Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure

Hypertension

Volumn 37, Issue 3, 2001, Pages 936-942

  Correia, Marcelo L G ^a   Morgan, Donald A ^a   Sivitz, William I ^a   Mark, Allyn L ^a   Haynes, William G ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Hormones; Hypertension, arterial; Obesity; Sodium; Sympathetic nervous system

Indexed keywords

LEPTIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BODY WEIGHT; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; ENERGY EXPENDITURE; FOOD INTAKE; HORMONAL REGULATION; HYPERTENSION; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; SALT INTAKE; TACHYCARDIA; TELEMETRY; WEIGHT REDUCTION;

EID: 0035100787     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.37.3.936     Document Type: Article

References (24)

1. Positional cloning of the mouse obese gene and its human homologue
2. The OB protein (leptin): A link between adipose tissue mass and central neural networks
3. Effects of the obese gene product on body weight regulation in ob/ob mice
4. Role of leptin in fat regulation
5. Receptor-mediated regional sympathetic nerve activation by leptin
6. Sympathetic activation by leptin is mediated by the hypothalamus
7. Chronic leptin infusion increases arterial pressure
8. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats
9. Effects of central leptin administration on blood pressure in normotensive rats
10. Caloric restriction lowers blood pressure in the spontaneously hypertensive rat
11. Food restriction reduces sympathetic support of blood pressure in spontaneously hypertensive rats
12. Effect of weight-reduction in moderately overweight patients on recorded ambulatory blood-pressure and free cytosolic platelet calcium
13. Weight reducing effects of the plasma protein encoded by the obese gene
14. Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats
15. Human leptin has natriuretic activity in the rat
16. A comparison of the natriuretic/diuretic effects of rat vs human leptin in the rat
17. Leptin induces direct vasodilation through distinct endothelial mechanisms
18. Pivotal role of nitric oxide in the control of blood pressure after leptin administration
19. Effects of leptin on insulin sensitivity in normal rats
20. Pathophysiological role of leptin in obesity-related hypertension
21. Sodium balance and hypertension in obese and fatty rats
22. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
23. Serum immunoreactive leptin concentrations in normal weight and obese humans
24. Sympathetic and cardiorenal actions of leptin