Anorexigenic peptides

Peptides in Energy Balance and Obesity: Frontiers in Nutritional Science

Volumn , Issue , 2009, Pages 33-60

  Perboni, Simona ^a   Ueno, Naohiko ^b   Mantovani, Giovanni ^a   Inui, Akio ^c  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84876711954     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (133)

1. Abizaid, A., Gao, Q. and Horvath, T.L. (2006) Thoughts for food: brain mechanisms and peripheral energy balance. Neuron 51, 691-702.
2. Adan, R.A., Tiesjema, B., Hillebrand, J.J., la Fleur, S.E., Kas, M.J. and de Krom, M. (2006) The MC4 receptor and control of appetite. British Journal of Pharmacology 149, 815-827.
3. Ahima, R.S. (2006) Adipose tissue as an endocrine organ. Obesity 14 (Suppl. 5), 242S-249S.
4. Ahima, R.S. and Osei, S.Y. (2004) Leptin signaling. Physiology and Behavior 81, 223-241.
5. Ahima, R.S., Qi, Y. and Singhal, N.S. (2006) Adipokines that link obesity and diabetes to the hypothalamus. Progress in Brain Research 153, 155-174.
6. Anderson, U., Filipsson, K., Abbott, C.R., Woods, A., Smith, K., Bloom, S.R., Carling, D. and Small, C.J. (2004) AMPK activated protein kinase play a role in the control of food intake. Journal of Biological Chemistry 279, 12005-12008.
7. Baggio, L.L., Huang, Q., Brown, T.J. and Drucker, D.J. (2004) Oxyntomodulin and glucagonlike peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology 127, 546-558.
8. Balthasar, N., Dalgaard, L.T., Lee, C.E., Yu, J., Funahashi, H., Williams, T., Ferreira, M., Tang, V., McGovern, R.A., Kenny, C.D., Christiansen, L.M., Edelstein, E., Choi, B., Boss, O., Aschkenasi, C., Zhang, C.Y., Mountjoy, K., Kishi, T., Elmquist, J.K. and Lowell, B.B. (2005) Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123, 493-505.
9. Banks, W.A. (2003) Is obesity a disease of the blood-brain barrier? Physiological, pathological and evolutionary considerations. Current Pharmaceutical Design 9, 801-809.
10. Banks, W.A. (2004) The many lives of leptin. Peptides 25, 331-338.
11. Banks, W.A., Kastin, A.J., Huang, W., Jaspan, J.B. and Meness, L.M. (1996) Leptin enters brain by a saturable system independent of insulin. Peptides 17, 305-311.
12. Barb, C.R., Robertson, A.S., Barrett, J.B., Kraaling, R.R. and Houseknecht, K.L. (2004) The role of melanocortin-3 and -4 receptor in regulating appetite, energy homeostasis and neuroendocrine function in the pig. Journal of Endocrinology 181, 39-52.
13. Bataille, D., Gespach, C., Tatemoto, K., Marie, J.C., Coudray, A.M., Rosselin, G. and Mutt, V. (1981) Bioactive enteroglucagon (oxyntomodulin): present knowledge on its chemical structure and its biological activities. Peptides 2, 41-44.
14. Bates, S.H., Stearns, W.H., Dundon, T.A., Schuber, T.M., Tso, A.W.K., Wanga, Y., Banks, A.S., Lavery, H.J., Haq, A.K., Flier, E.M., Neela, B.G., Schwartz, M.W. and Myers, M.G. (2003) STAT3 signaling is required for leptin regulation of energy balance but not reproduction. Nature 421, 856-859.
15. Benoit, S.C., Clegg, D.J., Seeley, R.J. and Woods, S.C. (2004) Insulin and leptin as adiposity signals. Recent Progress in Hormone Research 59, 267-285.
16. Bentebibel, A., Sebastián, D., Herrero, L., López-Viñas, E., Serra, D., Asins, G., Gómez-Puertas, P. and Hegardt, F.G. (2006) Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation. Biochemistry 45, 4339-4350.
17. Blüher, S. and Mantzoros, C.S. (2007) Leptin in reproduction. Current Opinion in Endocrinology, Diabetes, and Obesity 14, 458-464.
