Leptin modulates cell morphology and cytokine release in microglia

Brain, Behavior, and Immunity

Volumn 24, Issue 3, 2010, Pages 358-365

  Lafrance, Véronique ^a   Inoue, Wataru ^a   Kan, Bernard ^a   Luheshi, Giamal N ^a  

^a DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

Author keywords

Chemokines; Cytokines; Inflammation; Leptin; Lipopolysaccharide; Microglia

Indexed keywords

CXCL3 CHEMOKINE; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 1BETA; LEPTIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL STRUCTURE; CONTROLLED STUDY; CYTOKINE RELEASE; HORMONE ACTION; IMMUNOREGULATION; INCUBATION TIME; INFLAMMATION; MICROGLIA; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; RAT;

ANIMALS; BRAIN; BRAIN CHEMISTRY; CELLS, CULTURED; CHEMOKINES; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERLEUKIN-1BETA; LEPTIN; LIPOPOLYSACCHARIDES; MICROGLIA; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77951622892     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2009.11.003     Document Type: Article

References (58)

1. Banati R.B., Graeber M.B. Surveillance, intervention and cytotoxicity: is there a protective role of microglia?. Dev. Neurosci. 1994, 16:114-127.
2. Banks W.A., Kastin A.J., Huang W., Jaspan J.B., Maness L.M. Leptin enters the brain by a saturable system independent of insulin. Peptides 1996, 17:305-311.
3. Barron K.D. The microglial cell. A historical review. J. Neurol. Sci. 1995, 134(Suppl.):57-68.
4. Caldefie-Chezet F., Poulin A., Vasson M.P. Leptin regulates functional capacities of polymorphonuclear neutrophils. Free Radic. Res. 2003, 37:809-814.
5. Cartmell T., Poole S., Turnbull A.V., Rothwell N.J., Luheshi G.N. Circulating interleukin-6 mediates the febrile response to localised inflammation in rats. J. Physiol. 2000, 526(Pt. 3):653-661.
6. Chandra R.K. Cell-mediated immunity in genetically obese C57BL/6J ob/ob) mice. Am. J. Clin. Nutr. 1980, 33:13-16.
7. Chiang C.S., Chen F.H., Hong J.H., Jiang P.S., Huang H.L., Wang C.C., McBride W.H. Functional phenotype of macrophages depends on assay procedures. Int. Immunol. 2008, 20:215-222.
8. Dantzer R. Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity. Eur. J. Pharmacol. 2004, 500:399-411.
9. Dickson D.W., Lee S.C., Mattiace L.A., Yen S.H., Brosnan C. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 1993, 7:75-83.
10. Erwig L.P., Kluth D.C., Walsh G.M., Rees A.J. Initial cytokine exposure determines function of macrophages and renders them unresponsive to other cytokines. J. Immunol. 1998, 161:1983-1988.
11. Faggioni R., Moser A., Feingold K.R., Grunfeld C. Reduced leptin levels in starvation increase susceptibility to endotoxic shock. Am. J. Pathol. 2000, 156:1781-1787.
12. Fantuzzi G., Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J. Leukoc. Biol. 2000, 68:437-446.
13. Frederich R.C., Hamann A., Anderson S., Lollmann B., Lowell B.B., Flier J.S. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 1995, 1:1311-1314.
14. Friedman J.M., Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 1998, 395:763-770.
15. Giulian D., Baker T.J. Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 1986, 6:2163-2178.
16. Halaas J.L., Boozer C., Blair-West J., Fidahusein N., Denton D.A., Friedman J.M. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl. Acad. Sci. USA 1997, 94:8878-8883.
17. Harden L.M., du Plessis I., Poole S., Laburn H.P. Interleukin-6 and leptin mediate lipopolysaccharide-induced fever and sickness behavior. Physiol. Behav. 2006, 89:146-155.
18. Hosoi T., Okuma Y., Wada S., Nomura Y. Inhibition of leptin-induced IL-1beta expression by glucocorticoids in the brain. Brain Res. 2003, 969:95-101.
19. Inoue W., Poole S., Bristow A.F., Luheshi G.N. Leptin induces cyclooxygenase-2 via an interaction with interleukin-1beta in the rat brain. Eur. J. Neurosci. 2006, 24:2233-2245.
20. Inoue W., Somay G., Poole S., Luheshi G.N. Immune-to-brain signaling and central prostaglandin E2 synthesis in fasted rats with altered lipopolysaccharide-induced fever. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008, 295:R133-R143.
21. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996, 19:312-318.
22. Kuida K., Lippke J.A., Ku G., Harding M.W., Livingston D.J., Su M.S., Flavell R.A. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 1995, 267:2000-2003.
23. La Cava A., Matarese G. The weight of leptin in immunity. Nat. Rev. Immunol. 2004, 4:371-379.
24. Lam Q.L., Liu S., Cao X., Lu L. Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells. Eur. J. Immunol. 2006, 36:3118-3130.
25. Lawson L.J., Perry V.H., Dri P., Gordon S. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 1990, 39:151-170.
26. Li P., Allen H., Banerjee S., Franklin S., Herzog L., Johnston C., McDowell J., Paskind M., Rodman L., Salfeld J., et al. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 1995, 80:401-411.
27. Loffreda S., Yang S.Q., Lin H.Z., Karp C.L., Brengman M.L., Wang D.J., Klein A.S., Bulkley G.B., Bao C., Noble P.W., Lane M.D., Diehl A.M. Leptin regulates proinflammatory immune responses. FASEB J. 1998, 12:57-65.
