-
1
-
-
0000053704
-
Zwei falle von leucaemie.
-
Lissauer H. Zwei falle von leucaemie. Berl Klin Wochenschr. 1865;2:403-404.
-
(1865)
Berl Klin Wochenschr
, vol.2
, pp. 403-404
-
-
Lissauer, H.1
-
2
-
-
0012015059
-
Ueber carcinoma mammae [abstract]. 18th Congress of the German Society for Surgery
-
Schinzinger A. Ueber carcinoma mammae [abstract]. 18th Congress of the German Society for Surgery. Beilage zum Centmlblatt fur Chirurgie 1889;16:55-56.
-
(1889)
Beilage zum Centmlblatt fur Chirurgie
, vol.16
, pp. 55-56
-
-
Schinzinger, A.1
-
3
-
-
50549123220
-
On treatment of inoperable cases of carcinoma of the mamma: Suggestions for a new method of treatment with illustrative cases
-
Beatson C. On treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment with illustrative cases. Lancet. 1896;2:104-107.
-
(1896)
Lancet
, vol.2
, pp. 104-107
-
-
Beatson, C.1
-
4
-
-
0001005193
-
Experimental and clinical studies on the treatment of cancer by dichlorethylsulphide (mustard gas)
-
Adair FE, Bagg HJ. Experimental and clinical studies on the treatment of cancer by dichlorethylsulphide (mustard gas). Ann Surg. 1931;93:190-199.
-
(1931)
Ann Surg
, vol.93
, pp. 190-199
-
-
Adair, F.E.1
Bagg, H.J.2
-
5
-
-
0021754941
-
Landmark article September 21, 1946: Nitrogen mustard therapy. Use of methyl-bis(betachloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders
-
Goodman LS, Wintrobe MM, Dameshek W, Goodman MJ, Gilman A, McLennan MX Landmark article September 21, 1946: nitrogen mustard therapy. Use of methyl-bis(betachloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. JAMA. 1984;251:2255-2261.
-
(1984)
JAMA
, vol.251
, pp. 2255-2261
-
-
Goodman, L.S.1
Wintrobe, M.M.2
Dameshek, W.3
Goodman, M.J.4
Gilman, A.5
McLennan, M.X.6
-
6
-
-
78651010566
-
Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin)
-
Farber S, Diamond L, Mercer R, Sylvester R, Wolff J. Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin). N Engl J Med. 1948;238:787-793.
-
(1948)
N Engl J Med
, vol.238
, pp. 787-793
-
-
Farber, S.1
Diamond, L.2
Mercer, R.3
Sylvester, R.4
Wolff, J.5
-
7
-
-
0001347264
-
Some observations on the effect of folic acid antagonists on acute leukemia and other forms of incurable Cancer
-
Farber S. Some observations on the effect of folic acid antagonists on acute leukemia and other forms of incurable Cancer. Blood. 1949;4:160-167.
-
(1949)
Blood
, vol.4
, pp. 160-167
-
-
Farber, S.1
-
8
-
-
0141734632
-
-
Brockmann H, Bauer K. Rhodomycin, a red antibiotic from actinomycetes. Naturwissenschaften. 1950;37:492-493.
-
Brockmann H, Bauer K. Rhodomycin, a red antibiotic from actinomycetes. Naturwissenschaften. 1950;37:492-493.
-
-
-
-
9
-
-
11144242211
-
Timeline: Chemotherapy and the war on Cancer
-
Chabner BA, Roberts TG Jr. Timeline: chemotherapy and the war on Cancer. Nat Rev Cancer. 2005;5:65-72.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 65-72
-
-
Chabner, B.A.1
Roberts Jr, T.G.2
-
10
-
-
37049053957
-
Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode
-
Rosenberg B, Vancamp L, Krigas T. Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode. Nature. 1965;205:698-699.
-
(1965)
Nature
, vol.205
, pp. 698-699
-
-
Rosenberg, B.1
Vancamp, L.2
Krigas, T.3
-
11
-
-
78651156947
-
Experimental evaluation of potential anticancer agents. XIII. On the criteria and kinetics associated with "curability" of experimental leukemia
-
Skipper HE, Schabel FM Jr, Wilcox WS. Experimental evaluation of potential anticancer agents. XIII. On the criteria and kinetics associated with "curability" of experimental leukemia. Cancer Chemother Rep. 1964;35:1-111.
-
(1964)
Cancer Chemother Rep
, vol.35
, pp. 1-111
-
-
Skipper, H.E.1
Schabel Jr, F.M.2
Wilcox, W.S.3
-
13
-
-
0037687355
-
Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: First report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741
-
Citron ML, Berry DA, Cirrincione C, et al. Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741. J Clin Oncol. 2003;21:1431-1439.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1431-1439
-
-
Citron, M.L.1
Berry, D.A.2
Cirrincione, C.3
-
14
-
-
0018569942
-
A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate
-
Goldie JH, Coldman AJ. A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer Treat Rep. 1979;63:1727-1733.
-
(1979)
Cancer Treat Rep
, vol.63
, pp. 1727-1733
-
-
Goldie, J.H.1
Coldman, A.J.2
-
15
-
-
2442710541
-
Clinical relevance of different sequencing of doxorubicin and cyclophosphamide, methotrexate, and fluorouracil in operable breast Cancer
-
Bonadonna G, Zambetti M, Moliterni A, Gianni L, Valagussa P. Clinical relevance of different sequencing of doxorubicin and cyclophosphamide, methotrexate, and fluorouracil in operable breast Cancer. J Clin Oncol. 2004; 22:1614-1620.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1614-1620
-
-
Bonadonna, G.1
Zambetti, M.2
Moliterni, A.3
Gianni, L.4
Valagussa, P.5
-
16
-
-
0028813358
-
Sequential or alternating doxorubicin and CMF regimens in breast cancer with more than three positive nodes. Ten-year results
-
Bonadonna G, Zambetti M, Valagussa P. Sequential or alternating doxorubicin and CMF regimens in breast cancer with more than three positive nodes. Ten-year results. JAMA. 1995;273:542-547.
-
(1995)
JAMA
, vol.273
, pp. 542-547
-
-
Bonadonna, G.1
Zambetti, M.2
Valagussa, P.3
-
17
-
-
0034439970
-
-
Overwijk WW, Restifo NR Autoimmunity and the immunotherapy of cancer: targeting the self to destroy the other. Crit Rev Immunol. 2000;20:433-450.
-
Overwijk WW, Restifo NR Autoimmunity and the immunotherapy of cancer: targeting the "self" to destroy the "other." Crit Rev Immunol. 2000;20:433-450.
-
-
-
-
18
-
-
0034775122
-
Variability in B-cell antigen expression: Implications for the treatment of B-cell lymphomas and leukemias with monoclonal antibodies
-
Rossmann ED, Lundin J, Lenkei R, Mellstedt H, Osterborg A. Variability in B-cell antigen expression: implications for the treatment of B-cell lymphomas and leukemias with monoclonal antibodies. Hematol J. 2001;2:300-306.
-
(2001)
Hematol J
, vol.2
, pp. 300-306
-
-
Rossmann, E.D.1
Lundin, J.2
Lenkei, R.3
Mellstedt, H.4
Osterborg, A.5
-
19
-
-
0024232289
-
Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: Significance of elevated interstitial pressure
-
Jain RK, Baxter LT. Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res. 1988;48(24 pt 1):7022-7032.
-
(1988)
Cancer Res
, vol.48
, Issue.24 PART 1
, pp. 7022-7032
-
-
Jain, R.K.1
Baxter, L.T.2
-
20
-
-
16444363534
-
Cellular and molecular signal transduction pathways modulated by rituximab (rituxan, anti-CD20 mAb) in non-Hodgkin's lymphoma: Implications in chemosensitization and therapeutic intervention
-
Jazirehi AR, Bonavida B. Cellular and molecular signal transduction pathways modulated by rituximab (rituxan, anti-CD20 mAb) in non-Hodgkin's lymphoma: implications in chemosensitization and therapeutic intervention. Oncogene. 2005;24:2121-2143.
-
(2005)
Oncogene
, vol.24
, pp. 2121-2143
-
-
Jazirehi, A.R.1
Bonavida, B.2
-
21
-
-
0030806221
-
Homodimerization of tumor-reactive monoclonal antibodies markedly increases their ability to induce growth arrest or apoptosis of tumor cells
-
Ghetie MA, Podar EM, Ilgen A, Gordon BE, Uhr JW, Vitetta ES. Homodimerization of tumor-reactive monoclonal antibodies markedly increases their ability to induce growth arrest or apoptosis of tumor cells. Proc Natl Acad Sci USA. 1997;94:7509-7514.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 7509-7514
-
-
Ghetie, M.A.1
Podar, E.M.2
Ilgen, A.3
Gordon, B.E.4
Uhr, J.W.5
Vitetta, E.S.6
-
22
-
-
0027537357
-
Differential response in a patient treated with Campath-IH monoclonal antibody for refractory non-Hodgkin lymphoma
-
Lim SH, Davey G, Marcus R. Differential response in a patient treated with Campath-IH monoclonal antibody for refractory non-Hodgkin lymphoma. Lancet. 1993; 341:432-433.
-
(1993)
Lancet
, vol.341
, pp. 432-433
-
-
Lim, S.H.1
Davey, G.2
Marcus, R.3
-
23
-
-
0031757274
-
CAMPATH-IH monoclonal antibody in therapy for previously treated low-grade non-Hodgkin's lymphomas: A phase II multicenter study. European Study Group of CAMPATH-IH Treatment in Low-Grade Non-Hodgkin's Lymphoma
-
Lundin J, Osterborg A, Brittinger G, et al. CAMPATH-IH monoclonal antibody in therapy for previously treated low-grade non-Hodgkin's lymphomas: a phase II multicenter study. European Study Group of CAMPATH-IH Treatment in Low-Grade Non-Hodgkin's Lymphoma. J Clin Oncol. 1998;16:3257-3263.
-
(1998)
J Clin Oncol
, vol.16
, pp. 3257-3263
-
-
Lundin, J.1
Osterborg, A.2
Brittinger, G.3
-
24
-
-
0041582974
-
Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
-
Zamecnik PC, Stephenson ML. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc Natl Acad Sci USA. 1978;75:280-284.
-
(1978)
Proc Natl Acad Sci USA
, vol.75
, pp. 280-284
-
-
Zamecnik, P.C.1
Stephenson, M.L.2
-
25
-
-
33645550066
-
RNAi: A novel antisense technology and its therapeutic potential
-
Dallas A, Vlassov AV. RNAi: a novel antisense technology and its therapeutic potential. Med Sci Monit. 2006;12: RA67-RA74.
-
(2006)
Med Sci Monit
, vol.12
-
-
Dallas, A.1
Vlassov, A.V.2
-
26
-
-
11144282529
-
Role of Toll-like receptors in antisense and siRNA [corrected]
-
Agrawal S, Kandimalla ER. Role of Toll-like receptors in antisense and siRNA [corrected]. Nat Biotechnol. 2004;22:1533-1537.
-
(2004)
Nat Biotechnol
, vol.22
, pp. 1533-1537
-
-
Agrawal, S.1
Kandimalla, E.R.2
-
27
-
-
33745299723
-
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
-
Grimm D, Streetz KL, Jopling CL, et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature. 2006;441:537-541.
