B-lymphocyte lineage cells and the respiratory system

Journal of Allergy and Clinical Immunology

Volumn 131, Issue 4, 2013, Pages 933-957

  Kato, Atsushi ^a   Hulse, Kathryn E ^a   Tan, Bruce K ^a   Schleimer, Robert P ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

B cells; plasma cells; plasmablasts; respiratory diseases

Indexed keywords

APRIL PROTEIN; ATACICEPT; B LYMPHOCYTE RECEPTOR; BELIMUMAB; CD40 ANTIGEN; ENOKIZUMAB; IMMUNOGLOBULIN; INACTIVATED VACCINE; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 21; INTERLEUKIN 24; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 9; LEBRIKIZUMAB; LIVE VACCINE; MEASLES VACCINE; PITRAKINRA; RITUXIMAB; RONTALIZUMAB; SIFALIMUMAB; SILTUXIMAB; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRALOKINUMAB;

ADAPTIVE IMMUNITY; ADENOID; ALLERGIC PNEUMONITIS; ALLERGIC RHINITIS; ASTHMA; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL DIFFERENTIATION; CELL EXPANSION; CELL HOMING; CELL LINE; CELL LINEAGE; CELL STRUCTURE; CELL SURVIVAL; CHRONIC DISEASE; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC OBSTRUCTIVE LUNG DISEASE; DENDRITIC CELL; FIBROSING ALVEOLITIS; HUMAN; HUMORAL IMMUNE DEFICIENCY; IMMUNOGLOBULIN PRODUCTION; LOWER RESPIRATORY TRACT; LUNG GRAFT REJECTION; LYMPH FOLLICLE; NEOPLASM; NONHODGKIN LYMPHOMA; NONHUMAN; NOSE POLYP; PLASMA CELL; PRIORITY JOURNAL; RESPIRATORY SYSTEM; REVIEW; RHEUMATOID ARTHRITIS; SENSITIZATION; SIGNAL TRANSDUCTION; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; UPPER RESPIRATORY TRACT; WALDEYER RING;

ANTIGENS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINEAGE; DENDRITIC CELLS, FOLLICULAR; HUMANS; IMMUNITY, HUMORAL; IMMUNOGLOBULINS; INFLAMMATION; LYMPH NODES; LYMPHOCYTE ACTIVATION; PALATINE TONSIL; PLASMA CELLS; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION;

EID: 84875745151     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.02.023     Document Type: Review

References (254)

1. S. Salvi, and S.T. Holgate Could the airway epithelium play an important role in mucosal immunoglobulin A production? Clin Exp Allergy 29 1999 1597 1605 (Pubitemid 30012417)
2. J.P. Drolet, H. Frangie, J. Guay, O. Hajoui, Q. Hamid, and B.D. Mazer B lymphocytes in inflammatory airway diseases Clin Exp Allergy 40 2010 841 849
3. D.S. Wilkes, and H.L. Twigg 3rd B-lymphocytes in the lung: a topic to be revisited Sarcoidosis Vasc Diffuse Lung Dis 18 2001 34 49 (Pubitemid 32280535)
4. P. Brandtzaeg Potential of nasopharynx-associated lymphoid tissue for vaccine responses in the airways Am J Respir Crit Care Med 183 2011 1595 1604
5. T. Kurosaki, H. Shinohara, and Y. Baba B cell signaling and fate decision Annu Rev Immunol 28 2010 21 55
6. S. Pillai, and A. Cariappa The follicular versus marginal zone B lymphocyte cell fate decision Nat Rev Immunol 9 2009 767 777
7. J.C. Weill, S. Weller, and C.A. Reynaud Human marginal zone B cells Annu Rev Immunol 27 2009 267 285
8. E. Montecino-Rodriguez, H. Leathers, and K. Dorshkind Identification of a B-1 B cell-specified progenitor Nat Immunol 7 2006 293 301
9. N. Baumgarth The double life of a B-1 cell: self-reactivity selects for protective effector functions Nat Rev Immunol 11 2011 34 46
10. K.M. Ansel, R.B. Harris, and J.G. Cyster CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity Immunity 16 2002 67 76 (Pubitemid 34143217)
11. R. Berland, and H.H. Wortis Origins and functions of B-1 cells with notes on the role of CD5 Annu Rev Immunol 20 2002 253 300 (Pubitemid 34293426)
