Fatty acid synthase gene regulation in primary hypothalamic neurons

Neuroscience Letters

Volumn 423, Issue 3, 2007, Pages 200-204

  Kim, Eun Kyoung ^a,b,c   Kleman, Amy M ^a   Ronnett, Gabriele V ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Michigan State University   (United States)

^c East Lansing   (United States)

Author keywords

AICAR; Fatty acid synthase; Hypothalamus; Insulin; SREBP1c

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; C 75; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; GLUCOSE; INSULIN; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; FEEDING; FETUS; GENE CONTROL; GENE EXPRESSION REGULATION; HOMEOSTASIS; HYPOTHALAMUS; IMMUNOCYTOCHEMISTRY; NERVE CELL CULTURE; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACID SYNTHETASE COMPLEX; FETUS; GENE EXPRESSION REGULATION; GLUCOSE; HYPOTHALAMUS; INSULIN; NEURONS; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; RIBONUCLEOTIDES; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TIME FACTORS;

EID: 34548014993     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.06.056     Document Type: Article

References (25)

1. Andersson U., Filipsson K., Abbott C.R., Woods A., Smith K., Bloom S.R., Carling D., and Small C.J. AMP-activated protein kinase plays a role in the control of food intake. J. Biol. Chem. 279 (2004) 12005-12008
2. Azzout-Marniche D., Becard D., Guichard C., Foretz M., Ferre P., and Foufelle F. Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes. Biochem. J. 350 Pt 2 (2000) 389-393
3. Brown M.S., and Goldstein J.L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89 (1997) 331-340
4. Diraison F., Parton L., Ferre P., Foufelle F., Briscoe C.P., Leclerc I., and Rutter G.A. Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). Biochem. J. 378 (2004) 769-778
5. Frame S., Cohen P., and Biondi R.M. A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol. Cell 7 (2001) 1321-1327
6. Hardie D.G., and Hawley S.A. AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays 23 (2001) 1112-1119
7. Hasty A.H., Shimano H., Yahagi N., Amemiya-Kudo M., Perrey S., Yoshikawa T., Osuga J., Okazaki H., Tamura Y., Iizuka Y., Shionoiri F., Ohashi K., Harada K., Gotoda T., Nagai R., Ishibashi S., and Yamada N. Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level. J. Biol. Chem. 275 (2000) 31069-31077
8. Kim E.K., Miller I., Aja S., Landree L.E., Pinn M., McFadden J., Kuhajda F.P., Moran T.H., and Ronnett G.V. C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. J. Biol. Chem. 279 (2004) 19970-19976
9. Kim E.K., Miller I., Landree L.E., Borisy-Rudin F.F., Brown P., Tihan T., Townsend C.A., Witters L.A., Moran T.H., Kuhajda F.P., and Ronnett G.V. Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment. Am. J. Physiol. Endocrinol. Metab. 283 (2002) E867-E879
10. Kovacic S., Soltys C.L., Barr A.J., Shiojima I., Walsh K., and Dyck J.R. Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. J. Biol. Chem. 278 (2003) 39422-39427
11. Kumar M.V., Shimokawa T., Nagy T.R., and Lane M.D. Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. Proc. Natl. Acad. Sci. USA 99 (2002) 1921-1925
12. Leclerc I., Kahn A., and Doiron B. The 5′-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex. FEBS Lett. 431 (1998) 180-184
13. Loftus T.M., Jaworsky D.E., Frehywot G.L., Townsend C.A., Ronnett G.V., Lane M.D., and Kuhajda F.P. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288 (2000) 2379-2381
14. Mains R.E., and Eipper B.A. Phosphorylation of rat and human adrenocorticotropin-related peptides: physiological regulation and studies of secretion. Endocrinology 112 (1983) 1986-1995
15. Minokoshi Y., Alquier T., Furukawa N., Kim Y.B., Lee A., Xue B., Mu J., Foufelle F., Ferre P., Birnbaum M.J., Stuck B.J., and Kahn B.B. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428 (2004) 569-574
16. Roman E.A., Cesquini M., Stoppa G.R., Carvalheira J.B., Torsoni M.A., and Velloso L.A. Activation of AMPK in rat hypothalamus participates in cold-induced resistance to nutrient-dependent anorexigenic signals. J. Physiol. 568 (2005) 993-1001
17. Ronnett G.V., Kleman A.M., Kim E.K., Landree L.E., and Tu Y. Fatty acid metabolism, the central nervous system, and feeding. Obesity (Silver Spring) 14 Suppl 5 (2006) 201S-207S
18. Schwartz M., Woods S., Porte D.J., Seeley R., and Baskin D. Central nervous system control of food intake. Nature 404 (2000) 661-671
19. Sul H., and Wang D. Nutritional and hormonal regulation of enzymes in fat synthesis: studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription. Annu. Rev. Nutr. 18 (1998) 331-351
20. Sullivan J.E., Carey F., Carling D., and Beri R.K. Characterisation of 5′-AMP-activated protein kinase in human liver using specific peptide substrates and the effects of 5′-AMP analogues on enzyme activity. Biochem. Biophys. Res. Commun. 200 (1994) 1551-1556
21. Sundqvist A., Bengoechea-Alonso M.T., Ye X., Lukiyanchuk V., Jin J., Harper J.W., and Ericsson J. Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell Metab. 1 (2005) 379-391
22. Thupari J.N., Kim E.K., Moran T.H., Ronnett G.V., and Kuhajda F.P. Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. Am. J. Physiol. Endocrinol. Metab. 287 (2004) E97-E104
23. Tu Y., Thupari J.N., Kim E.K., Pinn M.L., Moran T.H., Ronnett G.V., and Kuhajda F.P. C75 alters central and peripheral gene expression to reduce food intake and increase energy expenditure. Endocrinology 146 (2005) 486-493
24. Wakil S.J., Stoops J.K., and Joshi V.C. Fatty acid synthesis and its regulation. Annu. Rev. Biochem. 52 (1983) 537-579
25. Wang D., and Sul H. Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. J. Biol. Chem. 273 (1998) 25420-25426