-
(2006)
Nature
, vol.441
, pp. 537-541
-
-
Grimm, D.1
Streetz, K.L.2
Jopling, C.L.3
-
28
-
-
0142106960
-
Nucleic acid aptamers as tools and drugs: Recent developments
-
Rimmele M. Nucleic acid aptamers as tools and drugs: recent developments. Chembiochem. 2003;4:963-971.
-
(2003)
Chembiochem
, vol.4
, pp. 963-971
-
-
Rimmele, M.1
-
29
-
-
0033790673
-
Escort aptamers: A delivery service for diagnosis and therapy
-
Hicke BJ, Stephens AW. Escort aptamers: a delivery service for diagnosis and therapy. J Clin Invest. 2000;106:923-928.
-
(2000)
J Clin Invest
, vol.106
, pp. 923-928
-
-
Hicke, B.J.1
Stephens, A.W.2
-
30
-
-
33749035470
-
Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting
-
Sok JC, Coppelli FM, Thomas SM, et al. Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. Clin Cancer Res. 2006;12:5064-5073.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5064-5073
-
-
Sok, J.C.1
Coppelli, F.M.2
Thomas, S.M.3
-
31
-
-
38949191321
-
Molecular targeting and treatment of composite EGFR and EGFRvIII-positive gliomas using boronated monoclonal antibodies
-
Yang W, Wu G, Barth RF, et al. Molecular targeting and treatment of composite EGFR and EGFRvIII-positive gliomas using boronated monoclonal antibodies. Clin Cancer Res. 2008;14:883-891.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 883-891
-
-
Yang, W.1
Wu, G.2
Barth, R.F.3
-
32
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. 2002;298:1912-1934.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
33
-
-
3442891161
-
Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): Combining anti-EGFR antibody with tyrosine kinase inhibitor
-
Huang S, Armstrong EA, Benavente S, Chinnaiyan P, Harari PM. Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor. Cancer Res. 2004;64:5355-5362.
-
(2004)
Cancer Res
, vol.64
, pp. 5355-5362
-
-
Huang, S.1
Armstrong, E.A.2
Benavente, S.3
Chinnaiyan, P.4
Harari, P.M.5
-
34
-
-
33745828702
-
EGF-ERBB signalling: Towards the systems level
-
Citri A, Yarden Y. EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol. 2006;7:505-516.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 505-516
-
-
Citri, A.1
Yarden, Y.2
-
35
-
-
0037162799
-
Structure of the extracellular region of HER3 reveals an interdomain tether
-
Cho HS, Leahy DJ. Structure of the extracellular region of HER3 reveals an interdomain tether. Science. 2002;297:1330-1333.
-
(2002)
Science
, vol.297
, pp. 1330-1333
-
-
Cho, H.S.1
Leahy, D.J.2
-
37
-
-
18644386251
-
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains
-
Ogiso H, Ishitani R, Nureki O, et al. Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell. 2002;110:775-787.
-
(2002)
Cell
, vol.110
, pp. 775-787
-
-
Ogiso, H.1
Ishitani, R.2
Nureki, O.3
-
38
-
-
0030944455
-
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
-
Graus-Porta D, Beerli RR, Daly JM, Hynes NE. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 1997;16:1647-1655.
-
(1997)
EMBO J
, vol.16
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.R.2
Daly, J.M.3
Hynes, N.E.4
-
39
-
-
0032526729
-
Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers
-
Lenferink AE, Pinkas-Kramarski R, van de Poll ML, et al. Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J. 1998;17:3385-3397.
-
(1998)
EMBO J
, vol.17
, pp. 3385-3397
-
-
Lenferink, A.E.1
Pinkas-Kramarski, R.2
van de Poll, M.L.3
-
40
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal Cancer
-
Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal Cancer. N Engl J Med. 2004;351:337-345.
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
41
-
-
34250180582
-
Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy
-
Vermorken JB, Trigo J, Hitt R, et al. Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. J Clin Oncol. 2007;25:2171-2177.
-
(2007)
J Clin Oncol
, vol.25
, pp. 2171-2177
-
-
Vermorken, J.B.1
Trigo, J.2
Hitt, R.3
-
42
-
-
33144461661
-
Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group study
-
Burtness B, Goldwasser MA, Flood W, Mattar B, Forastiere AA. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol. 2005;23:8646-8654.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8646-8654
-
-
Burtness, B.1
Goldwasser, M.A.2
Flood, W.3
Mattar, B.4
Forastiere, A.A.5
-
43
-
-
40849140457
-
Cetuximab extends survival of patients with recurrent or metastatic SCCHN when added to first line platinum based therapy-results of a randomized phase III (Extreme) study [abstract]
-
Chicago, Illinois, June 1-5, Abstract 6091
-
Vermorken J, Mesia R, Vega V et al. Cetuximab extends survival of patients with recurrent or metastatic SCCHN when added to first line platinum based therapy-results of a randomized phase III (Extreme) study [abstract]. Proceedings of the 43rd Annual Meeting of American Society of Clinical Oncology, Chicago, Illinois, June 1-5, 2007. Abstract 6091.
-
(2007)
Proceedings of the 43rd Annual Meeting of American Society of Clinical Oncology
-
-
Vermorken, J.1
Mesia, R.2
Vega, V.3
-
44
-
-
32144463481
-
Cetuximab and radiotherapy for head and neck Cancer
-
Posner MR, Wirth LJ. Cetuximab and radiotherapy for head and neck Cancer. N Engl J Med. 2006;354:634-636.
-
(2006)
N Engl J Med
, vol.354
, pp. 634-636
-
-
Posner, M.R.1
Wirth, L.J.2
-
45
-
-
32144433159
-
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
-
Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354:567-578.
-
(2006)
N Engl J Med
, vol.354
, pp. 567-578
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
-
46
-
-
53949097242
-
-
Medical News Today: Health News. Data available from ERBITUX phase III study in first-line treatment of advanced lung cancer 2007. Available at: http://www.medicalnewstoday.com/articles/76863.php. Accessed February 2, 2008.
-
Medical News Today: Health News. Data available from ERBITUX phase III study in first-line treatment of advanced lung cancer 2007. Available at: http://www.medicalnewstoday.com/articles/76863.php. Accessed February 2, 2008.
-
-
-
-
47
-
-
53949105317
-
-
Philip P, Benedetti J, Fenoglio-Preiser C, et al. Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study [abstract]. J Clin Oncol. 2007;25(18S). Abstract LBA4509.
-
Philip P, Benedetti J, Fenoglio-Preiser C, et al. Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study [abstract]. J Clin Oncol. 2007;25(18S). Abstract LBA4509.
-
-
-
-
48
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal Cancer
-
Van Cutsem E, Peeters M, Siena S, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal Cancer. J Clin Oncol. 2007;25:1658-1664.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
-
49
-
-
53949102989
-
-
Amgen Inc. Amgen discontinues Vectibix treatment in PACCE trial evaluating Vectibix as part of triple combination regimen, Available at:, Accessed February 2, 2008
-
Amgen Inc. Amgen discontinues Vectibix treatment in PACCE trial evaluating Vectibix as part of triple combination regimen 2007. Available at: http://www.amgen.com/media/media_pr_detail.jsp?releaseID=977186. Accessed February 2, 2008.
-
(2007)
-
-
-
50
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced nonsmall-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced nonsmall-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet. 2005;366:1527-1537.
-
(2005)
Lancet
, vol.366
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
-
51
-
-
22044445517
-
Erlotinib in previously treated nonsmall-cell lung Cancer
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated nonsmall-cell lung Cancer. N Engl J Med. 2005;353:123-132.
-
(2005)
N Engl J Med
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
-
52
-
-
37349092482
-
Gefitinib (Iressa) versus docetaxel in patients with locally advanced or metastatic nonsmall-cell lung cancer pretreated with platinum-based chemotherapy: A randomized, open-label Phase III study (INTEREST): PRS-02
-
Douillard J-Y, Kim E, Hirsh V, et al. Gefitinib (Iressa) versus docetaxel in patients with locally advanced or metastatic nonsmall-cell lung cancer pretreated with platinum-based chemotherapy: a randomized, open-label Phase III study (INTEREST): PRS-02. J Thorac Oncol. 2007;2:S305-S306.
-
(2007)
J Thorac Oncol
, vol.2
-
-
Douillard, J.-Y.1
Kim, E.2
Hirsh, V.3
-
53
-
-
53949090875
-
-
is as effective as docetaxel in pretreated advanced NSCLC 2007. Available at:, Accessed February 2, 2008
-
AstraZeneca. Study shows Iressa (gefitinib) is as effective as docetaxel in pretreated advanced NSCLC 2007. Available at: http://www.astrazeneca.com/ pressrelease/5345.aspx. Accessed February 2, 2008.
-
Study shows Iressa (gefitinib)
-
-
-
54
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast Cancer
-
Vogel CL, Cobleigh MA, Tripathy D, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast Cancer. J Clin Oncol. 2002;20:719-726.
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
-
55
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
-
Cobleigh MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol. 1999;17:2639-2648.
-
(1999)
J Clin Oncol
, vol.17
, pp. 2639-2648
-
-
Cobleigh, M.A.1
Vogel, C.L.2
Tripathy, D.3
-
56
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344:783-792.
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
57
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast Cancer
-
Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast Cancer. N Engl J Med. 2005;353:1673-1684.
-
(2005)
N Engl J Med
, vol.353
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
-
58
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast Cancer
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast Cancer. N Engl J Med. 2005;353:1659-1672.
-
(2005)
N Engl J Med
, vol.353
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
-
59
-
-
33344478381
-
Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast Cancer
-
Joensuu H, Kellokumpu-Lehtinen PL, Bono P, et al. Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast Cancer. N Engl J Med. 2006;354:809-820.
-
(2006)
N Engl J Med
, vol.354
, pp. 809-820
-
-
Joensuu, H.1
Kellokumpu-Lehtinen, P.L.2
Bono, P.3
-
60
-
-
1842605531
-
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
-
Franklin MC, Carey KD, Vajdos FF, Leahy DJ, de Vos AM, Sliwkowski MX. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell. 2004;5:317-328.
-
(2004)
Cancer Cell
, vol.5
, pp. 317-328
-
-
Franklin, M.C.1
Carey, K.D.2
Vajdos, F.F.3
Leahy, D.J.4
de Vos, A.M.5
Sliwkowski, M.X.6
-
61
-
-
0037434791
-
Structure of the extracellular region of HER2 alone and in complex with the herceptin Fab
-
Cho HS, Mason K, Ramyar KX, et al. Structure of the extracellular region of HER2 alone and in complex with the herceptin Fab. Nature. 2003;421:756-760.
-
(2003)
Nature
, vol.421
, pp. 756-760
-
-
Cho, H.S.1
Mason, K.2
Ramyar, K.X.3
-
62
-
-
1942474587
-
The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells
-
Nahta R, Hung MC, Esteva FJ. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res. 2004; 64:2343-2346.
-
(2004)
Cancer Res
, vol.64
, pp. 2343-2346
-
-
Nahta, R.1
Hung, M.C.2
Esteva, F.J.3
-
63
-
-
36248938567
-
Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC) which has progressed during treatment with T
-
Abstract 1004
-
Baselga J, Cameron D, Miles D, et al. Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC) which has progressed during treatment with T. J Clin Oncol. 2007; 25(18S). Abstract 1004.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Baselga, J.1
Cameron, D.2
Miles, D.3
-
64
-
-
34948826998
-
Results from a phase II randomized, placebo-controlled, double-blind trial suggest improved PFS with the addition of pertuzumab to gemcitabine in patients with platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer [abstract]
-
Abstract 5507
-
Makhija S, Glenn D, Ueland F, et al. Results from a phase II randomized, placebo-controlled, double-blind trial suggest improved PFS with the addition of pertuzumab to gemcitabine in patients with platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer [abstract]. J Clin Oncol. 2007;25(18S). Abstract 5507.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Makhija, S.1
Glenn, D.2
Ueland, F.3
-
65
-
-
4644289313
-
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
-
Wood ER, Truesdale AT, McDonald OB, et al. A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 2004;64:6652-6659.