12. T. Dorner, N. Kinnman, and P.P. Tak Targeting B cells in immune-mediated inflammatory disease: a comprehensive review of mechanisms of action and identification of biomarkers Pharmacol Ther 125 2010 464 475
13. Y.S. Choi, and N. Baumgarth Dual role for B-1a cells in immunity to influenza virus infection J Exp Med 205 2008 3053 3064
14. D.O. Griffin, and T.L. Rothstein Human b1 cell frequency: isolation and analysis of human b1 cells Front Immunol 3 2012 122
15. D.O. Griffin, N.E. Holodick, and T.L. Rothstein Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70 J Exp Med 208 2011 67 80
16. D.O. Griffin, and T.L. Rothstein A small CD11b(+) human B1 cell subpopulation stimulates T cells and is expanded in lupus J Exp Med 208 2011 2591 2598
17. D.O. Griffin, and T.L. Rothstein Human "orchestrator" CD11b(+) B1 cells spontaneously secrete interleukin-10 and regulate T-cell activity Mol Med 18 2012 1003 1008
18. C.F. Inman, T.Z. Murray, M. Bailey, and S. Cose Most B cells in non-lymphoid tissues are naive Immunol Cell Biol 90 2012 235 242
19. D.M. Carragher, J. Rangel-Moreno, and T.D. Randall Ectopic lymphoid tissues and local immunity Semin Immunol 20 2008 26 42
20. K. Reif, E.H. Ekland, L. Ohl, H. Nakano, M. Lipp, and R. Forster Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position Nature 416 2002 94 99 (Pubitemid 34215407)
21. J.G. Cyster B cell follicles and antigen encounters of the third kind Nat Immunol 11 2010 989 996
22. T. Okada, M.J. Miller, I. Parker, M.F. Krummel, M. Neighbors, and S.B. Hartley Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells PLoS Biol 3 2005 e150
23. C.C. Goodnow, C.G. Vinuesa, K.L. Randall, F. Mackay, and R. Brink Control systems and decision making for antibody production Nat Immunol 11 2010 681 688
24. A. Bergtold, D.D. Desai, A. Gavhane, and R. Clynes Cell surface recycling of internalized antigen permits dendritic cell priming of B cells Immunity 23 2005 503 514 (Pubitemid 41587890)
25. F. Mackay, and P. Schneider Cracking the BAFF code Nat Rev Immunol 9 2009 491 502
26. T.D. Chan, D. Gatto, K. Wood, T. Camidge, A. Basten, and R. Brink Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts J Immunol 183 2009 3139 3149
27. A. Inamine, Y. Takahashi, N. Baba, K. Miyake, T. Tokuhisa, and T. Takemori Two waves of memory B-cell generation in the primary immune response Int Immunol 17 2005 581 589 (Pubitemid 41417855)
28. D. Paus, T.G. Phan, T.D. Chan, S. Gardam, A. Basten, and R. Brink Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation J Exp Med 203 2006 1081 1091
29. T.D. Chan, S. Gardam, D. Gatto, V.M. Turner, J. Silke, and R. Brink In vivo control of B-cell survival and antigen-specific B-cell responses Immunol Rev 237 2010 90 103
30. D. Gatto, K. Wood, and R. Brink EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center J Immunol 187 2011 4621 4628
31. J.P. Pereira, L.M. Kelly, and J.G. Cyster Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses Int Immunol 22 2010 413 419
32. S. Hannedouche, J. Zhang, T. Yi, W. Shen, D. Nguyen, and J.P. Pereira Oxysterols direct immune cell migration via EBI2 Nature 475 2011 524 527
33. C. Liu, X.V. Yang, J. Wu, C. Kuei, N.S. Mani, and L. Zhang Oxysterols direct B-cell migration through EBI2 Nature 475 2011 519 523
34. M.J. Shlomchik, and F. Weisel Germinal center selection and the development of memory B and plasma cells Immunol Rev 247 2012 52 63
