High-fat-diet exposure induces IgG accumulation in hypothalamic microglia

DMM Disease Models and Mechanisms

Volumn 5, Issue 5, 2012, Pages 686-690

  Yi, Chun Xia ^a   Tschöp, Matthias H ^a   Woods, Stephen C ^b   Hofmann, Susanna M ^c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G3;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; DENSITOMETRY; IMMUNOFLUORESCENCE TEST; IMMUNOREACTIVITY; LIPID DIET; MALE; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; WEIGHT GAIN;

ANIMALS; ARCUATE NUCLEUS; DENSITOMETRY; DIET, HIGH-FAT; FLUORESCENT ANTIBODY TECHNIQUE; GLIAL FIBRILLARY ACIDIC PROTEIN; HYPOTHALAMUS; IMMUNOGLOBULIN G; MICE; MICE, INBRED C57BL; MICE, OBESE; MICROGLIA; WEIGHT GAIN;

ANIMALIA; MUS;

EID: 84865466160     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.009464     Document Type: Article

References (18)

1. Bard, F., Cannon, C., Barbour, R., Burke, R. L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K. et al. (2000). Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6, 916-919. (Pubitemid 30644751)
2. De Souza, C. T., Araujo, E. P., Bordin, S., Ashimine, R., Zollner, R. L., Boschero, A. C., Saad, M. J. and Velloso, L. A. (2005). Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146, 4192-4199. (Pubitemid 41324012)
3. Frei, K., Siepl, C., Groscurth, P., Bodmer, S., Schwerdel, C. and Fontana, A. (1987). Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cells. Eur. J. Immunol. 17, 1271-1278. (Pubitemid 17148166)
4. Gross, P. M. (1992). Circumventricular organ capillaries. Prog. Brain Res. 91, 219-233.
5. Haire, M., Fraser, K. B. and Millar, J. H. (1973). Measles and other virus-specific immunoglobulins in multiple sclerosis. Br. Med. J. 3, 612-615.
6. Hazama, G. I., Yasuhara, O., Morita, H., Aimi, Y., Tooyama, I. and Kimura, H. (2005). Mouse brain IgG-like immunoreactivity: strain-specific occurrence in microglia and biochemical identification of IgG. J. Comp. Neurol. 492, 234-249. (Pubitemid 41443723)
7. Lumeng, C. N. and Saltiel, A. R. (2011). Inflammatory links between obesity and metabolic disease. J. Clin. Invest. 121, 2111-2117.
8. McRae-Degueurce, A., Rosengren, L., Haglid, K., Booj, S., Gottfries, C. G., Granerus, A. C. and Dahlstrom, A. (1988). Immunocytochemical investigations on the presence of neuron-specific antibodies in the CSF of Parkinsons disease cases. Neurochem. Res. 13, 679-684.
9. Munzberg, H., Flier, J. S. and Bjorbaek, C. (2004). Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145, 4880-4889. (Pubitemid 39551104)
10. Nelson, P. T., Soma, L. A. and Lavi, E. (2002). Microglia in diseases of the central nervous system. Ann. Med. 34, 491-500. (Pubitemid 36113806)
11. Neumann, H., Kotter, M. R. and Franklin, R. J. (2009). Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132, 288-295.
12. Obici, S., Zhang, B. B., Karkanias, G. and Rossetti, L. (2002). Hypothalamic insulin signaling is required for inhibition of glucose production. Nat. Med. 8, 1376-1382. (Pubitemid 36019422)
13. Persidsky, Y., Ghorpade, A., Rasmussen, J., Limoges, J., Liu, X. J., Stins, M., Fiala, M., Way, D., Kim, K. S., Witte, M. H. et al. (1999). Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis. Am. J. Pathol. 155, 1599-1611.
14. Pocai, A., Lam, T. K., Gutierrez-Juarez, R., Obici, S., Schwartz, G. J., Bryan, J., Aguilar-Bryan, L. and Rossetti, L. (2005). Hypothalamic K(ATP) channels control hepatic glucose production. Nature 434, 1026-1031. (Pubitemid 40586051)
15. Posey, K. A., Clegg, D. J., Printz, R. L., Byun, J., Morton, G. J., Vivekanandan-Giri, A., Pennathur, S., Baskin, D. G., Heinecke, J. W., Woods, S. C. et al. (2009). Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am. J. Physiol. Endocrinol. Metab. 296, E1003-E1012.
16. Thaler, J. P. and Schwartz, M. W. (2010). Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology 151, 4109-4115.
17. Thaler, J. P., Yi, C. X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R. et al. (2012). Obesity is associated with hypothalamic injury in rodents and humans. J. Clin. Invest. 122, 153-162.
18. Winer, D. A., Winer, S., Shen, L., Wadia, P. P., Yantha, J., Paltser, G., Tsui, H., Wu, P., Davidson, M. G., Alonso, M. N. et al. (2011). B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat. Med. 17, 610-617.