-
(2004)
Cancer Res
, vol.64
, pp. 6652-6659
-
-
Wood, E.R.1
Truesdale, A.T.2
McDonald, O.B.3
-
66
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast Cancer
-
Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast Cancer. N Engl J Med. 2006;355:2733-2743.
-
(2006)
N Engl J Med
, vol.355
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
-
67
-
-
34848899905
-
EGF105084, a phase II study of lapatinib for brain metastases in patients (pts) with HER2+ breast cancer following trastuzumab (H) based systemic therapy and cranial radiotherapy (RT) [abstract]
-
Abstract 1012
-
Lin N, Dieras V, Paul D, et al. EGF105084, a phase II study of lapatinib for brain metastases in patients (pts) with HER2+ breast cancer following trastuzumab (H) based systemic therapy and cranial radiotherapy (RT) [abstract]. J Clin Oncol. 2007;25(18S). Abstract 1012.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Lin, N.1
Dieras, V.2
Paul, D.3
-
68
-
-
53949108185
-
Lapatinib and capecitabine for the treatment of brain metastases in patients with HER2+ breast cancer an updated analysis from EGF105084 [abstract]
-
Abstract 6076
-
Lin NU, Paul D, Dieras V, et al. Lapatinib and capecitabine for the treatment of brain metastases in patients with HER2+ breast cancer an updated analysis from EGF105084 [abstract]. Breast Cancer Res Treat. 2007; 106(suppl 1):S272. Abstract 6076.
-
(2007)
Breast Cancer Res Treat
, vol.106
, Issue.SUPPL. 1
-
-
Lin, N.U.1
Paul, D.2
Dieras, V.3
-
70
-
-
33751288182
-
Efficacy of lapatinib in patients with high tumor EGFR expression: Results of a phase III trial in advanced renal cell carcinoma (RCC) [abstract]
-
Abstract 4502
-
Ravaud A, Gardner J, Hawkins R, et al. Efficacy of lapatinib in patients with high tumor EGFR expression: results of a phase III trial in advanced renal cell carcinoma (RCC) [abstract]. J Clin Oncol. 2006;24(18S). Abstract 4502.
-
(2006)
J Clin Oncol
, vol.24
, Issue.18 S
-
-
Ravaud, A.1
Gardner, J.2
Hawkins, R.3
-
71
-
-
38649093257
-
S0413: A phase II SWOG study of GW572016 (lapatinib) as first line therapy in patients (pts) with advanced or metastatic gastric cancer [abstract]
-
Abstract 4621
-
Iqbal S, Goldman B, Lenz H, Fenoglio-Preiser C, Blanke C. S0413: a phase II SWOG study of GW572016 (lapatinib) as first line therapy in patients (pts) with advanced or metastatic gastric cancer [abstract]. J Clin Oncol. 2007;25(18S). Abstract 4621.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Iqbal, S.1
Goldman, B.2
Lenz, H.3
Fenoglio-Preiser, C.4
Blanke, C.5
-
72
-
-
53949106167
-
A multicenter phase II study of lapatinib in hormone sensitive prostate cancer (HSPC) [abstract]
-
Orlando, Florida, February 22-24, Abstract 261
-
Sridhar S, Hotte S, Chin J, et al. A multicenter phase II study of lapatinib in hormone sensitive prostate cancer (HSPC) [abstract]. Proceedings of the 2007 ASCO Prostate Cancer Symposium, Orlando, Florida, February 22-24, 2007. Abstract 261.
-
(2007)
Proceedings of the 2007 ASCO Prostate Cancer Symposium
-
-
Sridhar, S.1
Hotte, S.2
Chin, J.3
-
73
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989;246:1306-1309.
-
(1989)
Science
, vol.246
, pp. 1306-1309
-
-
Leung, D.W.1
Cachianes, G.2
Kuang, W.J.3
Goeddel, D.V.4
Ferrara, N.5
-
74
-
-
0027197245
-
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
-
Kim KJ, Li B, Winer J, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature. 1993;362:841-844.
-
(1993)
Nature
, vol.362
, pp. 841-844
-
-
Kim, K.J.1
Li, B.2
Winer, J.3
-
75
-
-
34547802193
-
Pegaptanib and ranibizumab for neovascular age-related macular degeneration: A systematic review
-
Takeda A, Colquitt J, Clegg A, Jones J. Pegaptanib and ranibizumab for neovascular age-related macular degeneration: a systematic review. Br J Ophthalmol. 2007;91:1177-1182.
-
(2007)
Br J Ophthalmol
, vol.91
, pp. 1177-1182
-
-
Takeda, A.1
Colquitt, J.2
Clegg, A.3
Jones, J.4
-
76
-
-
0034796595
-
Normalizing tumor vasculature with antiangiogenic therapy: A new paradigm for combination therapy
-
Jain RK. Normalizing tumor vasculature with antiangiogenic therapy: a new paradigm for combination therapy. Nat Med. 2001;7:987-989.
-
(2001)
Nat Med
, vol.7
, pp. 987-989
-
-
Jain, R.K.1
-
77
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal Cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal Cancer. N Engl J Med. 2004;350:2335-2342.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
78
-
-
33749016960
-
Safety and efficacy of oxaliplatin/fluoropyrimidine regimens with or without bevacizumab as firstline treatment of metastatic colorectal cancer (mCRC): Final analysis of the TREE Study [abstract]
-
Abstract 3510
-
Hochster H, Hart L, Ramanathan R, Hainsworth J, Hedrick E, Childs B. Safety and efficacy of oxaliplatin/fluoropyrimidine regimens with or without bevacizumab as firstline treatment of metastatic colorectal cancer (mCRC): final analysis of the TREE Study [abstract]. J Clin Oncol. 2006;24(18S). Abstract 3510.
-
(2006)
J Clin Oncol
, vol.24
, Issue.18 S
-
-
Hochster, H.1
Hart, L.2
Ramanathan, R.3
Hainsworth, J.4
Hedrick, E.5
Childs, B.6
-
79
-
-
34248173883
-
Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
-
Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 2007;25:1539-1544.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1539-1544
-
-
Giantonio, B.J.1
Catalano, P.J.2
Meropol, N.J.3
-
80
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for nonsmall-cell lung Cancer
-
Sandier A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for nonsmall-cell lung Cancer. N Engl J Med. 2006;355:2542-2550.
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandier, A.1
Gray, R.2
Perry, M.C.3
-
81
-
-
35549006672
-
A randomized, controlled, double-blind phase III study (AVOREN) of bevacizumab/interferon-α2a vs placebo/interferon-α2a as first-line therapy in metastatic renal cell carcinoma [abstract]
-
Abstract 3
-
Escudier B, Koralewski P, Pluzanska A, et al. A randomized, controlled, double-blind phase III study (AVOREN) of bevacizumab/interferon-α2a vs placebo/interferon-α2a as first-line therapy in metastatic renal cell carcinoma [abstract]. J Clin Oncol. 2007;25(18S). Abstract 3.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Escudier, B.1
Koralewski, P.2
Pluzanska, A.3
-
82
-
-
36849056497
-
Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous Cancer
-
Cannistra SA, Matulonis UA, Penson RT, et al. Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous Cancer. J Clin Oncol. 2007;25:5180-5186.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5180-5186
-
-
Cannistra, S.A.1
Matulonis, U.A.2
Penson, R.T.3
-
83
-
-
36849019301
-
Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: A Gynecologic Oncology Group study
-
Burger RA, Sill MW, Monk BJ, Greer BE, Sorosky JI. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group study. J Clin Oncol. 2007;25:5165-5171.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5165-5171
-
-
Burger, R.A.1
Sill, M.W.2
Monk, B.J.3
Greer, B.E.4
Sorosky, J.I.5
-
84
-
-
43449107359
-
A multi-institutional evaluation of factors predictive of toxicity and efficacy of bevacizumab for recurrent ovarian Cancer
-
Wright JD, Secord AA, Numnum TM, et al. A multi-institutional evaluation of factors predictive of toxicity and efficacy of bevacizumab for recurrent ovarian Cancer. Int J Gynecol Cancer. 2008;18:400-406.
-
(2008)
Int J Gynecol Cancer
, vol.18
, pp. 400-406
-
-
Wright, J.D.1
Secord, A.A.2
Numnum, T.M.3
-
85
-
-
34047179153
-
A double-blind, placebo controlled, randomized phase III trial of gemcitabine (G) plus bevacizumab (B) versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC): A preliminary analysis of Cancer and Leukemia Group B (CALGB) 80303 [abstract)
-
Orlando, Florida, January 19-21, Abstract 108
-
Kindler H, Niedzwiecki D, Hollis D, et al. A double-blind, placebo controlled, randomized phase III trial of gemcitabine (G) plus bevacizumab (B) versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC): a preliminary analysis of Cancer and Leukemia Group B (CALGB) 80303 [abstract). Proceedings of the 2007 Gastrointestinal Cancers Symposium, Orlando, Florida, January 19-21, 2007. Abstract 108.
-
(2007)
Proceedings of the 2007 Gastrointestinal Cancers Symposium
-
-
Kindler, H.1
Niedzwiecki, D.2
Hollis, D.3
-
86
-
-
33750631676
-
Efficacy and safety of sunitinib malate (SU11248) in bevacizumab-refractory metastatic renal cell carcinoma (mRCC) [abstract]
-
Abstract 4522
-
Rini B, George D, Michaelson M, et al. Efficacy and safety of sunitinib malate (SU11248) in bevacizumab-refractory metastatic renal cell carcinoma (mRCC) [abstract]. J Clin Oncol. 2006;24(18S). Abstract 4522.
-
(2006)
J Clin Oncol
, vol.24
, Issue.18 S
-
-
Rini, B.1
George, D.2
Michaelson, M.3
-
87
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356:115-124.
-
(2007)
N Engl J Med
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
88
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007;356:125-134.
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
89
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64:7099-7109.
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
90
-
-
19744365702
-
A small molecule-kinase interaction map for clinical kinase inhibitors
-
Fabian MA, Biggs WH 3rd, Treiber DK, et al. A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol. 2005;23:329-336.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 329-336
-
-
Fabian, M.A.1
Biggs 3rd, W.H.2
Treiber, D.K.3
-
91
-
-
33749505836
-
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
-
Demetri GD, van Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet. 2006;368:1329-1338.
-
(2006)
Lancet
, vol.368
, pp. 1329-1338
-
-
Demetri, G.D.1
van Oosterom, A.T.2
Garrett, C.R.3
-
92
-
-
35648938219
-
Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell Cancer
-
Bukowski RM, Kabbinavar FF, Figlin RA, et al. Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell Cancer. J Clin Oncol. 2007;25:4536-4541.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4536-4541
-
-
Bukowski, R.M.1
Kabbinavar, F.F.2
Figlin, R.A.3
-
93
-
-
36048982143
-
Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung Cancer
-
Herbst RS, O'Neill VJ, Fehrenbacher L, et al. Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung Cancer. J Clin Oncol. 2007; 25:4743-4750.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4743-4750
-
-
Herbst, R.S.1
O'Neill, V.J.2
Fehrenbacher, L.3
-
95
-
-
1942534043
-
The evolution of thalidomide and its IMiD derivatives as anticancer agents
-
Bartlett JB, Dredge K, Dalgleish AG. The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nat Rev Cancer. 2004;4:314-322.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 314-322
-
-
Bartlett, J.B.1
Dredge, K.2
Dalgleish, A.G.3
-
96
-
-
0031171663
-
Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization
-
Kenyon BM, Browne F, D'Amato RJ. Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization. Exp Eye Res. 1997;64:971-978.