35. L.J. McHeyzer-Williams, and M.G. McHeyzer-Williams Antigen-specific memory B cell development Annu Rev Immunol 23 2005 487 513 (Pubitemid 40563178)
36. D. Gatto, and R. Brink The germinal center reaction J Allergy Clin Immunol 126 2010 898 909
37. C.G. Vinuesa, M.A. Linterman, C.C. Goodnow, and K.L. Randall T cells and follicular dendritic cells in germinal center B-cell formation and selection Immunol Rev 237 2010 72 89
38. J.B. Beltman, C.D. Allen, J.G. Cyster, and R.J. de Boer B cells within germinal centers migrate preferentially from dark to light zone Proc Natl Acad Sci U S A 108 2011 8755 8760
39. B.E. Barnett, M.L. Ciocca, R. Goenka, L.G. Barnett, J. Wu, and T.M. Laufer Asymmetric B cell division in the germinal center reaction Science 335 2012 342 344
40. S. Crotty Follicular helper CD4 T cells (TFH) Annu Rev Immunol 29 2011 621 663
41. C.D. Allen, T. Okada, and J.G. Cyster Germinal-center organization and cellular dynamics Immunity 27 2007 190 202 (Pubitemid 47284923)
42. M. Tsuji, N. Komatsu, S. Kawamoto, K. Suzuki, O. Kanagawa, and T. Honjo Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches Science 323 2009 1488 1492
43. J.E. Moyron-Quiroz, J. Rangel-Moreno, K. Kusser, L. Hartson, F. Sprague, and S. Goodrich Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity Nat Med 10 2004 927 934 (Pubitemid 39273733)
44. F.E. Lund, S. Partida-Sanchez, B.O. Lee, K.L. Kusser, L. Hartson, and R.J. Hogan Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza J Immunol 169 2002 5236 5243 (Pubitemid 35217195)
45. B.J. Lee, S. Santee, S. Von Gesjen, C.F. Ware, and S.R. Sarawar Lymphotoxin-alpha-deficient mice can clear a productive infection with murine gammaherpesvirus 68 but fail to develop splenomegaly or lymphocytosis J Virol 74 2000 2786 2792 (Pubitemid 30117590)
46. F. Aloisi, and R. Pujol-Borrell Lymphoid neogenesis in chronic inflammatory diseases Nat Rev Immunol 6 2006 205 217 (Pubitemid 43290990)
47. K.G. McDonald, J.S. McDonough, and R.D. Newberry Adaptive immune responses are dispensable for isolated lymphoid follicle formation: antigen-naive, lymphotoxin-sufficient B lymphocytes drive the formation of mature isolated lymphoid follicles J Immunol 174 2005 5720 5728 (Pubitemid 40593215)
48. A. Cerutti, K. Chen, and A. Chorny Immunoglobulin responses at the mucosal interface Annu Rev Immunol 29 2011 273 293
49. L. Cameron, Q. Hamid, E. Wright, Y. Nakamura, P. Christodoulopoulos, and S. Muro Local synthesis of epsilon germline gene transcripts, IL-4, and IL-13 in allergic nasal mucosa after ex vivo allergen exposure J Allergy Clin Immunol 106 2000 46 52 (Pubitemid 30482851)
50. H.J. Gould, and B.J. Sutton IgE in allergy and asthma today Nat Rev Immunol 8 2008 205 217 (Pubitemid 351323292)
51. H. Tezuka, Y. Abe, M. Iwata, H. Takeuchi, H. Ishikawa, and M. Matsushita Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells Nature 448 2007 929 933 (Pubitemid 47312771)
52. P. Brandtzaeg Mucosal immunity: induction, dissemination, and effector functions Scand J Immunol 70 2009 505 515
53. B. Corthesy Role of secretory immunoglobulin A and secretory component in the protection of mucosal surfaces Future Microbiol 5 2010 817 829
54. C.S. Kaetzel, J.K. Robinson, K.R. Chintalacharuvu, J.P. Vaerman, and M.E. Lamm The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA Proc Natl Acad Sci U S A 88 1991 8796 8800 (Pubitemid 21915442)
55. T.B. Tomasi Jr., E.M. Tan, A. Solomon, and R.A. Prendergast Characteristics of an immune system common to certain external secretions J Exp Med 121 1965 101 124
