Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model

Physiological Genomics

Volumn 16, Issue , 2004, Pages 240-246

  Lavoie, Julie L ^a   Cassell, Martin D ^a   Gross, Kennetli W ^b   Sigmund, Curt D ^a  

^a UNIVERSITY OF IOWA   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

ACE angiotensin receptors, gene expression, genetically altered mice; Astrocyte; Brain; Neuron; Oligodendrocytes; Renin

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN RECEPTOR; ANTISERUM; DIPEPTIDYL CARBOXYPEPTIDASE; DNA; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; RENIN; HYBRID PROTEIN; PHOTOPROTEIN;

ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN; CELLULAR DISTRIBUTION; CEREBELLUM CORTEX; GENE EXPRESSION; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OLIGODENDROGLIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TRANSGENIC MOUSE; ANIMAL; CYTOLOGY; FEMALE; GENETICS; MALE; METABOLISM; NERVE CELL;

ANIMALIA; MUS MUSCULUS; RODENTIA;

ANIMALS; ASTROCYTES; BRAIN; FEMALE; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MALE; MICE; NEURONS; OLIGODENDROGLIA; RECOMBINANT FUSION PROTEINS; RENIN;

EID: 1842587534     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00131.2003     Document Type: Article

References (34)

1. Allen AM, Moeller I, Jenkins TA, Zhuo J, Aldred GP, Chai SY, and Mendelsohn FAO. Angiotensin receptors in the nervous system. Brain Res Bull 47: 17-28, 1998.
2. Chiang TS, Erdos EG, Miwa I, Tague LL, and Coalson JJ. Isolation from the salivary gland of granules containing renin and kallikrein. Circ Res 23: 507-517, 1968.
3. Clausmeyer S, Sturzebecher R, and Peters J. An alternative transcript of the rat renin gene can result in a truncated prorenin that is transported into adrenal mitochondria. Circ Res 84: 337-344, 1999.
4. Dzau VJ, Brenner A, and Emmett NL. Evidence for renin in rat brain: differentiation from other reninlike enzymes. Am J Physiol Endocrinol Metab 242: E292-E297, 1982.
5. Dzau VJ, Ingelfinger J, Pratt RE, and Ellison KE. Identification of renin and angiotensinogen messenger RNA sequences in mouse and rat brains. Hypertension 8: 544-548, 1986.
6. Fischer-Ferraro C, Nahmod VE, Goldstein DJ, and Finkielman S. Angiotensin and renin in rat and dog brain. J Exp Med 133: 353-361, 1971.
7. Franklin KBJ and Paxinos G. The Mouse Brain in Stereotaxic Coordinates. San Diego: Academic, 1997.
8. Fuxe K, Ganten D, Hokfelt T, Locatelli V, Poulsen K, Stock G, Rix E, and Taugner R. Renin-like immunocytochemical activity in the rat and mouse brain. Neurosci Lett 18: 245-250, 1980.
9. Ganten D, Marquez-Julio A, Granger P, Hayduk K, Karsunky KP, Boucher R, and Genest J. Renin in dog brain. Am J Physiol 221: 1733-1737, 1971.
10. Ganten D and Speck G. The brain renin-angiotensin system: a model for the synthesis of peptides in the brain. Biochem Pharmacol 27: 2379-2389, 1978.
11. Genest J, Cantin M, Garcia R, Thibault G, Gutkowska J, Schiffrin E, Kuchel O, and Hamet P. Extrarenal angiotensin-forming enzymes. Clin Exp Hypertens A 5: 1065-1080, 1983.
12. Gomez RA, Lynch KR, Chevalier RL, Everett AD, Johns DW, Wilfong N, Peach MJ, and Carey RM. Renin and angiotensinogen gene expression and intrarenal renin distribution during ACE inhibition. Am J Physiol Renal Fluid Electrolyte Physiol 254: F900-F906, 1988.
13. Gomez RA, Lynch KR, Sturgill BC, Elwood JP, Chevalier RL, Carey RM, and Peach MJ. Distribution of renin mRNA and its protein in the developing kidney. Am J Physiol Renal Fluid Electrolyte Physiol 257: F850-F858, 1989.
