메뉴 건너뛰기




Volumn 3, Issue 3, 2002, Pages 216-227

Innate immunity: The missing link in neuroprotection and neurodegeneration?

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; CYTOKINE; DROSOPHILA PROTEIN; MEMBRANE PROTEIN; TOLL LIKE RECEPTOR;

EID: 0036518997     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn752     Document Type: Article
Times cited : (635)

References (101)
  • 1
    • 0033966411 scopus 로고    scopus 로고
    • Toll signaling pathways in the innate immune response
    • Anderson, K. V. Toll signaling pathways in the innate immune response. Curr. Opin. Immunol. 12, 13-19 (2000).
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 13-19
    • Anderson, K.V.1
  • 2
    • 0033557176 scopus 로고    scopus 로고
    • Toll, a new piece in the puzzle of innate immunity
    • Wright, S. D. Toll, a new piece in the puzzle of innate immunity. J. Exp. Med. 189, 605-609 (1999).
    • (1999) J. Exp. Med , vol.189 , pp. 605-609
    • Wright, S.D.1
  • 3
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira, S., Takeda, K. & Kaisho, T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nature Immunol. 2, 675-680 (2001).
    • (2001) Nature Immunol , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 4
    • 0033844166 scopus 로고    scopus 로고
    • Toll-like receptors: A growing family of immune receptors that are differentially expressed and regulated by different leukocytes
    • Muzio, M., Polentarutti, N., Bosisio, D., Prahladan, M. K. & Mantovani, A. Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes. J. Leukoc. Biol. 67, 450-456 (2000).
    • (2000) J. Leukoc. Biol , vol.67 , pp. 450-456
    • Muzio, M.1    Polentarutti, N.2    Bosisio, D.3    Prahladan, M.K.4    Mantovani, A.5
  • 5
    • 0033952703 scopus 로고    scopus 로고
    • Tlr4: Central component of the sole mammalian LPS sensor
    • Beutler, B. Tlr4: central component of the sole mammalian LPS sensor. Curr. Opin. Immunol. 12, 20-26 (2000).
    • (2000) Curr. Opin. Immunol , vol.12 , pp. 20-26
    • Beutler, B.1
  • 6
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
    • Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088 (1998).
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1
  • 7
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
    • Takeuchi, O. et al. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 11, 443-451 (1999).
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1
  • 8
    • 0035953543 scopus 로고    scopus 로고
    • The innate immune response to bacterial flagellin is mediated by Toll-like receptor
    • Hayashi, F. et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor. Nature 410, 1099-1103 (2001).
    • (2001) Nature , vol.410 , pp. 1099-1103
    • Hayashi, F.1
  • 9
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi, H. et al. A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745 (2000).
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1
  • 10
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF- κB by Toll-like receptor
    • Alexopoulou, L., Holt, A. C., Medzhitov, R. & Flavell, R. A. Recognition of double-stranded RNA and activation of NF- κB by Toll-like receptor. Nature 413, 732-738 (2001).
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 11
    • 0034610291 scopus 로고    scopus 로고
    • The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
    • Ozinsky, A. et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc. Natl Acad. Sci. USA 97, 13766-13771 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 13766-13771
    • Ozinsky, A.1
  • 12
    • 0033257795 scopus 로고    scopus 로고
    • JNK2 and IKKβ are required for activating the innate response to viral infection
    • Chu, W. M. et al. JNK2 and IKKβ are required for activating the innate response to viral infection. Immunity 11, 721-731 (1999).
    • (1999) Immunity , vol.11 , pp. 721-731
    • Chu, W.M.1
  • 13
    • 0033537719 scopus 로고    scopus 로고
    • Positive and negative regulation of I κB kinase activity through IKKβ subunit phosphorylation
    • Delhase, M., Hayakawa, M., Chen, Y & Karin, M. Positive and negative regulation of I κB kinase activity through IKKβ subunit phosphorylation. Science 284, 309-313 (1999).
    • (1999) Science , vol.284 , pp. 309-313
    • Delhase, M.1    Hayakawa, M.2    Chen, Y.3    Karin, M.4
  • 14
    • 0033537767 scopus 로고    scopus 로고
    • Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
    • Hu, Y. et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase. Science 284, 316-320 (1999).
    • (1999) Science , vol.284 , pp. 316-320
    • Hu, Y.1
  • 15
    • 0031683603 scopus 로고    scopus 로고
    • The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations
    • Lacroix, S., Feinstein, D. & Rivest, S. The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations. Brain Pathol. 8, 625-640 (1998).
    • (1998) Brain Pathol , vol.8 , pp. 625-640
    • Lacroix, S.1    Feinstein, D.2    Rivest, S.3
  • 16
    • 0035170282 scopus 로고    scopus 로고
    • Toll-like receptor 4: The missing link of the cerebral innate immune response triggered by circulating Gram-negative bacterial cell wall components
    • Laflamme, N. & Rivest, S. Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating Gram-negative bacterial cell wall components. FASEB J. 15, 155-163 (2001).