56. F.E. Johansen, E.S. Baekkevold, H.S. Carlsen, I.N. Farstad, D. Soler, and P. Brandtzaeg Regional induction of adhesion molecules and chemokine receptors explains disparate homing of human B cells to systemic and mucosal effector sites: dispersion from tonsils Blood 106 2005 593 600 (Pubitemid 40981256)
57. K. Sun, F.E. Johansen, L. Eckmann, and D.W. Metzger An important role for polymeric Ig receptor-mediated transport of IgA in protection against Streptococcus pneumoniae nasopharyngeal carriage J Immunol 173 2004 4576 4581 (Pubitemid 39280690)
58. A. Tjarnlund, A. Rodriguez, P.J. Cardona, E. Guirado, J. Ivanyi, and M. Singh Polymeric IgR knockout mice are more susceptible to mycobacterial infections in the respiratory tract than wild-type mice Int Immunol 18 2006 807 816 (Pubitemid 43779070)
59. S.S. Crago, S.J. Prince, R. Kulhavy, and J. Mestecky Molecular-cellular interactions in the secretory IgA system Adv Exp Med Biol 107 1978 209 217
60. C. Czerkinsky, S.J. Prince, S.M. Michalek, S. Jackson, M.W. Russell, and Z. Moldoveanu IgA antibody-producing cells in peripheral blood after antigen ingestion: evidence for a common mucosal immune system in humans Proc Natl Acad Sci U S A 84 1987 2449 2453 (Pubitemid 17082366)
61. P. Brandtzaeg, H. Kiyono, R. Pabst, and M.W. Russell Terminology: nomenclature of mucosa-associated lymphoid tissue Mucosal Immunol 1 2008 31 37
62. H. Kiyono, and S. Fukuyama NALT- versus Peyer's-patch-mediated mucosal immunity Nat Rev Immunol 4 2004 699 710 (Pubitemid 39223076)
63. M. Quiding-Jarbrink, G. Granstrom, I. Nordstrom, J. Holmgren, and C. Czerkinsky Induction of compartmentalized B-cell responses in human tonsils Infect Immun 63 1995 853 857
64. P.L. Ogra Effect of tonsillectomy and adenoidectomy on nasopharyngeal antibody response to poliovirus N Engl J Med 284 1971 59 64
65. K. Chen, W. Xu, M. Wilson, B. He, N.W. Miller, and E. Bengten Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils Nat Immunol 10 2009 889 898
66. J. Westermann, and R. Pabst How organ-specific is the migration of 'naive' and 'memory' T cells? Immunol Today 17 1996 278 282 (Pubitemid 26183492)
67. Y. Chvatchko, M.H. Kosco-Vilbois, S. Herren, J. Lefort, and J.Y. Bonnefoy Germinal center formation and local immunoglobulin E (IgE) production in the lung after an airway antigenic challenge J Exp Med 184 1996 2353 2360 (Pubitemid 27023734)
68. J.E. Moyron-Quiroz, J. Rangel-Moreno, L. Hartson, K. Kusser, M.P. Tighe, and K.D. Klonowski Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs Immunity 25 2006 643 654 (Pubitemid 44529043)
69. C.H. GeurtsvanKessel, M.A. Willart, I.M. Bergen, L.S. van Rijt, F. Muskens, and D. Elewaut Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice J Exp Med 206 2009 2339 2349
70. J. Rangel-Moreno, J.E. Moyron-Quiroz, L. Hartson, K. Kusser, and T.D. Randall Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenza Proc Natl Acad Sci U S A 104 2007 10577 10582 (Pubitemid 47185707)
71. J.G. Cyster Homing of antibody secreting cells Immunol Rev 194 2003 48 60 (Pubitemid 36886428)
72. S. Goya, H. Matsuoka, M. Mori, H. Morishita, H. Kida, and Y. Kobashi Sustained interleukin-6 signalling leads to the development of lymphoid organ-like structures in the lung J Pathol 200 2003 82 87 (Pubitemid 36592640)
73. B.R. Vuillemenot, J.F. Rodriguez, and G.W. Hoyle Lymphoid tissue and emphysema in the lungs of transgenic mice inducibly expressing tumor necrosis factor-alpha Am J Respir Cell Mol Biol 30 2004 438 448 (Pubitemid 38457177)
