Effect of alkyl chain length on sphingosine kinase 2 selectivity

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 22, 2012, Pages 6817-6820

  Knott, Kenneth ^a   Kharel, Yugesh ^b   Raje, Mithun R ^a   Lynch, Kevin R ^b   Santos, Webster L ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Cancer; FTY720; Kinase inhibitors; Sphingosine; Sphingosine kinase; Structure activity relationships

Indexed keywords

ALKYL GROUP; CYCLOHEXYLAMINE; FINGOLIMOD; ISOENZYME; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2;

ARTICLE; STRUCTURE ACTIVITY RELATION;

CYCLOHEXYLAMINES; ENZYME INHIBITORS; ISOENZYMES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROPYLENE GLYCOLS; PROTEIN BINDING; SPHINGOSINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867850672     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.050     Document Type: Article

References (19)

1. N.J. Pyne, and S. Pyne Nat. Rev. Cancer 10 2010 489
2. H. Liu, D. Chakravarty, M. Maceyka, S. Milstien, and S. Spiegel Prog. Nucleic Acid Res. Mol. Biol. 71 2002 493
3. J.A. Cohen, F. Barkhof, G. Comi, H.P. Hartung, B.O. Khatri, X. Montalban, J. Pelletier, R. Capra, P. Gallo, G. Izquierdo, K. Tiel-Wilck, A. de Vera, J. Jin, T. Stites, S. Wu, S. Aradhye, and L.N. Kappos Engl. J. Med. 362 2010 402
4. L. Kappos, E.W. Radue, P. O'Connor, C. Polman, R. Hohlfeld, P. Calabresi, K. Selmaj, C. Agoropoulou, M. Leyk, L. Zhang-Auberson, and P.N. Burtin Engl. J. Med. 362 2010 387
5. S. Pyne, R. Bittman, and N. Pyne J. Cancer Res. 71 2011 6576
6. N.C. Hait, J. Allegood, M. Maceyka, G.M. Strub, K.B. Harikumar, S.K. Singh, C. Luo, R. Marmorstein, T. Kordula, S. Milstien, and S. Spiegel Science 325 2009 1254
7. H. Liu, R.E. Toman, S.K. Goparaju, M. Maceyka, V.E. Nava, H. Sankala, S.G. Payne, M. Bektas, I. Ishii, J. Chun, S. Milstien, and S. Spiegel J. Biol. Chem. 278 2003 40330
8. J.R. Van Brocklyn, C.A. Jackson, D.K. Pearl, M.S. Kotur, P.J. Snyder, and T.W. Prior J. Neuropathol. Exp. Neurol, 64 2005 695
9. H.M. Sankala, N.C. Hait, S.W. Paugh, D. Shida, S. Lepine, L.W. Elmore, P. Dent, S. Milstien, and S. Spiegel Cancer Res. 67 2007 10466
10. N.C. Hait, S. Sarkar, H. Le Stunff, A. Mikami, M. Maceyka, S. Milstien, and S. Spiegel J. Biol. Chem. 280 2005 29462
11. P. Gao, and C.D. Smith Mol. Cancer Res. 9 2011 1509
12. N. Takasugi, T. Sasaki, K. Suzuki, S. Osawa, H. Isshiki, Y. Hori, N. Shimada, T. Higo, S. Yokoshima, T. Fukuyama, V.M. Lee, J.Q. Trojanowski, T. Tomita, and T. Iwatsubo J. Neurosci. 31 2011 6850
13. Y. Shi, H. Rehman, V.K. Ramshesh, J. Schwartz, Q. Liu, Y. Krishnasamy, X. Zhang, J.J. Lemasters, C.D. Smith, and Z. Zhong J. Hepatol. 156 2011 137
14. K.J. French, Y. Zhuang, L.W. Maines, P. Gao, W.X. Wang, V. Beljanski, J.J. Upson, C.L. Green, S.N. Keller, and C.D. Smith J. Pharmacol. Exp. Ther. 333 2010 129
15. K.G. Lim, C. Sun, R. Bittman, N.J. Pyne, and S. Pyne Cell. Signal. 23 2011 1590
16. M.R. Raje, K. Knott, Y. Kharel, P. Bissel, K.R. Lynch, and W.L. Santos Bioorg. Med. Chem. 20 2012 183
17. T.P. Boyle, J.B. Bremner, J.A. Coates, J. Deadman, P.A. Keller, S.G. Pyne, and K. Somphol Eur. J. Med. Chem. 44 2006 1001
18. B. Panunzi, L. Rotiroti, and M. Tingoli Tetrahedron Lett. 44 2003 8753
19. Y. Kharel, T.P. Mathews, A.J. Kennedy, J.D. Houck, and K.R. Lynch Anal. Biochem. 411 2011 230