    • (2001) FASEB J , vol.15 , pp. 155-163
    • Laflamme, N.1    Rivest, S.2
  • 17
    • 0034765855 scopus 로고    scopus 로고
    • Circulating cell wall components derived from Gram-negative and not Gram- positive bacteria cause a profound transcriptional activation of the gene encoding toll-like receptor 2 in the CNS
    • Laflamme, N., Souci, G. & Rivest, S. Circulating cell wall components derived from Gram-negative and not Gram- positive bacteria cause a profound transcriptional activation of the gene encoding toll-like receptor 2 in the CNS. J. Neurochem. 70, 648-657 (2001).
    • (2001) J. Neurochem. , vol.70 , pp. 648-657
    • Laflamme, N.1    Souci, G.2    Rivest, S.3
  • 18
    • 0033568068 scopus 로고    scopus 로고
    • Neuronal activity and transcription of proinflammatory cytokines, IκBα, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei
    • Brochu, S., Olivier, M. & Rivest, S. Neuronal activity and transcription of proinflammatory cytokines, IκBα, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei. J. Neurosci. Res. 57, 801-816 (1999).
    • (1999) J. Neurosci. Res , vol.57 , pp. 801-816
    • Brochu, S.1    Olivier, M.2    Rivest, S.3
  • 19
    • 0032952972 scopus 로고    scopus 로고
    • Regulation of the gene encoding tumor necrosis factor α in the rat brain and pituitary in response to different models of systemic immune challenge
    • Nadeau, S. & Rivest, S. Regulation of the gene encoding tumor necrosis factor α in the rat brain and pituitary in response to different models of systemic immune challenge. J. Neuropathol. Exp. Neurol. 58, 61-77 (1999).
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 61-77
    • Nadeau, S.1    Rivest, S.2
  • 20
    • 0034193376 scopus 로고    scopus 로고
    • Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and NF-kB activity in the brain during endotoxemia
    • Nadeau, S. & Rivest, S. Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and NF-kB activity in the brain during endotoxemia. J. Neurosci. 20, 3456-3468 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 3456-3468
    • Nadeau, S.1    Rivest, S.2
  • 21
    • 0035377576 scopus 로고    scopus 로고
    • The complement system is an integrated part of the natural innate immune response in the brain
    • Nadeau, S. & Rivest, S. The complement system is an integrated part of the natural innate immune response in the brain. FASEB J. 15, 1410-1412 (2001).
    • (2001) FASEB J , vol.15 , pp. 1410-1412
    • Nadeau, S.1    Rivest, S.2
  • 22
    • 0032031630 scopus 로고    scopus 로고
    • Time course and localization patterns of interleukin-1 β mRNA expression in the brain and pituitary after peripheral administration of lipopolysaccharide
    • Quan, N., Whiteside, M. & Herkenham, M. Time course and localization patterns of interleukin-1 β mRNA expression in the brain and pituitary after peripheral administration of lipopolysaccharide. Neuroscience 83, 281-293 (1997).
    • (1997) Neuroscience , vol.83 , pp. 281-293
    • Quan, N.1    Whiteside, M.2    Herkenham, M.3
  • 23
    • 0035844702 scopus 로고    scopus 로고
    • Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines
    • Thibeault, I., Laflamme, N. & Rivest, S. Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines. J. Comp. Neurol. 434, 461-477 (2001).
    • (2001) J. Comp. Neurol , vol.434 , pp. 461-477
    • Thibeault, I.1    Laflamme, N.2    Rivest, S.3
  • 24
    • 0030829208 scopus 로고    scopus 로고
    • Role of tumor necrosis factor a in induction of murine CD14 gene expression by lipopolysaccharide
    • Fearns, C. & Loskutoff, D. J. Role of tumor necrosis factor a in induction of murine CD14 gene expression by lipopolysaccharide. Infect. Immun. 65, 4822-4831 (1997).
    • (1997) Infect. Immun , vol.65 , pp. 4822-4831
    • Fearns, C.1    Loskutoff, D.J.2
  • 25
    • 0032015110 scopus 로고    scopus 로고
    • Effect of recombinant interleukin-1 β on murine CD14 gene expression in vivo
    • Fearns, C. & Ulevitch, R. J. Effect of recombinant interleukin-1 β on murine CD14 gene expression in vivo. Shock 9, 157-163 (1998).
    • (1998) Shock , vol.9 , pp. 157-163
    • Fearns, C.1    Ulevitch, R.J.2
  • 26
    • 84984752567 scopus 로고    scopus 로고
    • Zekki, H., Feinstein, D. L. & Rivest, S. The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS. Brain Pathol. (in the press).
    • Zekki, H.1    Feinstein, D.L.2    Rivest, S.3
  • 27
    • 0034765498 scopus 로고    scopus 로고
    • Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: No requirement for proapoptotic interleukin-1 β in neurodegeneration
    • Nguyen, M. D., Julien, J.-P & Rivest, S. Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1 β in neurodegeneration. Ann. Neurol. 50, 630-639 (2001).
    • (2001) Ann. Neurol , vol.50 , pp. 630-639
    • Nguyen, M.D.1    Julien, J.-P.2    Rivest, S.3
  • 28
    • 0031881687 scopus 로고    scopus 로고
    • Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system
    • Castano, A., Herrera, A. J., Cano, J. & Machado, A. Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system. J. Neurochem. 70, 1584-1592 (1998).