-
(1997)
Exp Eye Res
, vol.64
, pp. 971-978
-
-
Kenyon, B.M.1
Browne, F.2
D'Amato, R.J.3
-
97
-
-
13444256401
-
Efficacy of lenalidomide in myelodysplastic syndromes
-
List A, Kurtin S, Roe DJ, et al. Efficacy of lenalidomide in myelodysplastic syndromes. N Engl J Med. 2005;352:549-557.
-
(2005)
N Engl J Med
, vol.352
, pp. 549-557
-
-
List, A.1
Kurtin, S.2
Roe, D.J.3
-
98
-
-
33846449862
-
Lenalidomide: Targeted anemia therapy for myelodysplastic syndromes
-
List AF, Baker AF, Green S, Bellamy W. Lenalidomide: targeted anemia therapy for myelodysplastic syndromes. Cancer Control. 2006;13(suppl):4-11.
-
(2006)
Cancer Control
, vol.13
, Issue.SUPPL.
, pp. 4-11
-
-
List, A.F.1
Baker, A.F.2
Green, S.3
Bellamy, W.4
-
99
-
-
34547579487
-
Kit: Molecule of interest for the diagnosis and treatment of mastocytosis and other neoplastic disorders
-
Patnaik MM, Tefferi A, Pardanani A. Kit: molecule of interest for the diagnosis and treatment of mastocytosis and other neoplastic disorders. Curr Cancer Drug Targets. 2007;7:492-503.
-
(2007)
Curr Cancer Drug Targets
, vol.7
, pp. 492-503
-
-
Patnaik, M.M.1
Tefferi, A.2
Pardanani, A.3
-
100
-
-
0037087531
-
Inhibition of KIT tyrosine kinase activity: A novel molecular approach to the treatment of KIT-positive malignancies
-
Heinrich MC, Blanke CD, Druker BJ, Corless CL. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. J Clin Oncol. 2002;20:1692-1703.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1692-1703
-
-
Heinrich, M.C.1
Blanke, C.D.2
Druker, B.J.3
Corless, C.L.4
-
101
-
-
34250024319
-
Recent advances in the understanding of mastocytosis: The role of KIT mutations
-
Orfao A, Garcia-Montero AC, Sanchez L, Escribano L. Recent advances in the understanding of mastocytosis: the role of KIT mutations. Br J Haematol. 2007;138:12-30.
-
(2007)
Br J Haematol
, vol.138
, pp. 12-30
-
-
Orfao, A.1
Garcia-Montero, A.C.2
Sanchez, L.3
Escribano, L.4
-
102
-
-
12144261476
-
Oncogenic derivatives of plateletderived growth factor receptors
-
Jones AV, Cross NC. Oncogenic derivatives of plateletderived growth factor receptors. Cell Mol Life Sci. 2004; 61:2912-2923.
-
(2004)
Cell Mol Life Sci
, vol.61
, pp. 2912-2923
-
-
Jones, A.V.1
Cross, N.C.2
-
103
-
-
0034936404
-
Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia
-
Abu-Duhier FM, Goodeve AC, Wilson GA, Care RS, Peake IR, Reilly JT. Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia. Br J Haematol. 2001;113:983-988.
-
(2001)
Br J Haematol
, vol.113
, pp. 983-988
-
-
Abu-Duhier, F.M.1
Goodeve, A.C.2
Wilson, G.A.3
Care, R.S.4
Peake, I.R.5
Reilly, J.T.6
-
104
-
-
0033758958
-
FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group
-
Abu-Duhier FM, Goodeve AC, Wilson GA, et al. FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group. Br J Haematol. 2000;111:190-195.
-
(2000)
Br J Haematol
, vol.111
, pp. 190-195
-
-
Abu-Duhier, F.M.1
Goodeve, A.C.2
Wilson, G.A.3
-
105
-
-
0037103624
-
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the plateletderived growth factor receptor beta
-
Apperley JF, Gardembas M, Melo JV et al. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the plateletderived growth factor receptor beta. N Engl J Med. 2002; 347:481-487.
-
(2002)
N Engl J Med
, vol.347
, pp. 481-487
-
-
Apperley, J.F.1
Gardembas, M.2
Melo, J.V.3
-
106
-
-
33749319703
-
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
-
Galon I, Costes A, Sanchez-Cabo F, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313:1960-1964.
-
(2006)
Science
, vol.313
, pp. 1960-1964
-
-
Galon, I.1
Costes, A.2
Sanchez-Cabo, F.3
-
107
-
-
0028484545
-
CTLA-4 can function as a negative regulator of T cell activation
-
Walunas TL, Lenschow DJ, Bakker CY, et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994;1:405-413.
-
(1994)
Immunity
, vol.1
, pp. 405-413
-
-
Walunas, T.L.1
Lenschow, D.J.2
Bakker, C.Y.3
-
108
-
-
0036773319
-
Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells
-
Manzotti CN, Tipping H, Perry LC, et al. Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells. Eur J Immunol. 2002; 32:2888-2896.
-
(2002)
Eur J Immunol
, vol.32
, pp. 2888-2896
-
-
Manzotti, C.N.1
Tipping, H.2
Perry, L.C.3
-
109
-
-
0029899783
-
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
-
Krummel MF, Allison JP. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med. 1996;183:2533-2540.
-
(1996)
J Exp Med
, vol.183
, pp. 2533-2540
-
-
Krummel, M.F.1
Allison, J.P.2
-
110
-
-
53949090415
-
Postvaccination CTLA-4 expression correlates inversely with survival in patients vaccinated with allogeneic melanoma cell vaccine [abstract]
-
Abstract 2565
-
Faries MB, Hsueh EC, Shu S, Famatiga E, Morton DL. Postvaccination CTLA-4 expression correlates inversely with survival in patients vaccinated with allogeneic melanoma cell vaccine [abstract]. J Clin Oncol. 2004;22(14S). Abstract 2565.
-
(2004)
J Clin Oncol
, vol.22
, Issue.14 S
-
-
Faries, M.B.1
Hsueh, E.C.2
Shu, S.3
Famatiga, E.4
Morton, D.L.5
-
111
-
-
36248987929
-
The role of the CTLA4 blockade in the treatment of malignant melanoma
-
Cranmer LD, Hersh E. The role of the CTLA4 blockade in the treatment of malignant melanoma. Cancer Invest. 2007;25:613-631.
-
(2007)
Cancer Invest
, vol.25
, pp. 613-631
-
-
Cranmer, L.D.1
Hersh, E.2
-
112
-
-
16844376315
-
Oncogenic Ras in tumour progression and metastasis
-
Giehl K. Oncogenic Ras in tumour progression and metastasis. Biol Chem. 2005;386:193-205.
-
(2005)
Biol Chem
, vol.386
, pp. 193-205
-
-
Giehl, K.1
-
113
-
-
4344584507
-
A tagging-via-substrate technology for detection and proteomics of farnesylated proteins
-
Kho Y, Kim SC, Jiang C, et al. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. Proc Natl Acad Sci USA. 2004;101:12479-12484.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 12479-12484
-
-
Kho, Y.1
Kim, S.C.2
Jiang, C.3
-
114
-
-
27144482085
-
Recent advances in understanding the antineoplastic mechanisms of farnesyltransferase inhibitors
-
Pan J, Yeung SC. Recent advances in understanding the antineoplastic mechanisms of farnesyltransferase inhibitors. Cancer Res. 2005;65:9109-9112.
-
(2005)
Cancer Res
, vol.65
, pp. 9109-9112
-
-
Pan, J.1
Yeung, S.C.2
-
115
-
-
18144363210
-
Farnesyltransferase inhibitors induce DNA damage via reactive oxygen species in human cancer cells
-
Pan J, She M, Xu ZX, Sun L, Yeung SC. Farnesyltransferase inhibitors induce DNA damage via reactive oxygen species in human cancer cells. Cancer Res. 2005;65:3671-3681.
-
(2005)
Cancer Res
, vol.65
, pp. 3671-3681
-
-
Pan, J.1
She, M.2
Xu, Z.X.3
Sun, L.4
Yeung, S.C.5
-
116
-
-
5444241523
-
Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal Cancer
-
Rao S, Cunningham D, de Gramont A, et al. Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal Cancer. J Clin Oncol. 2004;22:3950-3957.
-
(2004)
J Clin Oncol
, vol.22
, pp. 3950-3957
-
-
Rao, S.1
Cunningham, D.2
de Gramont, A.3
-
117
-
-
2342645506
-
Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic Cancer
-
Van Cutsem E, van de Velde H, Karasek P, et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic Cancer. J Clin Oncol. 2004;22:1430-1438.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1430-1438
-
-
Van Cutsem, E.1
van de Velde, H.2
Karasek, P.3
-
118
-
-
13844251975
-
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
-
Weisberg E, Manley PW, Breitenstein W, et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell. 2005;7:129-141.
-
(2005)
Cancer Cell
, vol.7
, pp. 129-141
-
-
Weisberg, E.1
Manley, P.W.2
Breitenstein, W.3
-
119
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science. 2004;305:399-401.
-
(2004)
Science
, vol.305
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
Chen, P.4
Norris, D.5
Sawyers, C.L.6
-
120
-
-
37249048453
-
Preclinical pharmacokineu'cs and in vitro metabolism of dasatinib (BMS-354825): A potent oral multitargeted kinase inhibitor against SRC and BCR-ABL
-
Kamath AV, Wang J, Lee FY, Marathe PH. Preclinical pharmacokineu'cs and in vitro metabolism of dasatinib (BMS-354825): a potent oral multitargeted kinase inhibitor against SRC and BCR-ABL. Cancer Chemother Pharmacol. 2008;61:365-376.
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, pp. 365-376
-
-
Kamath, A.V.1
Wang, J.2
Lee, F.Y.3
Marathe, P.H.4
-
121
-
-
33745214166
-
Dasatinib (BMS-354825) overcomes multiple mechanisms of imatinib resistance in chronic myeloid leukemia (CML)
-
ASH Annual Meeting Abstracts, Abstract
-
Lee FY, Wen M-L, Bhide R, et al. Dasatinib (BMS-354825) overcomes multiple mechanisms of imatinib resistance in chronic myeloid leukemia (CML). Blood (ASH Annual Meeting Abstracts). 2005;106. Abstract 1994.
-
(1994)
Blood
, pp. 106
-
-
Lee, F.Y.1
Wen, M.-L.2
Bhide, R.3
-
122
-
-
33745102555
-
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
-
Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med. 2006;354:2531-2541.
-
(2006)
N Engl J Med
, vol.354
, pp. 2531-2541
-
-
Talpaz, M.1
Shah, N.P.2
Kantarjian, H.3
-
123
-
-
33745086350
-
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
-
Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med. 2006;354:2542-2551.
-
(2006)
N Engl J Med
, vol.354
, pp. 2542-2551
-
-
Kantarjian, H.1
Giles, F.2
Wunderle, L.3
-
124
-
-
0037438640
-
BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
-
Donato NJ, Wu JY, Stapley J, et al. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood. 2003;101:690-698.
