Neuroimmune communication in hypertension and obesity: A new therapeutic angle?

Pharmacology and Therapeutics

Volumn 138, Issue 3, 2013, Pages 428-440

  De Kloet, Annette D ^a   Krause, Eric G ^a   Shi, Peng D ^a,b   Zubcevic, Jasenka ^a   Raizada, Mohan K ^a   Sumners, Colin ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Angiotensin; Blood pressure; Inflammation; Microglia; Renin; Sympathetic nervous system

Indexed keywords

ADRENERGIC SYSTEM; ASTROCYTE; BLOOD BRAIN BARRIER; BLOOD PRESSURE REGULATION; ENCEPHALITIS; HUMAN; HYPERTENSION; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; MICROGLIA; NERVE CELL NETWORK; OBESITY; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW;

EID: 84877574844     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2013.02.005     Document Type: Review

References (238)

1. F.M. Abboud Effects of sodium, angiotensin, and steroids on vascular reactivity in man Fed Proc 33 1974 143 149
2. J.M. Adams, J.J. McCarthy, and S.D. Stocker Excess dietary salt alters angiotensinergic regulation of neurons in the rostral ventrolateral medulla Hypertension 52 2008 932 937
3. D. Agarwal, M.A. Welsch, J.N. Keller, and J. Francis Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR Basic Res Cardiol 106 2011 1069 1085
4. I. Allaman, M. Belanger, and P.J. Magistretti Astrocyte-neuron metabolic relationships: for better and for worse Trends Neurosci 34 2011 76 87
5. M. Alonso-Galicia, M.W. Brands, D.H. Zappe, and J.E. Hall Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activity Hypertension 28 1996 1047 1054
6. J.A. Armitage, S.L. Burke, L.J. Prior, B. Barzel, N. Eikelis, and K. Lim Rapid onset of renal sympathetic nerve activation in rabbits fed a high-fat diet Hypertension 60 2012 163 171
7. A.C. Arnold, H.A. Shaltout, P.E. Gallagher, and D.I. Diz Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus Hypertension 54 2009 1001 1008
8. M. Bader, and D. Ganten It's renin in the brain: transgenic animals elucidate the brain renin angiotensin system Circ Res 90 2002 8 10
9. E. Badoer Microglia: activation in acute and chronic inflammatory states and in response to cardiovascular dysfunction Int J Biochem Cell Biol 42 2010 1580 1585
10. J.S. Bains, A. Potyok, and A.V. Ferguson Angiotensin II actions in paraventricular nucleus: functional evidence for neurotransmitter role in efferents originating in subfornical organ Brain Res 599 1992 223 229
11. G. Banisadr, R.-D. Gosselin, P. Mechighel, P. Kitabgi, W. Rostène, and S.M. Parsadaniantz Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) in rat brain: evidence for its colocalization with neurotransmitters and neuropeptides J Comp Neurol 489 2005 275 292
12. W.A. Banks Blood-brain barrier transport of cytokines: a mechanism for neuropathology Curr Pharm Des 11 2005 973 984
13. W.A. Banks, and M.A. Erickson The blood-brain barrier and immune function and dysfunction Neurobiol Dis 37 2010 26 32
14. T.J. Bartness, and C.K. Song Brain-adipose tissue neural crosstalk Physiol Behav 91 2007 343 351
15. M. Belanger, I. Allaman, and P.J. Magistretti Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation Cell Metab 14 2011 724 738
16. J. Benicky, E. Sanchez-Lemus, M. Honda, T. Pang, M. Orecna, and J. Wang Angiotensin II AT1 receptor blockade ameliorates brain inflammation Neuropsychopharmacology 36 2011 857 870
17. J. Benicky, E. Sanchez-Lemus, J. Pavel, and J.M. Saavedra Anti-inflammatory effects of angiotensin receptor blockers in the brain and the periphery Cell Mol Neurobiol 29 2009 781 792
18. B. Bennett, D.E. Larson-Meyer, E. Ravussin, J. Volaufova, A. Soros, and W.T. Cefalu Impaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children Obesity 20 2012 371 375
19. A. Bessis, C. Bechade, D. Bernard, and A. Roumier Microglial control of neuronal death and synaptic properties Glia 55 2007 233 238
20. P. Bezzi, M. Domercq, L. Brambilla, R. Galli, D. Schols, and E. De Clercq CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity Nat Neurosci 4 2001 702 710
21. P. Bezzi, M. Domercq, S. Vesce, and A. Volterra Neuron-astrocyte cross-talk during synaptic transmission: physiological and neuropathological implications Prog Brain Res 132 2001 255 265
22. S. Bosnyak, I.K. Welungoda, A. Hallberg, M. Alterman, R.E. Widdop, and E.S. Jones Stimulation of angiotensin AT2 receptors by the non-peptide agonist, compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats Br J Pharmacol 159 2010 709 716
23. E.A. Bourassa, A.F. Sved, and R.C. Speth Angiotensin modulation of rostral ventrolateral medulla (RVLM) in cardiovascular regulation Mol Cell Endocrinol 302 2009 167 175
24. V.A. Braga Differential brain angiotensin-II type I receptor expression in hypertensive rats J Vet Sci 12 2011 291 293
25. M.W. Brands, A.K. Banes-Berceli, E.W. Inscho, H. Al-Azawi, A.J. Allen, and H. Labazi Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activation Hypertension 56 2010 879 884
26. C.D. Brown, M. Higgins, K.A. Donato, F.C. Rohde, R. Garrison, and E. Obarzanek Body mass index and the prevalence of hypertension and dyslipidemia Obes Res 8 2000 605 619
27. L.B. Buckman, M.M. Thompson, H.N. Moreno, and K.L.J. Ellacott Regional astrogliosis in the mouse hypothalamus in response to obesity J Comp Neurol 521 2013 1322 1333
28. G.M. Burke, D.A. Sica, and W.H. Frishman Renal sympathetic denervation for the treatment of systemic hypertension Cardiol Rev 20 2012 274 278
