메뉴 건너뛰기




Volumn 17, Issue 7, 2011, Pages 883-887

Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-Π2 and NF-ΰB

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 79960117277     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2372     Document Type: Article
Times cited : (199)

References (39)
  • 1
    • 12344277552 scopus 로고    scopus 로고
    • Diabetes obesity, and the brain
    • Schwartz, M.W. & Porte, D. Jr. Diabetes, obesity, and the brain. Science 307, 375-379 (2005).
    • (2005) Science , vol.307 , pp. 375-379
    • Schwartz, M.W.1    Porte Jr., D.2
  • 2
    • 17844401180 scopus 로고    scopus 로고
    • Molecular and anatomical determinants of central leptin resistance
    • DOI 10.1038/nn1454
    • Münzberg, H. & Myers, M.G. Jr. Molecular and anatomical determinants of central leptin resistance. Nat. Neurosci. 8, 566-570 (2005). (Pubitemid 40594195)
    • (2005) Nature Neuroscience , vol.8 , Issue.5 , pp. 566-570
    • Munzberg, H.1    Myers Jr., M.G.2
  • 3
    • 33750153292 scopus 로고    scopus 로고
    • Attenuation of leptin and insulin signaling by SOCS proteins
    • DOI 10.1016/j.tem.2006.09.007, PII S1043276006001779
    • Howard, J.K. & Flier, J.S. Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol. Metab. 17, 365-371 (2006). (Pubitemid 44596259)
    • (2006) Trends in Endocrinology and Metabolism , vol.17 , Issue.9 , pp. 365-371
    • Howard, J.K.1    Flier, J.S.2
  • 4
    • 34250217818 scopus 로고    scopus 로고
    • Circulating angiotensin II and dietary salt: Converging signals for neurogenic hypertension
    • DOI 10.1007/s11906-007-0041-3
    • Osborn, J.W., Fink, G.D., Sved, A.F., Toney, G.M. & Raizada, M.K. Circulating angiotensin II and dietary salt: converging signals for neurogenic hypertension. Curr. Hypertens. Rep. 9, 228-235 (2007). (Pubitemid 46900043)
    • (2007) Current Hypertension Reports , vol.9 , Issue.3 , pp. 228-235
    • Osborn, J.W.1    Fink, G.D.2    Sved, A.F.3    Toney, G.M.4    Raizada, M.K.5
  • 5
    • 0038606899 scopus 로고    scopus 로고
    • Brain renin-angiotensin system dysfunction in hypertension: Recent advances and perspectives
    • DOI 10.1038/sj.bjp.0705262
    • Veerasingham, S.J. & Raizada, M.K. Brain renin-angiotensin system dysfunction in hypertension: recent advances and perspectives. Br. J. Pharmacol. 139, 191-202 (2003). (Pubitemid 36760351)
    • (2003) British Journal of Pharmacology , vol.139 , Issue.2 , pp. 191-202
    • Veerasingham, S.J.1    Raizada, M.K.2
  • 6
    • 0842328645 scopus 로고    scopus 로고
    • Functional genomics as an emerging strategy for the investigation of central mechanisms in experimental hypertension
    • DOI 10.1016/j.pbiomolbio.2003.11.007
    • Veerasingham, S.J., Sellers, K.W. & Raizada, M.K. Functional genomics as an emerging strategy for the investigation of central mechanisms in experimental hypertension. Prog. Biophys. Mol. Biol. 84, 107-123 (2004). (Pubitemid 38215208)
    • (2004) Progress in Biophysics and Molecular Biology , vol.84 , Issue.2-3 , pp. 107-123
    • Veerasingham, S.J.1    Sellers, K.W.2    Raizada, M.K.3
  • 8
    • 33745712914 scopus 로고    scopus 로고
    • The sympathetic control of blood pressure
    • Guyenet, P.G. The sympathetic control of blood pressure. Nat. Rev. Neurosci. 7, 335-346 (2006).