    • (1998) J. Neurochem. , vol.70 , pp. 1584-1592
    • Castano, A.1    Herrera, A.J.2    Cano, J.3    Machado, A.4
  • 29
    • 0034663061 scopus 로고    scopus 로고
    • Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: Role of microglia
    • Kim, W. G. et al. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J. Neurosci. 20, 6309-6316 (2000).
    • (2000) J. Neurosci , vol.20 , pp. 6309-6316
    • Kim, W.G.1
  • 30
    • 0035064940 scopus 로고    scopus 로고
    • Bacterial endotoxin sensitizes the immature brain to hypoxic-ischaemic injury
    • Eklind, S. et al. Bacterial endotoxin sensitizes the immature brain to hypoxic-ischaemic injury. Eur. J. Neurosci. 13, 1101-1106 (2001).
    • (2001) Eur. J. Neurosci , vol.13 , pp. 1101-1106
    • Eklind, S.1
  • 31
    • 0034663946 scopus 로고    scopus 로고
    • Central neivous system-initiated inflammation and neurotropism in trauma: IL-1 β is required for the production of ciliary neurotrophic factor
    • Herx, L. M., Rivest, S. & Yong, V. W. Central neivous system-initiated inflammation and neurotropism in trauma: IL-1 β is required for the production of ciliary neurotrophic factor. J. Immunol. 165, 2232-2239 (2000).
    • (2000) J. Immunol , vol.165 , pp. 2232-2239
    • Herx, L.M.1    Rivest, S.2    Yong, V.W.3
  • 32
    • 0028326548 scopus 로고
    • Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord
    • Dusart, I. & Schwab, M. E. Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord. Eur. J. Neurosci. 6, 712-724 (1994).
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 712-724
    • Dusart, I.1    Schwab, M.E.2
  • 33
    • 0030106250 scopus 로고    scopus 로고
    • Cellular reactions at the lesion site after crushing of the rat optic nee
    • Frank, M. & Wolburg, H. Cellular reactions at the lesion site after crushing of the rat optic nee. Glia 16, 227-240 (1996).
    • (1996) Glia , vol.16 , pp. 227-240
    • Frank, M.1    Wolburg, H.2
  • 34
    • 0025173499 scopus 로고
    • Regional and cellular codistribution of interleukin-1 β and nerve growth factor mRNA in the adult rat brain
    • Bandtlow, C. E. et al. Regional and cellular codistribution of interleukin-1 β and nerve growth factor mRNA in the adult rat brain. J. Cell Biol. 111, 1701-1711 (1990).
    • (1990) J. Cell Biol , vol.111 , pp. 1701-1711
    • Bandtlow, C.E.1
  • 35
    • 0030032033 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain
    • DeKosky, S. T. et al. Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain. Ann. Neurol. 39, 123-127 (1996).
    • (1996) Ann. Neurol , vol.39 , pp. 123-127
    • Dekosky, S.T.1
  • 37
    • 0033578426 scopus 로고    scopus 로고
    • A new mechanism of neurodegeneration: A proinflammatory cytokine inhibits receptor signaling by a survival peptide
    • Venters, H. D. et al. A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide. Proc. Natl Acad. Sci. USA 96, 9879-9884 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 9879-9884
    • Venters, H.D.1
  • 38
    • 0035705454 scopus 로고    scopus 로고
    • TNFα promotes proliferation of oligodendrocyte progenitors and remyelination
    • Arnett, H. A. et al. TNFα promotes proliferation of oligodendrocyte progenitors and remyelination. Nature Neurosci. 4, 1116-1122 (2001).
    • (2001) Nature Neurosci , vol.4 , pp. 1116-1122
    • Arnett, H.A.1
  • 39
    • 0034656415 scopus 로고    scopus 로고
    • IFNγ enhances microglial reactions to hippocampal axonal degeneration
    • Jensen, M. B., Hegelund, I. V., Lomholt, N. D., Finsen, B. & Owens, T. IFNγ enhances microglial reactions to hippocampal axonal degeneration. J. Neurosci. 20, 3612-3621 (2000).
    • (2000) J. Neurosci , vol.20 , pp. 3612-3621
    • Jensen, M.B.1    Hegelund, I.V.2    Lomholt, N.D.3    Finsen, B.4    Owens, T.5
  • 40
    • 0034069944 scopus 로고    scopus 로고
    • Interferon-γ modulates human oligodendrocyte susceptibility to Fas-mediated apoptosis
    • Pouly, S., Becher, B., Blain, M. & Antel, J. P Interferon-γ modulates human oligodendrocyte susceptibility to Fas-mediated apoptosis. J. Neuropathol. Exp. Neurol. 59, 280-286 (2000).
    • (2000) J. Neuropathol. Exp. Neurol , vol.59 , pp. 280-286
    • Pouly, S.1    Becher, B.2    Blain, M.3    Antel, J.P.4
  • 41
    • 0032190264 scopus 로고    scopus 로고
    • Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions
    • Pasinetti, G. M. Cyclooxygenase and inflammation in Alzheimer's disease: experimental approaches and clinical interventions. J. Neurosci. Res. 54, 1-6 (1998).