-
(2003)
Blood
, vol.101
, pp. 690-698
-
-
Donato, N.J.1
Wu, J.Y.2
Stapley, J.3
-
125
-
-
49449112613
-
A Phase II study of nilotinib, a novel inhibitor of c-kit, PDGFR, and Bcr-Abl, administered to patients with systemic mastocytosis [abstract]
-
Abstract 2703
-
Hochhaus A, Ottmann O, Lauber S, et al. A Phase II study of nilotinib, a novel inhibitor of c-kit, PDGFR, and Bcr-Abl, administered to patients with systemic mastocytosis [abstract]. Blood. 2006;108:764a. Abstract 2703.
-
(2006)
Blood
, vol.108
-
-
Hochhaus, A.1
Ottmann, O.2
Lauber, S.3
-
126
-
-
34249981595
-
Dasatinib (Sprycel) therapy for patients with systemic mastocytosis [abstract]
-
Abstract 3627
-
Verstovsek S, Kantarjian H, Cortes J, et al. Dasatinib (Sprycel) therapy for patients with systemic mastocytosis [abstract]. Blood. 2006;108:1036a. Abstract 3627.
-
(2006)
Blood
, vol.108
-
-
Verstovsek, S.1
Kantarjian, H.2
Cortes, J.3
-
127
-
-
0038386452
-
Escape from Cbl-mediated downregulation: A recurrent theme for oncogenic deregulation of receptor tyrosine kinases
-
Peschard P, Park M. Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases. Cancer Cell. 2003;3:519-523.
-
(2003)
Cancer Cell
, vol.3
, pp. 519-523
-
-
Peschard, P.1
Park, M.2
-
128
-
-
0032539909
-
The ubiquitin-proteasome pathway: The complexity and myriad functions of proteins death
-
Ciechanover A, Schwartz AL. The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death. Proc Natl Acad Sci USA. 1998;95:2727-2730.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 2727-2730
-
-
Ciechanover, A.1
Schwartz, A.L.2
-
129
-
-
2342613652
-
The proteasome: A suitable antineoplastic target
-
Adams J. The proteasome: a suitable antineoplastic target. Nat Rev Cancer. 2004;4:349-360.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 349-360
-
-
Adams, J.1
-
130
-
-
27944431658
-
Bortezomib, a novel proteasome inhibitor, in the treatment of hematologic malignancies
-
Jackson G, Einsele H, Moreau P, Miguel JS. Bortezomib, a novel proteasome inhibitor, in the treatment of hematologic malignancies. Cancer Treat Rev. 2005;31:591-602.
-
(2005)
Cancer Treat Rev
, vol.31
, pp. 591-602
-
-
Jackson, G.1
Einsele, H.2
Moreau, P.3
Miguel, J.S.4
-
131
-
-
33646841837
-
Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate
-
Kisselev AF, Callard A, Goldberg AL. Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate. J Biol Chem. 2006;281:8582-8590.
-
(2006)
J Biol Chem
, vol.281
, pp. 8582-8590
-
-
Kisselev, A.F.1
Callard, A.2
Goldberg, A.L.3
-
132
-
-
27644562277
-
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib
-
Chauhan D, Catley L, Li G, et al. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib. Cancer Cell. 2005;8:407-419.
-
(2005)
Cancer Cell
, vol.8
, pp. 407-419
-
-
Chauhan, D.1
Catley, L.2
Li, G.3
-
133
-
-
27644436740
-
Maintenance immunosuppression with target-ofrapamycin inhibitors is associated with a reduced incidence of de novo malignancies
-
Kauffman HM, Cherikh WS, Cheng Y, Hanto DW, Kahan BD. Maintenance immunosuppression with target-ofrapamycin inhibitors is associated with a reduced incidence of de novo malignancies. Transplantation. 2005;80:883-889.
-
(2005)
Transplantation
, vol.80
, pp. 883-889
-
-
Kauffman, H.M.1
Cherikh, W.S.2
Cheng, Y.3
Hanto, D.W.4
Kahan, B.D.5
-
134
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003; 115:577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
135
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov DD, Ali SM, Kim DH, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. 2004;14:1296-12302.
-
(2004)
Curr Biol
, vol.14
, pp. 1296-12302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
-
136
-
-
23844438209
-
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
-
Sun SY, Rosenberg LM, Wang X, et al. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res. 2005;65:7052-7058.
-
(2005)
Cancer Res
, vol.65
, pp. 7052-7058
-
-
Sun, S.Y.1
Rosenberg, L.M.2
Wang, X.3
-
137
-
-
32944457518
-
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly KE, Rojo F, She QB, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 2006;66:1500-1508.
-
(2006)
Cancer Res
, vol.66
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
-
138
-
-
2342584183
-
eIF4E-from translation to transformation
-
Mamane Y, Petroulakis E, Rong L, Yoshida K, Ler LW, Sonenberg N. eIF4E-from translation to transformation. Oncogene. 2004;23:3172-3179.
-
(2004)
Oncogene
, vol.23
, pp. 3172-3179
-
-
Mamane, Y.1
Petroulakis, E.2
Rong, L.3
Yoshida, K.4
Ler, L.W.5
Sonenberg, N.6
-
139
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mT0RC2 assembly and Akt/PKB
-
Sarbassov DD, Ali SM, Sengupta S, et al. Prolonged rapamycin treatment inhibits mT0RC2 assembly and Akt/PKB. Mol Cell. 2006;22:159-168.
-
(2006)
Mol Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
-
140
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med. 2007;356:2271-2281.
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
-
142
-
-
27544477748
-
The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing
-
Kaelin WG Jr. The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing. Biochem Biophys Res Commun. 2005;338:627-638.
-
(2005)
Biochem Biophys Res Commun
, vol.338
, pp. 627-638
-
-
Kaelin Jr., W.G.1
-
143
-
-
33847065486
-
The epigenomics of Cancer
-
Jones PA, Baylin SB. The epigenomics of Cancer. Cell. 2007;128:683-692.
-
(2007)
Cell
, vol.128
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
144
-
-
0019888115
-
Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells
-
Jones PA, Taylor SM. Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells. Nucleic Acids Res. 1981;9:2933-2947.
-
(1981)
Nucleic Acids Res
, vol.9
, pp. 2933-2947
-
-
Jones, P.A.1
Taylor, S.M.2
-
145
-
-
37549022694
-
DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes
-
Griffiths EA, Gore SD. DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes. Semin Hematol. 2008;45:23-30.
-
(2008)
Semin Hematol
, vol.45
, pp. 23-30
-
-
Griffiths, E.A.1
Gore, S.D.2
-
146
-
-
0035886022
-
Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2'-deoxycytidine treatment
-
Serrano A, Tanzarella S, Lionello I, et al. Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2'-deoxycytidine treatment. Int J Cancer. 2001;94:243-251.
-
(2001)
Int J Cancer
, vol.94
, pp. 243-251
-
-
Serrano, A.1
Tanzarella, S.2
Lionello, I.3
-
147
-
-
0034105545
-
DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: Clinical results and possible mechanisms of action
-
Lubbert M. DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: clinical results and possible mechanisms of action. Curr Top Microbiol Immunol. 2000;249:135-164.
-
(2000)
Curr Top Microbiol Immunol
, vol.249
, pp. 135-164
-
-
Lubbert, M.1
-
148
-
-
0036386359
-
Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation
-
Lehrmann H, Pritchard LL, Harel-Bellan A. Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation. Adv Cancer Res. 2002;86:41-65.
-
(2002)
Adv Cancer Res
, vol.86
, pp. 41-65
-
-
Lehrmann, H.1
Pritchard, L.L.2
Harel-Bellan, A.3
-
149
-
-
34547864236
-
Histone deacetylase inhibitors: Molecular mechanisms of action
-
Xu WS, Parmigiani RB, Marks PA. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene. 2007;26:5541-5552.
-
(2007)
Oncogene
, vol.26
, pp. 5541-5552
-
-
Xu, W.S.1
Parmigiani, R.B.2
Marks, P.A.3
-
150
-
-
36048958965
-
Histone deacetylase inhibitors: Overview and perspectives
-
Dokmanovic M, Clarke C, Marks PA. Histone deacetylase inhibitors: overview and perspectives. Mol Cancer Res. 2007;5:981-989.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 981-989
-
-
Dokmanovic, M.1
Clarke, C.2
Marks, P.A.3
-
151
-
-
85047699941
-
Histone deacetylases inhibitors as antiangiogenic agents altering vascular endothelial growth factor signaling
-
Deroanne CF, Bonjean K, Servotte S, et al. Histone deacetylases inhibitors as antiangiogenic agents altering vascular endothelial growth factor signaling. Oncogene. 2002; 21:427-436.
-
(2002)
Oncogene
, vol.21
, pp. 427-436
-
-
Deroanne, C.F.1
Bonjean, K.2
Servotte, S.3
-
152
-
-
4644304383
-
Histone deacetylase inhibitors specifically kill nonproliferating tumour cells
-
Burgess A, Ruefli A, Beamish H, et al. Histone deacetylase inhibitors specifically kill nonproliferating tumour cells. Oncogene. 2004;23:6693-6701.
-
(2004)
Oncogene
, vol.23
, pp. 6693-6701
-
-
Burgess, A.1
Ruefli, A.2
Beamish, H.3
-
153
-
-
13444274622
-
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
-
Insinga A, Monestiroli S, Ronzoni S, et al. Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nat Med. 2005;11:71-76.
-
(2005)
Nat Med
, vol.11
, pp. 71-76
-
-
Insinga, A.1
Monestiroli, S.2
Ronzoni, S.3
-
154
-
-
11144221007
-
Apoptotic and autophagic cell death induced by histone deacetylase inhibitors
-
Shao Y, Gao Z, Marks PA, Jiang X. Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc Natl Acad Sci USA. 2004;101:18030-18035.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 18030-18035
-
-
Shao, Y.1
Gao, Z.2
Marks, P.A.3
Jiang, X.4
-
155
-
-
37549043547
-
Mechanisms of resistance to histone deacetylase inhibitors and their therapeutic implications
-
Fantin VR, Richon VM. Mechanisms of resistance to histone deacetylase inhibitors and their therapeutic implications. Clin Cancer Res. 2007;13:7237-7242.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 7237-7242
-
-
Fantin, V.R.1
Richon, V.M.2
-
156
-
-
0029562554
-
The RXR heterodimers and orphan receptors
-
Mangelsdorf DJ, Evans RM. The RXR heterodimers and orphan receptors. Cell. 1995;83:841-850.
-
(1995)
Cell
, vol.83
, pp. 841-850
-
-
Mangelsdorf, D.J.1
Evans, R.M.2
-
157
-
-
0037050017
-
Coregulator recruitment and the mechanism of retinoic acid receptor synergy
-
Germain P, Iyer J, Zechel C, Gronemeyer H. Coregulator recruitment and the mechanism of retinoic acid receptor synergy. Nature. 2002;415:187-192.
-
(2002)
Nature
, vol.415
, pp. 187-192
-
-
Germain, P.1
Iyer, J.2
Zechel, C.3
Gronemeyer, H.4
-
158
-
-
0035749803
-
The promise of retinoids to fight against Cancer
-
Altucci L, Gronemeyer H. The promise of retinoids to fight against Cancer. Nat Rev Cancer. 2001;1:181-193.