18. Bouret, S.G. and Simerly, R.B. (2004) Minireview: leptin and development of hypothalamic feeding circuits. Endocrinology 145, 2621-2626.
19. Bouret, S.G., Draper, S.J. and Simerly, R.B. (2004) Trophic action of leptin on hypothalamic neurons that regulate feeding. Nature 304, 108-110.
20. Bray, G.A. and Greenway, F.L. (1999) Current and potential drugs for treatment of obesity. Endocrine Reviews 20, 805-875.
21. Caro, J.F., Kolaczynski, J.W., Nyce, M.R., Ohannesian, J.P., Opentanova, I., Goldman, W.R., Lynn, R.B., Zhang, P.L., Sinha, M.K. and Considine, R.V. (1996) Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. The Lancet 348, 159-161.
22. Cha, S.H., Hu, Z. and Lane, M.L. (2004) Long-term effects of a fatty acid synthase inhibitor on obese mice: food intake, hypothalamic neuropeptides and UPC3. Biochemical and Biophysical Research Communications 317, 301-308.
23. Chen, C.Y., Inui, A., Asakawa, A., Fujino, K., Kato, I., Chen, C.C., Ueno, N. and Fujimiya, M. (2005) Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Gastroenterology 129, 8-25.
24. Cheng, A., Uetani, N., Simoncic, P.D., Chaubey, V.P., Lee-Loy, A., McGlade, C.J., Kennedy, B.P. and Tremblay, M.L. (2002) Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Developmental Cell 2, 497-503.
25. Cheng, F., Wang, Q., Chen, M., Quiocho, F.A. and Ma, J. (2008) Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands. Proteins 70, 1228-1234.
26. Choi, Y.H., Li, C., Page, K., Westby, A., Della-Fera, M.A., Lin, J., Hartzell, D.L. and Baile, C.A. (2003) Melanocortin receptors mediate leptin effects on feeding and body weight but not adipose apoptosis. Physiology and Behavior 79, 795-801.
27. Coll, A.P., Farooqi, I.S. and O'Rahilly, S. (2007) The hormonal control of food intake. Cell 129, 251-262.
28. Collins, C.A. and Kim, P.R. (2003) Prospects for obesity treatment: MCH receptor antagonists. Current Opinion in Investigational Drugs 4, 386-394.
29. Crowe, S., Turpin, S.M., Ke, F., Kemp, B.E. and Watt, M.J. (2008) Metabolic remodelling in adipocytes promotes CNTF-mediated fat loss in obesity. Endocrinology 149, 2546-2556.
30. Cummings, D.E. and Overduin, J. (2007) Gastrointestinal regulation of food intake. Journal of Clinical Investigation 117, 13-23.
31. Darkin, C.L. (2001) Oxyntomodulin inhibits food intake on the rat. Endocrinology 142, 4244-4252.
32. Darkin, C.L., Small, C.J., Batterham, R.L., Neary, N.M., Cohen, M.A., Patterson, M., Ghatei, M.A. and Bloom, S.R. (2004) Peripheral oxyntomodulin reduces food intake and body weight gain in rats. Endocrinology 145, 2687-2695.
33. Dautzenberg, M.F. and Hauger, R.L. (2002) The CRF peptide family and their receptors: yet more partners discovered. Trends in Pharmacological Sciences 23, 71-77.
34. Dhillon, H., Zigman, J.M., Ye, C., Lee, C.E., McGovern, R.A., Tang, V., Kenny, C.D., Christiansen, L.M., White, R.D., Edelstein, E.A., Coppari, R., Balthasar, N., Cowley, M.A., Chua, S. Jr, Elmquist, J.K. and Lowell, BB. (2006) Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal bodyweight homeostasis. Neuron 49, 191-203.
35. Druce, M.R., Small, C.J. and Bloom, S.R. (2004) Minireview: gut peptides regulating satiety. Endocrinology 145, 2660-2665.
36. Drucker, D.J. (2006) The biology of incretin hormones. Cell Metabolism 3,153-165.
37. Elmquist, J.K., Ahima, R.S., Elias, C.F., Flier, J.S. and Saper, C.B. (1998) Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Neurobiology 95, 741-746.
