Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension

Circulation Research

Volumn 107, Issue 2, 2010, Pages 263-270

  Marvar, Paul J ^a   Thabet, Salim R ^a   Guzik, Tomasz J ^c   Lob, Heinrich E ^a   McCann, Louise A ^a   Weyand, Connie ^a   Gordon, Frank J ^a   Harrison, David G ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ATLANTA VA MEDICAL CENTER   (United States)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

central nervous system; hypertension; T cells; vascular inflammation

Indexed keywords

ANGIOTENSIN II; HYDRALAZINE; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BRAIN INJURY; BRAIN THIRD VENTRICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; HYPERTENSION; MOUSE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VASCULITIS;

ADMINISTRATION, ORAL; ADOPTIVE TRANSFER; ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; GENES, T-CELL RECEPTOR ALPHA; GENES, T-CELL RECEPTOR BETA; HOMEODOMAIN PROTEINS; HYDRALAZINE; HYPERTENSION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NOREPINEPHRINE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SUPEROXIDES; T-LYMPHOCYTES; THIRD VENTRICLE; TIME FACTORS; VASCULITIS;

EID: 77955171998     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.217299     Document Type: Article

References (31)

1. Chapleau MW, Abboud FM. Neuro-cardiovascular regulation: from molecules to man. Introduction. Ann N Y Acad Sci. 2001;940:xiii-xxii.
2. Guyenet PG. The sympathetic control of blood pressure. Nat Rev Neurosci. 2006;7:335-346.
3. Paton JF, Waki H, Abdala AP, Dickinson J, Kasparov S. Vascular-brain signaling in hypertension: role of angiotensin II and nitric oxide. Curr Hypertens Rep. 2007;9:242-247.
4. Zimmerman MC, Lazartigues E, Sharma RV, Davisson RL. Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Circ Res. 2004;95:210-216.
5. Brody MJ, Johnson AK. Role of the anteroventral third ventricle region in fluid and electrolyte balance, arterial pressure regulation, and hypertension. Front Neuroendocrinol. 1980;6:249-292.
6. Brody M, Fink G, Buggy J, Haywood J, Gordon F, Knuepfer M, Mow M, Mahoney L, Johnson A. Critical role of the av3v region in development and maintenance of experimental hypertension. Perspect Nephrol Hypertens. 1978;6:76-84.
7. Johnson RF, Beltz TG, Thunhorst RL, Johnson AK. Investigations on the physiological controls of water and saline intake in C57BL/6 mice. Am J Physiol Regul Integr Comp Physiol. 2003;285:R394-R403.
8. Rodriguez-Iturbe B, Quiroz Y, Nava M, Bonet L, Chavez M, Herrera-Acosta J, Johnson RJ, Pons HA. Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats. Am J Physiol Renal Physiol. 2002;282:F191-F201.
9. Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, Dikalov S, Goronzy J, Weyand C, Harrison DG. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med. 2007;204:2449-2460. (Pubitemid 47529329)
10. Cassis LA, Gupte M, Thayer S, Zhang X, Charnigo R, Howatt DA, Rateri DL, Daugherty A. Ang II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholes-terolemic mice. Am J Physiol Heart Circ Physiol. 2009;296: H1660-H1665.
11. Paxinos G, Franklin, K. The Mouse Brain in Stereotaxic Coordinates. San Diego, Calif: Academic Press; 2006.
12. Brody MJ, Fink GD, Buggy J, Haywood JR, Gordon FJ, Johnson AK. The role of the anteroventral third ventricle (av3v) region in experimental hypertension. Circ Res. 1978;43:1-13.
13. Buggy J, Fink GD, Haywood JR, Johnson AK, Brody MJ. Interruption of the maintenance phase of established hypertension by ablation of the anteroventral third ventricle (AV3V) in rats. Clin Exp Hypertens. 1978; 1:337-353.
14. Whyte DG, Johnson AK. Lesions of the anteroventral third ventricle region (AV3V) disrupt cardiovascular responses to an elevation in core temperature. Am J Physiol Regul Integr Comp Physiol. 2005;288: R1783-R1790.
15. Fink B, Laude K, McCann L, Doughan A, Harrison DG, Dikalov S. Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay. Am J Physiol Cell Physiol. 2004;287:C895-C902.
16. Gongora MC, Lob HE, Landmesser U, Guzik TJ, Martin WD, Ozumi K, Wall SM, Wilson DS, Murthy N, Gravanis M, Fukai T, Harrison DG. Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome. Am J Pathol. 2008; 173:915-926.
17. Guzik TJ, Marvar PJ, Czesnikiewicz-Guzik M, Korbut R. Perivascular adipose tissue as a messenger of the brain-vessel axis: role in vascular inflammation and dysfunction. J Physiol Pharmacol. 2007;58: 591-610.
18. Lob HE, Marvar PJ, Guzik TJ, Sharma S, McCann LA, Weyand C, Gordon FJ, Harrison DG. Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system. Hypertension. 2010;55:277-283.
19. Madhur MS, Lob HE, McCann LA, Iwakura Y, Blinder Y, Guzik TJ, Harrison DG. Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction. Hypertension. 2010;55:500-507.
20. Brody MJ. Central nervous system and mechanisms of hypertension. Clin Physiol Biochem. 1988;6:230-239.
21. Hendel MD, Collister JP. Contribution of the subfornical organ to angiotensin II-induced hypertension. Am J Physiol Heart Circ Physiol. 2005; 288:H680-H685.
22. Buggy J, Jonhson AK. Preoptic-hypothalamic periventricular lesions: thirst deficits and hypernatremia. Am J Physiol. 1977;233:R44-R52.
23. Saper CB, Levisohn D. Afferent connections of the median preoptic nucleus in the rat: anatomical evidence for a cardiovascular integrative mechanism in the anteroventral third ventricular (AV3V) region. Brain Res. 1983;288:21-31.
24. Buggy J, Johnson AK. Angiotensin-induced thirst: effects of third ventricle obstruction and periventricular ablation. Brain Res. 1978;149: 117-128.
25. Kohm AP, Sanders VM. Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo. Pharmacol Rev. 2001;53:487-525.
26. Ganta CK, Lu N, Helwig BG, Blecha F, Ganta RR, Zheng L, Ross CR, Musch TI, Fels RJ, Kenney MJ. Central angiotensin II-enhanced splenic cytokine gene expression is mediated by the sympathetic nervous system. Am J Physiol Heart Circ Physiol. 2005;289:H1683-H1691. (Pubitemid 41369013)
27. Konno S, Hirooka Y, Araki S, Koga Y, Kishi T, Sunagawa K. Azelni-dipine decreases sympathetic nerve activity via antioxidant effect in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats. J Cardiovasc Pharmacol. 2008;52:555-560.
28. Munzel T, Kurz S, Rajagopalan S, Thoenes M, Berrington WR, Thompson JA, Freeman BA, Harrison DG. Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug. J Clin Invest. 1996; 98:1465-1470.
29. Jackson SH, Devadas S, Kwon J, Pinto LA, Williams MS. T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat Immunol. 2004;5:818-827.
30. Bang L, Nielsen-Kudsk JE, Gruhn N, Trautner S, Theilgaard SA, Olesen SP, Boesgaard S, Aldershvile J. Hydralazine-induced vasodilation involves opening of high conductance Ca2 +-activated K+ channels. Eur J Pharmacol. 1998;361:43-49. 31.
31. Panyi G, Possani LD, Rodriguez de la Vega RC, Gaspar R, Varga Z. K + channel blockers: novel tools to inhibit t cell activation leading to specific immunosuppression. Curr Pharm Des. 2006;12:2199-2220.