29. S. Busche, S. Gallinat, M.A. Fleegal, M.K. Raizada, and C. Sumners Novel role of macrophage migration inhibitory factor in angiotensin II regulation of neuromodulation in rat brain Endocrinology 142 2001 4623 4630
30. P.D. Cani, J. Amar, M.A. Iglesias, M. Poggi, C. Knauf, and D. Bastelica Metabolic endotoxemia initiates obesity and insulin resistance Diabetes 56 2007 1761 1772
31. X. Cao, J.R. Peterson, G. Wang, J. Anrather, C.N. Young, and M.R. Guruju Angiotensin II-dependent hypertension requires cyclooxygenase 1-derived prostaglandin E2 and EP1 receptor signaling in the subfornical organ of the brain Hypertension 59 2012 869 876
32. J.P. Cardinale, S. Sriramula, N. Mariappan, D. Agarwal, and J. Francis Angiotensin II-induced hypertension is modulated by nuclear factor-kappaB in the paraventricular nucleus Hypertension 59 2012 113 121
33. S. Caspar-Bauguil, B. Cousin, S. Bour, L. Casteilla, L. Penicaud, and C. Carpene Adipose tissue lymphocytes: types and roles J Physiol Biochem 65 2009 423 436
34. P.A. Cassano, M.R. Segal, P.S. Vokonas, and S.T. Weiss Body fat distribution, blood pressure, and hypertension. A prospective cohort study of men in the normative aging study Ann Epidemiol 1 1990 33 48
35. L.A. Cassis Role of angiotensin-Ii in brown adipose thermogenesis during cold-acclimation Am J Physiol 265 1993 E860 E865
36. L.A. Cassis, and L.P. Dwoskin Presynaptic modulation of neurotransmitter release by endogenous angiotensin II in brown adipose tissue J Neural Transm Suppl 34 1991 129 137
37. L.A. Cassis, V. English, and M. Helton Angiotensin II regulates leptin secretion: a potential link between obesity and hypertension FASEB J 15 2001 A78
38. D.F. Cechetto, and C.B. Saper Neurochemical organization of the hypothalamic projection to the spinal cord in the rat J Comp Neurol 272 1988 579 604
39. G. Conductier, N. Blondeau, A. Guyon, J.-L. Nahon, and C. Rovère The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases J Neuroimmunol 224 2010 93 100
40. R. Cooper, T. Forrester, O. Ogunbiyi, and J. Muffinda Angiotensinogen levels and obesity in four black populations. ICSHIB Investigators J Hypertens 16 1998 571 575
41. M.L. Correia, D.A. Morgan, W.I. Sivitz, A.L. Mark, and W.G. Haynes Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure Hypertension 37 2001 936 942
42. S.D. Crowley, Y.S. Song, E.E. Lin, R. Griffiths, H.S. Kim, and P. Ruiz Lymphocyte responses exacerbate angiotensin II-dependent hypertension Am J Physiol Regul Integr Comp Physiol 298 2010 R1089 R1097
43. A.E. Cuadra, Z. Shan, C. Sumners, and M.K. Raizada A current view of brain renin-angiotensin system: is the (pro)renin receptor the missing link? Pharmacol Ther 125 2010 27 38
44. C. D'Mello, T. Le, and M.G. Swain Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation J Neurosci 29 2009 2089 2102
45. R. Dampney Medullary pathways regulating sympathetic outflow: the need for more lateral thinking Am J Physiol Regul Integr Comp Physiol 286 2004 R446 R448
46. R.A. Dampney, M.J. Coleman, M.A. Fontes, Y. Hirooka, J. Horiuchi, and Y.W. Li Central mechanisms underlying short- and long-term regulation of the cardiovascular system Clin Exp Pharmacol Physiol 29 2002 261 268
47. R. Dantzer, and K.W. Kelley Twenty years of research on cytokine-induced sickness behavior Brain Behav Immun 21 2007 153 160
48. T.L. Davidson, A. Monnot, A.U. Neal, A.A. Martin, J.J. Horton, and W. Zheng The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood-brain barrier integrity differ for diet-induced obese and diet-resistant rats Physiol Behav 107 2012 26 33
49. A.D. de Kloet, E.G. Krause, K.A. Scott, M.T. Foster, J.P. Herman, and R.R. Sakai Central angiotensin-II has catabolic action at white and brown adipose tissue Am J Physiol Endocrinol Metab 301 2011 E1081 E1091
50. A.D. de Kloet, E.G. Krause, and S.C. Woods The renin angiotensin system and the metabolic syndrome Physiol Behav 100 2010 525 534
51. C. De Miguel, S. Das, H. Lund, and D.L. Mattson T lymphocytes mediate hypertension and kidney damage in Dahl salt-sensitive rats Am J Physiol Regul Integr Comp Physiol 298 2010 R1136 R1142
52. C. De Miguel, C. Guo, H. Lund, D. Feng, and D.L. Mattson Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of hypertension and renal disease Am J Physiol Renal Physiol 300 2011 F734 F742
53. C. De Miguel, H. Lund, and D.L. Mattson High dietary protein exacerbates hypertension and renal damage in Dahl SS rats by increasing infiltrating immune cells in the kidney Hypertension 57 2011 269 274
54. C. Dean, J.L. Seagard, F.A. Hopp, and J.P. Kampine Differential control of sympathetic activity to kidney and skeletal muscle by ventral medullary neurons J Auton Nerv Syst 37 1992 1 10
55. S. Der Sarkissian, M.J. Huentelman, J. Stewart, M.J. Katovich, and M.K. Raizada ACE2: a novel therapeutic target for cardiovascular diseases Prog Biophys Mol Biol 91 2006 163 198
56. D.A. DeWitt, G. Perry, M. Cohen, C. Doller, and J. Silver Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease Exp Neurol 149 1998 329 340
57. C. Diez-Freire, J. Vazquez, M.F. Correa de Adjounian, M.F. Ferrari, L. Yuan, and X. Silver ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR Physiol Genomics 27 2006 12 19
58. Z.Q. Ding, Y.W. Li, S.L. Wesselingh, and W.W. Blessing Transneuronal labelling of neurons in rabbit brain after injection of herpes simplex virus type 1 into the renal nerve J Auton Nerv Syst 42 1993 23 31