38. Enriori, P.J., Evans, A.E., Sinnayah, P., Jobst, E.E., Tonelli-Lemos, L., Billes, S.K., Glavas, M.M., Grayson, B.E., Perello, M., Nillni, E.A., Grove, K.L. and Cowley, M.A. (2007) Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metabolism 5, 181-194.
39. Farooqi, I.S. (2008) Monogenic human obesity. Frontiers of Hormone Research 36, 1-11.
40. Farooqi, I.S. and O'Rahilly, S. (2007) Genetic factors in human obesity. Obesity Reviews 8 (Suppl. 1), 37-40.
41. Farooqi, I.S., Matarese, G., Lord, G.M., Keogh, J.M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S.A., Perna, F., Fontana, S., Lechler, R.I., DePaoli, A.M. and O'Rahilly, S. (2002) Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/ metabolic dysfunction of human congenital leptin deficiency. Journal of Clinical Investigation 110, 1093-1103.
42. Farooqi, I.S., Keogh, J.M., Yeo, G.S.H., Lank, E.J., Cheetham, T. and O'Rahilly, S. (2003) Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. New England Journal of Medicine 348, 1085-1095.
43. Farooqi, I.S., Wangensteen, T., Collins, S., Kimber, W., Matarese, G., Keogh, J.M., Lank, E., Bottomley, B., Lopez-Fernandez, J., Ferraz-Amaro, I., Dattani, M.T., Ercan, O., Myhre, A.G., Retterstol, L., Stanhope, R., Edge, J.A., McKenzie, S., Lessan, N., Ghodsi, M., De Rosa, V., Perna, F., Fontana, S., Barroso, I., Undlien, D.E. and O'Rahilly, S. (2007) Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. New England Journal of Medicine 356, 237-247.
44. Febbraio, M.A. (2007) gp130 receptor ligands as potential therapeutic targets for obesity. Journal of Clinical Investigation 117, 841-849.
45. Flier, J.S. (2006) AgRP in energy balance: will the real AgRP please stand up?. Cell Metabolism 3, 83-85.
46. Friedman, J.M. and Halaas, J.L. (1998) Leptin and the regulation of body weight in mammals. Nature 395, 763-770.
47. Frühbeck, G. (2006) Intracellular signalling pathways activated by leptin. Biochemical Journal 393, 7-20.
48. Gao, Q. and Horvath, T.L. (2007) Neurobiology of feeding and energy expenditure. Annual Reviews in Neuroscience 30, 367-398.
49. Gao, Q. and Horvath, T.L. (2008) Neuronal control of energy homeostasis. FEBS Letters 582, 132-141.
50. Gibson, W.T., Farooqi, I.S., Moreau, M., DePaoli, A.M., Lawrence, E., O'Rahilly, S. and Trussell, R.A. (2004) Congenital leptin deficiency due to homozygosity for the Δ133G mutation: report of another case and evaluation of response to four years of leptin therapy. Journal of Clinical Endocrinology and Metabolism 89, 4821-4826.
51. Gray, J., Yeo, G.S., Cox, J.J., Morton, J., Adlam, A.L., Keogh, J.M., Yanovski, J.A., El Gharbawy, A., Han, J.C., Tung, Y.C., Hodges, J.R., Raymond, F.L., O'Rahilly, S. and Farooqi, I.S. (2006) Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes 55, 3366-3371.
52. Gray, J., Yeo, G.S., Hung, C., Keogh, J., Clayton, P., Banerjee, K., McAulay, A., O'Rahilly, S. and Farooqi, I.S. (2007) Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity. International Journal of Obesity 31, 359-364.
53. Halaas, J.L. and Friedman, J.M. (1997) Leptin and its receptor. Journal of Endocrinology 155, 215-216.
54. Han, Z., Yan, J.-Q., Luo, G.-G., Liu, Y. and Wang, Y.-L. (2003) Leptin receptor expression in the basolateral nucleus of amygdala of conditioned taste aversion rats. World Journal of Gastroenterology 9, 1034-1037.
55. Harrold, J.A. (2004) Leptin leads hypothalamic feeding circuits in a new direction. BioEssays 26, 1043-1045.
56. Havel, P.J. (2001) Peripheral signals conveying metabolic information to the brain: shortterm and long-term regulation of food intake and energy homeostasis. Experimental Biology and Medicine 226, 963-977.
