FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C δ signaling

Cancer Research

Volumn 68, Issue 4, 2008, Pages 1204-1212

  Hung, Jui Hsiang ^a   Lu, Yen Shen ^b   Wang, Yu Chieh ^a   Ma, Yi Hui ^a   Wang, Da Sheng ^a   Kulp, Samuel K ^a   Muthusamy, Natarajan ^a   Byrd, John C ^a   Cheng, Ann Lii ^b   Chen, Ching Shih ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 3 INHIBITOR; FINGOLIMOD; GLUTATHIONE TRANSFERASE P1; OXIDOREDUCTASE INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE C DELTA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SHORT HAIRPIN RNA; SYNAPTOPHYSIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOSYNTHESIS; CANCER CELL CULTURE; CANCER RESISTANCE; CELL PROTECTION; CELL VIABILITY; CHEMOSENSITIVITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG MECHANISM; ENZYMATIC DEGRADATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; KNOCKOUT GENE; LIVER CELL CARCINOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; ENZYME ACTIVATION; HUMANS; LIVER NEOPLASMS; PROPYLENE GLYCOLS; PROTEIN KINASE C-DELTA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 39449103924     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-2621     Document Type: Article

References (50)

1. Tedesco-Silva H, Mourad G, Kahan BD, et al. FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation. Transplantation 2004;77:1826-33.
2. Kappos L, Antel J, Comi G, et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med 2006;355:1124-40.
3. Brinkmann V, Davis MD, Heise CE, et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 2002;277:21453-7.
4. Graler MH, Goetzl EJ. The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. FASEB J 2004;18:551-3.
5. Matsuoka Y, Nagahara Y, Ikekita M, et al. A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells. Br J Pharmacol 2003;138:1303-12.
6. Yasui H, Hideshima T, Raje N, et al. FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. Cancer Res 2005;65:7478-84.
7. Ho JW, Man K, Sun CK, et al. Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma. Mol Cancer Ther 2005;4:1430-8.
8. Lee TK, Man K, Ho JW, et al. FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. Carcinogenesis 2004;25:2397-405.
9. Chua CW, Lee DT, Ling MT, et al. FTY720, a fungus metabolite, inhibits in vivo growth of androgenin-dependent prostate cancer. Int J Cancer 2005;117:1039-48.
10. Permpongkosol S, Wang JD, Takahara S, et al. Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis. Int J Cancer 2002;98:167-72.
11. Wang JD, Takahara S, Nonomura N, et al. Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation. Prostate 1999;40:50-5.
12. Zhou C, Ling MT, Kin-Wah Lee T, et al. FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase. Cancer Lett 2006;233:36-47.
13. Azuma H, Horie S, Muto S, et al. Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity. Anticancer Res 2003;23:3183-93.
14. Ubai T, Azuma H, Kotake Y, et al. FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft. Anticancer Res 2007;27:75-88.
15. Tanaka T, Takahara S, Hatori M, et al. A novel immunosuppressive drug, FTY720, prevents the cancer progression induced by cyclosporine. Cancer Lett 2002;181:165-71.
16. Brinkmann V, Wilt C, Kristofic C, et al. FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects. Transplant Proc 2001;33:3078-80.
17. Ries LAG, Melbert D, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2004, National Cancer Institute. Bethesda (MD): 2007.
18. Rougier P, Mitry E, Barbare JC, et al. Hepatocellular carcinoma (HCC): an update. Semin Oncol 2007;34:S12-20.
19. Abou-Alfa GK, Schwartz L, Ricci S, et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006;24:4293-300.
20. Anantharam V, Kitazawa M, Wagner J, et al. Caspase-3-dependent proteolytic cleavage of protein kinase Cδ is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. J Neurosci 2002;22:1738-51.
21. Kitazawa M, Anantharam V, Kanthasamy AG. Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cδ in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Neuroscience 2003;119:945-64.
22. Frasch SC, Henson PM, Kailey JM, et al. Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cδ. J Biol Chem 2000;275:23065-73.