    • (1998) J. Neurosci. Res , vol.54 , pp. 1-6
    • Pasinetti, G.M.1
  • 42
    • 0032942060 scopus 로고    scopus 로고
    • Microglia as mediators of inflammatory and degenerative diseases
    • Gonzalez-Scarano, F. & Baltuch, G. Microglia as mediators of inflammatory and degenerative diseases. Annu. Rev. Neurosci. 22, 219-240 (1999).
    • (1999) Annu. Rev. Neurosci. , vol.22 , pp. 219-240
    • Gonzalez-Scarano, F.1    Baltuch, G.2
  • 43
    • 0035936804 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: Unfolding the toxicity of the misfolded
    • Julien, J.-P. Amyotrophic lateral sclerosis: unfolding the toxicity of the misfolded. Cell 104, 581-591 (2001)
    • (2001) Cell , vol.104 , pp. 581-591
    • Julien, J.-P.1
  • 44
    • 0027160921 scopus 로고
    • Tumor necrosis factor-α in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system
    • Stoll, G., Jung, S., Jander, S., van der Meide, P. & Hartung, H. P. Tumor necrosis factor-α in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system. J. Neuroimmunol. 45, 175-182 (1993).
    • (1993) J. Neuroimmunol. , vol.45 , pp. 175-182
    • Stoll, G.1    Jung, S.2    Jander, S.3    Van Der Meide, P.4    Hartung, H.P.5
  • 45
    • 0034915133 scopus 로고    scopus 로고
    • Therapeutic neutralization of CD95- ligand and TNF attenuates brain damage in stroke
    • Martin-Villalba, A. et al. Therapeutic neutralization of CD95- ligand and TNF attenuates brain damage in stroke. Cell Death Differ. 8, 679-686 (2001).
    • (2001) Cell Death Differ , vol.8 , pp. 679-686
    • Martin-Villalba, A.1
  • 46
    • 0035889079 scopus 로고    scopus 로고
    • Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-α
    • Robertson, J. et al. Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-α. J. Cell Biol. 155, 217-226 (2001).
    • (2001) J. Cell Biol , vol.155 , pp. 217-226
    • Robertson, J.1
  • 47
    • 0035487313 scopus 로고    scopus 로고
    • Cytokines and acute neurodegeneration
    • Allan, S. M. & Rothwell, N. J. Cytokines and acute neurodegeneration. Nature Rev. Neurosci. 2, 734-744 (2001).
    • (2001) Nature Rev. Neurosci. , vol.2 , pp. 734-744
    • Allan, S.M.1    Rothwell, N.J.2
  • 48
    • 0023949553 scopus 로고
    • Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
    • Hickey, W. F. & Kimura, H. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 239, 290-292 (1988).
    • (1988) Science , vol.239 , pp. 290-292
    • Hickey, W.F.1    Kimura, H.2
  • 49
    • 0033396991 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases
    • Mattson, M. P, Pedersen, W. A., Duan, W., Culmsee, C. & Camandola, S. Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases. Ann. NY Acad. Sci. 893, 154-175 (1999).
    • (1999) Ann. NY Acad. Sci , vol.893 , pp. 154-175
    • Mattson, M.P.1    Pedersen, W.A.2    Duan, W.3    Culmsee, C.4    Camandola, S.5
  • 50
    • 0033624419 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease
    • Albers, D. S. & Beal, M. F. Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. J. Neural Transm. 59, 133-154 (2000).
    • (2000) J. Neural Transm , vol.59 , pp. 133-154
    • Albers, D.S.1    Beal, M.F.2
  • 51
    • 0029079852 scopus 로고
    • Induction of MHC class I genes in neurons
    • Neumann, H., Cavalie, A., Jenne, D. E. & Wekerle, H. Induction of MHC class I genes in neurons. Science 269, 549-552 (1995).
    • (1995) Science , vol.269 , pp. 549-552
    • Neumann, H.1    Cavalie, A.2    Jenne, D.E.3    Wekerle, H.4
  • 52
    • 0031054508 scopus 로고    scopus 로고
    • Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: Differential regulation by interferon (IFN)-γ and tumor necrosis factor (TNF)-α
    • Neumann, H., Schmidt, H., Cavalie, A., Jenne, D. & Wekerle, H. Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-γ and tumor necrosis factor (TNF)-α. J. Exp. Med. 185, 305-316 (1997).
    • (1997) J. Exp. Med , vol.185 , pp. 305-316
    • Neumann, H.1    Schmidt, H.2    Cavalie, A.3    Jenne, D.4    Wekerle, H.5
  • 53
    • 0032168898 scopus 로고    scopus 로고
    • Regulation of class I MHC gene expression in the developing and mature CNS by neural activity
    • Corriveau, R. A., Huh, G. S. & Shatz, C. J. Regulation of class I MHC gene expression in the developing and mature CNS by neural activity. Neuron 21, 505-520 (1998).
    • (1998) Neuron , vol.21 , pp. 505-520
    • Corriveau, R.A.1    Huh, G.S.2    Shatz, C.J.3
  • 54
    • 0032215712 scopus 로고    scopus 로고
    • Immunologic complexity in neurons
    • Darnell, R. B. Immunologic complexity in neurons. Neuron 21, 947-950 (1998).