59. K. Dobrenis, H.Y. Chang, M.H. Pina-Benabou, A. Woodroffe, S.C. Lee, and R. Rozental Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons J Neurosci Res 82 2005 306 315
60. M. Donoghue, F. Hsieh, E. Baronas, K. Godbout, M. Gosselin, and N. Stagliano A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 Circ Res 87 2000 E1 E9
61. J.A. Dorresteijn, F.L. Visseren, and W. Spiering Mechanisms linking obesity to hypertension Obes Rev 13 2012 17 26
62. B.M. Egan, Y. Zhao, and R. Axon US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008 JAMA 303 2010 2043 2050
63. I.J. Elenkov, R.L. Wilder, G.P. Chrousos, and E.S. Vizi The sympathetic nerve - an integrative interface between two supersystems: the brain and the immune system Pharmacol Rev 52 2000 595 638
64. M.D. Esler, H. Krum, P.A. Sobotka, M.P. Schlaich, R.E. Schmieder, and M. Bohm Renal sympathetic denervation in patients with treatment-resistant hypertension (the Symplicity HTN-2 trial): a randomised controlled trial Lancet 376 2010 1903 1909
65. E.A. Eugenin, D. Eckardt, M. Theis, K. Willecke, M.V. Bennett, and J.C. Saez Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha Proc Natl Acad Sci USA 98 2001 4190 4195
66. B. Finsen, and T. Owens Innate immune responses in central nervous system inflammation FEBS Lett 585 2011 3806 3812
67. J.P. Fisher, and P.J. Fadel Therapeutic strategies for targeting excessive central sympathetic activation in human hypertension Exp Physiol 95 2010 572 580
68. A.H. Freiria-Oliveira, G.T. Blanch, H. Li, E. Colombari, D.S. Colombari, and C. Sumners Macrophage migration inhibitory factor in the nucleus of solitary tract decreases blood pressure in SHRs Cardiovasc Res 97 2013 153 160
69. L. Fuchtbauer, M. Groth-Rasmussen, T.H. Holm, M. Lobner, H. Toft-Hansen, and R. Khorooshi Angiotensin II Type 1 receptor (AT1) signaling in astrocytes regulates synaptic degeneration-induced leukocyte entry to the central nervous system Brain Behav Immun 25 2011 897 904
70. C.K. Ganta, N. Lu, B.G. Helwig, F. Blecha, R.R. Ganta, and L. Zheng Central angiotensin II-enhanced splenic cytokine gene expression is mediated by the sympathetic nervous system Am J Physiol Heart Circ Physiol 289 2005 H1683 H1691
71. R.J. Garrison, W.B. Kannel, J. Stokes III, and W.P. Castelli Incidence and precursors of hypertension in young adults: the Framingham Offspring Study Prev Med 16 1987 235 251
72. A.R. Gerber, and T.L. Bale Antiinflammatory treatment ameliorates HPA stress axis dysfunction in a mouse model of stress sensitivity Endocrinology 153 2012 4830 4837
73. A.R. Glabinski, V. Balasingam, M. Tani, S.L. Kunkel, R.M. Strieter, and V.W. Yong Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain J Immunol 156 1996 4363 4368
74. D.S. Goldstein Plasma catecholamines and essential hypertension. An analytical review Hypertension 5 1983 86 99
75. A.D. Gonzalez, G. Wang, E.M. Waters, K.L. Gonzales, R.C. Speth, and T.A. Van Kempen Distribution of angiotensin type 1a receptor-containing cells in the brains of bacterial artificial chromosome transgenic mice Neuroscience 226 2012 489 509
76. R. Gorina, M. Font-Nieves, L. Márquez-Kisinousky, T. Santalucia, and A.M. Planas Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways Glia 59 2011 242 255
77. N.G. Gourmala, M. Buttini, S. Limonta, A. Sauter, and H.W. Boddeke Differential and time-dependent expression of monocyte chemoattractant protein-1 mRNA by astrocytes and macrophages in rat brain: effects of ischemia and peripheral lipopolysaccharide administration J Neuroimmunol 74 1997 35 44
78. G. Grassi Role of the sympathetic nervous system in human hypertension J Hypertens 16 1998 1979 1987
79. G. Grassi Sympathetic neural activity in hypertension and related diseases Am J Hypertens 23 2010 1052 1060
80. G. Grassi, G. Seravalle, B.M. Cattaneo, G.B. Bolla, A. Lanfranchi, and M. Colombo Sympathetic activation in obese normotensive subjects Hypertension 25 1995 560 563
81. G. Grassi, G. Seravalle, M. Colombo, G. Bolla, B.M. Cattaneo, and F. Cavagnini Body weight reduction, sympathetic nerve traffic, and arterial baroreflex in obese normotensive humans Circulation 97 1998 2037 2042
82. G. Grassi, G. Seravalle, R. Dell'Oro, F.Q. Trevano, M. Bombelli, and F. Scopelliti Comparative effects of candesartan and hydrochlorothiazide on blood pressure, insulin sensitivity, and sympathetic drive in obese hypertensive individuals: results of the CROSS study J Hypertens 21 2003 1761 1769
83. G. Grassi, G. Seravalle, and F. Quarti-Trevano The 'neuroadrenergic hypothesis' in hypertension: current evidence Exp Physiol 95 2010 581 586
84. J.L. Grobe, C.L. Grobe, T.G. Beltz, S.G. Westphal, D.A. Morgan, and D. Xu The brain renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance Cell Metab 12 2010 431 442
85. J.L. Grobe, D. Xu, and C.D. Sigmund An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy Physiology (Bethesda) 23 2008 187 193
86. F. Guo, B. Liu, F. Tang, S. Lane, E.A. Souslova, and D.M. Chudakov Astroglia are a possible cellular substrate of angiotensin(1-7) effects in the rostral ventrolateral medulla Cardiovasc Res 87 2010 578 584
87. H. Gurden, N. Uchida, and Z.F. Mainen Sensory-evoked intrinsic optical signals in the olfactory bulb are coupled to glutamate release and uptake Neuron 52 2006 335 345
88. P.G. Guyenet The sympathetic control of blood pressure Nat Rev Neurosci 7 2006 335 346
