Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation

Journal of Biological Chemistry

Volumn 284, Issue 16, 2009, Pages 10422-10432

  Nemoto, Satoshi ^a,f   Nakamura, Mitsuhiro ^b   Osawa, Yosuke ^a   Kono, Saki ^a   Itoh, Yoshinori ^a   Okano, Yukio ^a   Murate, Takashi ^c   Hara, Akira ^b   Ueda, Hiroshi ^d   Nozawa, Yoshinori ^e   Banno, Yoshiko ^a,g  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY   (Japan)

^d GIFU UNIVERSITY   (Japan)

^e International Institute of Biotechnology   (Japan)

^f SHONAN KAMAKURA GENERAL HOSPITAL   (Japan)

^g NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AKT ACTIVATION; CASPASE; CASPASE ACTIVATION; CELL VIABILITY; CERAMIDE; CERAMIDES; CHEMOSENSITIVITY; COLON CANCER CELLS; FUMONISIN B1; HUMAN COLON CANCER CELLS; ISOFORMS; MYRIOCIN; OXALIPLATIN; P53 AND P21; POLY POLYMERASE; PRE-TREATMENT; PROTEIN EXPRESSIONS; PROTEIN LEVEL; RNA INTERFERENCE; SALVAGE PATHWAY; SPHINGOMYELINASE; SPHINGOSINE KINASE; TIME-DEPENDENT;

ACTIVATION ANALYSIS; AMIDES; CELL CULTURE; MASS SPECTROMETRY; NUCLEIC ACIDS; PHOSPHORYLATION; RNA;

CELL MEMBRANES;

CASPASE; CERAMIDE; FUMONISIN B1; OXALIPLATIN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; SMALL INTERFERING RNA; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE KINASE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; THERMOZYMOCIDIN; ANTINEOPLASTIC AGENT; COL11A2 PROTEIN, HUMAN; COLLAGEN TYPE 11; DIHYDROCERAMIDE DESATURASE; ENZYME INHIBITOR; ISOENZYME; OXIDOREDUCTASE; PHOSPHOTRANSFERASE; PLATINUM COMPLEX; SMPD3 PROTEIN, HUMAN;

ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CELL LEVEL; CELL SPECIFICITY; CELL STRAIN CACO 2; CELL STRAIN HCT116; CELL VIABILITY; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; LIPID STORAGE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ANIMAL; COLON TUMOR; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; GENETICS; METABOLISM; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CERAMIDES; COLLAGEN TYPE XI; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; ISOENZYMES; ORGANOPLATINUM COMPOUNDS; OXIDOREDUCTASES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 67449098149     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M900735200     Document Type: Article

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