74. J.J. Lee, M.P. McGarry, S.C. Farmer, K.L. Denzler, K.A. Larson, and P.E. Carrigan Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma J Exp Med 185 1997 2143 2156 (Pubitemid 27265998)
75. K.G. Smith, and M.R. Clatworthy FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications Nat Rev Immunol 10 2010 328 343
76. K.A. Fairfax, A. Kallies, S.L. Nutt, and D.M. Tarlinton Plasma cell development: from B-cell subsets to long-term survival niches Semin Immunol 20 2008 49 58
77. S.A. Oracki, J.A. Walker, M.L. Hibbs, L.M. Corcoran, and D.M. Tarlinton Plasma cell development and survival Immunol Rev 237 2010 140 159
78. S. Hirokawa, H. Sato, I. Kato, and A. Kudo EBF-regulating Pax5 transcription is enhanced by STAT5 in the early stage of B cells Eur J Immunol 33 2003 1824 1829 (Pubitemid 37120853)
79. H. Kwon, D. Thierry-Mieg, J. Thierry-Mieg, H.P. Kim, J. Oh, and C. Tunyaplin Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors Immunity 31 2009 941 952
80. A. Kato, and R.P. Schleimer Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity Curr Opin Immunol 19 2007 711 720 (Pubitemid 350236807)
81. B.N. Lambrecht, and H. Hammad Biology of lung dendritic cells at the origin of asthma Immunity 31 2009 412 424
82. F. Mackay, W.A. Figgett, D. Saulep, M. Lepage, and M.L. Hibbs B-cell stage and context-dependent requirements for survival signals from BAFF and the B-cell receptor Immunol Rev 237 2010 205 225
83. M. Kraus, M.B. Alimzhanov, N. Rajewsky, and K. Rajewsky Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer Cell 117 2004 787 800 (Pubitemid 38748894)
84. M.P. Cancro Signalling crosstalk in B cells: managing worth and need Nat Rev Immunol 9 2009 657 661
85. A.H. Lazarus, K. Kawauchi, M.J. Rapoport, and T.L. Delovitch Antigen-induced B lymphocyte activation involves the p21ras and ras.GAP signaling pathway J Exp Med 178 1993 1765 1769 (Pubitemid 23318455)
86. L.B. King, and B.D. Freedman B-lymphocyte calcium influx Immunol Rev 231 2009 265 277
87. R.C. Rickert Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex Curr Opin Immunol 17 2005 237 243 (Pubitemid 40692657)
88. N.E. Harwood, and F.D. Batista Early events in B cell activation Annu Rev Immunol 28 2010 185 210
89. T. Kurosaki Regulation of B-cell signal transduction by adaptor proteins Nat Rev Immunol 2 2002 354 363 (Pubitemid 37328758)
90. I. Yusuf, X. Zhu, M.G. Kharas, J. Chen, and D.A. Fruman Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors Blood 104 2004 784 787 (Pubitemid 38970574)
91. M.E. Conley, A.K. Dobbs, D.M. Farmer, S. Kilic, K. Paris, and S. Grigoriadou Primary B cell immunodeficiencies: comparisons and contrasts Annu Rev Immunol 27 2009 199 227
92. M.C. van Zelm, J. Smet, B. Adams, F. Mascart, L. Schandene, and F. Janssen CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency J Clin Invest 120 2010 1265 1274
93. H. Eibel, U. Salzer, and K. Warnatz Common variable immunodeficiency at the end of a prospering decade: towards novel gene defects and beyond Curr Opin Allergy Clin Immunol 10 2010 526 533
94. L. Alinari, B. Christian, and R.A. Baiocchi Novel targeted therapies for mantle cell lymphoma Oncotarget 3 2012 203 211
95. M.H. Buch, and P. Emery New therapies in the management of rheumatoid arthritis Curr Opin Rheumatol 23 2011 245 251
