versus pure Alzheimer disease: differences in cognition, neuropathology, cholinergic dysfunction, and synapse density. J Neuropathol Exp Neurol 56 (1997) 499-508
126. Merdes A.R., Hansen L.A., Jeste D.V., et al. Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies. Neurology 60 (2003) 1586-1590
127. Del Ser T., Hachinski V., Merskey H., et al. Clinical and pathologic features of two groups of patients with Dementia with Lewy bodies: Effect of coexisting Alzheimer-type lesion load. Alzheimer Dis and Assoc Dis 15 (2001) 31-44
128. Samuel W.A., Henderson V.W., and Miller C.A. Severity of dementia in Alzheimer disease and neurofibrillary tangles in multiple brain regions. Alzheimer Dis Assoc Disord 5 (1991) 1-11
129. Arriagada P.V., Growdon J.H., Hedley-Whyte E.T., et al. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42 (1992) 631-639
130. Haroutunian V., Serby M., Purohit D.P., et al. Contribution of Lewy body inclusions to dementia in patients with and without Alzheimer disease neuropathological conditions. Arch Neurol 57 (2000) 1145-1150
131. Hurtig H.I., Trojanowski J.Q., Galvin J., et al. Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease. Neurology 54 (2000) 1916-1921
132. Churchyard A., and Lees A.J. The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson's disease. Neurology 49 (1997) 1570-1576
133. Ransmayr G., Cervera P., Hirsch E.C., et al. Alzheimer's disease: is the decrease of the cholinergic innervation of the hippocampus related to intrinsic hippocampal pathology?. Neuroscience 47 (1992) 843-851
134. West M.J., Coleman P.D., Flood D.G., et al. Differences in the pattern of hippocampal neuronal loss in normal aging and Alzheimer's disease. Lancet 344 (1994) 769-772
135. Nagy Z., Jobst K.A., Esiri M.M., et al. Hippocampal pathology reflects memory deficit and brain imaging measurements in Alzheimer's disease: clinicopathologic correlations using three sets of pathologic diagnostic criteria. Dementia 7 (1996) 76-81
136. Harding A.J., Lakay B., and Halliday G.M. Selective hippocampal neuron loss in dementia with Lewy bodies. Ann Neurol 51 (2002) 125-128
137. Lippa C.F., Pulaski-Salo D., Dickson D.W., et al. Alzheimer's disease, Lewy body disease and aging: a comparative study of the perforant pathway. J Neurol Sci 147 (1997) 161-166
138. Mesulam M.M., Mufson E.J., Levey A.I., et al. Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey. J Comp Neurol 214 (1983) 170-197
139. Himmelheber A.M., Sarter M., and Bruno J.P. The effects of manipulations of attentional demand on cortical acetylcholine release. Brain Res Cogn Brain Res 12 (2001) 353-370
140. McGaughy J., Kaiser T., and Sarter M. Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density. Behav Neurosci 110 (1996) 247-265
141. McGaughy J., Everitt B.J., Robbins T.W., et al. The role of cortical cholinergic afferent projections in cognition: impact of new selective immunotoxins. Behav Brain Res 115 (2000) 251-263
142. Torres E.M., Perry T.A., Blockland A., et al. Behavioural, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system. Neuroscience 63 (1994) 95-122
143. Voytko M.L., Olton D.S., Richardson R.T., et al. Basal forebrain lesions in monkeys disrupt attention but not learning and memory. J Neurosci 14 (1994) 167-186
144. Davis K.L., Mohs R.C., Marin D., et al. Cholinergic markers in elderly patients with early signs of Alzheimer disease. JAMA 281 15 (1999) 1401-1406
145. Perry E.K., Irving D., Kerwin J.M., et al. Cholinergic transmitter and neurotrophic activities in Lewy body dementia: similarity to Parkinson's and distinction from Alzheimer disease. Alzheimer Dis Assoc Disord 7 (1993) 69-79
146. Perry E.K., Haroutunian V., Davis K.L., et al. Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer's disease. Neuroreport 5 (1994) 747-749
147. Tiraboschi P., Hansen L.A., Alford M., et al. Early and widespread cholinergic losses differentiate dementia with Lewy bodies from Alzheimer disease. Arch Gen Psychiatry 59 (2002) 946-951