57. Horvath, T.L. (2005) The hardship of obesity: a soft-wired hypothalamus. Nature Neuroscience 8, 561-565.
58. Hu, Z., Cha, S.H., Chohnan, S. and Lane, M.D. (2003) Hypothalamic malonyl-CoA as a mediator of feeding behavior. Proceedings of the National Academy of Sciences of the United States of America 100, 12624-12629.
59. Hukshorn, C.J. and Saris, W.H. (2004) Leptin and energy expenditure. Current Opinion in Clinical Nutrition and Metabolic Care 7, 629-633.
60. Huo, L., Grill, H.J. and Bjorbaek, C. (2006) Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus. Diabetes 55, 567-573.
61. Huszar, D., Lynch, C.A., Fairchild-Huntress, V., Dunmore, J.H., Fang, Q., Berkemeier, L.R., Gu, W., Kesterson, R.A., Boston, B.A., Cone, R.D., Smith, F.J., Campfield, L.A., Burn, P. and Lee, F. (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131-141.
62. Inui, A. (2000) Transgenic approach to the study of body weight regulation. Pharmacological Reviews 52, 35-61.
63. Inui, A. (2001) Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nature Reviews Neuroscience 2, 551-560.
64. Inui, A. (2003) Neuropeptide gene polymorphisms and human behavioural disorders. Nature Reviews Drug Discovery 2, 986-998.
65. Inui, A. (2004) Melanocortin signalling, single nucleotide polymorphism and eating disorders. International Journal of Psychiatry in Medicine 34, 397-401.
66. Jequier, E. (2002) Leptin signaling, adiposity and energy balance. Annals of the New York Academy of Sciences 967, 378-388.
67. Jequier, E. and Tappy, L. (1999) Regulation of body weight in humans. Physiological Reviews 79, 451-480.
68. Kalra, S.P. and Kalra, P.S. (2004) NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy. Neuropeptides 38, 201-211.
69. Kamiji, M.M. and Inui, A. (2007) Neuropeptide y receptor selective ligands in the treatment of obesity. Endocrine Reviews 28, 664-84.
70. Kim, E.K., Kleman, A.M. and Ronnett, G.V. (2007) Fatty acid synthase gene regulation in primary hypothalamic neurons. Neuroscience Letters 423, 200-204.
71. Klok, M.D., Jakobsdottir, S. and Drent, M.L. (2007) The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obesity Reviews 8, 21-34.
72. Knecht, S., Ellger, T. and Levine, J. A. (2008) Obesity in neurobiology. Progress in Neurobiology 84, 85-103.
73. Kokoeva, M.V., Yin, H. and Flier, J.S. (2005) Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science 310, 679-683.
74. Kokoeva, M.V., Yin, H. and Flier, J.S. (2007) Evidence for constitutive neural cell proliferation in the adult murine hypothalamus. Journal of Comparative Neurology 505, 209-220.
75. Konturek, S.J., Konturek, J.W., Pawlik, T. and Brzozowki, T. (2004) Brain-gut axis and its role in the control of food intake. Journal of Physiology and Pharmacology 55, 137-154.
76. Korner, J. and Aronne, J.L. (2003) The emerging science of body weight regulation and its impact on obesity treatment. The Journal of Clinical Investigation 111, 565-570.
77. Kristensen, P., Judge, M.E., Thim, L., Ribel, U., Christjansen, K.N., Wulff, B.S., Clausen, J.T., Jensen, P.B., Madsen, O.D., Vrang, N., Larsen, P.J. and Hastrup, S. (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393, 72-76.
78. La Cava, A. and Matarese, G. (2004) The weight of leptin in immunity. Nature Reviews Immunology 4, 371-379.
79. Lahlou, N., Issad, T., Lebouc, Y., Carel, J.C., Camoin, L., Roger, M. and Girard, J. (2002) Mutations in the human leptin and leptin receptor genes as models of serum leptin receptor regulation. Diabetes 51, 1980-1985.
80. Landree, L.E., Hanlon, A.L., Strong, D.W., Rumbaugh, G., Miller, I.M., Thupari, J.N., Connolly, E.C., Huganir, R.L., Richardson, C., Witters, L.A., Kuhajda, F.P. and Ronnett, G.V. (2004) C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism. Journal of Biological Chemistry 279, 3817-3827.