89. T.J. Guzik, N.E. Hoch, K.A. Brown, L.A. McCann, A. Rahman, and S. Dikalov Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction J Exp Med 204 2007 2449 2460
90. T.J. Guzik, P.J. Marvar, M. Czesnikiewicz-Guzik, and R. Korbut Perivascular adipose tissue as a messenger of the brain-vessel axis: role in vascular inflammation and dysfunction J Physiol Pharmacol 58 2007 591 610
91. D.G. Harrison, T.J. Guzik, J. Goronzy, and C. Weyand Is hypertension an immunologic disease? Curr Cardiol Rep 10 2008 464 469
92. D.G. Harrison, T.J. Guzik, H.E. Lob, M.S. Madhur, P.J. Marvar, and S.R. Thabet Inflammation, immunity, and hypertension Hypertension 57 2011 132 140
93. D.G. Harrison, P.J. Marvar, and J.M. Titze Vascular inflammatory cells in hypertension Front Physiol 3 2012 128
94. S.C. Harwani, M.W. Chapleau, K.L. Legge, Z.K. Ballas, and F.M. Abboud Neurohormonal modulation of the innate immune system is proinflammatory in the prehypertensive spontaneously hypertensive rat, a genetic model of essential hypertension Circ Res 111 2012 1190 1197
95. W.G. Haynes Role of leptin in obesity-related hypertension Exp Physiol 90 2005 683 688
96. W.G. Haynes, D.A. Morgan, A. Djalali, W.I. Sivitz, and A.L. Mark Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic Hypertension 33 1999 542 547
97. M.D. Hendel, and J.P. Collister Contribution of the subfornical organ to angiotensin II-induced hypertension Am J Physiol Heart Circ Physiol 288 2005 H680 H685
98. A.M. Hilzendeger, D.A. Morgan, L. Brooks, D. Dellsperger, X. Liu, and J.L. Grobe A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity Am J Physiol Heart Circ Physiol 303 2012 H197 H206
99. G.S. Hotamisligil Inflammatory pathways and insulin action Int J Obes Relat Metab Disord 27 Suppl. 3 2003 S53 S55
100. G.S. Hotamisligil Inflammation and metabolic disorders Nature 444 2006 860 867
101. X.C. Huang, E.M. Richards, and C. Sumners Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type 1 receptors and inhibited by angiotensin II type 2 receptors J Biol Chem 271 1996 15635 15641
102. F. Imai, M. Sawada, H. Suzuki, B.V. Zlokovic, J. Kojima, and S. Kuno Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions Neurosci Lett 272 1999 127 130
103. F. Imai, H. Suzuki, J. Oda, T. Ninomiya, K. Ono, and H. Sano Neuroprotective effect of exogenous microglia in global brain ischemia J Cereb Blood Flow Metab 27 2007 488 500
104. A.D. Intebi, M.S. Flaxman, W.F. Ganong, and C.F. Deschepper Angiotensinogen production by rat astroglial cells in vitro and in vivo Neuroscience 34 1990 545 554
105. R. Jankord, R. Zhang, J.N. Flak, M.B. Solomon, J. Albertz, and J.P. Herman Stress activation of IL-6 neurons in the hypothalamus Am J Physiol Regul Integr Comp Physiol 299 2010 R343 R351
106. N. Jiang, P. Shi, H. Li, S. Lu, L. Braseth, and A.E. Cuadra Phosphate-activated glutaminase-containing neurons in the rat paraventricular nucleus express angiotensin type 1 receptors Hypertension 54 2009 845 851
107. M.J. Joyner, N. Charkoudian, and B.G. Wallin A sympathetic view of the sympathetic nervous system and human blood pressure regulation Exp Physiol 93 2008 715 724
108. J.Y. Jun, J. Zubcevic, Y. Qi, A. Afzal, J.M. Carvajal, and J.S. Thinschmidt Brain-mediated dysregulation of the bone marrow activity in angiotensin II-induced hypertension Hypertension 60 2012 1316 1323
109. Y. Kakinuma, H. Hama, F. Sugiyama, K. Yagami, K. Goto, and K. Murakami Impaired blood-brain barrier function in angiotensinogen-deficient mice Nat Med 4 1998 1078 1080
110. N.S. Kalupahana, F. Massiera, A. Quignard-Boulange, G. Ailhaud, B.H. Voy, and D.H. Wasserman Overproduction of angiotensinogen from adipose tissue induces adipose inflammation, glucose intolerance, and insulin resistance Obesity (Silver Spring) 20 2012 48 56
111. U. Kandalam, and M.A. Clark Angiotensin II activates JAK2/STAT3 pathway and induces interleukin-6 production in cultured rat brainstem astrocytes Regul Pept 159 2010 110 116
112. S.S. Kang, M.P. Keasey, J. Cai, and T. Hagg Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice J Neurosci 32 2012 9277 9287
113. Y.M. Kang, Y. Ma, J.P. Zheng, C. Elks, S. Sriramula, and Z.M. Yang Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension Cardiovasc Res 82 2009 503 512
114. H. Kannan, Y. Tanaka, T. Kunitake, Y. Ueta, Y. Hayashida, and H. Yamashita Activation of sympathetic outflow by recombinant human interleukin-1 beta in conscious rats Am J Physiol 270 1996 R479 R485
115. S.E. Kanoski, Y. Zhang, W. Zheng, and T.L. Davidson The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat J Alzheimers Dis 21 2010 207 219
116. Y. Katayama, M. Battista, W.-M. Kao, A. Hidalgo, A.J. Peired, and S.A. Thomas Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow Cell 124 2006 407 421
117. M.J. Katovich, J.L. Grobe, M. Huentelman, and M.K. Raizada Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension Exp Physiol 90 2005 299 305
118. H. Kettenmann, U.K. Hanisch, M. Noda, and A. Verkhratsky Physiology of microglia Physiol Rev 91 2011 461 553
119. A.C. Kleiber, H. Zheng, N.M. Sharma, and K.P. Patel Chronic AT1 receptor blockade normalizes NMDA-mediated changes in renal sympathetic nerve activity and NR1 expression within the PVN in rats with heart failure Am J Physiol Heart Circ Physiol 298 2010 H1546 H1555
120. C.U. Kloss, G.W. Kreutzberg, and G. Raivich Proliferation of ramified microglia on an astrocyte monolayer: characterization of stimulatory and inhibitory cytokines J Neurosci Res 49 1997 248 254