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 181-193
-
-
Altucci, L.1
Gronemeyer, H.2
-
159
-
-
0036096774
-
Induction of apoptosis by bexarotene in cutaneous T-cell lymphoma cells: Relevance to mechanism of therapeutic action
-
Zhang C, Hazarika P, Ni X, Weidner DA, Duvic M. Induction of apoptosis by bexarotene in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action. Clin Cancer Res. 2002;8:1234-1240.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1234-1240
-
-
Zhang, C.1
Hazarika, P.2
Ni, X.3
Weidner, D.A.4
Duvic, M.5
-
160
-
-
33645264301
-
A randomized phase III trial comparing bexarotene/carboplatin/paclitaxel versus carboplatin/paclitaxel in chemotherapynaive patients with advanced or metastatic nonsmall cell lung cancer {NSCLC) [abstract)
-
Abstract 7001
-
Blumenschein G, Khuri F, Gatzemeier U, et al. A randomized phase III trial comparing bexarotene/carboplatin/paclitaxel versus carboplatin/paclitaxel in chemotherapynaive patients with advanced or metastatic nonsmall cell lung cancer {NSCLC) [abstract). J Clin Oncol. 2005; 23(16S). Abstract 7001.
-
(2005)
J Clin Oncol
, vol.23
, Issue.16 S
-
-
Blumenschein, G.1
Khuri, F.2
Gatzemeier, U.3
-
161
-
-
33645264301
-
A randomized phase III trial comparing bexarotene/cisplatin/vinorelbine versus cisplatin/vmorelbine in chemotherapy-naive patients with advanced or metastatic nonsmall cell lung cancer (NSCLC) (abstract]
-
Abstract 7024
-
Jassem J, Zatloukal P, Ramlau R, et al. A randomized phase III trial comparing bexarotene/cisplatin/vinorelbine versus cisplatin/vmorelbine in chemotherapy-naive patients with advanced or metastatic nonsmall cell lung cancer (NSCLC) (abstract]. J Clin Oncol. 2005;23(16S). Abstract 7024.
-
(2005)
J Clin Oncol
, vol.23
, Issue.16 S
-
-
Jassem, J.1
Zatloukal, P.2
Ramlau, R.3
-
162
-
-
37849030454
-
Modulation of apoptosis to reverse chemoresistance
-
Mor G, Montagna MK, Alvero AB. Modulation of apoptosis to reverse chemoresistance. Methods Mol Biol. 2008; 414:1-12.
-
(2008)
Methods Mol Biol
, vol.414
, pp. 1-12
-
-
Mor, G.1
Montagna, M.K.2
Alvero, A.B.3
-
163
-
-
0034663032
-
Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis
-
Roboz GJ, Dias S, Lam G, et al. Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis. Blood. 2000;96:1525-1530.
-
(2000)
Blood
, vol.96
, pp. 1525-1530
-
-
Roboz, G.J.1
Dias, S.2
Lam, G.3
-
164
-
-
0031137591
-
Delicious poison: Arsenic trioxide for the treatment of leukemia
-
Kwong YL, Todd D. Delicious poison: arsenic trioxide for the treatment of leukemia. Blood. 1997;89:3487-3488.
-
(1997)
Blood
, vol.89
, pp. 3487-3488
-
-
Kwong, Y.L.1
Todd, D.2
-
165
-
-
0000531696
-
Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells
-
Shao W, Fanelli M, Ferrara FF, et al. Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells. J Natl Cancer Inst. 1998;90:124-133.
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 124-133
-
-
Shao, W.1
Fanelli, M.2
Ferrara, F.F.3
-
166
-
-
0010740572
-
In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins
-
Chen GQ, Zhu J, Shi XG, et al. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. Blood. 1996;88:1052-1061.
-
(1996)
Blood
, vol.88
, pp. 1052-1061
-
-
Chen, G.Q.1
Zhu, J.2
Shi, X.G.3
-
167
-
-
0030610686
-
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells
-
Chen GQ, Shi XG, Tang W, et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood. 1997;89:3345-3353.
-
(1997)
Blood
, vol.89
, pp. 3345-3353
-
-
Chen, G.Q.1
Shi, X.G.2
Tang, W.3
-
168
-
-
0032170898
-
-
Wang ZG, Rivi R, Delva L, et al. Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RABalpha independent manner. Blood. 1998;92.1497-1504.
-
Wang ZG, Rivi R, Delva L, et al. Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RABalpha independent manner. Blood. 1998;92.1497-1504.
-
-
-
-
169
-
-
0033568238
-
Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway
-
Jing Y, Dai J, Chalmers-Redman RM, Tatton WG, Waxman S. Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood. 1999;94:2102-2111.
-
(1999)
Blood
, vol.94
, pp. 2102-2111
-
-
Jing, Y.1
Dai, J.2
Chalmers-Redman, R.M.3
Tatton, W.G.4
Waxman, S.5
-
170
-
-
0029858594
-
The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase
-
Cavigelli M, Li WW, Lin A, Su B, Yoshioka K, Karin M. The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase. EMBO J. 1996;15:6269-6279.
-
(1996)
EMBO J
, vol.15
, pp. 6269-6279
-
-
Cavigelli, M.1
Li, W.W.2
Lin, A.3
Su, B.4
Yoshioka, K.5
Karin, M.6
-
171
-
-
0031842973
-
Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc
-
Chen W, Martindale JL, Holbrook NJ, Liu Y. Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc. Mol Cell Biol. 1998;18:5178-5188.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 5178-5188
-
-
Chen, W.1
Martindale, J.L.2
Holbrook, N.J.3
Liu, Y.4
-
172
-
-
0032853334
-
Antisense oligonucleotides as therapeutic agents
-
Galderisi U, Cascino A, Giordano A. Antisense oligonucleotides as therapeutic agents. J Cell Physiol. 1999;181:251-257.
-
(1999)
J Cell Physiol
, vol.181
, pp. 251-257
-
-
Galderisi, U.1
Cascino, A.2
Giordano, A.3
-
173
-
-
34047217206
-
Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia
-
O'Brien S, Moore JO, Boyd TE, et al. Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia. J Clin Oncol. 2007;25:1114-1120.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1114-1120
-
-
O'Brien, S.1
Moore, J.O.2
Boyd, T.E.3
-
174
-
-
53949121678
-
Addition of oblimersen (Bcl-2 antisense) to fludarabine/cyclophosphamide for relapsed/refractory chronic lymphocytic leukemia extends survival in patients who achieve CR/nPR: Results from a randomized phase 3 study
-
Abstract 751
-
O'Brien S, Moore J, Ding L, Novick S, Rai KR. Addition of oblimersen (Bcl-2 antisense) to fludarabine/cyclophosphamide for relapsed/refractory chronic lymphocytic leukemia extends survival in patients who achieve CR/nPR: results from a randomized phase 3 study. Blood. 2007;110:231a. Abstract 751.
-
(2007)
Blood
, vol.110
-
-
O'Brien, S.1
Moore, J.2
Ding, L.3
Novick, S.4
Rai, K.R.5
-
175
-
-
23844475163
-
Long-term survival results of a randomized multinational phase 3 trial of dacarbazine (DTIC) with or without Bcl-2 antisense (oblimersen sodium) in patients (pts) with advanced malignant melanoma (MM)[abstract]
-
Abstract 7506
-
Kirkwood J, Bedikian A, Millward M, et al. Long-term survival results of a randomized multinational phase 3 trial of dacarbazine (DTIC) with or without Bcl-2 antisense (oblimersen sodium) in patients (pts) with advanced malignant melanoma (MM)[abstract]. J Clin Oncol. 2005; 23(16S). Abstract 7506.
-
(2005)
J Clin Oncol
, vol.23
, Issue.16 S
-
-
Kirkwood, J.1
Bedikian, A.2
Millward, M.3
-
176
-
-
33644586050
-
Reversible posterior leukoencephalopathy syndrome and bevacizumab [letter]
-
discussion 980-982
-
Glusker P, Recht L, Lane B. Reversible posterior leukoencephalopathy syndrome and bevacizumab [letter]. N Engl J Med. 2006;354:980-982; discussion 980-982.
-
(2006)
N Engl J Med
, vol.354
, pp. 980-982
-
-
Glusker, P.1
Recht, L.2
Lane, B.3
-
177
-
-
33644586050
-
Reversible posterior leukoencephalopathy syndrome and bevacizumab [letter]
-
discussion 980-982
-
Ozcan C, Wong SJ, Hari P. Reversible posterior leukoencephalopathy syndrome and bevacizumab [letter]. N Engl J Med. 2006;354:980-982; discussion 980-982.
-
(2006)
N Engl J Med
, vol.354
, pp. 980-982
-
-
Ozcan, C.1
Wong, S.J.2
Hari, P.3
-
178
-
-
34247849335
-
Target practice: Lessons from phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal Cancer
-
Los M, Roodhart JM, Voest EE. Target practice: lessons from phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal Cancer. Oncologist. 2007;12:443-450.
-
(2007)
Oncologist
, vol.12
, pp. 443-450
-
-
Los, M.1
Roodhart, J.M.2
Voest, E.E.3
-
179
-
-
11144354418
-
Bradycardia during therapy for multiple myeloma with thalidomide
-
Fahdi IE, Gaddam V, Saucedo JF, et al. Bradycardia during therapy for multiple myeloma with thalidomide. Am J Cardiol. 2004;93:1052-1055.
-
(2004)
Am J Cardiol
, vol.93
, pp. 1052-1055
-
-
Fahdi, I.E.1
Gaddam, V.2
Saucedo, J.F.3
-
180
-
-
0141939058
-
Effect of arsenic trioxide on QT interval in patients with advanced malignancies
-
Barbey JT, Pezzullo JC, Soignet SL. Effect of arsenic trioxide on QT interval in patients with advanced malignancies. J Clin Oncol. 2003;21:3609-3615.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3609-3615
-
-
Barbey, J.T.1
Pezzullo, J.C.2
Soignet, S.L.3
-
181
-
-
34548276036
-
Molecularly targeted oncology therapeutics and prolongation of the QT interval
-
Strevel EL, Ing DJ, Siu LL. Molecularly targeted oncology therapeutics and prolongation of the QT interval. J Clin Oncol. 2007;25:3362-3371.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3362-3371
-
-
Strevel, E.L.1
Ing, D.J.2
Siu, L.L.3
-
182
-
-
33746035691
-
Cardiotoxicity of histone deacetylase inhibitor depsipeptide in patients with metastatic neuroendocrine tumors
-
Shah MH, Binkley P, Chan K, et al. Cardiotoxicity of histone deacetylase inhibitor depsipeptide in patients with metastatic neuroendocrine tumors. Clin Cancer Res. 2006;12:3997-4003.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3997-4003
-
-
Shah, M.H.1
Binkley, P.2
Chan, K.3
-
183
-
-
33746845181
-
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate
-
Kerkela R, Grazette L, Yacobi R, et al. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med. 2006;12:908-916.
-
(2006)
Nat Med
, vol.12
, pp. 908-916
-
-
Kerkela, R.1
Grazette, L.2
Yacobi, R.3
-
184
-
-
34548523623
-
Pleural effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failure
-
Quintas-Cardama A, Kantarjian H, O'Brien S, et al. Pleural effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failure. J Clin Oncol. 2007;25:3908-3914.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3908-3914
-
-
Quintas-Cardama, A.1
Kantarjian, H.2
O'Brien, S.3
-
185
-
-
0036498781
-
Cardiac dysfunction in the trastuzumab clinical trials experience
-
Seidman A, Hudis C, Pierri MK, et al. Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol. 2002;20:1215-1221.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1215-1221
-
-
Seidman, A.1
Hudis, C.2
Pierri, M.K.3
-
186
-
-
10744234019
-
Activity and safety of CTLA-4 blockade combined with vaccines in cynomolgus macaques
-
Keler T, Halk E, Vitale L, et al. Activity and safety of CTLA-4 blockade combined with vaccines in cynomolgus macaques. J Immunol. 2003;171:6251-6259.