    • (1998) Neuron , vol.21 , pp. 947-950
    • Darnell, R.B.1
  • 55
    • 0034922092 scopus 로고    scopus 로고
    • Paraneoplastic neurologic disease antigens: RNA-binding proteins and signaling proteins in neuronal degeneration
    • Musunuru, K. & Darnell, R. B. Paraneoplastic neurologic disease antigens: RNA-binding proteins and signaling proteins in neuronal degeneration. Annu. Rev. Neurosci. 24, 239-262 (2001).
    • (2001) Annu. Rev. Neurosci , vol.24 , pp. 239-262
    • Musunuru, K.1    Darnell, R.B.2
  • 56
    • 0033635740 scopus 로고    scopus 로고
    • P Synaptic autoimmunity and the Salk factor
    • Solimena, M. & De Camilli, P Synaptic autoimmunity and the Salk factor. Neuron 28, 309-310 (2000).
    • (2000) Neuron , vol.28 , pp. 309-310
    • Solimena, M.1    De, C.2
  • 57
    • 0032964881 scopus 로고    scopus 로고
    • Autoimmunity and neurological disease: Antibody modulation of synaptic transmission
    • Whitney, K. D. & McNamara, J. O. Autoimmunity and neurological disease: antibody modulation of synaptic transmission. Annu. Rev. Neurosci. 22, 175-195 (1999).
    • (1999) Annu. Rev. Neurosci , vol.22 , pp. 175-195
    • Whitney, K.D.1    McNamara, J.O.2
  • 58
    • 0031868110 scopus 로고    scopus 로고
    • Experimental destruction of substantia nigra initiated by Parkinson disease immunoglobulins
    • Chen, S. et al. Experimental destruction of substantia nigra initiated by Parkinson disease immunoglobulins. Arch. Neurol. 55, 1075-1080 (1998).
    • (1998) Arch. Neurol , vol.55 , pp. 1075-1080
    • Chen, S.1
  • 59
    • 0031886287 scopus 로고    scopus 로고
    • Glutamate receptor GluR3 antibodies and death of cortical cells
    • He, X. P. et al. Glutamate receptor GluR3 antibodies and death of cortical cells. Neuron 20, 153-163 (1998).
    • (1998) Neuron , vol.20 , pp. 153-163
    • He, X.P.1
  • 60
    • 0029007095 scopus 로고
    • Antibodies to calcium channels from ALS patients passively transferred to mice selectively increase intracellular calcium and induce ultrastructural changes in motoneurons
    • Engelhardt, J. I., Siklos, L., Komuves, L., Smith, R. G. & Appel, S. H. Antibodies to calcium channels from ALS patients passively transferred to mice selectively increase intracellular calcium and induce ultrastructural changes in motoneurons. Synapse 20, 185-199 (1995).
    • (1995) Synapse , vol.20 , pp. 185-199
    • Engelhardt, J.I.1    Siklos, L.2    Komuves, L.3    Smith, R.G.4    Appel, S.H.5
  • 61
    • 0034065273 scopus 로고    scopus 로고
    • Stereotaxic injection of IgG from patients with Alzheimer disease initiates injury of cholinergic neurons of the basal forebrain
    • Engelhardt, J. I. et al. Stereotaxic injection of IgG from patients with Alzheimer disease initiates injury of cholinergic neurons of the basal forebrain. Arch. Neurol. 57, 681-686 (2000).
    • (2000) Arch. Neurol. , vol.57 , pp. 681-686
    • Engelhardt, J.I.1
  • 62
    • 0030992812 scopus 로고    scopus 로고
    • The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo
    • Buckanovich, R. J. & Darnell, R. B. The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo. Mol. Cell. Biol. 17, 3194-3201 (1997).
    • (1997) Mol. Cell. Biol , vol.17 , pp. 3194-3201
    • Buckanovich, R.J.1    Darnell, R.B.2
  • 63
    • 0029875911 scopus 로고    scopus 로고
    • The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies
    • Buckanovich, R. J., Yang, Y. Y & Darnell, R. B. The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies. J. Neurosci. 16, 1114-1122 (1996).
    • (1996) J. Neurosci , vol.16 , pp. 1114-1122
    • Buckanovich, R.J.1    Yang, Y.Y.2    Darnell, R.B.3
  • 64
    • 0027374048 scopus 로고
    • Nova, the paraneoplastic Ri antigen, is homologous to an RNA- binding protein and is specifically expressed in the developing motor system
    • Buckanovich, R. J., Posner, J. B. & Darnell, R. B. Nova, the paraneoplastic Ri antigen, is homologous to an RNA- binding protein and is specifically expressed in the developing motor system. Neuron 11, 657-672 (1993).
    • (1993) Neuron , vol.11 , pp. 657-672
    • Buckanovich, R.J.1    Posner, J.B.2    Darnell, R.B.3
  • 65
    • 0033757702 scopus 로고    scopus 로고
    • Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability
    • Jensen, K. B. et al. Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability. Neuron 25, 359-371 (2000).
    • (2000) Neuron , vol.25 , pp. 359-371
    • Jensen, K.B.1
  • 66
    • 0028153174 scopus 로고
    • Apoptotic cell death of a hybrid motoneuron cell line induced by immunoglobulins from patients with amyotrophic lateral sclerosis
    • Alexianu, M. E., Mohamed, A. H., Smith, R. G., Colom, L. V. & Appel, S. H. Apoptotic cell death of a hybrid motoneuron cell line induced by immunoglobulins from patients with amyotrophic lateral sclerosis. J. Neurochem. 63, 2365-2368 (1994).
