Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice

Journal of Hypertension

Volumn 17, Issue 12 SUPPL., 1999, Pages 1949-1953

  Mark, Allyn L ^a,b   Shaffer, Richard A ^a,b   Correia, Marcelo L G ^a,b   Morgan, Donald A ^a,b   Sigmund, Curt D ^a,b   Haynes, William G ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Blood pressure; Hypertension; Leptin; Melanocortins; Obesity

Indexed keywords

LEPTIN; MELANOCORTIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; BODY WEIGHT; CONFERENCE PAPER; CONTROLLED STUDY; GENE MUTATION; MALE; MOUSE; NEUROENDOCRINOLOGY; NONHUMAN; OBESITY; PRIORITY JOURNAL;

EID: 0033512117     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199917121-00026     Document Type: Conference Paper

References (26)

1. Stamler RA, J. Stamler J, Riedlinger WF, Algera G, Roberts RH. Weight and blood pressure findings in hypertension screening of 1 million Americans. JAMA 1978; 240:1607-1610.
2. Manson JE, Willett WC, Stampfer MJ, Colditz GA, Hunter DJ, Hankinson SE, et al. Body weight and mortality among women. N Engl J Med 1995; 333:677-685.
3. Reaven GM. Role of insulin-resistance in human disease. Diabetes 1988; 37:1595-1607.
4. Anderson EA, Mark AL. The vasodilator action of insulin: implications for the insulin hypothesis of hypertension. Hypertension 1993; 21:136-141.
5. Hall JE. Mechanisms of abnormal renal sodium handling in obesity hypertension. Am J Hypertens 1997; 10(5:part 2):49S-55S.
6. Kassab S, Kato T, Wilkins FC, Chen R, Hall JE, Granger JP. Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension 1995; 25:893-895.
7. Mark AL, Correia M, Morgan DA, Shaffer DA, Haynes WG. Obesity-induced hypertension. New concepts from the emerging biology of obesity. Hypertension 1999; 33:537-541.
8. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372:425-432.
9. Haynes WG, Sivitz WI, Morgan DA, Walsh S, Mark AL. Sympathetic and cardiorenal actions of leptin. Hypertension 1997; 30:619-623.
10. Haynes WG, Morgan DA, Walsh S, Mark AL, Sivitz WI. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 1997; 100:270-278.
11. Osei SY, Ahima RS, Krupinski J, Flier JS, Hollenberg NK. Augmentation of renal vasoconstrictor responses to norepinephrine and angiotensin II by leptin [Abstract]. Am J Hypertens 1999; 12:32A.
12. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension 1998; 31:409-414.
13. Correia MLG, Morgan DA, Sivitz WS, Mark AL, Haynes WG. Intracerebroventricular leptin potentiates the presser response to acute environmental stress, and opposes fasting-induced hypotension [Abstract]. FASEB J 1999; 13:A773.
14. Ogawa Y, Masuzaki H, Aizawa M, Yura S, Satoh N, Iwai H, et al. Blood pressure elevation in transgenic mice overexpressing leptin, the obese gene product [Abstract]. J Hypertens 1998; 16:S7.
15. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997; 88:131-141.
16. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997; 385:165-168.
17. Li S-J, Varga K, Hruby VJ, Sharma SD, Kesterson RA, Cone RD, et al. Melanocortin antagonists define two distinct pathways of cardiovascular control by α- and γ-melanocyte-stimulating hormones. J Neurosci 1996; 16:5182-5188.
18. Boston BA, Blaydon KM, Vamerin J, Cone RD. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 1997; 278:1641-1644.
19. Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA, Friedman JM. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 1997; 94:8878-8883.
20. Young JB, Landsberg L. Diminished sympathetic nervous system activity in genetically obese (ob/ob) mouse. Am J Physiol 1983;245:E148-E154.
21. Haynes WG, Morgan DA, Ernsberger P, Koletsky RJ, DiBona GF, Mark AL. Evidence for an interaction between genetic obesity, hypertension and hemodynamic responses to salt and stress [Abstract]. J Hypertens 1996; 14(suppl 1):S7.
22. Montague CT, Farooq IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, et al. Congenital leptin deficiency is associated with severe early onset obesity in humans. Nature 1997; 387:903-907.
23. Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392:388-401.
24. Strobel A, lsaad T, Carmoin L, Ozata M, Strosberg AD. A leptin missense mutation associated with hypogonadism and morbid obesity. Nature Genet 1998; 18:213-215.
25. Yeo GSH, Farooq IS, Aminian S, Halsall DJ, Stanhope RE, O'Rahilly S. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nature Genet 1998; 20:111-112.
26. Vaisse C, Clement C, Guy-Grand B, Froquel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nature Genet 1998; 20:113-114.