-
(2003)
J Immunol
, vol.171
, pp. 6251-6259
-
-
Keler, T.1
Halk, E.2
Vitale, L.3
-
187
-
-
20044395957
-
Autoimmunity in a phase I trial of a fully human anticytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma
-
Sanderson K, Scotland R, Lee P, et al. Autoimmunity in a phase I trial of a fully human anticytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma. J Clin Oncol. 2005;23:741-750.
-
(2005)
J Clin Oncol
, vol.23
, pp. 741-750
-
-
Sanderson, K.1
Scotland, R.2
Lee, P.3
-
188
-
-
24944459890
-
Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anticytotoxic T-lymphocyte antigen-4
-
Attia P, Phan GQ, Maker AV, et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anticytotoxic T-lymphocyte antigen-4. J Clin Oncol. 2005;23:6043-6053.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6043-6053
-
-
Attia, P.1
Phan, G.Q.2
Maker, A.V.3
-
189
-
-
1542503801
-
Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, CAMPATH-1H) treatment as first-line therapy for B-cell chronic lymphocytic leukaemia
-
Lundin J, Porwit-MacDonald A, Rossmann ED, et al. Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, CAMPATH-1H) treatment as first-line therapy for B-cell chronic lymphocytic leukaemia. Leukemia. 2004;18:484-490.
-
(2004)
Leukemia
, vol.18
, pp. 484-490
-
-
Lundin, J.1
Porwit-MacDonald, A.2
Rossmann, E.D.3
-
190
-
-
33644790476
-
Spectrum of infection, risk and recommendations for prophylaxis and screening among patients with lymphoproliferative disorders treated with alemtuzumab
-
Thursky KA, Worth LJ, Seymour JF, Miles Prince H, Slavin MA. Spectrum of infection, risk and recommendations for prophylaxis and screening among patients with lymphoproliferative disorders treated with alemtuzumab. Br J Haematol. 2006;132:3-12.
-
(2006)
Br J Haematol
, vol.132
, pp. 3-12
-
-
Thursky, K.A.1
Worth, L.J.2
Seymour, J.F.3
Miles Prince, H.4
Slavin, M.A.5
-
191
-
-
33751167425
-
Imatinib mesylate selectively impairs expansion of memory cytotoxic T cells without affecting the control of primary viral infections
-
Mumprecht S, Matter M, Pavelic V, Ochsenbein AF. Imatinib mesylate selectively impairs expansion of memory cytotoxic T cells without affecting the control of primary viral infections. Blood. 2006;108:3406-3413.
-
(2006)
Blood
, vol.108
, pp. 3406-3413
-
-
Mumprecht, S.1
Matter, M.2
Pavelic, V.3
Ochsenbein, A.F.4
-
192
-
-
15244351682
-
Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner
-
Seggewiss R, Lore K, Greiner E, et al. Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood. 2005;105:2473-2479.
-
(2005)
Blood
, vol.105
, pp. 2473-2479
-
-
Seggewiss, R.1
Lore, K.2
Greiner, E.3
-
193
-
-
38949210227
-
Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation
-
Schade AE, Schieven GL, Townsend R, et al. Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation. Blood. 2008;111:1366-1377.
-
(2008)
Blood
, vol.111
, pp. 1366-1377
-
-
Schade, A.E.1
Schieven, G.L.2
Townsend, R.3
-
194
-
-
0032903599
-
Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate antitumor immune responses in vivo
-
Fernandez NC, Lozier A, Flament C, et al. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate antitumor immune responses in vivo. Nat Med. 1999;5:405-411.
-
(1999)
Nat Med
, vol.5
, pp. 405-411
-
-
Fernandez, N.C.1
Lozier, A.2
Flament, C.3
-
195
-
-
4043134677
-
Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects
-
Borg C, Terme M, Taieb J, et al. Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects. J Clin Invest. 2004;114:379-388.
-
(2004)
J Clin Invest
, vol.114
, pp. 379-388
-
-
Borg, C.1
Terme, M.2
Taieb, J.3
-
196
-
-
0018179141
-
Effects of retinoic acid on the immune system: Stimulation of T killer cell induction
-
Dennert G, Lotan R. Effects of retinoic acid on the immune system: stimulation of T killer cell induction. Eur J Immunol. 1978;8:23-29.
-
(1978)
Eur J Immunol
, vol.8
, pp. 23-29
-
-
Dennert, G.1
Lotan, R.2
-
197
-
-
0032897317
-
Retinoids synergize with interleukin-2 to augment IFN-gamma and interleukin-12 production by human peripheral blood mononuclear cells
-
Fox FE, Kubin M, Cassin M, et al. Retinoids synergize with interleukin-2 to augment IFN-gamma and interleukin-12 production by human peripheral blood mononuclear cells. J Interferon Cytokine Res. 1999;19:407-415.
-
(1999)
J Interferon Cytokine Res
, vol.19
, pp. 407-415
-
-
Fox, F.E.1
Kubin, M.2
Cassin, M.3
-
198
-
-
33748416499
-
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
-
Suntharalingam G, Perry MR, Ward S, et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med. 2006;355:1018-1028.
-
(2006)
N Engl J Med
, vol.355
, pp. 1018-1028
-
-
Suntharalingam, G.1
Perry, M.R.2
Ward, S.3
-
199
-
-
33644605483
-
Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy
-
Yousry TA, Major EO, Ryschkewitsch C, et al. Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N Engl J Med. 2006;354:924-933.
-
(2006)
N Engl J Med
, vol.354
, pp. 924-933
-
-
Yousry, T.A.1
Major, E.O.2
Ryschkewitsch, C.3
-
200
-
-
0032145190
-
Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids
-
Vu-Dac N, Gervois P, Torra IP, et al. Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids. J Clin Invest. 1998;102:625-632.
-
(1998)
J Clin Invest
, vol.102
, pp. 625-632
-
-
Vu-Dac, N.1
Gervois, P.2
Torra, I.P.3
-
201
-
-
0033535580
-
Central hypothyroidism associated with retinoid X receptor-selective ligands
-
Sherman SI, Gopal J, Haugen BR, et al. Central hypothyroidism associated with retinoid X receptor-selective ligands. N Engl J Med. 1999;340:1075-1079.
-
(1999)
N Engl J Med
, vol.340
, pp. 1075-1079
-
-
Sherman, S.I.1
Gopal, J.2
Haugen, B.R.3
-
203
-
-
33645996405
-
Imaging of gefitinib-related interstitial lung disease: Multi-institutional analysis by the West Japan Thoracic Oncology Group
-
Endo M, Johkoh T, Kimura K, Yamamoto N. Imaging of gefitinib-related interstitial lung disease: multi-institutional analysis by the West Japan Thoracic Oncology Group. Lung Cancer. 2006;52:135-140.
-
(2006)
Lung Cancer
, vol.52
, pp. 135-140
-
-
Endo, M.1
Johkoh, T.2
Kimura, K.3
Yamamoto, N.4
-
204
-
-
0028363387
-
Distribution of epidermal growth factor and epidermal growth factor receptor in human lung: Immunohistochemical and immunoelectron-microscopic studies
-
Aida S, Tamai S, Sekiguchi S, Shimizu N. Distribution of epidermal growth factor and epidermal growth factor receptor in human lung: immunohistochemical and immunoelectron-microscopic studies. Respiration. 1994;61:161-166.
-
(1994)
Respiration
, vol.61
, pp. 161-166
-
-
Aida, S.1
Tamai, S.2
Sekiguchi, S.3
Shimizu, N.4
-
205
-
-
11344278661
-
Rheumatoid arthritis complicated with acute interstitial pneumonia induced by leflunomide as an adverse reaction
-
Kamata Y, Nara H, Kamimura T, et al. Rheumatoid arthritis complicated with acute interstitial pneumonia induced by leflunomide as an adverse reaction. Intern Med. 2004; 43;1201-1204.
-
(2004)
Intern Med
, vol.43
, pp. 1201-1204
-
-
Kamata, Y.1
Nara, H.2
Kamimura, T.3
-
206
-
-
33645292701
-
Severe pulmonary complications in Japanese patients after bortezomib treatment for refractory multiple myeloma
-
Miyakoshi S, Kami M, Yuji K, et al. Severe pulmonary complications in Japanese patients after bortezomib treatment for refractory multiple myeloma. Blood. 2006;107:3492-3494.
-
(2006)
Blood
, vol.107
, pp. 3492-3494
-
-
Miyakoshi, S.1
Kami, M.2
Yuji, K.3
-
207
-
-
0036380543
-
Correlation of red marrow radiation dosimetry with myelotoxicity: Empirical factors influencing the radiation-induced myelotoxicity of radiolabeled antibodies, fragments and peptides in preclinical and clinical settings
-
Behr TM, Behe M, Sgouros G. Correlation of red marrow radiation dosimetry with myelotoxicity: empirical factors influencing the radiation-induced myelotoxicity of radiolabeled antibodies, fragments and peptides in preclinical and clinical settings. Cancer Biother Radiopharm. 2002;17:445-464.
-
(2002)
Cancer Biother Radiopharm
, vol.17
, pp. 445-464
-
-
Behr, T.M.1
Behe, M.2
Sgouros, G.3
-
208
-
-
20944450476
-
A phase I and pharmacologic trial of two schedules of the proteasome inhibitor, PS-341 (bortezomib, velcade), in patients with advanced Cancer
-
Dy GK, Thomas JP, Wilding G, et al. A phase I and pharmacologic trial of two schedules of the proteasome inhibitor, PS-341 (bortezomib, velcade), in patients with advanced Cancer. Clin Cancer Res. 2005;11:3410-3416.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3410-3416
-
-
Dy, G.K.1
Thomas, J.P.2
Wilding, G.3
-
209
-
-
28444436266
-
Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma
-
Lonial S, Waller EK, Richardson PG, et al. Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma. Blood. 2005; 106:3777-3784.
-
(2005)
Blood
, vol.106
, pp. 3777-3784
-
-
Lonial, S.1
Waller, E.K.2
Richardson, P.G.3
-
210
-
-
0037092645
-
Demonstration of an activation regulated NF-kappaB/I-kappaBalpha complex in human platelets
-
Liu F, Morris S, Epps J, Carroll R. Demonstration of an activation regulated NF-kappaB/I-kappaBalpha complex in human platelets. Thromb Res. 2002;106:199-203.
-
(2002)
Thromb Res
, vol.106
, pp. 199-203
-
-
Liu, F.1
Morris, S.2
Epps, J.3
Carroll, R.4
-
211
-
-
0014385992
-
Thalidomide neuropathy: A clinical electrophysiological, and histological follow-up study
-
Fullerton PM, O'Sullivan DJ. Thalidomide neuropathy: a clinical electrophysiological, and histological follow-up study. J Neurol Neurosurg Psychiatry. 1968;31:543-551.
-
(1968)
J Neurol Neurosurg Psychiatry
, vol.31
, pp. 543-551
-
-
Fullerton, P.M.1
O'Sullivan, D.J.2
-
212
-
-
5344258973
-
Adverse effects of thalidomide administration in patients with neoplastic diseases
-
Dimopoulos MA, Eleutherakis-Papaiakovou V. Adverse effects of thalidomide administration in patients with neoplastic diseases. Am J Med. 2004;117:508-515.
