Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: Functional differences between sphingosine kinase 1a and 1b

International Journal of Biochemistry and Cell Biology

Volumn 44, Issue 9, 2012, Pages 1457-1464

  Lim, Keng Gat ^a   Tonelli, Francesca ^a   Berdyshev, Evgeny ^b   Gorshkova, Irina ^b   Leclercq, Tamara ^c   Pitson, Stuart M ^c,d   Bittman, Robert ^e   Pyne, Susan ^a   Pyne, Nigel J ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c University of Adelaide   (Australia)

^d UNIVERSITY OF ADELAIDE   (Australia)

^e CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Allosteric; Apoptosis; Diacylglycerol kinase' cancer; Enzyme kinetics; Sphingosine kinase 1

Indexed keywords

2 (4 HYDROXYANILINO) 4 (4 CHLOROPHENYL)THIAZOLE; ANTINEOPLASTIC AGENT; FINGOLIMOD; FINGOLIMOD VINYLPHOSPHONATE; PHOSPHOTRANSFERASE INHIBITOR; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 1A; SPHINGOSINE KINASE 1B; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING SITE; CANCER CELL; CATALYSIS; CONTROLLED STUDY; ENZYME BINDING; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; MOLECULARLY TARGETED THERAPY; PROSTATE CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC SITE; CATALYTIC DOMAIN; CELL LINE, TUMOR; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ISOENZYMES; KINETICS; MALE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROSTATIC NEOPLASMS; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 84862766241     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.05.012     Document Type: Article

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