Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice

Blood

Volumn 119, Issue 3, 2012, Pages 707-716

  Juarez, Julius G ^a   Harun, Nadia ^a   Thien, Marilyn ^a   Welschinger, Robert ^a   Baraz, Rana ^a   Pena, Aileen Dela ^a   Pitson, Stuart M ^b   Rettig, Michael ^c   DiPersio, John F ^c   Bradstock, Kenneth F ^d   Bendall, Linda J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b University of Adelaide   (Australia)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d WESTMEAD HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; PLERIXAFOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEADY STATE; STEM CELL MOBILIZATION;

EID: 84856077778     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-04-348904     Document Type: Article

References (43)

1. Raaijmakers M, Scadden D. Evolving concepts on the microenvironmental niche for hematopoietic stem cells. Curr Opin Hematol. 2008;15(4): 301-306.
2. Méndez-Ferrer S, Lucas D, Battista M, Frenette P. Haematopoietic stem cell release is regulated by circadian oscillations. Nature. 2008;452(7186):442- 447.
3. Levesque JP, Winkler IG. Mobilization of hematopoietic stem cells: state of the art. Curr Opin Organ Transplant. 2008;13(1):53-58.
4. Jansen J, Hanks S, Thompson J, Dugan M, Akard L. Transplantation of hematopoietic stem cells from the peripheral blood. J Cell Mol Med. 2005;9(1):37-50.
5. D'Souza A, Jaiyesimi I, Trainor L, Venuturumili P. Granulocyte colony-stimulating factor administration: adverse events. Transfus Med Rev. 2008; 22(4):280-290.
6. Matloubian M, Lo C, Cinamon G, et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004;427(6972):355-360. (Pubitemid 38133663)
7. Rivera J, Proia R, Olivera A. The alliance of sphingosine-1-phosphate and its receptors in immunity. Nat Rev Immunol. 2008;8(10):753-763.
8. Schwab S, Pereira J, Matloubian M, Xu Y, Huang Y, Cyster J. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science. 2005;309(5741):1735-1739. (Pubitemid 41285945)
9. Kimura T, Boehmler A, Seitz G, et al. The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells. Blood. 2004;103(12):4478-4486. (Pubitemid 38745973)
10. Massberg S, Schaerli P, Knezevic-Maramica I, et al. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell. 2007;131(5):994-1008. (Pubitemid 350138089)
11. Allende ML, Tuymetova G, Lee BG, Bonifacino E, Wu YP, Proia RL. S1P1 receptor directs the release of immature B cells from bone marrow into blood. J Exp Med. 2010;207(5):1113-1124.
12. Ratajczak MZ, Lee H, Wysoczynski M, et al. Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/ membrane attack complex. Leukemia. 2010; 24(5):976-985.
13. Tamamura H, Omagari A, Hiramatsu K, et al. Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. Bioorg Med Chem Lett. 2001;11(14):1897-1902. (Pubitemid 32675313)
14. Schols D, Struyf S, Van Damme J, Este JA, Henson G, De Clercq E. Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4. J Exp Med. 1997;186(8):1383-1388. (Pubitemid 27469034)
15. Sheridan WP, Begley CG, Juttner CA, et al. Effect of peripheral-blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after highdose chemotherapy. Lancet. 1992;339(8794):640-644.
16. Allende M, Yamashita T, Proia R. G-proteincoupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood. 2003;102(10):3665-3667. (Pubitemid 37409386)
17. Allende M, Sasaki T, Kawai H, et al. Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem. 2004;279(50):52487-52492. (Pubitemid 39656625)
18. Leclercq TM, Moretti PA, Vadas MA, Pitson SM. Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity. J Biol Chem. 2008;283(15):9606-9614.
19. Khan NI, Cisterne A, Devidas M, et al. Expression of CD44, but not CD44v6, predicts relapse in children with B cell progenitor acute lymphoblastic leukemia lacking adverse or favorable genetics. Leuk Lymphoma. 2008;49(4):710-718. (Pubitemid 351517216)
20. Gräler M, Goetzl E. The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. FASEB J. 2004;18(3):551-553.