148. Perry E.K., and Perry R.H. Acetylcholine and hallucinations: disease-related compared to drug-induced alterations in human consciousness. Brain Cogn 28 (1995) 240-258
149. Perry R., McKeith I., and Perry E. Lewy body dementia-clinical, pathological and neurochemical interconnections. J Neural Transm Suppl 51 (1997) 95-109
150. Tune L.E., and Egeli S. Acetylcholine and delirium. Dement Geriatr Cogn Disord 10 (1999) 342-344
151. Flacker J.M., Cummings V., Mach Jr. J.R., et al. The association of serum anticholinergic activity with delirium in elderly medical patients. Am J Geriatr Psychiatry 6 (1998) 31-41
152. Han L., McCusker J., Cole M., et al. Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients. Arch Intern Med 161 (2001) 1099-1105
153. Tune L.E., Damlouji N.F., Holland A., et al. Association of postoperative delirium with raised serum levels of anticholinergic drugs. Lancet 2 (1981) 651-653
154. Perry E., Walker M., Grace J., et al. Acetylcholine in mind: a neurotransmitter correlate of consciousness?. Trends Neurosci 22 (1999) 273-280
155. Lebert F., Pasquier F., Souliez L., et al. Tacrine efficacy in Lewy body dementia. Int J Geriatr Psychiatry 13 (1998) 516-519
156. Wengel S.P., Roccaforte W.H., and Burke W.J. Donepezil improves symptoms of delirium in dementia: implications for future research. J Geriatr Psychiatry Neurol 11 (1998) 159-161
157. Samuel W., Caligiuri M., Galasko D., et al. Better cognitive and psychopathologic response to donepezil in patients prospectively diagnosed as dementia with Lewy bodies: a preliminary study. Int J Geriatr Psychiatry 15 (2000) 794-802
158. Maclean L.E., Collins C.C., and Byrne E.J. Dementia with Lewy bodies treated with rivastigmine: effects on cognition, neuropsychiatric symptoms, and sleep. Int Psychogeriatr 13 (2001) 277-288
159. Bergman J., and Lerner V. Successful use of donepezil for the treatment of psychotic symptoms in patients with Parkinson's disease. Clin Neuropharmacol 25 (2002) 107-110
160. Francis J., Martin D., and Kapoor W.N. A prospective study of delirium in hospitalized elderly. Jama 263 (1990) 1097-1101
161. Moore D.P. Rapid treatment of delirium in critically ill patients. Am J Psychiatry 134 (1977) 1431-1432
162. Allen R.L., Walker Z., D'Ath P.J., et al. Risperidone for psychotic and behavioural symptoms in Lewy body dementia. Lancet 346 (1995) 185
163. Miller C.H., Mohr F., Umbricht D., et al. The prevalence of acute extrapyramidal signs and symptoms in patients treated with clozapine, risperidone, and conventional antipsychotics. J Clin Psychiatry 59 (1998) 69-75
164. Burke W.J., Pfeiffer R.F., and McComb R.D. Neuroleptic sensitivity to clozapine in dementia with Lewy bodies. J Neuropsychiatry Clin Neurosci 10 (1998) 227-229
165. Sechi G., Agnetti V., Masuri R., et al. Risperidone, neuroleptic malignant syndrome and probable dementia with Lewy bodies. Prog Neuropsychopharmacol Biol Psychiatry 24 (2000) 1043-1051
166. Rosebush P.I., and Mazurek M.F. Neurologic side effects in neuroleptic-naive patients treated with haloperidol or risperidone. Neurology 52 (1999) 782-785
167. Piggott M.A., Perry E.K., Marshall E.F., et al. Nigrostriatal dopaminergic activities in dementia with Lewy bodies in relation to neuroleptic sensitivity: comparisons with Parkinson's disease. Biol Psychiatry 44 (1998) 765-774
168. Court J.A., Piggott M.A., Lloyd S., et al. Nicotine binding in human striatum: elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease and in relation to neuroleptic medication. Neuroscience 98 (2000) 79-87
169. Cummings J.L., Street J., Masterman D., et al. Efficacy of olanzapine in the treatment of psychosis in dementia with Lewy bodies. Dementia and Geriatric Cognitive Disorders 13 (2002) 67-73