81. Lawrence, C.B., Ellacott, K.L.J. and Luckman, S.M. (2002) PRL-releasing peptide reduces food intake and may mediate satiety signaling. Endocrinology 143, 360-367.
82. Lee, Y.S., Challis, B.G., Thompson, D.A., Yeo, G.S., Keogh, J.M., Madonna, M.E., Wraight, V., Sims, M., Vatin, V., Meyre, D., Shield, J., Burren, C., Ibrahim, Z., Cheetham, T., Swift, P., Blackwood, A., Hung, C.C., Wareham, N.J., Froguel, P., Millhauser, G.L., O'Rahilly, S. and Farooqi, I.S. (2006) A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cellular Metabolism 3, 135-140.
83. Licinio, J., Caglayan, S., Ozata, M., Yildiz, B.O., de Miranda, P.B., O'Kirwan, F., Whitby, R., Liang, L., Cohen, P., Bhasin, S., Krauss, R.M., Veldhuis, J.D., Wagner, A.J., DePaoli, A.M., McCann, S.M. and Wong, ML. (2004) Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proceedings of the National Academy of Sciences of the United States of America 101, 4531-4536.
84. Loftus, T.M., Jaworsky, D.E., Frehywot, G.L., Towsend, C.A., Ronnett, G.V., Lane, M.D. and Kuhajda, F.P. (2000) Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288, 2379-2381.
85. López, M., Tovar, S., Vázquez, M.J., Williams, L.M. and Diéguez C. (2007) Peripheral tissue-brain interactions in the regulation of food intake. Proceedings of the Nutrition Society 66, 131-155.
86. McDuffie, J.R., Riggs, P.A., Calis, K.A., Freedman, R.J., Oral, E.A., DePaoli, A.M. and Yanovski, J.A. (2004) Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency. Journal of Clinical Endocrinology and Metabolism 89, 4258-4263.
87. Maffei, M., Halaas, J., Ravussin, E., Pratley, R.E., Lee, G.H., Zhang, Y., Fei, H. and Kim, S. (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjected. Nature Medicine 1, 1155-1161.
88. Martin, R.L., Perez, E., He, Y.J., Dawson, R. Jr and Millard, W.J. (2000) Leptin resistance is associated with hypothalamic leptin receptor mRNA and protein downregulation. Metabolism 49, 1479-1484.
89. Mergen, M., Mergen, H., Ozata, M., Oner, R. and Oner, C. (2001) A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity. Journal of Clinical Endocrinology and Metabolism 86, 3448-3451.
90. Miller, I., Ronnett, G.V., Moran, T.H. and Aja, S. (2004) Anorexigenic C75 alters c-Fos in mouse hypothalamic and hindbrain subnuclei. Neuroreport for Rapid Communication of Neuroscience Research 15, 925-929.
91. Miraglia Del Giudice, E., Cirillo, G., Nigro, V., Santoro, N., D'Urso, L., Raimondo, P., Cozzolino, D., Scafato, D. and Perrone L. (2002) Low frequency of melanocortin-4 receptor (MC4R) mutations in a Mediterranean population with early-onset obesity. International Journal of Obesity 26, 647-651.
92. Montague, C.T., Farooqi, I.S., Whitehead, J.P., Soos, M.A., Rau, H. and Wareham, N.J. (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903-908.
93. Moran, O. and Phillip, M. (2003) Leptin: obesity, diabetes and other peripheral effects -a review. Pediatric Diabetes 4, 101-109.
94. Moran, T.H. (2006) Gut peptide signaling in the controls of food intake. Obesity 14 (Suppl. 5), 250S-253S.
95. Morton, G.J., Cummings, D.E., Baskin, D.G., Barsh, G.S. and Schwartz, M.W. (2006) Central nervous system control of food intake and body weight. Nature 443, 289-295.
96. Niswender, K.D. and Schwartz, M.W. (2003) Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Frontiers in Neuroendocrinology 24, 1-10.
