Prospects for obesity treatment: MCH receptor antagonists

Current Opinion in Investigational Drugs

Volumn 4, Issue 4, 2003, Pages 386-394

  Collins, Christine A ^a   Kym, Philip R ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Food intake; Melanin concentrating hormone; MHC; Obesity; SLC 1

Indexed keywords

4 AMINOPIPERADINE DERIVATIVE; AMIDE; ANTIOBESITY AGENT; APPETITE STIMULANT; BENZAZEPINE DERIVATIVE; BENZAZEPINONE DERIVATIVE; BENZYLPIPERIDINE DERIVATIVE; COMPOUND 6422358; DEXFENFLURAMINE; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; INOSITOL PHOSPHATE; MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONIST; MELANIN CONCETRATING HORMONE RECEPTOR 1; MELANIN CONCETRATING HORMONE RECEPTOR 1 ANTAGONIST; MELANIN CONCETRATING HORMONE RECEPTOR 2; MITOGEN ACTIVATED PROTEIN KINASE; N (6 DIMETHYLAMINOMETHYL 5,6,7,8 TETRAHYDRO 2 NAPHTHYL) 4' FLUORO 1,1' BIPHENYL 4 CARBOXAMIDE; NAPHTHALENE DERIVATIVE; NEUROPEPTIDE Y; OREXIN; PIPERIDINE DERIVATIVE; QUINOLINE DERIVATIVE; SNAP 7941; SOMATOSTATIN; TETRACYCLIC PIPERIDINE DERIVATIVE; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE;

ANXIETY DISORDER; BODY WEIGHT; DEPRESSION; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; DRUG STRUCTURE; ENERGY EXPENDITURE; ENERGY METABOLISM; FEEDING BEHAVIOR; FOOD DRUG INTERACTION; FOOD INTAKE; GENETICS; HORMONAL REGULATION; HUMAN; IC 50; IN VIVO STUDY; NONHUMAN; OBESITY; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; WEIGHT REDUCTION;

AMINO ACID SEQUENCE; ANIMALS; ANTI-OBESITY AGENTS; BODY WEIGHT; HUMANS; HYPOTHALAMIC HORMONES; MELANINS; MOLECULAR SEQUENCE DATA; OBESITY; PITUITARY HORMONES;

EID: 0037869116     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (77)

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65. Synaptic Pharma Corp (Lagu B, Wetzel J, Marzabadi MR, Deleon JE, Gluchowski C, Noble S, Nagarathnam D, Chiu G): Preparation and use of arylpyrimidines as selective melanin concentrating hormone-1 (MCH-1) receptor antagonists. WO-00206245 (2002).
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