Leptin resistance is associated with hypothalamic leptin receptor mRNA and protein downregulation

Metabolism: Clinical and Experimental

Volumn 49, Issue 11, 2000, Pages 1479-1484

  Martin, Robin Leigh ^a   Perez, Evelyn ^a   He, Yun Ju ^a   Dawson, Ralph ^a   Millard, William J ^a  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN RECEPTOR; MESSENGER RNA;

ADOLESCENT; ANIMAL TISSUE; ANOREXIA; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FOOD INTAKE; GENE EXPRESSION; HORMONE RESISTANCE; HYPOTHALAMUS; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION;

EID: 0033756298     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1053/meta.2000.17695     Document Type: Article

References (29)

1. Positional cloning of the mouse obese gene and its human homologue
2. Weight-reducing effects of the plasma protein encoded by the obese gene
3. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
4. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
5. Effects of the obese gene product on body weight regulation in ob/ob mice
6. Radioimmunological measurement of leptin in plasma of obese and diabetic human subjects
7. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus
8. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
9. Serum-immunoreactive leptin concentrations in normal weight and obese humans
10. Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction
11. Abnormal splicing of the leptin receptor in diabetic mice
12. Direct stimulation of basal insulin secretion by physiological concentrations of leptin in pancreatic β-cells
13. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
14. Expression and characterization of a putative high affinity human soluble leptin receptor
15. Congenital leptin deficiency is associated with severe early-onset obesity in humans
16. Effects of recombinant leptin therapy in a child with congenital leptin deficiency
17. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
18. Diet-induced obese mice develop peripheral, but not central, resistance to leptin
19. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
20. Insulin-like growth factors in vitreous: Studies in control and diabetic subjects with neovascularization
21. Expression and localization of the leptin receptor in endocrine and neuroendocrine tissues of the rat
22. Leptin in human plasma is derived in part from the brain, and cleared by the kidneys
23. Leptin is released from the human brain: Influence of adiposity and gender
24. Attenuation of leptin-mediated effects by monosodium glutamate-induced arcuate nucleus damage
25. Energetic pursuit of leptin function
26. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
27. Leptin enters the brain by a saturable system independent of insulin
28. Unraveling the central nervous system pathways underlying responses to leptin
29. Modulation of brain reward circuitry by leptin