97. Nogueiras, R., Wiedmer, P., Perez-Tilve, D., Veyrat-Durebex, C., Keogh, J.M., Sutton, G.M., Pfluger, P.T., Castaneda, T.R., Neschen, S., Hofmann, S.M., Howles, P.N., Morgan, D.A., Benoit, S.C., Szanto, I., Schrott, B., Schürmann, A., Joost, H.G., Hammond, C., Hui, D.Y., Woods, S.C., Rahmouni, K., Butler, A.A., Farooqi, I.S., O'Rahilly, S., Rohner-Jeanrenaud, F. and Tschöp, M.H. (2007) The central melanocortin system directly controls peripheral lipid metabolism. Journal of Clinical Investigation 117, 3475-3488.
98. Patel, H.R., Qi, Y., Hawkins, E.J., Hileman, S.M., Elmquist, J.K., Imai, Y. and Ahima, R.S. (2006) Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice. Diabetes 55, 3091-3098.
99. Peters, J.H., McKay, B.M., Simasko, S.M. and Ritter, R.C. (2005) Leptin-induced satiation mediated by abdominal vagal afferents. American Journal of Physiology -Regulatory, Integrative and Comparative Physiology 288, R879-R884.
100. Peters, J.H., Simasko, S.M. and Ritter, R.C. (2007) Leptin analog antagonizes leptin effects on food intake and body weight but mimics leptin-induced vagal afferent activation. Endocrinology 148, 2878-2885.
101. Petrovich, G.D., Setlow, B., Holland, P.C. and Gallagher, M. (2002) Amygdalo-hypothalamic circuit allows learned cues to override satiety and promote eating. Journal of Neuroscience 22, 8748-8753.
102. Pinto, S., Roseberry, A.G., Liu, H., Diano, S., Shanabrough, M., Cai, X., Friedman, J.M. and Horvath, T.L. (2004) Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304, 110-115.
103. Pliquett, R.U., Führer, D., Falk, S., Zysset, S., von Cramon, D.Y. and Stumvoll, M. (2006) The effects of insulin on the central nervous system -focus on appetite regulation. Hormone and Metabolic Research 38, 442-446.
104. Prolo, P., Wong, M.L. and Licinio, J. (1998) Leptin. International Journal of Biochemistry and Cell Biology 30, 1285-1290.
105. Ramos, E.J., Xu, Y., Romanova, I., Middleton, F., Chen, C., Quinn, R., Inui, A., Das, U. and Meguid, M.M. (2003) Is obesity an inflammatory disease?. Surgery 134, 329-335.
106. Richard, D., Huang, Q. and Timofeeva, E. (2000) The corticotropin-releasing hormone system in the regulation of energy balance in obesity. International Journal of Obesity 24, 36-39.
107. Richard, D., Lin, Q. and Timofeeva, E. (2002) The corticotropin-releasing factor family of peptides and CRF receptors: their roles in the regulation of energy balance. European Journal of Pharmacology 440, 189-197.
108. Rios, M., Fan, G., Fekete, C., Kelly, J., Bates, B., Kuehn, R., Lechan, R.M. and Jaenisch, R. (2001) Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Molecular Endocrinology 15, 1748-1757.
109. Sahu, A. (2004) Minireview: a hypothalamic role in energy balance with special emphasis on leptin. Endocrinology 145, 2613-2620.
110. Sarkar, S., Legradi, G. and Lechan, R.M. (2002) Intracerebroventricular administration of a-melanocyte-stimulating hormone increases phosphorylation of CREB in TRH-and CRH-producing neurons of the hypothalamic paraventricular nucleus. Brain Research 945, 50-59.
111. Savontaus, E., Breen, T.L., Kim, A., Yang, L.M., Chua, S.C. and Wardlaw, S.L. (2004) Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice. Endocrinology 145, 3881-3891.
112. Scarpace, P.J., Nicolson, M. and Matheny, M. (1998) UCP2, UCP3 and leptin gene expression: modulation by food restriction and leptin. Journal of Endocrinology 159, 349-357.
113. Schulz, C. and Lehnert, H. (2004) Central nervous and metabolic effects of intranasally applied leptin. Endocrinology 145, 2696-2701.
114. Schwartz, M.W., Baskin, D.G., Kaiyala, K.J. and Woods, S.C. (1999) Model for regulation of energy balance and adiposity by the central nervous system. American Journal of Clinical Nutrition 69, 584-596.