96. K.T. Flaherty, J.R. Infante, A. Daud, R. Gonzalez, R.F. Kefford, and J. Sosman Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations N Engl J Med 367 2012 1694 1703
97. H. Kantarjian, P. le Coutre, J. Cortes, J. Pinilla-Ibarz, A. Nagler, and A. Hochhaus Phase 1 study of INNO-406, a dual Abl/Lyn kinase inhibitor, in Philadelphia chromosome-positive leukemias after imatinib resistance or intolerance Cancer 116 2010 2665 2672
98. L. Lee, H. Niu, P. Goelzer, R. Rueger, J. Deutsch, and R. Busse-Reid The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of RO5068760, an MEK inhibitor, in healthy volunteers: assessment of target suppression J Clin Pharmacol 50 2010 1397 1405
99. S. Leijen, M.R. Middleton, P. Tresca, F. Kraeber-Bodere, V. Dieras, and M.E. Scheulen Phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of the MEK inhibitor RO4987655 (CH4987655) in patients with advanced solid tumors Clin Cancer Res 18 2012 4794 4805
100. L. Liu, J.S. Halladay, Y. Shin, S. Wong, M. Coraggio, and H. La Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor Drug Metab Dispos 39 2011 1840 1849
101. S.K. Pal, K. Reckamp, H. Yu, and R.A. Figlin Akt inhibitors in clinical development for the treatment of cancer Expert Opin Investig Drugs 19 2010 1355 1366
102. S.P. Patel, A.J. Lazar, N.E. Papadopoulos, P. Liu, J.R. Infante, and M.R. Glass Clinical responses to selumetinib (AZD6244; ARRY-142886)-based combination therapy stratified by gene mutations in patients with metastatic melanoma Cancer 119 2013 799 805
103. D. Singh, L. Smyth, Z. Borrill, L. Sweeney, and R. Tal-Singer A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients J Clin Pharmacol 50 2010 94 100
104. J. Vansteenkiste, R. Ramlau, J. von Pawel, B. San Antonio, C. Eschbach, and A. Szczesna A phase II randomized study of cisplatin-pemetrexed plus either enzastaurin or placebo in chemonaive patients with advanced non-small cell lung cancer Oncology 82 2012 25 29
105. D. Chen, M. Frezza, S. Schmitt, J. Kanwar, and Q.P. Dou Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives Curr Cancer Drug Targets 11 2011 239 253
106. S.V. Navarra, R.M. Guzman, A.E. Gallacher, S. Hall, R.A. Levy, and R.E. Jimenez Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial Lancet 377 2011 721 731
107. W. Stohl Biologic differences between various inhibitors of the BLyS/BAFF pathway: should we expect differences between belimumab and other inhibitors in development? Curr Rheumatol Rep 14 2012 303 309
108. M.V. Kopp Omalizumab: anti-IgE therapy in allergy Curr Allergy Asthma Rep 11 2011 101 106
109. S. Webb Attacks on asthma Nat Biotechnol 29 2011 860 863
110. S.J. Levine, and S.E. Wenzel Narrative review: the role of Th2 immune pathway modulation in the treatment of severe asthma and its phenotypes Ann Intern Med 152 2010 232 237
111. J. Corren, R.F. Lemanske, N.A. Hanania, P.E. Korenblat, M.V. Parsey, and J.R. Arron Lebrikizumab treatment in adults with asthma N Engl J Med 365 2011 1088 1098
112. P.J. Barnes The cytokine network in asthma and chronic obstructive pulmonary disease J Clin Invest 118 2008 3546 3556
113. K. Fizazi, J.S. De Bono, A. Flechon, A. Heidenreich, E. Voog, and N.B. Davis Randomised phase II study of siltuximab (CNTO 328), an anti-IL-6 monoclonal antibody, in combination with mitoxantrone/prednisone versus mitoxantrone/prednisone alone in metastatic castration-resistant prostate cancer Eur J Cancer 48 2012 85 93
114. M.F. Maurer, U. Garrigues, S.R. Jaspers, B. Meengs, M.W. Rixon, and B.L. Stevens Generation and characterization of human anti-human IL-21 neutralizing monoclonal antibodies MAbs 4 2012 69 83