21. Ryser M, Ugarte F, Lehmann R, Bornhaüser M, Brenner S. S1P(1) overexpression stimulates S1P-dependent chemotaxis of human CD34+hematopoietic progenitor cells but strongly inhibits SDF-1/CXCR4-dependent migration and in vivo homing. Mol Immunol. 2008;46(1):166-171.
22. Brinkmann V, Davis MD, Heise CE, et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002; 277(24):21453-21457. (Pubitemid 34952287)
23. Liu Y, Wada R, Yamashita T, et al. Edg-1, the G protein-coupled receptor for sphingosine-1- phosphate, is essential for vascular maturation. J Clin Invest. 2000;106(8):951-961.
24. Pusic I, DiPersio JF. Update on clinical experience with AMD3100, an SDF-1/CXCL12-CXCR4 inhibitor, in mobilization of hematopoietic stem and progenitor cells. Curr Opin Hematol. 2010;17(4):319-326.
25. Nagler A, Shimoni A, Avivi I, et al. BKT140 is a novel CXCR4 antagonist with stem cell mobilization and antimyeloma effects: an open-label firsthuman trial in patients with multiple myeloma undergoing stem cell mobilization for autologous transplantation. Paper presented at: 52nd Annual Meeting of the American Society of Hematology; December 4-7, 2010; Orlando, FL.
26. Schmitt S, Weinhold N, Dembowsky K, et al. First results of a phase-II study with the new CXCR4 antagonist POL6326 to mobilize hematopoietic stem cells (HSCs) in multiple myeloma (MM). Paper presented at: 52nd Annual Meeting of the American Society of Hematology; December 4-7, 2010; Orlando, FL.
27. Petit I, Szyper-Kravitz M, Nagler A, et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol. 2002;3(7):687-694. (Pubitemid 34752479)
28. Gazitt Y, Liu Q. Plasma levels of SDF-1 and expression of SDF-1 receptor on CD34+ cells in mobilized peripheral blood of non-Hodgkin's lymphoma patients. Stem Cells. 2001;19(1):37-45. (Pubitemid 32057970)
29. Venkataraman K, Lee YM, Michaud J, et al. Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ Res. 2008;102(6): 669-676. (Pubitemid 351457860)
30. Papayannopoulou T, Nakamoto B. Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin. Proc Natl Acad Sci U S A. 1993;90(20):9374-9378. (Pubitemid 23315786)
31. Fondi A, Jarrier F, Zhang Y, et al. Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4 -/- chimeric mice. Blood. 2006;107(6): 2243-2251. (Pubitemid 43345541)
32. Lévesque J, Takamatsu Y, Nilsson S, Haylock D, Simmons P. Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor. Blood. 2001;98(5):1289-1297.
33. Lévesque J, Hendy J, Takamatsu Y, Simmons P, Bendall L. Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. J Clin Invest. 2003;111(2):187-196. (Pubitemid 36105917)
34. Schwab SR, Cyster JG. Finding a way out: lymphocyte egress from lymphoid organs. Nat Immunol. 2007;8(12):1295-1301. (Pubitemid 350131168)
35. Rosen H, Sanna MG, Cahalan SM, Gonzalez-Cabrera PJ. Tipping the gatekeeper: S1P regulation of endothelial barrier function. Trends Immunol. 2007;28(3):102-107. (Pubitemid 46283694)
36. Weiss L. Cell and Tissue Biology. A Textbook of Histology. 6th ed. Baltimore, MD: Urban & Schwarzenberg; 1988.
37. He X, H'Ng SC, Leong DT, Hutmacher DW, Melendez AJ. Sphingosine-1- phosphate mediates proliferation maintaining the multipotency of human adult bone marrow and adipose tissuederived stem cells. J Mol Cell Biol. 2010;2(4):199-208.
38. Lévesque J, Hendy J, Takamatsu Y, Williams B, Winkler I, Simmons P. Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment. Exp Hematol. 2002;30(5):440-449. (Pubitemid 34556735)
39. Lévesque J, Hendy J, Winkler I, Takamatsu Y, Simmons P. Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells. Exp Hematol. 2003;31(2):109-117. (Pubitemid 36184635)
40. De Clercq E. The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil). Biochem Pharmacol. 2009;77(11):1655-1664.
41. Kappos L, Radue EW, O'Connor P, et al. A placebo- controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med. 2010;362(5):387-401.
42. Shea BS, Brooks SF, Fontaine BA, Chun J, Luster AD, Tager AM. Prolonged S1P1 agonist exposure exacerbates vascular leak, fibrosis, and mortality after lung injury. Am J Respir Cell Mol Biol. 2010;43(6):662-673.
43. Murakami A, Takasugi H, Ohnuma S, et al. Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol Pharmacol. 2010;77(4):704-713.