28. Luheshi G.N., Gardner J.D., Rushforth D.A., Loudon A.S., Rothwell N.J. Leptin actions on food intake and body temperature are mediated by IL-1. Proc. Natl. Acad. Sci. USA 1999, 96:7047-7052.
29. Marti A., Marcos A., Martinez J.A. Obesity and immune function relationships. Obes. Rev. 2001, 2:131-140.
30. Marty S., Dusart I., Peschanski M. Glial changes following an excitotoxic lesion in the CNS-I. Microglia/macrophages. Neuroscience 1991, 45:529-539.
31. Mastronardi C.A., Srivastava V., Yu W.H., Les Dees W., McCann S.M. Lipopolysaccharide-induced leptin synthesis and release are differentially controlled by alpha-melanocyte-stimulating hormone. Neuroimmunomodulation 2005, 12:182-188.
32. Mastronardi C.A., Yu W.H., Srivastava V.K., Dees W.L., McCann S.M. Lipopolysaccharide-induced leptin release is neurally controlled. Proc. Natl. Acad. Sci. USA 2001, 98:14720-14725.
33. Matarese G., Di Giacomo A., Sanna V., Lord G.M., Howard J.K., Di Tuoro A., Bloom S.R., Lechler R.I., Zappacosta S., Fontana S. Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J. Immunol. 2001, 166:5909-5916.
34. Mattioli B., Straface E., Quaranta M.G., Giordani L., Viora M. Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming. J. Immunol. 2005, 174:6820-6828.
35. Mattson M.P. Energy intake, meal frequency, and health: a neurobiological perspective. Annu. Rev. Nutr. 2005, 25:237-260.
36. Nakamura Y., Si Q.S., Kataoka K. Lipopolysaccharide-induced microglial activation in culture: temporal profiles of morphological change and release of cytokines and nitric oxide. Neurosci. Res. 1999, 35:95-100.
37. Nonaka N., Hileman S.M., Shioda S., Vo T.Q., Banks W.A. Effects of lipopolysaccharide on leptin transport across the blood-brain barrier. Brain Res. 2004, 1016:58-65.
38. Papathanassoglou E., El-Haschimi K., Li X.C., Matarese G., Strom T., Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J. Immunol. 2006, 176:7745-7752.
39. Perry V.H., Gordon S. Macrophages and microglia in the nervous system. Trends Neurosci. 1988, 11:273-277.
40. Pinteaux E., Inoue W., Schmidt L., Molina-Holgado F., Rothwell N.J., Luheshi G.N. Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism. J. Neurochem. 2007, 102:826-833.
41. Pinteaux E., Parker L.C., Rothwell N.J., Luheshi G.N. Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells. J. Neurochem. 2002, 83:754-763.
42. Rivest S. Molecular insights on the cerebral innate immune system. Brain Behav. Immun. 2003, 17:13-19.
43. Rothwell N.J., Luheshi G. Pharmacology of interleukin-1 actions in the brain. Adv. Pharmacol. 1994, 25:1-20.
44. Rothwell N.J., Luheshi G.N. Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci. 2000, 23:618-625.
45. Rummel, C., Inoue, W., Poole, S., Luheshi, G.N., 2009. Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation. Mol. Psychiatry, In press [Epub ahead of print].
46. Rummel C., Inoue W., Sachot C., Poole S., Hubschle T., Luheshi G.N. Selective contribution of interleukin-6 and leptin to brain inflammatory signals induced by systemic LPS injection in mice. J. Comp. Neurol. 2008, 511:373-395.
47. Sachot C., Poole S., Luheshi G.N. Circulating leptin mediates lipopolysaccharide-induced anorexia and fever in rats. J. Physiol. 2004, 561:263-272.
48. Sanna V., Di Giacomo A., La Cava A., Lechler R.I., Fontana S., Zappacosta S., Matarese G. Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J. Clin. Invest. 2003, 111:241-250.
49. Schwartz M., Butovsky O., Bruck W., Hanisch U.K. Microglial phenotype: is the commitment reversible?. Trends Neurosci. 2006, 29:68-74.
50. Shen J., Sakaida I., Uchida K., Terai S., Okita K. Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells. Life Sci. 2005, 77:1502-1515.
51. Shimabukuro M., Wang M.Y., Zhou Y.T., Newgard C.B., Unger R.H. Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. Proc. Natl. Acad. Sci. USA 1998, 95:9558-9561.
52. Stout R.D., Jiang C., Matta B., Tietzel I., Watkins S.K., Suttles J. Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences. J. Immunol. 2005, 175:342-349.
53. Stout R.D., Suttles J. Functional plasticity of macrophages: reversible adaptation to changing microenvironments. J. Leukoc. Biol. 2004, 76:509-513.
54. Streit W.J., Graeber M.B., Kreutzberg G.W. Functional plasticity of microglia: a review. Glia 1988, 1:301-307.
55. Suzumura A., Marunouchi T., Yamamoto H. Morphological transformation of microglia in vitro. Brain Res. 1991, 545:301-306.
56. Tang C.H., Lu D.Y., Yang R.S., Tsai H.Y., Kao M.C., Fu W.M., Chen Y.F. Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J. Immunol. 2007, 179:1292-1302.
57. Valerio A., Dossena M., Bertolotti P., Boroni F., Sarnico I., Faraco G., Chiarugi A., Frontini A., Giordano A., Liou H.C., De Simoni M.G., Spano P., Carruba M.O., Pizzi M., Nisoli E. Leptin is induced in the ischemic cerebral cortex and exerts neuroprotection through NF-kappaB/c-Rel-dependent transcription. Stroke 2009, 40:610-617.
58. Zhao Y., Sun R., You L., Gao C., Tian Z. Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem. Biophys. Res. Commun. 2003, 300:247-252.