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 335-346
    • Guyenet, P.G.1
  • 9
    • 6344226830 scopus 로고    scopus 로고
    • Pathophysiology and treatment of obesity hypertension
    • DOI 10.2174/1381612043382855
    • Wofford, M.R. & Hall, J.E. Pathophysiology and treatment of obesity hypertension. Curr. Pharm. Des. 10, 3621-3637 (2004). (Pubitemid 39386578)
    • (2004) Current Pharmaceutical Design , vol.10 , Issue.29 , pp. 3621-3637
    • Wofford, M.R.1    Hall, J.E.2
  • 11
    • 26044452059 scopus 로고    scopus 로고
    • Role of leptin in obesity-related hypertension
    • DOI 10.1113/expphysiol.2005.031237
    • Haynes, W.G. Role of leptin in obesity-related hypertension. Exp. Physiol. 90, 683-688 (2005). (Pubitemid 41406056)
    • (2005) Experimental Physiology , vol.90 , Issue.5 , pp. 683-688
    • Haynes, W.G.1
  • 12
    • 11244349747 scopus 로고    scopus 로고
    • Obesity-associated hypertension: New insights into mechanisms
    • DOI 10.1161/01.HYP.0000151325.83008.b4
    • Rahmouni, K., Correia, M.L., Haynes, W.G. & Mark, A.L. Obesity-associated hypertension: new insights into mechanisms. Hypertension 45, 9-14 (2005). (Pubitemid 40066405)
    • (2005) Hypertension , vol.45 , Issue.1 , pp. 9-14
    • Rahmouni, K.1    Correia, M.L.G.2    Haynes, W.G.3    Mark, A.L.4
  • 13
    • 77952893301 scopus 로고    scopus 로고
    • Obesity-induced hypertension: Role of sympathetic nervous system, leptin, and melanocortins
    • Hall, J.E. et al. Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins. J. Biol. Chem. 285, 17271-17276 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 17271-17276
    • Hall, J.E.1
  • 14
    • 64149101055 scopus 로고    scopus 로고
    • Getting away from glucose: Fanning the flames of obesity-induced inflammation
    • Shoelson, S.E. & Goldfine, A.B. Getting away from glucose: fanning the flames of obesity-induced inflammation. Nat. Med. 15, 373-374 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 373-374
    • Shoelson, S.E.1    Goldfine, A.B.2
  • 15
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • DOI 10.1038/nature05485, PII NATURE05485
    • Hotamisligil, G.S. Inflammation and metabolic disorders. Nature 444, 860-867 (2006). (Pubitemid 46024993)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 860-867
    • Hotamisligil, G.S.1
  • 16
    • 1642633752 scopus 로고    scopus 로고
    • Inflamed about obesity
    • DOI 10.1038/nm0204-126
    • Lehrke, M. & Lazar, M.A. Inflamed about obesity. Nat. Med. 10, 126-127 (2004). (Pubitemid 38524875)
    • (2004) Nature Medicine , vol.10 , Issue.2 , pp. 126-127
    • Lehrke, M.1    Lazar, M.A.2
  • 17
    • 33645074450 scopus 로고    scopus 로고
    • Etiology of insulin resistance
    • Petersen, K.F. & Shulman, G.I. Etiology of insulin resistance. Am. J. Med. 119, S10-S16 (2006).
    • (2006) Am. J. Med. , vol.119
    • Petersen, K.F.1    Shulman, G.I.2
  • 18
    • 19044393872 scopus 로고    scopus 로고
    • Adipose tissue, inflammation, and cardiovascular disease
    • DOI 10.1161/01.RES.0000163635.62927.34
    • Berg, A.H. & Scherer, P.E. Adipose tissue, inflammation and cardiovascular disease. Circ. Res. 96, 939-949 (2005). (Pubitemid 40712793)
    • (2005) Circulation Research , vol.96 , Issue.9 , pp. 939-949
    • Berg, A.H.1    Scherer, P.E.2
  • 19
    • 33746377553 scopus 로고    scopus 로고
    • Obesity-related derangements in metabolic regulation
    • DOI 10.1146/annurev.biochem.75.103004.142512
    • Muoio, D.M. & Newgard, C.B. Obesity-related derangements in metabolic regulation. Annu. Rev. Biochem. 75, 367-401 (2006). (Pubitemid 44118037)
    • (2006) Annual Review of Biochemistry , vol.75 , pp. 367-401
    • Muoio, D.M.1    Newgard, C.B.2
  • 20
    • 51349156218 scopus 로고    scopus 로고
    • Insulin sensitivity: Modulation by nutrients and inflammation
    • Schenk, S., Saberi, M. & Olefsky, J.M. Insulin sensitivity: modulation by nutrients and inflammation. J. Clin. Invest. 118, 2992-3002 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 2992-3002
    • Schenk, S.1    Saberi, M.2    Olefsky, J.M.3
  • 25
    • 69249211226 scopus 로고    scopus 로고
    • NFkappaB-mediated metabolic inflammation in peripheral tissues versus central nervous system
    • Cai, D. NFkappaB-mediated metabolic inflammation in peripheral tissues versus central nervous system. Cell Cycle 8, 2542-2548 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 2542-2548
    • Cai, D.1
  • 26
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKK/NF-B and ER stress link overnutrition to energy imbalance and obesity
    • Zhang, X. et al. Hypothalamic IKK/NF-B and ER stress link overnutrition to energy imbalance and obesity. Cell 135, 61-73 (2008).
