The emerging science of body weight regulation and its impact on obesity treatment

Journal of Clinical Investigation

Volumn 111, Issue 5, 2003, Pages 565-570

  Korner, Judith ^a   Aronne, Louis J ^b  

^a Columbia Univ Coll of Phys/Surg ^*  (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; AMFEBUTAMONE; AMFEPRAMONE; ANOREXIGENIC AGENT; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; CANNABINOID RECEPTOR ANTAGONIST; CHOLECYSTOKININ; DEXFENFLURAMINE; FATTY ACID; GASTRIC INHIBITORY POLYPEPTIDE; GHRELIN; GROWTH HORMONE; INSULIN; INSULIN RECEPTOR; INTERMEDIN DERIVATIVE; LEPTIN; LEPTIN RECEPTOR; LIOTHYRONINE; MELANOCORTIN; MELANOCORTIN RECEPTOR; METFORMIN; METHAMPHETAMINE; PEPTIDE YY; PHENTERMINE; PHENTERMINE RESIN; PROOPIOMELANOCORTIN; RECOMBINANT CILIARY NEUROTROPHIC FACTOR; SIBUTRAMINE; TETRAHYDROLIPSTATIN; THYROXINE; TOPIRAMATE; UNINDEXED DRUG;

ADIPOSE TISSUE; ARTICLE; BEHAVIOR THERAPY; BODY MASS; BODY WEIGHT; CARDIOTOXICITY; CLINICAL TRIAL; CONSTIPATION; DIET THERAPY; EXERCISE; GASTROPLASTY; HEALTH CARE COST; HOMEOSTASIS; HUMAN; HYPOTHALAMUS; INSOMNIA; LIMBIC SYSTEM; LUNG TOXICITY; NONHUMAN; OBESITY; PRIORITY JOURNAL; STOMACH BYPASS; XEROSTOMIA;

EID: 0037370258     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI17953     Document Type: Article

References (26)

1. Bjørbæk, C., Elmquist, J.K., Frantz, J.D., Shoelson, S.E., and Flier, J.S. 1998. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell. 1:619-625.
2. Leibel, R.L. 2002. The role of leptin in the control of body weight. Nutr. Rev. 60:S15-S19.
3. Borowsky, B., et al. 2002. Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nat. Med. 8:825-830.
4. Tritos, N.A., and Maratos-Flier, E. 1999. Two important systems in energy homeostasis: melanocortins and melanin-concentrating hormone. Neuropeptides. 33:339-349.
5. Di Marzo, V., et al. 2001. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature. 410:822-825.
6. Wardlaw, S.L. 2001. Clinical review 127: Obesity as a neuroendocrine disease: lessons to be learned from proopiomelanocortin and melanocortin receptor mutations in mice and men. J. Clin. Endocrinol. Metab. 86:1442-1446.
7. Air, E.L., et al. 2002. Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity. Nat. Med. 8:179-183.
8. Obici, S., Feng, Z., Karkanias, G., Baskin, D.G., and Rossetti, L. 2002. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat. Neurosci. 5:566-572.
9. Nakazato, M., et al. 2001. A role for ghrelin in the central regulation of feeding. Nature. 409:194-198.
10. Cummings, D.E., et al. 2002. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N. Engl. J. Med. 346:1623-1630.
11. English, P.J., Ghatei, M.A., Malik, I.A., Bloom, S.R., and Wilding, J.P. 2002. Food fails to suppress ghrelin levels in obese humans. J. Clin. Endocrinol. Metab. 87:2984-2987.
12. (3-36) physiologically inhibits food intake. Nature. 418:650-654.
13. Miyawaki, K., et al. 2002. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat. Med. 8:738-742.
14. Abu-Elheiga, L., Matzuk, M.M., Abo-Hashema, K.A., and Wakil, S.J. 2001. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science. 291:2613-2616.
15. Loftus, T. M., et al. 2000. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science. 288:2379-2381.
16. Makimura, H., et al. 2001. Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting. Diabetes. 50:733-739.
17. Fruebis, J., et al. 2001. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. U. S. A. 98:2005-2010.
18. Leibel, R.L., Rosenbaum, M., and Hirsch, J. 1995. Changes in energy expenditure resulting from altered body weight. N. Engl. J. Med. 332:621-628.
19. Ahima, R.S., et al. 1996. Role of leptin in the neuroendocrine response to fasting. Nature. 382:250-252.
20. Legradi, G., Emerson, C.H., Ahima, R.S., Flier, J.S., and Lechan, R.M. 1997. Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology. 138:2569-2576.
21. Korner, J., et al. 2001. Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus. J. Neuroendocrinol. 13:959-966.
22. Rosenbaum, M., Murphy, E.M., Heymsfield, S.B., Matthews, D.E., and Leibel, R.L. 2002. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J. Clin. Endocrinol. Metab 87:2391-2394.
23. Knowler, W.C., et al. 2002. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346:393-403.
24. National Institutes of Health, National Heart Lung and Blood Institute, and North American Association for the Study of Obesity. 2000. The practical guide: identification, evaluation, and treatment of overweight and obesity in adults. NIH. Bethesda, Maryland, USA. Publication no. 00-4084.
25. Lee, C.D., Blair, S.N., and Jackson, A.S. 1999. Cardiorespiratory fitness, body composition, and all-cause and cardiovascular disease mortality in men. Am. J. Clin. Nutr. 69:373-380.
26. Pories, W.J., et al. 1995. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann. Surg. 222:339-350.