14. Hermann K, Raizada MK, Sumners C, and Phillips MI. Presence of renin in primary neuronal and glial cells from rat brain. Brain Res 437: 205-213, 1987.
15. Hirose S, Yokosawa H, and Inagami T. Immunochemical identification of renin in rat brain and distinction from acid proteases. Nature 274: 392-393, 1978.
16. Jones CA, Hurley MI, Black TA, Kane CM, Pan L, Pruitt SC, and Gross KW. Expression of a renin/GFP transgene in mouse embryonic, extra-embryonic and adult tissues. Physiol Genomics 4: 75-81, 2000.
17. Lee-Kirsch MA, Gaudet F, Cardoso MC, and Lindpaintner K. Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing. Circ Res 84: 240-246, 1999.
18. Lind RW, Swanson LW, and Ganten D. Organization of angiotensin II immunoreactive cells and fibers in the rat central nervous system. An immunohistochemical study. Neuroendocrinology 40: 2-24, 1985.
19. McKinley MJ, Albiston AL, Allen AM, Mathai ML, May CN, McAllen RM, Oldlield BJ, Mendelsohn FA, and Chai SY. The brain renin-angiotensin system: location and physiological roles. Int J Biochem Cell Biol 35: 901-918, 2003.
20. Morimoto S, Cassell MD, Beltz TG, Johnson AK, Davisson RL, and Sigmund CD. Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter. Circ Res 89: 365-372, 2001.
21. Morimoto S, Cassell MD, and Sigmund CD. Glial- and neuronal-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference. J Biol Chem 277: 33235-33241, 2002.
22. Morimoto S, Cassell MD, and Sigmund CD. Neuron-specific expression of human angiotensinogen in brain causes increased salt appetite. Physiol Genomics 9: 113-120, 2002. First published March 26, 2002; 10.1152/physiolgenomics.00007.2002.
23. Morimoto S, Cassell MD, and Sigmund CD. The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene. Circ Res 90: 80-86, 2002.
24. Mungall BA, Shinkel TA, and Sernia C. Immunocytochemical localization of angiotensinogen in the fetal and neonatal rat brain. Neuroscience 67: 505-524, 1995.
25. Phillips MI. Functions of angiotensin in the central nervous system. Annu Rev Physiol 49: 413-435, 1987.
26. Printz MP, Ganten D, Unger T, and Phillips MI. The Brain Renin-Angiotensin System. In: The Renin-Angiotensin System in the Brain: A Model for the Synthesis of Peptides in the Brain, edited by Ganten D, Printz MP, Phillips MI, and Scholkens BA. Berlin: Springer-Verlag, 2003.
27. Re RN. The intracrine hypothesis and intracellular peptide hormone action. Bioessays 25: 401-409, 2003.
28. Samani NJ, Swales JD, and Brammer WJ. Expression of the renin gene in extra-renal tissues of the rat. Biochem J 253: 907-910, 1988.
29. Sernia C. Location and secretion of brain angiotensinogen. Regul Pept 57: 1-18, 1995.
30. Sinn PL and Sigmund CD. Identification of three human renin mRNA isoforms resulting from alternative tissue-specific transcriptional initiation. Physiol Genomics 3: 25-31, 2000.
31. Slater EE, Defendini R, and Zimmerman E. Wide distribution of immunoreactive renin in nerve cells of human brain. Proc Natl Acad Sci USA 77: 5458-5460, 1980.
32. Speck G, Poulsen K, Unger T, Rettig R, Bayer C, Scholkens B, and Ganten D. In vivo activity of purified mouse brain renin. Brain Res 219: 371-384, 1981.
33. Thomas WG and Sernia C. Immunocytochemical localization of angiotensinogen in the rat brain. Neuroscience 25: 319-341, 1988.
34. Yang G, Gray TS, Sigmund CD and Cassell MD. The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system. Brain Res 817: 123-131, 1999.