115. Schwartz, M.W., Woods, S.C., Seeley, R.J., Barsh, G.S., Baskin, D.G. and Leibel, R.L. (2003) Is the energy homeostasis system inherently biased toward weight gain?. Diabetes 52, 232-238.
116. Seeley, R.J. (2005) More neurons, less weight. Nature Medicine 11, 1276-1278.
117. Seeley, R.J. and Woods, S.C. (2003) Monitoring of stored and available fuel by the CNS: implications for obesity. Nature Reviews Neuroscience 4, 901-909.
118. Seeley, R.J., Yagaloff, K.A., Fisher, S.L., Burn, P., Thiele, T.E., van Dijk, G., Baskin, D.G. and Schwartz, M.W. (1997) Melanocortin receptors in leptin effects. Nature 390, 349.
119. Shimizu, H., Inoue, K. and Mori, M. (2007) The leptin-dependent and -independent melanocortin signaling system: regulation of feeding and energy expenditure. Journal of Endocrinology 193, 1-9.
120. Tabarin, A., Diz-Chaves, Y., Consoli, D., Monsaingeon, M., Bale, T.L., Culler, M.D., Datta, R., Drago, F., Vale, W.W., Koob, G.F., Zorrilla, E.P. and Contarino, A. (2007) Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis. European Journal of Neuroscience 26, 2303-2314.
121. Tartaglia, L.A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G.J., Campfield, L.A., Clark, F.T., Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, K.J., Smutko, J.S., Mays, G.G., Woolf, E.A., Monroe, C.A. and Tepper, R.I. (1995) Identifi-cation and expression cloning of a leptin receptor, OB-R. Cell 83, 1263-1271.
122. Tilg, H. and Moschen, A.R. (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nature Reviews Immunology 6, 772-783.
123. Tsuruta, Y., Yoshimatsu, H., Hidaka, S., Kondou, S., Okamoto, K. and Sakata, T. (2002) Hyperleptinemia in Ay/a mice upregulates arcuate cocaine-and amphetamineregulated transcript expression. American Journal of Physiology -Endocrinology and Metabolism 282, 967-973.
124. Tu, Y., Thupari, J.N., Kim, E.-K., Pinn, M.L., Moran, T.H., Ronnett, G.V. and Kuhajda, F.P. (2005) C75 alters central and peripheral gene expression to reduce food intake and increase energy expenditure. Endocrinology 146, 486-493.
125. Unger, T.J., Calderon, G.A., Bradley, L.C., Sena-Esteves, M. and Rios, M. (2007) Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. Journal of Neuroscience 27, 14265-14274.
126. Valassi, E., Scacchi, M. and Cavagnini, F. (2008) Neuroendocrine control of food intake. Nutrition, Metabolism and Cardiovascular Diseases 18, 158-168.
127. Watt, M.J., Dzamko, N., Thomas, W.G., Rose-John, S., Ernst, M., Carling, D., Kemp, B.E., Febbraio, M.A. and Steinberg, G.R. (2006) CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nature Medicine 12, 541-548.
128. Woods, S.C. (2005) Signals that influence food intake and body weight. Physiology and Behavior 86, 709-716.
129. Xu, B., Goulding, E.H., Zang, K., Cepoi, D., Cone, R.D., Jones, K.R., Tecott, L.H. and Reichardt, L.F. (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nature Neuroscience 6, 736-742.
130. Yaswen, L., Diehl, N., Brennan, M.B. and Hochgeschwender, U. (1999) Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nature Medicine 5, 1066-1070.
131. Yeo, G.S., Connie Hung, C.C., Rochford, J., Keogh, J., Gray, J., Sivaramakrishnan, S., O'Rahilly, S. and Farooqi, I.S. (2004) A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nature Neuroscience 7, 1187-1189.
132. Zabolotny, J.M., Bence-Hanulec, K.K., Stricker-Krongrad, A.S., Haj, F., Wang, Y., Minokoshi, Y., Kim, Y.B., Elmquist, J.K., Tartaglia, L.A., Kahn, B.B. and Neel, B.G. (2002) PTP-1B regulates leptin signal transduction in vivo. Developmental Cell 2, 489-495.
133. Zorrilla, E.P., Inoue, K., Valdez, G.R., Tabarin, A. and Koob, G.F. (2005) Leptin and postprandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat. Psychopharmacology 177, 324-335.