Angiotensin II stimulates spinally projecting paraventricular neurons through presynaptic disinhibition

Journal of Neuroscience

Volumn 23, Issue 12, 2003, Pages 5041-5049

  Li, De Pei ^a   Chen, Shao Rui ^a   Pan, Hui Lin ^a,b  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Angiotensin receptors; GABA; Hypothalamus; Renin angiotensin system; Sympathetic nervous system; Synaptic transmission

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; 4 AMINOBUTYRIC ACID; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; BICUCULLINE; GLUTAMIC ACID; LIDOCAINE ETHOBROMIDE; LOSARTAN; SYNAPTOPHYSIN;

AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CELL LABELING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; NONHUMAN; PATCH CLAMP; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RECEPTOR UPREGULATION; RETROGRADE NERVE FIBER TRANSPORT; STATISTICAL SIGNIFICANCE; SYMPATHETIC FUNCTION; THALAMUS MIDLINE NUCLEUS;

EID: 0038452698     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-12-05041.2003     Document Type: Article

References (44)

1. Aguilera G, Kiss A, Luo X (1995) Increased expression of type 1 angiotensin II receptors in the hypothalamic paraventricular nucleus following stress and glucocorticoid administration. J Neuroendocrinol 7:775-783.
2. Allen AM (2002) Inhibition of the hypothalamic paraventricular nucleus in spontaneously hypertensive rats dramatically reduces sympathetic vasomotor tone. Hypertension 39:275-280.
3. Bains JS, Ferguson AV (1995) Paraventricular nucleus neurons projecting to the spinal cord receive excitatory input from the subfornical organ. Am J Physiol 268:R625-R633.
4. Boudaba C, Szabo K, Tasker JG (1996) Physiological mapping of local in hibitory inputs to the hypothalamic paraventricular nucleus. J Neurosci 16:7151-7160.
5. Chen QH, Toney GM (2001) AT(1)-receptor blockade in the hypothalamic PVN reduces central hyperosmolality-induced renal sympathoexcitation. Am J Physiol Regul Integr Comp Physiol 281:R1844-R1853.
6. Cui LN, Coderre E, Renaud LP (2001) Glutamate and GABA mediate suprachiasmatic nucleus inputs to spinal-projecting paraventricular neurons. Am J Physiol Regul Integr Comp Physiol 281:R1283-R1289.
7. Decavel C, Van den Pol AN (1990) GABA: a dominant neurotransmitter in the hypothalamus. J Comp Neurol 302:1019-1037.
8. de Wardener HE (2001) The hypothalamus and hypertension. Physiol Rev 81:1599-1658.
9. Dumont EC, Rafrafi S, Laforest S, Drolet G (1999) Involvement of central angiotensin receptors in stress adaptation. Neuroscience 93:877-884.
10. Ferguson AV, Washburn DL (1998) Angiotensin II: a peptidergic neurotransmitter in central autonomic pathways. Prog Neurobiol 54:169-192.
11. Gehlert DR, Gackenheimer SL, Schober DA (1991) Autoradiographic localization of subtypes of angiotensin II antagonist binding in the rat brain. Neuroscience 44:501-514.
12. Harding JW, Jensen LL, Hanesworth JM, Roberts KA, Page TA, Wright JW (1992) Release of angiotensins in paraventricular nucleus of rat in response to physiological and chemical stimuli. Am J Physiol 262:F17-F23.
13. Hardy SG (2001) Hypothalamic projections to cardiovascular centers of the medulla. Brain Res 894:233-240.
14. Hermes ML, Coderre EM, Buijs RM, Renaud LP (1996) GABA and glutamate mediate rapid neurotransmission from suprachiasmatic nucleus to hypothalamic paraventricular nucleus in rat. J Physiol (Lond) 496:749-757.
15. Hiscock JJ, Murphy S, Willoughby JO (2000) Confocal microscopic estimation of GABAergic nerve terminals in the central nervous system. J Neurosci Methods 95:1-11.
16. Hogarty DC, Speakman EA, Puig V, Phillips MI (1992) The role of angiotensin, AT1 and AT2 receptors in the pressor, drinking and vasopressin responses to central angiotensin. Brain Res 586:289-294.
17. Li DP, Pan HL (2001) Potentiation of glutamatergic synaptic input to supraoptic neurons by presynaptic nicotinic receptors. Am J Physiol Regul Integr Comp Physiol 281:R110S-R1113.
18. Li DP, Chen SR, Pan HL (2002a) Nitric oxide inhibits spinally projecting paraventricular neurons through potentiation of presynaptic GABA release. J Neurophysiol 88:2664-2674.
19. Li DP, Chen SR, Pan YZ, Levey AI, Pan HL (2002b) Role of presynaptic muscarinic and GABAB receptors in synaptic glutamate release onto lamina II neurons in rats. J Physiol (Lond) 543:807-818.
20. Li P, Morris M, Diz DI, Ferrario CM, Ganten D, Callahan MF (1996) Role of paraventricular angiotensin AT1 receptors in salt-sensitive hypertension in mRen-2 transgenic rats. Am J Physiol 270:R1178-R1181.