121. E.G. Krause, A.D. de Kloet, K.A. Scott, J.N. Flak, K. Jones, and M.D. Smeltzer Blood-borne angiotensin II acts in the brain to influence behavioral and endocrine responses to psychogenic stress J Neurosci 31 2011 15009 15015
122. E.G. Krause, S.J. Melhorn, J.F. Davis, K.A. Scott, L.Y. Ma, and A.D. de Kloet Angiotensin type 1 receptors in the subfornical organ mediate the drinking and hypothalamic-pituitary-adrenal response to systemic isoproterenol Endocrinology 149 2008 6416 6424
123. G.W. Kreutzberg Microglia: a sensor for pathological events in the CNS Trends Neurosci 19 1996 312 318
124. H. Krum, M. Schlaich, R. Whitbourn, P.A. Sobotka, J. Sadowski, and K. Bartus Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study Lancet 373 2009 1275 1281
125. H. Krum, P. Sobotka, F. Mahfoud, M. Bohm, M. Esler, and M. Schlaich Device-based antihypertensive therapy: therapeutic modulation of the autonomic nervous system Circulation 123 2011 209 215
126. V. Lafrance, W. Inoue, B. Kan, and G.N. Luheshi Leptin modulates cell morphology and cytokine release in microglia Brain Behav Immun 24 2010 358 365
127. W. Langhans Signals generating anorexia during acute illness Proc Nutr Soc 66 2007 321 330
128. J.L. Lavoie, M.D. Cassell, K.W. Gross, and C.D. Sigmund Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model Physiol Genomics 16 2004 240 246
129. L.J. Lawson, V.H. Perry, and S. Gordon Turnover of resident microglia in the normal adult mouse brain Neuroscience 48 1992 405 415
130. Z. Lenkei, M. Palkovits, P. Corvol, and C. Llorens-Cortès Expression of angiotensin type-1 (AT1) and type-2 (AT2) receptor mRNAs in the adult rat brain: a functional neuroanatomical review Front Neuroendocrinol 18 1997 383
131. S.P. Levick, D.B. Murray, J.S. Janicki, and G.L. Brower Sympathetic nervous system modulation of inflammation and remodeling in the hypertensive heart Hypertension 55 2010 270 276
132. D.-P. Li, S.-R. Chen, and H.-L. Pan Angiotensin II stimulates spinally projecting paraventricular neurons through presynaptic disinhibition J Neurosci 23 2003 5041 5049
133. D.-P. Li, and H.-L. Pan Angiotensin II attenuates synaptic GABA release and excites paraventricular-rostral ventrolateral medulla output neurons J Pharmacol Exp Ther 313 2005 1035 1045
134. H. Li, Y. Gao, C.D. Freire, M.K. Raizada, G.M. Toney, and C. Sumners Macrophage migration inhibitory factor in the PVN attenuates the central pressor and dipsogenic actions of angiotensin II FASEB J 20 2006 1748 1750
135. H. Li, Y. Gao, Y. Qi, M.J. Katovich, N. Jiang, and L.N. Braseth Macrophage migration inhibitory factor in hypothalamic paraventricular nucleus neurons decreases blood pressure in spontaneously hypertensive rats FASEB J 22 2008 3175 3185
136. Z. Li, and A.V. Ferguson Subfornical organ efferents to paraventricular nucleus utilize angiotensin as a neurotransmitter Am J Physiol Regul Integr Comp Physiol 265 1993 R302 R309
137. R.W. Lind, L.W. Swanson, and D. Ganten Angiotensin II immunoreactivity in the neural afferents and efferents of the subfornical organ of the rat Brain Res 321 1984 209 215
138. W. Liu, Y. Tang, and J. Feng Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system Life Sci 89 2011 141 146
139. H.E. Lob, P.J. Marvar, T.J. Guzik, S. Sharma, L.A. McCann, and C. Weyand Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system Hypertension 55 2010 277 283 (276 pp. following 283)
140. C.J. Madden, and A.F. Sved Cardiovascular regulation after destruction of the C1 cell group of the rostral ventrolateral medulla in rats Am J Physiol Heart Circ Physiol 285 2003 H2734 H2748
141. M.S. Madhur, H.E. Lob, L.A. McCann, Y. Iwakura, Y. Blinder, and T.J. Guzik Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction Hypertension 55 2010 500 507
142. T.M. Malm, M. Koistinaho, M. Parepalo, T. Vatanen, A. Ooka, and S. Karlsson Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice Neurobiol Dis 18 2005 134 142
143. A.L. Mark, K. Agassandian, D.A. Morgan, X. Liu, M.D. Cassell, and K. Rahmouni Leptin signaling in the nucleus tractus solitarii increases sympathetic nerve activity to the kidney Hypertension 53 2009 375 380
144. A.L. Mark, R.A. Shaffer, M.L. Correia, D.A. Morgan, C.D. Sigmund, and W.G. Haynes Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice J Hypertens 17 1999 1949 1953
145. P.J. Marvar, and D.G. Harrison Stress-dependent hypertension and the role of T lymphocytes Exp Physiol 2012
146. P.J. Marvar, S.R. Thabet, T.J. Guzik, H.E. Lob, L.A. McCann, and C. Weyand Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension Circ Res 107 2010 263 270
147. P.J. Marvar, A. Vinh, S. Thabet, H.E. Lob, D. Geem, and K.J. Ressler T lymphocytes and vascular inflammation contribute to stress-dependent hypertension Biol Psychiatry 71 2012 774 782
148. F. Massiéra, M. Bloch-Faure, D. Ceiler, K. Murakami, A. Fukamizu, and J.-M. Gasc Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation FASEB J 15 2001 2727 2729
149. D. Mathis, and S.E. Shoelson Immunometabolism: an emerging frontier Nat Rev Immunol 11 2011 81
150. C.S. McKimmie, and G.J. Graham Astrocytes modulate the chemokine network in a pathogen-specific manner Biochem Biophys Res Commun 394 2010 1006 1011
151. M.J. McKinley, A.L. Albiston, A.M. Allen, M.L. Mathai, C.N. May, and R.M. McAllen The brain renin-angiotensin system: location and physiological roles Int J Biochem Cell Biol 35 2003 901 918