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1
  • 27
    • 70349484212 scopus 로고    scopus 로고
    • MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
    • Kleinridders, A. et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab. 10, 249-259 (2009).
    • (2009) Cell Metab. , vol.10 , pp. 249-259
    • Kleinridders, A.1
  • 28
    • 66149118129 scopus 로고    scopus 로고
    • Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet
    • Posey, K.A. et al. Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am. J. Physiol. Endocrinol. Metab. 296, E1003-E1012 (2009).
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296
    • Posey, K.A.1
  • 29
    • 59849125655 scopus 로고    scopus 로고
    • Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction
    • Goncalves, A.C. et al. Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction. Hypertension 53, 387-392 (2009).
    • (2009) Hypertension , vol.53 , pp. 387-392
    • Goncalves, A.C.1
  • 30
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-B signaling
    • Hayden, M.S. & Ghosh, S. Shared principles in NF-B signaling. Cell 132, 344-362 (2008).
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 31
    • 33645312379 scopus 로고    scopus 로고
    • Circuitry of nuclear factor B signaling
    • Hoffmann, A. & Baltimore, D. Circuitry of nuclear factor B signaling. Immunol. Rev. 210, 171-186 (2006).
    • (2006) Immunol. Rev. , vol.210 , pp. 171-186
    • Hoffmann, A.1    Baltimore, D.2
  • 32
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-B transcription factors in the immune system
    • Vallabhapurapu, S. & Karin, M. Regulation and function of NF-B transcription factors in the immune system. Annu. Rev. Immunol. 27, 693-733 (2009).
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 33
    • 0036781052 scopus 로고    scopus 로고
    • NF-B regulation in the immune system
    • Li, Q. & Verma, I.M. NF-B regulation in the immune system. Nat. Rev. Immunol. 2, 725-734 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 34
    • 77953136143 scopus 로고    scopus 로고
    • TNF receptor 2 pathway: Drug target for autoimmune diseases
    • Faustman, D. & Davis, M. TNF receptor 2 pathway: drug target for autoimmune diseases. Nat. Rev. Drug Discov. 9, 482-493 (2010).
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 482-493
    • Faustman, D.1    Davis, M.2
  • 36
    • 0842311502 scopus 로고    scopus 로고
    • Role of adrenergic activity in pressor responses to chronic melanocortin receptor activation
    • DOI 10.1161/01.HYP.0000111836.54204.93
    • Kuo, J.J., da Silva, A.A., Tallam, L.S. & Hall, J.E. Role of adrenergic activity in pressor responses to chronic melanocortin receptor activation. Hypertension 43, 370-375 (2004). (Pubitemid 38174141)
    • (2004) Hypertension , vol.43 , Issue.2 , pp. 370-375
    • Kuo, J.J.1    Da Silva, A.A.2    Tallam, L.S.3    Hall, J.E.4
  • 37
    • 58249087146 scopus 로고    scopus 로고
    • Modulation of blood pressure by central melanocortinergic pathways
    • Greenfield, J.R. et al. Modulation of blood pressure by central melanocortinergic pathways. N. Engl. J. Med. 360, 44-52 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 44-52
    • Greenfield, J.R.1
  • 38
    • 23244451186 scopus 로고    scopus 로고
    • Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia
    • DOI 10.1161/01.HYP.0000175474.99326.bf
    • Tallam, L.S., Stec, D.E., Willis, M.A., da Silva, A.A. & Hall, J.E. Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia. Hypertension 46, 326-332 (2005). (Pubitemid 41099165)
    • (2005) Hypertension , vol.46 , Issue.2 , pp. 326-332
    • Tallam, L.S.1    Stec, D.E.2    Willis, M.A.3    Da Silva, A.A.4    Hall, J.E.5
  • 39
    • 6344284383 scopus 로고    scopus 로고
    • Acute and chronic stress influence blood pressure variability in mice
    • DOI 10.1016/j.physbeh.2004.08.004, PII S0031938404003300
    • Farah, V.M., Joaquim, L.F., Bernatova, I. & Morris, M. Acute and chronic stress influence blood pressure variability in mice. Physiol. Behav. 83, 135-142 (2004). (Pubitemid 39387702)
    • (2004) Physiology and Behavior , vol.83 , Issue.1 SPEC. ISS. , pp. 135-142
    • Farah, V.M.A.1    Joaquim, L.F.2    Bernatova, I.3    Morris, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.