Increasing endogenous ceramide using inhibitors of sphingolipid metabolism maximizes ionizing radiation-induced mitochondrial injury and apoptotic cell killing

International Journal of Cancer

Volumn 101, Issue 6, 2002, Pages 589-598

  Rodriguez Lafrasse, Claire ^a   Alphonse, Gersende ^a   Aloy, Marie Thérèse ^a   Ardail, Dominique ^a   Gérard, Jean Pierre ^b   Louisot, Pierre ^a   Rousson, Robert ^a  

^a INSERM   (France)

^b CENTRE HOSPITALIER LYON SUD   (France)

Author keywords

radiation; Apoptosis; Ceramide; Jurkat cells; Lymphoid cells; Mitochondria

Indexed keywords

CASPASE; CERAMIDE; GLUTATHIONE; IMIPRAMINE; REACTIVE OXYGEN METABOLITE; SPHINGOLIPID; SPHINGOMYELIN PHOSPHODIESTERASE;

APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; GAMMA RADIATION; HUMAN; HUMAN CELL; IONIZING RADIATION; LEUKEMIA CELL LINE; LIPID METABOLISM; LYMPHOID CELL; LYMPHOID CELL LINE; MITOCHONDRIAL MYOPATHY; MITOCHONDRION; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; RADIATION DOSE;

APOPTOSIS; CASPASES; CELL CYCLE; CERAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; FLOW CYTOMETRY; GLUTATHIONE; HUMANS; IMIPRAMINE; JURKAT CELLS; MITOCHONDRIA; MORPHOLINES; MYRISTATES; PROPANOLAMINES; RADIATION, IONIZING; REACTIVE OXYGEN SPECIES; SPHINGOLIPIDS; TIME FACTORS;

EID: 0037145310     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10652     Document Type: Article

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