152. M. Milanski, A.P. Arruda, A. Coope, L.M. Ignacio-Souza, C.E. Nunez, and E.A. Roman Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver Diabetes 61 2012 1455 1462
153. M. Miyoshi, K. Miyano, N. Moriyama, M. Taniguchi, and T. Watanabe Angiotensin type 1 receptor antagonist inhibits lipopolysaccharide-induced stimulation of rat microglial cells by suppressing nuclear factor kappaB and activator protein-1 activation Eur J Neurosci 27 2008 343 351
154. S. Morimoto, M.D. Cassell, and C.D. Sigmund Glia- and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference J Biol Chem 277 2002 33235 33241
155. K. Nakajima, and S. Kohsaka Microglia: activation and their significance in the central nervous system J Biochem 130 2001 169 175
156. M.D. Nguyen, J.P. Julien, and S. Rivest Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat Rev Neurosci 3 2002 216 227
157. F.C. Nunes, and V.A. Braga Chronic angiotensin II infusion modulates angiotensin II type I receptor expression in the subfornical organ and the rostral ventrolateral medulla in hypertensive rats J Renin Angiotensin Aldosterone Syst 12 2011 440 445
158. E.A. Old, and M. Malcangio Chemokine mediated neuron-glia communication and aberrant signalling in neuropathic pain states Curr Opin Pharmacol 12 2012 67 73
159. S. Oparil, M.A. Zaman, and D.A. Calhoun Pathogenesis of hypertension Ann Intern Med 139 2003 761 776
160. J.W. Osborn, M.D. Hendel, J.P. Collister, P.A. Ariza-Guzman, and G.D. Fink The role of the subfornical organ in angiotensin II-salt hypertension in the rat Exp Physiol 97 2012 80 88
161. W. Panenka, H. Jijon, L.M. Herx, J.N. Armstrong, D. Feighan, and T. Wei P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase J Neurosci 21 2001 7135 7142
162. J.B. Park, J.Y. Jo, H. Zheng, K.P. Patel, and J.E. Stern Regulation of tonic GABA inhibitory function, presympathetic neuronal activity and sympathetic outflow from the paraventricular nucleus by astroglial GABA transporters J Physiol 587 2009 4645 4660
163. J.F. Paton, and S. Kasparov Differential effects of angiotensin II on cardiorespiratory reflexes mediated by nucleus tractus solitarii - a microinjection study in the rat J Physiol 521 Pt 1 1999 213 225
164. E. Pinteaux, W. Inoue, L. Schmidt, F. Molina-Holgado, N.J. Rothwell, and G.N. Luheshi Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism J Neurochem 102 2007 826 833
165. P.J. Pistell, C.D. Morrison, S. Gupta, A.G. Knight, J.N. Keller, and D.K. Ingram Cognitive impairment following high fat diet consumption is associated with brain inflammation J Neuroimmunol 219 2010 25 32
166. J.W. Polson, R.A. Dampney, P. Boscan, A.E. Pickering, and J.F. Paton Differential baroreflex control of sympathetic drive by angiotensin II in the nucleus tractus solitarii Am J Physiol Regul Integr Comp Physiol 293 2007 R1954 R1960
167. K.A. Posey, D.J. Clegg, R.L. Printz, J. Byun, G.J. Morton, and A. Vivekanandan-Giri Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet Am J Physiol Endocrinol Metab 296 2009 E1003 E1012
168. S. Purkayastha, G. Zhang, and D. Cai Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-beta and NF-kappaB Nat Med 17 2011 883 887
169. S. Pyner, and J.H. Coote Identification of branching paraventricular neurons of the hypothalamus that project to the rostroventrolateral medulla and spinal cord Neuroscience 100 2000 549 556
170. R.M. Ransohoff, and M.A. Brown Innate immunity in the central nervous system J Clin Invest 122 2012 1164 1171
171. T.M. Reyes, J.R. Walker, C. DeCino, J.B. Hogenesch, and P.E. Sawchenko Categorically distinct acute stressors elicit dissimilar transcriptional profiles in the paraventricular nucleus of the hypothalamus J Neurosci 23 2003 5607 5616
172. B. Rodriguez-Iturbe, Y. Quiroz, M. Nava, L. Bonet, M. Chavez, and J.
173. M.S. Rumantir, M. Vaz, G.L. Jennings, G. Collier, D.M. Kaye, and D.R. Seals Neural mechanisms in human obesity-related hypertension J Hypertens 17 1999 1125 1133
174. R.A. Santos, A.J. Ferreira, and E.S.A.C. Simoes Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis Exp Physiol 93 2008 519 527
175. M. Schilling, J.K. Strecker, E.B. Ringelstein, R. Kiefer, and W.R. Schabitz Turn-over of meningeal and perivascular macrophages in the brain of MCP-1-, CCR-2- or double knockout mice Exp Neurol 219 2009 583 585
176. M. Schilling, J.K. Strecker, W.R. Schabitz, E.B. Ringelstein, and R. Kiefer Effects of monocyte chemoattractant protein 1 on blood-borne cell recruitment after transient focal cerebral ischemia in mice Neuroscience 161 2009 806 812
177. M.P. Schlaich, D. Hering, P. Sobotka, H. Krum, G.W. Lambert, and E. Lambert Effects of renal denervation on sympathetic activation, blood pressure, and glucose metabolism in patients with resistant hypertension Front Physiol 3 2012 10
178. M.P. Schlaich, P.A. Sobotka, H. Krum, E. Lambert, and M.D. Esler Renal sympathetic-nerve ablation for uncontrolled hypertension N Engl J Med 361 2009 932 934
179. M.P. Schlaich, P.A. Sobotka, H. Krum, R. Whitbourn, A. Walton, and M.D. Esler Renal denervation as a therapeutic approach for hypertension: novel implications for an old concept Hypertension 54 2009 1195 1201
180. K. Schuette-Nuetgen, J.K. Strecker, J. Minnerup, E.B. Ringelstein, and M. Schilling MCP-1/CCR-2-double-deficiency severely impairs the migration of hematogenous inflammatory cells following transient cerebral ischemia in mice Exp Neurol 233 2012 849 858