    • (1994) J. Neurochem , vol.63 , pp. 2365-2368
    • Alexianu, M.E.1    Mohamed, A.H.2    Smith, R.G.3    Colom, L.V.4    Appel, S.H.5
  • 67
    • 0030638138 scopus 로고    scopus 로고
    • Altered calcium homeostasis and ultrastructure in motoneurons of mice caused by passively transferred anti-motoneuronal IgG
    • Engelhardt, J. I., Siklos, L. & Appel, S. H. Altered calcium homeostasis and ultrastructure in motoneurons of mice caused by passively transferred anti-motoneuronal IgG. J. Neuropathol. Exp. Neurol. 56, 21-39 (1997).
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 21-39
    • Engelhardt, J.I.1    Siklos, L.2    Appel, S.H.3
  • 68
    • 0034327381 scopus 로고    scopus 로고
    • Ultrastructural analysis of spinal motoneurones from mice treated with IgG from ALS patients, healthy individuals, or disease controls
    • Pullen, A. H. & Humphreys, P. Ultrastructural analysis of spinal motoneurones from mice treated with IgG from ALS patients, healthy individuals, or disease controls. J. Neurol. Sci. 180, 35-45 (2000).
    • (2000) J. Neurol. Sci , vol.180 , pp. 35-45
    • Pullen, A.H.1    Humphreys, P.2
  • 69
    • 0035828147 scopus 로고    scopus 로고
    • Recruitment of activated microglia cells in the spinal cord of mice by ALS IgG
    • Obal, I., Jakab, J. S., Siklos, L. & Engelhardt, J. I. Recruitment of activated microglia cells in the spinal cord of mice by ALS IgG. Neuroreport 12, 2449-2452 (2001).
    • (2001) Neuroreport , vol.12 , pp. 2449-2452
    • Obal, I.1    Jakab, J.S.2    Siklos, L.3    Engelhardt, J.I.4
  • 70
    • 0028095257 scopus 로고
    • Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis
    • Rogers, S. W. et al. Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis. Science 265, 648-651 (1994).
    • (1994) Science , vol.265 , pp. 648-651
    • Rogers, S.W.1
  • 71
    • 0033638708 scopus 로고    scopus 로고
    • Autoimmunity to munc-18 in Rasmussen's encephalitis
    • Yang, R. et al. Autoimmunity to munc-18 in Rasmussen's encephalitis. Neuron 28, 375-383 (2000).
    • (2000) Neuron , vol.28 , pp. 375-383
    • Yang, R.1
  • 72
    • 0027517423 scopus 로고
    • The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer
    • De Camilli, P. et al. The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer. J. Exp. Med. 178, 2219-2223 (1993).
    • (1993) J. Exp. Med , vol.178 , pp. 2219-2223
    • De Camilli, P.1
  • 73
    • 0028267951 scopus 로고
    • Identification of autoantibody epitopes of glutamic acid decarboxylase in stiff-man syndrome patients
    • Li, L., Hagopian, W. A., Brashear, H. R., Daniels, T. & Lernmark, A. Identification of autoantibody epitopes of glutamic acid decarboxylase in stiff-man syndrome patients. J. Immunol. 152, 930-934 (1994).
    • (1994) J. Immunol , vol.152 , pp. 930-934
    • Li, L.1    Hagopian, W.A.2    Brashear, H.R.3    Daniels, T.4    Lernmark, A.5
  • 74
    • 0033681271 scopus 로고    scopus 로고
    • Autoimmunity to gephyrin in Stiff-Man syndrome
    • Butler, M. H. et al. Autoimmunity to gephyrin in Stiff-Man syndrome. Neuron 26, 307-312 (2000).
    • (2000) Neuron , vol.26 , pp. 307-312
    • Butler, M.H.1
  • 75
    • 0031066631 scopus 로고    scopus 로고
    • Local-clonal expansion of infiltrating T lymphocytes in chronic encephalitis of Rasmussen
    • Li, Y. et al. Local-clonal expansion of infiltrating T lymphocytes in chronic encephalitis of Rasmussen. J. Immunol. 158, 1428-1437 (1997).
    • (1997) J. Immunol , vol.158 , pp. 1428-1437
    • Li, Y.1
  • 76
    • 0031786356 scopus 로고    scopus 로고
    • Tumor-specific killer cells in paraneoplastic cerebellar degeneration
    • Albert, M. L. et al. Tumor-specific killer cells in paraneoplastic cerebellar degeneration. Nature Med. 4, 1321-1324 (1998).
    • (1998) Nature Med , vol.4 , pp. 1321-1324
    • Albert, M.L.1
  • 77
    • 0033546888 scopus 로고    scopus 로고
    • Immunoglobulin G and complement immunoreactivity in the cerebral cortex of patients with Rasmussen's encephalitis
    • Whitney, K. D., Andrews, P. I. & McNamara, J. O. Immunoglobulin G and complement immunoreactivity in the cerebral cortex of patients with Rasmussen's encephalitis. Neurology 53, 699-708 (1999).