23. Emoto Y, Kisaki H, Manome Y, et al. Activation of protein kinase Cδ in human myeloid leukemia cells treated with 1-β-D- arabinofuranosylcytosine. Blood 1996;87:1990-6.
24. Matassa AA, Carpenter L, Biden TJ, et al. PKCδ is required for mitochondrial-dependent apoptosis in salivary epithelial cells. J Biol Chem 2001;276:29719-28.
25. Kiuchi M, Adachi K, Kohara T, et al. Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols. J Med Chem 2000;43:2946-61.
26. Takehara T, Liu X, Fujimoto J, et al. Expression and role of Bcl-xL in human hepatocellular carcinomas. Hepatology 2001;34:55-61.
27. Wan X, Helman LJ. Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells. Oncogene 2003;22:8205-11.
28. Denning MF, Wang Y, Tibudan S, et al. Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C. Cell Death Differ 2002;9:40-52.
29. Konishi H, Yamauchi E, Taniguchi H, et al. Phosphorylation sites of protein kinase C δ in H2O2-treated cells and its activation by tyrosine kinase in vitro. Proc Natl Acad Sci U S A 2001;98:6587-92.
30. Kajimoto T, Ohmori S, Shirai Y, et al. Subtype-specific translocation of the δ subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells. Mol Cell Biol 2001;21:1769-83.
31. Emoto Y, Manome Y, Meinhardt G, et al. Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells. EMBO J 1995;14:6148-56.
32. Denning MF, Wang Y, Nickoloff BJ, et al. Protein kinase Cδ is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes. J Biol Chem 1998;273:29995-30002.
33. Aliya S, Reddanna P, Thyagaraju K. Does glutathione S-transferase π (GST-π) a marker protein for cancer? Mol Cell Biochem 2003;253:319-27.
34. Simeone AM, Ekmekcioglu S, Broemeling LD, et al. A novel mechanism by which N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell growth: the production of nitric oxide. Mol Cancer Ther 2002;1:1009-17.
35. Wu JM, DiPietrantonio AM, Hsieh TC. Mechanism of fenretinide (4-HPR)-induced cell death. Apoptosis 2001;6:377-88.
36. Jing Y, Dai J, Chalmers-Redman RM, et al. Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood 1999;94:2102-11.
37. Wen J, You KR, Lee SY, et al. Oxidative stressmediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide. J Biol Chem 2002;277:38954-64.
38. Siddik ZH. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 2003;22:7265-79.
39. Pelicano H, Carney D, Huang P. ROS stress in cancer cells and therapeutic implications. Drug Resist Updat 2004;7:97-110.
40. McIlwain CC, Townsend DM, Tew KD. Glutathione S-transferase polymorphisms: cancer incidence and therapy. Oncogene 2006;25:1639-48.
41. Ban N, Takahashi Y, Takayama T, et al. Transfection of glutathione S-transferase (GST)- π antisense complementary DNA increases the sensitivity of a colon cancer cell line to adriamycin, cisplatin, melphalan, and etoposide. Cancer Res 1996;56:3577-82.
42. Turcotte S, Averill-Bates DA. Sensitization to the cytotoxicity of melphalan by ethacrynic acid and hyperthermia in drug-sensitive and multidrug-resistant Chinese hamster ovary cells. Radiat Res 2001;156:272-82.
43. Brodie C, Blumberg PM. Regulation of cell apoptosis by protein kinase c δ. Apoptosis 2003;8:19-27.
44. Jackson DN, Foster DA. The enigmatic protein kinase Cy: complex roles in cell proliferation and survival. FASEB J 2004;18:627-36.
45. Blass M, Kronfeld I, Kazimirsky G, et al. Tyrosine phosphorylation of protein kinase Cδ is essential for its apoptotic effect in response to etoposide. Mol Cell Biol 2002;22:182-95.
46. Zrachia A, Dobroslav M, Blass M, et al. Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C δ. Implications for Sindbis virus-induced apoptosis. J Biol Chem 2002;277:23693-701.
47. Liu Q, Zhao X, Frissora F, et al. FTY720 demonstrates promising pre-clinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. Blood 2007;111:275-84.
48. Neviani P, Santhanam R, Oaks JJ, et al. FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. J Clin Invest 2007;117:2408-21.
49. Reyland ME, Anderson SM, Matassa AA, et al. Protein kinase C δ is essential for etoposide-induced apoptosis in salivary gland acinar cells. J Biol Chem 1999;274:19115-23.
50. Tchou JC, Lin X, Freije D, et al. GSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas. Int J Oncol 2000;16:663-76.