181. H. Sell, C. Habich, and J. Eckel Adaptive immunity in obesity and insulin resistance Nat Rev Endocrinol 8 2012 709 716
182. A.D. Shafton, A. Ryan, and E. Badoer Neurons in the hypothalamic paraventricular nucleus send collaterals to the spinal cord and to the rostral ventrolateral medulla in the rat Brain Res 801 1998 239 243
183. M. Sherrod, D.R. Davis, X. Zhou, M.D. Cassell, and C.D. Sigmund Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice Am J Physiol Regul Integr Comp Physiol 289 2005 R1763 R1769
184. P. Shi, C. Diez-Freire, J.Y. Jun, Y. Qi, M.J. Katovich, and Q. Li Brain microglial cytokines in neurogenic hypertension Hypertension 56 2010 297 303
185. P. Shi, J.L. Grobe, F.A. Desland, M.K. Raizada, and C. Sumners Microglial activation by the brain renin-angiotensin system FASEB J 25 2011 661 662
186. S.E. Shoelson, and A.B. Goldfine Getting away from glucose: fanning the flames of obesity-induced inflammation Nat Med 15 2009 373 374
187. S.E. Shoelson, J. Lee, and A.B. Goldfine Inflammation and insulin resistance J Clin Invest 116 2006 1793 1801
188. A.R. Simard, D. Soulet, G. Gowing, J.P. Julien, and S. Rivest Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease Neuron 49 2006 489 502
189. S. Sriramula, J.P. Cardinale, E. Lazartigues, and J. Francis ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension Cardiovasc Res 92 2011 401 408
190. S. Sriramula, M. Haque, D.S. Majid, and J. Francis Involvement of tumor necrosis factor-alpha in angiotensin II-mediated effects on salt appetite, hypertension, and cardiac hypertrophy Hypertension 51 2008 1345 1351
191. A.K. Stalder, F. Ermini, L. Bondolfi, W. Krenger, G.J. Burbach, and T. Deller Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice J Neurosci 25 2005 11125 11132
192. U.M. Steckelings, L. Paulis, P. Namsolleck, and T. Unger AT2 receptor agonists: hypertension and beyond Curr Opin Nephrol Hypertens 21 2012 142 146
193. S.D. Stocker, J.R. Simmons, R.L. Stornetta, G.M. Toney, and P.G. Guyenet Water deprivation activates a glutamatergic projection from the hypothalamic paraventricular nucleus to the rostral ventrolateral medulla J Comp Neurol 494 2006 673 685
194. R.L. Stornetta, C.L. Hawelu-Johnson, P.G. Guyenet, and K.R. Lynch Astrocytes synthesize angiotensinogen in brain Science 242 1988 1444 1446
195. N.E. Straznicky, E.A. Lambert, G.W. Lambert, K. Masuo, M.D. Esler, and P.J. Nestel Effects of dietary weight loss on sympathetic activity and cardiac risk factors associated with the metabolic syndrome J Clin Endocrinol Metab 90 2005 5998 6005
196. C. Sun, H. Li, Y. Gao, T. Matsuura, P.A. Upchurch, and M.K. Raizada Lack of macrophage migration inhibitory factor regulation is linked to the increased chronotropic action of angiotensin II in SHR neurons Hypertension 49 2007 528 534
197. C. Sun, H. Li, L. Leng, M.K. Raizada, R. Bucala, and C. Sumners Macrophage migration inhibitory factor: an intracellular inhibitor of angiotensin II-induced increases in neuronal activity J Neurosci 24 2004 9944 9952
198. L.W. Swanson, and H.G. Kuypers The paraventricular nucleus of the hypothalamus: cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double-labeling methods J Comp Neurol 194 1980 555 570
199. C.H. Tang, D.Y. Lu, R.S. Yang, H.Y. Tsai, M.C. Kao, and W.M. Fu Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia J Immunol 179 2007 1292 1302
200. M.A. Thacker, A.K. Clark, T. Bishop, J. Grist, P.K. Yip, and L.D. Moon CCL2 is a key mediator of microglia activation in neuropathic pain states Eur J Pain 13 2009 263 272
201. J.P. Thaler, and M.W. Schwartz Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up Endocrinology 151 2010 4109 4115
202. J.P. Thaler, C.X. Yi, E.A. Schur, S.J. Guyenet, B.H. Hwang, and M.O. Dietrich Obesity is associated with hypothalamic injury in rodents and humans J Clin Invest 122 2012 153 162
203. N.J. Timpson, R. Harbord, G. Davey Smith, J. Zacho, A. Tybjaerg-Hansen, and B.G. Nordestgaard Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype Hypertension 54 2009 84 90
204. L.T. Tran, K.M. MacLeod, and J.H. McNeill Chronic etanercept treatment prevents the development of hypertension in fructose-fed rats Mol Cell Biochem 330 2009 219 228
205. Y.M. Ulrich-Lai, K.R. Jones, D.R. Ziegler, W.E. Cullinan, and J.P. Herman Forebrain origins of glutamatergic innervation to the rat paraventricular nucleus of the hypothalamus: differential inputs to the anterior versus posterior subregions J Comp Neurol 519 2011 1301 1319
206. P. Van Der Voorn, J. Tekstra, R.H.J. Beelen, C.P. Tensen, P. Van Der Valk, and C.J.A. De Groot Expression of MCP-1 by reactive astrocytes in demyelinating multiple sclerosis lesions Am J Pathol 154 1999 45 51
207. J. Van Steenwinckel, A. Reaux-Le Goazigo, B. Pommier, A. Mauborgne, M.-A. Dansereau, and P. Kitabgi CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury J Neurosci 31 2011 5865 5875
208. M. Vaz, G. Jennings, A. Turner, H. Cox, G. Lambert, and M. Esler Regional sympathetic nervous activity and oxygen consumption in obese normotensive human subjects Circulation 96 1997 3423 3429
209. M. Venegas-Pont, M.B. Manigrasso, S.C. Grifoni, B.B. LaMarca, C. Maric, and L.C. Racusen Tumor necrosis factor-alpha antagonist etanercept decreases blood pressure and protects the kidney in a mouse model of systemic lupus erythematosus Hypertension 56 2010 643 649
210. H. Wake, A.J. Moorhouse, S. Jinno, S. Kohsaka, and J. Nabekura Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals J Neurosci 29 2009 3974 3980