    • (1999) Neurology , vol.53 , pp. 699-708
    • Whitney, K.D.1    Rews, P.I.2    McNamara, J.O.3
  • 78
    • 0033962379 scopus 로고    scopus 로고
    • Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration
    • Albert, M. L., Austin, L. M. & Darnell, R. B. Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration. Ann. Neurol. 47, 9-17 (2000).
    • (2000) Ann. Neurol , vol.47 , pp. 9-17
    • Albert, M.L.1    Austin, L.M.2    Darnell, R.B.3
  • 79
    • 0024231045 scopus 로고
    • Immunity assessment in the early stages of amyotrophic lateral sclerosis: A study of virus antibodies and lymphocyte subsets
    • Provinciali, L. et al. Immunity assessment in the early stages of amyotrophic lateral sclerosis: a study of virus antibodies and lymphocyte subsets. Acta Neurol. Scand. 78, 449-454 (1988)
    • (1988) Acta Neurol. Scand. , vol.78 , pp. 449-454
    • Provinciali, L.1
  • 80
    • 0024997449 scopus 로고
    • Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis
    • Lampson, L. A., Kushner, P D. & Sobel, R. A. Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis. Ann. Neurol. 28, 365-372 (1990).
    • (1990) Ann. Neurol , vol.28 , pp. 365-372
    • Lampson, L.A.1    Kushner, P.D.2    Sobel, R.A.3
  • 81
    • 0025185079 scopus 로고
    • Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis. Neuropathol
    • Troost, D., van den Oord, J. J. & Vianney de Jong, J. M. Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis. Neuropathol. Appl. Neurobiol. 16, 401-410 (1990).
    • (1990) Appl. Neurobiol , vol.16 , pp. 401-410
    • Troost, D.1    Van Den Oord, J.J.2    Vianney De Jong, J.M.3
  • 82
    • 0032700036 scopus 로고    scopus 로고
    • T cell receptor BV gene rearrangements in the spinal cords and cerebrospinal fluid of patients with amyotrophic lateral sclerosis
    • Panzara, M. A. et al. T cell receptor BV gene rearrangements in the spinal cords and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Neurobiol. Dis. 6, 392-405 (1999).
    • (1999) Neurobiol. Dis , vol.6 , pp. 392-405
    • Panzara, M.A.1
  • 83
    • 0035576934 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tightjunctions in the blood-brain barrier
    • Huber, J. D., Egleton, R. D. & Davis, T. P. Molecular physiology and pathophysiology of tightjunctions in the blood-brain barrier. Trends Neurosci. 24, 719-725 (2001).
    • (2001) Trends Neurosci , vol.24 , pp. 719-725
    • Huber, J.D.1    Egleton, R.D.2    Davis, T.P.3
  • 84
    • 0033528254 scopus 로고    scopus 로고
    • Intravascular infusions of soluble β-amyloid compromise the blood-brain barrier, activate CNS glial cells and induce peripheral hemorrhage
    • Su, G. C., Arendash, G. W., Kalaria, R. N., Bjugstad, K. B. & Mullan, M. Intravascular infusions of soluble β-amyloid compromise the blood-brain barrier, activate CNS glial cells and induce peripheral hemorrhage. Brain Res. 818, 105-117 (1999).
    • (1999) Brain Res , vol.818 , pp. 105-117
    • Su, G.C.1    Arendash, G.W.2    Kalaria, R.N.3    Bjugstad, K.B.4    Mullan, M.5
  • 85
    • 0031779653 scopus 로고    scopus 로고
    • Increased blood-brain barrier permeability and endothelial abnormalities induced by vascular endothelial growth factor
    • Dobrogowska, D. H., Lossinsky, A. S., Tarnawski, M. & Vorbrodt, A. W. Increased blood-brain barrier permeability and endothelial abnormalities induced by vascular endothelial growth factor. J. Neurocytol. 27, 163-173 (1998).
    • (1998) J. Neurocytol. , vol.27 , pp. 163-173
    • Dobrogowska, D.H.1    Lossinsky, A.S.2    Tarnawski, M.3    Vorbrodt, A.W.4
  • 86
    • 0033797255 scopus 로고    scopus 로고
    • VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain
    • Zhang, Z. G. et al. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J. Clin. Invest. 106, 829-838 (2000).
    • (2000) J. Clin. Invest , vol.106 , pp. 829-838
    • Zhang, Z.G.1
  • 87
    • 0032991449 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) modulates vascular permeability and inflammation in rat brain
    • Proescholdt, M. A. et al. Vascular endothelial growth factor (VEGF) modulates vascular permeability and inflammation in rat brain. J. Neuropathol. Exp. Neurol. 58, 613-627 (1999).
    • (1999) J. Neuropathol. Exp. Neurol , vol.58 , pp. 613-627
    • Proescholdt, M.A.1
  • 88
    • 0034978562 scopus 로고    scopus 로고
    • Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
    • Oosthuyse, B. et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nature Genet. 28, 131-138 (2001).
    • (2001) Nature Genet , vol.28 , pp. 131-138
    • Oosthuyse, B.1
  • 89
    • 0035949791 scopus 로고    scopus 로고
    • An ALS-like syndrome with new HIV infection and complete response to antiretroviral therapy
    • MacGowan, D. J., Scelsa, S. N. & Waldron, M. An ALS-like syndrome with new HIV infection and complete response to antiretroviral therapy. Neurology 57, 1094-1097 (2001).