170. Aarsland D., Larsen J.P., Lim N.G., et al. Olanzapine for psychosis in patinets with Parkinson's disease with and without dementia. J of Neuropsy and Clin Neurosc 11 (1999) 392-394
171. Ellingrod V.L., Schultz S.K., Ekstam-Smith K., et al. Comparison of risperdone with olanzepine in elderly patients with dementia and psychosis. Pharmacotherapy 22 (2002) 1-5
172. Mulsant B.H., Gharabawi G.M., Bossie C.A., et al. Correlates of anticholinergic activity in patients with dementia and psychosis treated with risperidone or olanzepine. J of Clinical Psychiatry 65 (2004) 1708-1714
173. Ballard C., Margallo-Lana M., Juszczak E., Swann D.S., et al. Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease: randomised double blind placebo controlled trial. BMJ 333 (2005) 857-858
174. Juncos J.L., Roberts V.J., Evatt M.L., et al. Quetiapine improves psychotic symptoms and cognition in Parkinson's disease. Movement Disorders 19 (2004) 29-35
175. Morrison C.E., Borod J.C., Brin M.F., et al. Effects of levodopa on cognitive functioning in moderate-to-severe Parkinson's disease (MSPD). J Neural Transm 111 (2004) 1333-1341
176. Kulisevsky J., Garcia-Sanchez C., Berthier M.L., et al. Chronic effects of dopaminergic replacement on cognitive function in Parkinson's disease: a two-year follow-up study of previously untreated patients. Movement Disorders 15 (2000) 613-626
177. Bedard M.A., Pillon B., Dubois B., et al. Acute and long-term administration of anticholinergics in Parkinson's disease: specific effects on the subcortico-frontal syndrome. Brain Cogn 40 (1999) 289-313
178. McKeith I., Del Ser T., Spano P., et al. Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. Lancet 356 (2000) 2031-2036
179. Kaufer D.I., Catt K.E., Lopez O.L., et al. Dementia with Lewy bodies: response of delirium-like features to donepezil. Neurology 51 (1998) 1512
180. Wilcock G.K., and Scott M.I. Tacrine for senile dementia of Alzheimer's or Lewy body type. Lancet 344 (1994) 544
181. Levy R., Eagger S., Griffiths M., et al. Lewy bodies and response to tacrine in Alzheimer's disease. Lancet 343 (1994) 176
182. Grace J., Daniel S., Stevens T., et al. Long term use of rivastigmine in patients with dementia with Lewy bodies: an open-label trials. Int Psychogeriatr 13 (2001) 199-205
183. Bosboom JL, Stoffers D, Wolters ECh. Cognitive dysfunction and dementia in Parkinson's disease. J of Neural Transm 2004;111:1303-15.
184. Minett T.S., Thomas A., Wilkinson L.M., et al. What happens when donepezil is suddently withdrawn? An open label trial in dementia with Lewy bodies and Parkinson's disease with dementia. International J of Geriatric Psychiatry 18 (2003) 988-993
185. Thomas A.J., Burn D.J., Rowan E.N., et al. A comparison of the efficacy of donepezil in Parkison's'disease with dementia and dementia with Lewy bodies. Int J Geriatr Psychiatry 20 (2005) 938-944
186. Cummings J. Reconsidering diagnostic criteria for dementia with Lewy bodies. Highlights from the Third International Workshop on Dementia with Lewy bodies and Parkinson's disease dementia, September 17-20, 2003, Newcastle upon Tyne, United Kingdom. Rev Neurol Dis 1 1 (2004) 31-34
187. Boeve B., Silber M., Ferman T.J., et al. Current management of sleep disturbances in dementia. Curr Neurol Neurosci Rep 2 (2001) 169-177
188. Boeve B., Silber M., and Ferman T. Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. Sleep med 4 (2003) 281-284
189. Carlson D., Fleming K., Smith G.E., et al. Management of dementia-related behavioral disturbances: a non-pharmacological approach. Mayo Clin Proc 70 (1995) 1108-1115
190. Haupt M., Karger A., and Janner M. Improvement of agitation and anxiety in demented patients after psychoeducative group intervention with their caregivers. International J of Geriatric Psychiatry 15 (2000) 1125-1129
191. Zarit S.H., Stephens M.A., Townsend A., et al. Stress reduction for family caregivers: effect of adult day care use. J Gerontol 53 (1998) S267-S277