21. Li Z, Ferguson AV (1993) Angiotensin II responsiveness of rat paraventricular and subfornical organ neurons in vitro. Neuroscience 55:197-207.
22. Li Z, Ferguson AV (1996) Electrophysiological properties of paraventricular magnocellular neurons in rat brain slices: modulation of IA by angiotensin II. Neuroscience 71:133-145.
23. Lind RW, Swanson LW, Bruhn TO, Ganten D (1985) The distribution of angiotensin II-immunoreactive cells and fibers in the paraventriculohypophysial system of the rat. Brain Res 338:81-89.
24. Lon S, Szczepanska-Sadowska E, Szczypaczewska M (1996) Evidence that centrally released arginine vasopressin is involved in central pressor action of angiotensin II. Am J Physiol 270:H167-H173.
25. Luchner A, Stevens TL, Borgeson DD, Redfield MM, Bailey JE, Sandberg SM, Heublein DM, Burnett Jr JC (1996) Angiotensin II in the evolution of experimental heart failure. Hypertension 28:472-477.
26. Martin DS, Haywood JR (1993) Hemodynamic responses to paraventricular nucleus disinhibition with bicuculline in conscious rats. Am J Physiol 265:H1727-H1733.
27. Miyakubo H, Hayashi Y, Tanaka J (2002) Enhanced response of subfornical organ neurons projecting to the hypothalamic paraventricular nucleus to angiotensin II in spontaneously hypertensive rats. Auton Neurosci 95:131-136.
28. Morato M, Sousa T, Guimaraes S, Moura D, Albino-Teixeira A (2002) The role of angiotensin II in hypertension due to adenosine receptors blockade. Eur J Pharmacol 455:135-141.
29. Obermuller N, Unger T, Culman J, Gohlke P, de Gasparo M, Bottari SP (1991) Distribution of angiotensin II receptor subtypes in rat brain nuclei. Neurosci Lett 132:11-15.
30. Ohya Y, Sperelakis N (1991) Involvement of a GTP-binding protein in stimulating action of angiotensin II on calcium channels in vascular smooth muscle cells. Circ Res 68:763-771.
31. Oz M, Renaud LP (2002) Angiotensin AT(1)-receptors depolarize neonatal spinal motoneurons and other ventral horn neurons via two different conductances. J Neurophysiol 88:2857-2863.
32. Pan YZ, Li DP, Chen SR, Pan HL (2002) Activation of delta-opioid receptors excites spinally projecting locus coeruleus neurons through inhibition of GABAergic inputs. J Neurophysiol 88:2675-2683.
33. Pyner S, Coote JH (2000) Identification of branching paraventricular neurons of the hypothalamus that project to the rostroventrolateral medulla and spinal cord. Neuroscience 100:549-556.
34. Qadri F, Edling O, Wolf A, Gohlke P, Culman J, Unger T (1994) Release of angiotensin in the paraventricular nucleus in response to hyperosmotic stimulation in conscious rats: a microdialysis study. Brain Res 637:45-49.
35. Qu L, McQueeney AJ, Barnes KL (1996) Presynaptic or postsynaptic location of receptors for angiotensin II and substance P in the medial solitary tract nucleus. J Neurophysiol 75:2220-2228.
36. Ranson RN, Motawei K, Pyner S, Coote JH (1998) The paraventricular nucleus of the hypothalamus sends efferents to the spinal cord of the rat that closely appose sympathetic preganglionic neurones projecting to the stellate ganglion. Exp Brain Res 120:164-172.
37. Rowe BP, Grove KL, Saylor DL, Speth RC (1991) Discrimination of angiotensin II receptor subtype distribution in the rat brain using non-peptidic receptor antagonists. Regul Pept 33:45-53.
38. Schlenker E, Barnes L, Hansen S, Martin D (2001) Cardiorespiratory and metabolic responses to injection of bicuculline into the hypothalamic paraventricular nucleus (PVN) of conscious rats. Brain Res 895:33-40.
39. Shafton AD, Ryan A, Badoer E (1998) Neurons in the hypothalamic paraventricular nucleus send collaterals to the spinal cord and to the rostral ventrolateral medulla in the rat. Brain Res 801:239-243.
40. Song K, Allen AM, Paxinos G, Mendelsohn FA (1992) Mapping of angiotensin II receptor subtype heterogeneity in rat brain. J Comp Neurol 316:467-484.
41. Swanson LW, Sawchenko PE (1983) Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Annu Rev Neurosci 6:269-324.
42. Tasker JG, Dudek FE (1993) Local inhibitory synaptic inputs to neurones of the paraventricular nucleus in slices of rat hypothalamus. J Physiol (Lond) 469:179-192.
43. Zhang ZH, Francis J, Weiss RM, Felder RB (2002) The renin-angiotensin-aldosterone system excites hypothalamic paraventricular nucleus neurons in heart failure. Am J Physiol Heart Circ Physiol 283:H423-H433.
44. Zhu GQ, Patel KP, Zucker IH, Wang W (2002) Microinjection of ANG II into paraventricular nucleus enhances cardiac sympathetic afferent reflex in rats. Am J Physiol Heart Circ Physiol 282:H2039-H2045.