    • (2001) Neurology , vol.57 , pp. 1094-1097
    • Macgowan, D.J.1    Scelsa, S.N.2    Waldron, M.3
  • 91
    • 0026706840 scopus 로고
    • Motor neuron diseases and viruses: Poliovirus, retroviruses, and lymphomas
    • Jubelt, B. Motor neuron diseases and viruses: poliovirus, retroviruses, and lymphomas. Curr. Opin. Neurol. Neurosurg. 5, 655-658 (1992).
    • (1992) Curr. Opin. Neurol. Neurosurg , vol.5 , pp. 655-658
    • Jubelt, B.1
  • 92
    • 0024439527 scopus 로고
    • Enteroviral-related antigen in circulating immune complexes of amyotrophic lateral sclerosis patients
    • Bartfeld, H. et al. Enteroviral-related antigen in circulating immune complexes of amyotrophic lateral sclerosis patients. Intervirology 30, 202-212 (1989).
    • (1989) Intervirology , vol.30 , pp. 202-212
    • Bartfeld, H.1
  • 93
    • 0027280621 scopus 로고
    • Amyotrophic lateral sclerosis an enigmatic disease with B-cellular and anti-retroviral immune responses
    • Westarp, M. E. et al. Amyotrophic lateral sclerosis an enigmatic disease with B-cellular and anti-retroviral immune responses. Eur. J. Med. 2, 327-332 (1993).
    • (1993) Eur. J. Med , vol.2 , pp. 327-332
    • Westarp, M.E.1
  • 94
    • 0029043835 scopus 로고
    • HTLV tax-rex DNA and antibodies in idiopathic amyotrophic lateral sclerosis
    • Ferrante, P. et al. HTLV tax-rex DNA and antibodies in idiopathic amyotrophic lateral sclerosis. J. Neurol. Sci. 129, 140-144 (1995).
    • (1995) J. Neurol. Sci , vol.129 , pp. 140-144
    • Ferrante, P.1
  • 95
    • 0033981056 scopus 로고    scopus 로고
    • Detection and cellular localization of enterovirus RNA sequences in spinal cord of patients with ALS
    • Berger, M. M. et al. Detection and cellular localization of enterovirus RNA sequences in spinal cord of patients with ALS. Neurology 54, 20-25 (2000).
    • (2000) Neurology , vol.54 , pp. 20-25
    • Berger, M.M.1
  • 96
    • 0030442033 scopus 로고    scopus 로고
    • AIDS dementia complex: A complex, slow virus 'model' of acquired genetic neurodegenerative disease
    • Price, R. W. AIDS dementia complex: a complex, slow virus 'model' of acquired genetic neurodegenerative disease. Cold Spring Harb. Symp. Quant. Biol. 61, 759-770 (1996).
    • (1996) Cold Spring Harb. Symp. Quant. Biol , vol.61 , pp. 759-770
    • Price, R.W.1
  • 97
  • 98
    • 0031929574 scopus 로고    scopus 로고
    • Degeneration of the cerebellar granule cell layer in transgenic mice expressing genes of human foamy virus
    • Lampe, J., Marino, S., Rethwilm, A. & Aguzzi, A. Degeneration of the cerebellar granule cell layer in transgenic mice expressing genes of human foamy virus. Neuropathol. Appl. Neurobiol. 24, 36-43 (1998).
    • (1998) Neuropathol. Appl. Neurobiol , vol.24 , pp. 36-43
    • Lampe, J.1    Marino, S.2    Rethwilm, A.3    Aguzzi, A.4
  • 99
    • 0034704377 scopus 로고    scopus 로고
    • Spatial memory and learning deficits after experimental pneumococcal meningitis in mice
    • Wellmer, A., Noeske, C., Gerber, J., Munzel, U. & Nau, R. Spatial memory and learning deficits after experimental pneumococcal meningitis in mice. Neurosci. Lett. 296, 137-140 (2000).
    • (2000) Neurosci. Lett. , vol.296 , pp. 137-140
    • Wellmer, A.1    Noeske, C.2    Gerber, J.3    Munzel, U.4    Nau, R.5
  • 100
    • 0035103936 scopus 로고    scopus 로고
    • LP-BM5 virus-infected mice produce activating autoantibodies to the AMPA receptor
    • Koustova, E. et al. LP-BM5 virus-infected mice produce activating autoantibodies to the AMPA receptor. J. Clin. Invest. 107, 737-744 (2001).
    • (2001) J. Clin. Invest , vol.107 , pp. 737-744
    • Koustova, E.1
  • 101
    • 0034927789 scopus 로고    scopus 로고
    • Age-dependent poliomyelitis in mice is associated with respiratory failure and viral replication in the central nervous system and lung
    • Schlenker, E. H., Jones, Q. A., Rowland, R. R., Steffen-Bien, M. & Cafruny, W. A. Age-dependent poliomyelitis in mice is associated with respiratory failure and viral replication in the central nervous system and lung. J. Neurovirol. 7, 265-271 (2001).
    • (2001) J. Neurovirol , vol.7 , pp. 265-271
    • Schlenker, E.H.1    Jones, Q.A.2    Rowland, R.R.3    Steffen-Bien, M.4    Cafruny, W.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.