S1P1 overexpression stimulates S1P-dependent chemotaxis of human CD34+ hematopoietic progenitor cells but strongly inhibits SDF-1/CXCR4-dependent migration and in vivo homing

Molecular Immunology

Volumn 46, Issue 1, 2008, Pages 166-171

  Ryser, Martin F ^a,b   Ugarte, Fernando ^a   Lehmann, Romy ^a   Bornhäuser, Martin ^a,b   Brenner, Sebastian ^a,b  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

CXCR4; Homing; HSC; Migration; S1P1; SDF 1

Indexed keywords

CALCIUM; CD34 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; GREEN FLUORESCENT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RETROVIRUS VECTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; SPHINGOSINE 1 PHOSPHATE RECEPTOR 3; SPHINGOSINE 1 PHOSPHATE RECEPTOR 4; SPHINGOSINE 1 PHOSPHATE RECEPTOR 5; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CALCIUM TRANSPORT; CELL HOMING; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOREGULATION; IN VIVO STUDY; INTERNAL RIBOSOME ENTRY SITE; LEUKEMIA CELL LINE; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SCID MOUSE; TARGET CELL; TRANSGENE;

ANIMALS; ANTIGENS, CD34; BONE MARROW; CELL ADHESION; CHEMOKINE CXCL12; CHEMOTAXIS; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; JURKAT CELLS; LYSOPHOSPHOLIPIDS; MICE; MICE, SCID; PHENOTYPE; RECEPTORS, CXCR4; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; SPHINGOSINE; SPLEEN;

MUS;

EID: 52949135175     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.07.016     Document Type: Article

References (17)

1. Abkowitz J.L., Robinson A.E., Kale S., Long M.W., and Chen J. The mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure. Blood (2003)
2. Anliker B., and Chun J. Lysophospholipid G protein-coupled receptors. J. Biol. Chem. 279 (2004) 20555-20558
3. Brenner S., Whiting-Theobald N., Kawai T., Linton G.F., Rudikoff A.G., Choi U., Ryser M.F., Murphy P.M., Sechler J.M., and Malech H.L. CXCR4-transgene expression significantly improves marrow engraftment of cultured hematopoietic stem cells. Stem Cells 22 (2004) 1128-1133
4. Dorsam G., Graeler M.H., Seroogy C., Kong Y., Voice J.K., and Goetzl E.J. Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor. J. Immunol. 171 (2003) 3500-3507
5. Graler M.H., and Goetzl E.J. The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. FASEB J. 18 (2004) 551-553
6. Kimura T., Boehmler A.M., Seitz G., Kuci S., Wiesner T., Brinkmann V., Kanz L., and Mohle R. The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells. Blood 103 (2004) 4478-4486
7. Lataillade J.J., Clay D., Dupuy C., Rigal S., Jasmin C., Bourin P., and Bousse-Kerdiles M.C. Chemokine SDF-1 enhances circulating CD34(+) cell proliferation in synergy with cytokines: possible role in progenitor survival. Blood 95 (2000) 756-768
8. Ma Q., Jones D., Borghesani P.R., Segal R.A., Nagasawa T., Kishimoto T., Bronson R.T., and Springer T.A. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in C. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 9448-9453
9. Matloubian M., Lo C.G., Cinamon G., Lesneski M.J., Xu Y., Brinkmann V., Allende M.L., Proia R.L., and Cyster J.G. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427 (2004) 355-360
10. Oo M.L., Thangada S., Wu M.T., Liu C.H., Macdonald T.L., Lynch K.R., Lin C.Y., and Hla T. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J. Biol. Chem. 282 (2007) 9082-9089
11. Peled A., Petit I., Kollet O., Magid M., Ponomaryov T., Byk T., Nagler A., Ben Hur H., Many A., Shultz L., Lider O., Alon R., Zipori D., and Lapidot T. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 283 (1999) 845-848
12. Peled A., Kollet O., Ponomaryov T., Petit I., Franitza S., Grabovsky V., Slav M.M., Nagler A., Lider O., Alon R., Zipori D., and Lapidot T. The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice. Blood 95 (2000) 3289-3296
13. Schmid G., Guba M., Ischenko I., Papyan A., Joka M., Schrepfer S., Bruns C.J., Jauch K.W., Heeschen C., and Graeb C. The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1. J. Cell Biochem. 101 (2007) 259-270
14. Whetton A.D., Lu Y., Pierce A., Carney L., and Spooncer E. Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1. Blood 102 (2003) 2798-2802
15. Yanai N., Matsui N., Furusawa T., Okubo T., and Obinata M. Sphingosine-1-phosphate and lysophosphatidic acid trigger invasion of primitive hematopoietic cells into stromal cell layers. Blood 96 (2000) 139-144
16. Yopp A.C., Fu S., Honig S.M., Randolph G.J., Ding Y., Krieger N.R., and Bromberg J.S. FTY720-enhanced T cell homing is dependent on CCR2, CCR5, CCR7, and CXCR4: evidence for distinct chemokine compartments. J. Immunol. 173 (2004) 855-865
17. Zou Y.R., Kottmann A.H., Kuroda M., Taniuchi I., and Littman D.R. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393 (1998) 595-599