-
(2004)
Am J Med
, vol.117
, pp. 508-515
-
-
Dimopoulos, M.A.1
Eleutherakis-Papaiakovou, V.2
-
213
-
-
0034947693
-
Thalidomide neuropathy in patients treated for metastatic prostate Cancer
-
Molloy FM, Floeter MK, Syed NA, et al. Thalidomide neuropathy in patients treated for metastatic prostate Cancer. Muscle Nerve. 2001;24:1050-1057.
-
(2001)
Muscle Nerve
, vol.24
, pp. 1050-1057
-
-
Molloy, F.M.1
Floeter, M.K.2
Syed, N.A.3
-
214
-
-
0022649529
-
Thalidomideinduced peripheral neuropathy. A prospective clinical, neurophysiological and pharmacogenetic evaluation
-
Hess CW, Hunziker T, Kupfer A, Ludin HP. Thalidomideinduced peripheral neuropathy. A prospective clinical, neurophysiological and pharmacogenetic evaluation. J Neurol. 1986;233:83-89.
-
(1986)
J Neurol
, vol.233
, pp. 83-89
-
-
Hess, C.W.1
Hunziker, T.2
Kupfer, A.3
Ludin, H.P.4
-
216
-
-
21144445380
-
Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: Attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth
-
Kirchmair R, Walter DH, Ii M, et al. Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth. Circulation. 2005;111:2662-2670.
-
(2005)
Circulation
, vol.111
, pp. 2662-2670
-
-
Kirchmair, R.1
Walter, D.H.2
Ii, M.3
-
217
-
-
0034978562
-
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
-
Oosthuyse B, Moons L, Storkebaum E, et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet. 2001;28:131-138.
-
(2001)
Nat Genet
, vol.28
, pp. 131-138
-
-
Oosthuyse, B.1
Moons, L.2
Storkebaum, E.3
-
218
-
-
37549040613
-
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast Cancer
-
Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast Cancer. N Engl J Med. 2007;357:2666-2676.
-
(2007)
N Engl J Med
, vol.357
, pp. 2666-2676
-
-
Miller, K.1
Wang, M.2
Gralow, J.3
-
219
-
-
0142241307
-
Hair depigmentation is a biological readout for pharmacological inhibition of KIT in mice and humans
-
Moss KG, Toner GC, Cherrington JM, Mendel DB, Laird AD. Hair depigmentation is a biological readout for pharmacological inhibition of KIT in mice and humans. J Pharmacol Exp Ther. 2003;307:476-480.
-
(2003)
J Pharmacol Exp Ther
, vol.307
, pp. 476-480
-
-
Moss, K.G.1
Toner, G.C.2
Cherrington, J.M.3
Mendel, D.B.4
Laird, A.D.5
-
220
-
-
0035088316
-
SCF/c-kit signaling is required for cyclic regeneration of the hair pigmentation unit
-
Botchkareva NV, Khlgatian M, Longley BJ, Botchkarev VA, Gilchrest BA. SCF/c-kit signaling is required for cyclic regeneration of the hair pigmentation unit. FASEB J. 2001;15:645-658.
-
(2001)
FASEB J
, vol.15
, pp. 645-658
-
-
Botchkareva, N.V.1
Khlgatian, M.2
Longley, B.J.3
Botchkarev, V.A.4
Gilchrest, B.A.5
-
221
-
-
0027516758
-
White mutants in mice shedding light on humans
-
Halaban R, Moellmann G. White mutants in mice shedding light on humans. J Invest Dermatol. 1993;100(2 suppl):176S-185S.
-
(1993)
J Invest Dermatol
, vol.100
, Issue.2 SUPPL.
-
-
Halaban, R.1
Moellmann, G.2
-
222
-
-
40949096067
-
Epidermal growth factor receptor polymorphisms and clinical outcomes in nonsmall-cell lung cancer patients treated with gefitinib
-
Liu G, Gurubhagavatula S, Zhou W, et al. Epidermal growth factor receptor polymorphisms and clinical outcomes in nonsmall-cell lung cancer patients treated with gefitinib. Pharmacogenomics J. 2008;129-138.
-
(2008)
Pharmacogenomics J
, pp. 129-138
-
-
Liu, G.1
Gurubhagavatula, S.2
Zhou, W.3
-
223
-
-
34147197520
-
Gemtuzumab ozogamicin- associated sinusoidal obstructive syndrome (SOS): An overview from the Research on Adverse Drug Events and Reports (RADAR) Project
-
McKoy JM, Angelotta C, Bennett CL, et al. Gemtuzumab ozogamicin- associated sinusoidal obstructive syndrome (SOS): an overview from the Research on Adverse Drug Events and Reports (RADAR) Project. Leuk Res. 2007;31:599-604.
-
(2007)
Leuk Res
, vol.31
, pp. 599-604
-
-
McKoy, J.M.1
Angelotta, C.2
Bennett, C.L.3
-
224
-
-
33745308428
-
Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma: A retrospective analysis
-
Wright JD, Hagemann A, Rader JS, et al. Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma: a retrospective analysis. Cancer. 2006;107:83-89.
-
(2006)
Cancer
, vol.107
, pp. 83-89
-
-
Wright, J.D.1
Hagemann, A.2
Rader, J.S.3
-
226
-
-
1542713370
-
Gefltinib in combination with paclitaxel and carboplatin in advanced nonsmall-cell lung cancer: A phase III trial-INTACT 2
-
Herbst RS, Giaccone G, Schiller JH, et al. Gefltinib in combination with paclitaxel and carboplatin in advanced nonsmall-cell lung cancer: a phase III trial-INTACT 2. J Clin Oncol. 2004;22:785-794.
-
(2004)
J Clin Oncol
, vol.22
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
-
227
-
-
1542503746
-
Gefltinib in combination with gemcitabine and cisplatin in advanced nonsmall-cell lung cancer: A phase III trial-INTACT 1
-
Giaccone G, Herbst RS, Manegold C, et al. Gefltinib in combination with gemcitabine and cisplatin in advanced nonsmall-cell lung cancer: a phase III trial-INTACT 1. J Clin Oncol. 2004;22:777-784.
-
(2004)
J Clin Oncol
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
-
228
-
-
24944440830
-
TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced nonsmall-cell lung Cancer
-
Herbst RS, Prager D, Hermann R, et al. TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced nonsmall-cell lung Cancer. J Clin Oncol. 2005;23:5892-5899.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5892-5899
-
-
Herbst, R.S.1
Prager, D.2
Hermann, R.3
-
229
-
-
34248140107
-
Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced nonsmall-cell lung cancer the Tarceva Lung Cancer Investigation Trial
-
Gatzemeier U, Pluzanska A, Szczesna A, et al. Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced nonsmall-cell lung cancer the Tarceva Lung Cancer Investigation Trial. J Clin Oncol. 2007;25:1545-1552.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1545-1552
-
-
Gatzemeier, U.1
Pluzanska, A.2
Szczesna, A.3
-
230
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007;25:1960-1966.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
-
231
-
-
22344446208
-
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 Study Group
-
Marty M, Cognetti F, Maraninchi D, et al. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 Study Group. J Clin Oncol. 2005;23:4265-4274.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4265-4274
-
-
Marty, M.1
Cognetti, F.2
Maraninchi, D.3
-
232
-
-
20044364346
-
Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast Cancer
-
Miller KD, Chap LI, Holmes FA, et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast Cancer. J Clin Oncol. 2005;23:792-799.
-
(2005)
J Clin Oncol
, vol.23
, pp. 792-799
-
-
Miller, K.D.1
Chap, L.I.2
Holmes, F.A.3
-
233
-
-
23844548194
-
A randomized, doubleblind, placebo-controlled, phase III study in patients (Pts) with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5-fluorouracil/leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1) [abstract]
-
Abstract
-
Hecht J, Trarbach T, Jaeger E, et al. A randomized, doubleblind, placebo-controlled, phase III study in patients (Pts) with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5-fluorouracil/leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1) [abstract]. J Clin Oncol. 2005;23(16S). Abstract LBA3.
-
(2005)
J Clin Oncol
, vol.23
, Issue.16 S
-
-
Hecht, J.1
Trarbach, T.2
Jaeger, E.3
-
234
-
-
33749637207
-
Results of an interim analysis of a multinational randomized, double-blind, phase III study in patients (pts) with previously treated metastatic colorectal cancer (mCRC) receiving FOLFOX4 and PTK787/ZK 222584 (PTK/ZK) or placebo (CONFIRM 2) [abstract]
-
Abstract 3508
-
Koehne C, Bajetta E, Lin E, et al. Results of an interim analysis of a multinational randomized, double-blind, phase III study in patients (pts) with previously treated metastatic colorectal cancer (mCRC) receiving FOLFOX4 and PTK787/ZK 222584 (PTK/ZK) or placebo (CONFIRM 2) [abstract]. J Clin Oncol. 2006;24(18S). Abstract 3508.
-
(2006)
J Clin Oncol
, vol.24
, Issue.18 S
-
-
Koehne, C.1
Bajetta, E.2
Lin, E.3
-
235
-
-
53949083136
-
-
Llovet J, Ricci S, Mazzaferro V, et al, for the SHARP Investigators Study Group. Randomized phase HI trial of sorafenib versus placebo in patients with advanced hepatocellular carcinoma (HCC) [abstract]. J Clin Oncol. 2007;25(18S). Abstract LBA1.
-
Llovet J, Ricci S, Mazzaferro V, et al, for the SHARP Investigators Study Group. Randomized phase HI trial of sorafenib versus placebo in patients with advanced hepatocellular carcinoma (HCC) [abstract]. J Clin Oncol. 2007;25(18S). Abstract LBA1.
-
-
-
-
236
-
-
0037093195
-
Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the Cancer and Leukemia Group B
-
Silverman LR, Demakos EP, Peterson BL, et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the Cancer and Leukemia Group B. J Clin Oncol. 2002;20:2429-2440.
-
(2002)
J Clin Oncol
, vol.20
, pp. 2429-2440
-
-
Silverman, L.R.1
Demakos, E.P.2
Peterson, B.L.3
-
237
-
-
33646071894
-
Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study
-
Kantarjian H, Issa JP, Rosenfeld CS, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer. 2006;106:1794-1803.
-
(2006)
Cancer
, vol.106
, pp. 1794-1803
-
-
Kantarjian, H.1
Issa, J.P.2
Rosenfeld, C.S.3
-
238
-
-
20444433230
-
Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
-
Richardson PG, Sonneveld P, Schuster MW, et al. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med. 2005;352:2487-2498.
-
(2005)
N Engl J Med
, vol.352
, pp. 2487-2498
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.W.3
-
239
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2003;348:994-1004.
-
(2003)
N Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
240
-
-
20844433223
-
Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial
-
Verweij J, Casali PG, Zalcberg J, et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet. 2004;364:1127-1134.
-
(2004)
Lancet
, vol.364
, pp. 1127-1134
-
-
Verweij, J.1
Casali, P.G.2
Zalcberg, J.3
-
241
-
-
34249074686
-
Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: A randomized phase 2 trial
-
Kantarjian H, Pasquini R, Hamerschlak N, et al. Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial. Blood. 2007;109:5143-5150.
-
(2007)
Blood
, vol.109
, pp. 5143-5150
-
-
Kantarjian, H.1
Pasquini, R.2
Hamerschlak, N.3
|