Impaired insulin sensitivity and elevated ectopic fat in healthy obese vs. Nonobese prepubertal children

Obesity

Volumn 20, Issue 2, 2012, Pages 371-375

  Bennett, Brian ^a   Larson Meyer, D Enette ^b   Ravussin, Eric ^c   Volaufova, Julia ^a   Soros, Arlette ^d   Cefalu, William T ^c,d   Chalew, Stuart ^d   Gordon, Stewart ^d   Smith, Steven R ^c   Newcomer, Bradley R ^e   Goran, Michael ^f   Sothern, Melinda ^a,c,d  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF WYOMING   (United States)

^c PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^d LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ARTICLE; BODY FAT DISTRIBUTION; BODY MASS; CHILD; CHILD DEVELOPMENT; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DUAL ENERGY X RAY ABSORPTIOMETRY; ECTOPIC FAT; ECTOPIC TISSUE; ETHNIC DIFFERENCE; FEMALE; HOMEOSTASIS; HUMAN; IMPAIRED INSULIN SENSITIVITY; INSULIN METABOLISM; INTRAABDOMINAL FAT; INTRAVENOUS GLUCOSE TOLERANCE TEST; LIPID LIVER LEVEL; LIPID STORAGE; MALE; METABOLIC DISORDER; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESITY; PREPUBERTY; SCHOOL CHILD; SOLEUS MUSCLE; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL;

ABSORPTIOMETRY, PHOTON; BLOOD GLUCOSE; BODY COMPOSITION; CHILD; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FATTY LIVER; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; LIPIDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLIC SYNDROME X; OBESITY;

EID: 84856282020     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2011.264     Document Type: Article

References (30)

1. Ogden CL, Carroll MD, Curtin LR, Lamb MM, Flegal KM. Prevalence of high body mass index in US children and adolescents, 2007-2008. JAMA 2010;303:242-249.
2. Dietz WH. Overweight in childhood and adolescence. N Engl J Med 2004;350:855-857. (Pubitemid 38252530)
3. Broyles S, Katzmarzyk PT, Srinivasan SR et al. The pediatric obesity epidemic continues unabated in Bogalusa, Louisiana. Pediatrics 2010;125:900-905.
4. Weiss R, Dziura J, Burgert TS et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004;350:2362-2374. (Pubitemid 38702847)
5. Calcaterra V, Klersy C, Muratori T et al. Prevalence of metabolic syndrome (MS) in children and adolescents with varying degrees of obesity. Clin Endocrinol (Oxf) 2008;68:868-872. (Pubitemid 351703935)
6. Cali AM, Caprio S. Ectopic fat deposition and the metabolic syndrome in obese children and adolescents. Horm Res 2009;71 Suppl 1:2-7.
7. Chiarelli F, Marcovecchio ML. Insulin resistance and obesity in childhood. Eur J Endocrinol 2008;159 Suppl 1:S67-S74.
8. Kirchhoff K, Kantartzis K, Machann J et al. Impact of different fat depots on insulin sensitivity: predominant role of liver fat. J Diabetes Sci Technol 2007;1:753-759.
9. Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 2010;51:679-689.
10. D'Adamo E, Impicciatore M, Capanna R et al. Liver steatosis in obese prepubertal children: a possible role of insulin resistance. Obesity (Silver Spring) 2008;16:677-683. (Pubitemid 351328019)
11. D'Adamo E, Marcovecchio ML, Giannini C et al. The possible role of liver steatosis in defining metabolic syndrome in prepubertal children. Metab Clin Exp 2010;59:671-676.
12. Tompkins CL, Cefalu W, Ravussin E et al. Feasibility of intravenous glucose tolerance testing prior to puberty. Int J Pediatr Obes 2009;4:1-5.
13. Tanner J. Growth at Adolescence, 2nd edn. Oxford: Blackwell Scientific, 1962.
14. Boston RC, Stefanovski D, Moate PJ et al. MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test. Diabetes Technol Ther 2003;5:1003-1015. (Pubitemid 38009940)
15. Cutfield WS, Jefferies CA, Jackson WE, Robinson EM, Hofman PL. Evaluation of HOMA and QUICKI as measures of insulin sensitivity in prepubertal children. Pediatr Diabetes 2003;4:119-125. (Pubitemid 37161542)
16. Larson-Meyer DE, Newcomer BR, VanVrancken-Tompkins CL, Sothern M. Feasibility of assessing liver lipid by proton magnetic resonance spectroscopy in healthy normal and overweight prepubertal children. Diabetes Technol Ther 2010;12:207-212.
17. Larson-Meyer DE, Newcomer BR, Ravussin E et al. Intrahepatic and intramyocellular lipids are determinants of insulin resistance in prepubertal children. Diabetologia 2011;54:869-875.
18. Lee S, Janssen I, Ross R. Interindividual variation in abdominal subcutaneous and visceral adipose tissue: influence of measurement site. J Appl Physiol 2004;97:948-954. (Pubitemid 39121418)
19. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM et al. CDC growth charts: United States. Adv Data 2000:1-27.
20. Goodman E, Li C, Tu YK et al. Stability of the factor structure of the metabolic syndrome across pubertal development: confirmatory factor analyses of three alternative models. J Pediatr 2009;155:S5.e1-S5.e8.
21. Golley RK, Magarey AM, Steinbeck KS, Baur LA, Daniels LA. Comparison of metabolic syndrome prevalence using six different definitions in overweight pre-pubertal children enrolled in a weight management study. Int J Obes (Lond) 2006;30:853-860.
22. Lambert M, Paradis G, O'Loughlin J et al. Insulin resistance syndrome in a representative sample of children and adolescents from Quebec, Canada. Int J Obes Relat Metab Disord 2004;28:833-841. (Pubitemid 39005683)
23. Balkau B, Charles MA. Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR). Diabet Med 1999;16:442-443.
24. Williamson DA, Champagne CM, Han H et al. Increased obesity in children living in rural communities of Louisiana. Int J Pediatr Obes 2009;4: 160-165.
25. Park YW, Zhu S, Palaniappan L et al. The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med 2003;163:427-436. (Pubitemid 36241019)
26. Masuccio FG, Lattanzio FM, Matera S et al. Insulin sensitivity in prepubertal Caucasian normal weight children. J Pediatr Endocrinol Metab 2009;22:695-702.
27. Lara-Castro C, Garvey WT. Intracellular lipid accumulation in liver and muscle and the insulin resistance syndrome. Endocrinol Metab Clin North Am 2008;37:841-856.
28. Kuk JL, Kilpatrick K, Davidson LE, Hudson R, Ross R. Whole-body skeletal muscle mass is not related to glucose tolerance or insulin sensitivity in overweight and obese men and women. Appl Physiol Nutr Metab 2008;33:769-774.
29. Gower BA, Nagy TR, Goran MI. Visceral fat, insulin sensitivity, and lipids in prepubertal children. Diabetes 1999;48:1515-1521. (Pubitemid 29356857)
30. Maffeis C, Manfredi R, Trombetta M et al. Insulin sensitivity is correlated with subcutaneous but not visceral body fat in overweight and obese prepubertal children. J Clin Endocrinol Metab 2008;93:2122-2128. (Pubitemid 351831525)