211. H. Waki, S.S. Gouraud, M. Maeda, and J.F. Paton Gene expression profiles of major cytokines in the nucleus tractus solitarii of the spontaneously hypertensive rat Auton Neurosci 142 2008 40 44
212. H. Waki, S.S. Gouraud, M. Maeda, and J.F. Paton Specific inflammatory condition in nucleus tractus solitarii of the SHR: novel insight for neurogenic hypertension? Auton Neurosci 142 2008 25 31
213. H. Waki, B. Liu, M. Miyake, K. Katahira, D. Murphy, and S. Kasparov Junctional adhesion molecule-1 is upregulated in spontaneously hypertensive rats: evidence for a prohypertensive role within the brain stem Hypertension 49 2007 1321 1327
214. Y.-Y. Wang, S.-Y. Lin, Y.-H. Chuang, C.-J. Chen, K.-C. Tung, and W.H.-H. Sheu Adipose proinflammatory cytokine expression through sympathetic system is associated with hyperglycemia and insulin resistance in a rat ischemic stroke model Am. J. Physiol. Endocrinol. Metab. 300 2011 E155 E163
215. S.P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R.L. Leibel, and A.W. Ferrante Obesity is associated with macrophage accumulation in adipose tissue J Clin Invest 112 2003 1796
216. R. Weiss, M. Shaw, M. Savoye, and S. Caprio Obesity dynamics and cardiovascular risk factor stability in obese adolescents Pediatr Diabetes 10 2009 360 367
217. P. Wenzel, M. Knorr, S. Kossmann, J. Stratmann, M. Hausding, and S. Schuhmacher Lysozyme M-positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction Circulation 124 2011 1370 1381
218. E.L. Werry, G.J. Liu, M.D. Lovelace, R. Nagarajah, and M.R. Bennett Glutamate potentiates lipopolysaccharide-stimulated interleukin-10 release from neonatal rat spinal cord astrocytes Neuroscience 207 2012 12 24
219. M.R. Wofford, D.C. Anderson Jr.; C.A. Brown, D.W. Jones, M.E. Miller, and J.E. Hall Antihypertensive effect of alpha- and beta-adrenergic blockade in obese and lean hypertensive subjects Am J Hypertens 14 2001 694 698
220. K.L. Wu, S.H. Chan, and J.Y. Chan Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation J Neuroinflammation 9 2012 212
221. H. Xu, G.T. Barnes, Q. Yang, G. Tan, D. Yang, and C.J. Chou Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J Clin Invest 112 2003 1821
222. M. Yamazato, A.J. Ferreira, Y. Yamazato, C. Diez-Freire, L. Yuan, and R. Gillies Gene transfer of angiotensin-converting enzyme 2 in the nucleus tractus solitarius improves baroreceptor heart rate reflex in spontaneously hypertensive rats J Renin Angiotensin Aldosterone Syst 12 2011 456 461
223. H. Yang, L. Wang, and G. Ju Evidence for hypothalamic paraventricular nucleus as an integrative center of neuroimmunomodulation Neuroimmunomodulation 4 1997 120 127
224. L. Yang, J. Tanaka, B. Zhang, M. Sakanaka, and N. Maeda Astrocytes modulate nitric oxide production by microglial cells through secretion of serine and glycine Biochem Biophys Res Commun 251 1998 277 282
225. F. Yao, C. Sumners, S.T. O'Rourke, and C. Sun Angiotensin II increases GABAB receptor expression in nucleus tractus solitarii of rats Am J Physiol Heart Circ Physiol 294 2008 H2712 H2720
226. C.-X. Yi, O. Al-Massadi, E. Donelan, M. Lehti, J. Weber, and C. Ress Exercise protects against high-fat diet-induced hypothalamic inflammation Physiol Behav 106 2012 485 490
227. C.X. Yi, M.H. Tschop, S.C. Woods, and S.M. Hofmann High-fat-diet exposure induces IgG accumulation in hypothalamic microglia Dis Model Mech 2012
228. F. Yiannikouris, M. Gupte, K. Putnam, S. Thatcher, R. Charnigo, and D.L. Rateri Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice Hypertension 60 2012 1524 1530
229. F. Yiannikouris, M. Karounos, R. Charnigo, V.L. English, D.L. Rateri, and A. Daugherty Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice Am J Physiol Regul Integr Comp Physiol 302 2012 R244 R251
230. C.N. Young, X. Cao, M.R. Guruju, J.P. Pierce, D.A. Morgan, and G. Wang ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension J Clin Invest 122 2012 3960 3964
231. Y. Yu, Z.H. Zhang, S.G. Wei, J. Serrats, R.M. Weiss, and R.B. Felder Brain perivascular macrophages and the sympathetic response to inflammation in rats after myocardial infarction Hypertension 55 2010 652 659
232. M. Zhang, Y. Mao, S.H. Ramirez, R.F. Tuma, and T. Chabrashvili Angiotensin II induced cerebral microvascular inflammation and increased blood-brain barrier permeability via oxidative stress Neuroscience 171 2010 852 858
233. X. Zhang, G. Zhang, H. Zhang, M. Karin, H. Bai, and D. Cai Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity Cell 135 2008 61 73
234. M.G. Ziegler, P. Mills, and J.E. Dimsdale Hypertensives' pressor response to norepinephrine. Analysis by infusion rate and plasma levels Am J Hypertens 4 1991 586 591
235. M.C. Zimmerman, R.P. Dunlay, E. Lazartigues, Y. Zhang, R.V. Sharma, and J.F. Engelhardt Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain Circ Res 95 2004 532 539
236. M.C. Zimmerman, E. Lazartigues, R.V. Sharma, and R.L. Davisson Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system Circ Res 95 2004 210 216
237. J. Zubcevic, H. Waki, M.K. Raizada, and J.F. Paton Autonomic-immune- vascular interaction: an emerging concept for neurogenic hypertension Hypertension 57 2011 1026 1033
238. I.H. Zucker, H.D. Schultz, K.P. Patel, W. Wang, and L. Gao Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failure Am J Physiol Heart Circ Physiol 297 2009 H1557 H1566