115. T. Dorner, A. Radbruch, and G.R. Burmester B-cell-directed therapies for autoimmune disease Nat Rev Rheumatol 5 2009 433 441
116. R. Elgueta, M.J. Benson, V.C. de Vries, A. Wasiuk, Y. Guo, and R.J. Noelle Molecular mechanism and function of CD40/CD40L engagement in the immune system Immunol Rev 229 2009 152 172
117. A.C. Grammer, and P.E. Lipsky CD154-CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosus Arthritis Rheum 46 2002 1417 1429 (Pubitemid 34620186)
118. M. Muramatsu, K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai, and T. Honjo Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme Cell 102 2000 553 563
119. A.M. Vale, and H.W. Schroeder Jr. Clinical consequences of defects in B-cell development J Allergy Clin Immunol 125 2010 778 787
120. A. Chatzigeorgiou, M. Lyberi, G. Chatzilymperis, A. Nezos, and E. Kamper CD40/CD40L signaling and its implication in health and disease Biofactors 35 2009 474 483
121. W. Chalermskulrat, K.P. McKinnon, W.J. Brickey, I.P. Neuringer, R.C. Park, and D.G. Sterka Combined donor specific transfusion and anti-CD154 therapy achieves airway allograft tolerance Thorax 61 2006 61 67 (Pubitemid 43106980)
122. W.N. Khan B cell receptor and BAFF receptor signaling regulation of B cell homeostasis J Immunol 183 2009 3561 3567
123. K. Warnatz, U. Salzer, M. Rizzi, B. Fischer, S. Gutenberger, and J. Bohm B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans Proc Natl Acad Sci U S A 106 2009 13945 13950
124. F. Mackay, and P. Schneider TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties Cytokine Growth Factor Rev 19 2008 263 276
125. B. He, R. Santamaria, W. Xu, M. Cols, K. Chen, and I. Puga The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88 Nat Immunol 11 2010 836 845
126. P.F. Yong, J.E. Thaventhiran, and B. Grimbacher "A rose is a rose is a rose," but CVID is Not CVID common variable immune deficiency (CVID), what do we know in 2011? Adv Immunol 111 2011 47 107
127. R.C. Rickert, J. Jellusova, and A.V. Miletic Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease Immunol Rev 244 2011 115 133
128. A. Kato, A. Peters, L. Suh, R. Carter, K.E. Harris, and R. Chandra Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps J Allergy Clin Immunol 121 2008 1385 1392 e1-2
129. A. Kato, H. Xiao, R.T. Chustz, M.C. Liu, and R.P. Schleimer Local release of B cell-activating factor of the TNF family after segmental allergen challenge of allergic subjects J Allergy Clin Immunol 123 2009 369 375
130. F. Polverino, S. Baraldo, E. Bazzan, S. Agostini, G. Turato, and F. Lunardi A novel insight into adaptive immunity in chronic obstructive pulmonary disease: B cell activating factor belonging to the tumor necrosis factor family Am J Respir Crit Care Med 182 2010 1011 1019
131. J. Bilsborough, E. Chadwick, S. Mudri, X. Ye, W.R. Henderson Jr., and K. Waggie TACI-Ig prevents the development of airway hyperresponsiveness in a murine model of asthma Clin Exp Allergy 38 2008 1959 1968
132. T. Kawai, and S. Akira The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors Nat Immunol 11 2010 373 384
133. D. Chiron, I. Bekeredjian-Ding, C. Pellat-Deceunynck, R. Bataille, and G. Jego Toll-like receptors: lessons to learn from normal and malignant human B cells Blood 112 2008 2205 2213
134. M. Dorner, S. Brandt, M. Tinguely, F. Zucol, J.P. Bourquin, and L. Zauner Plasma cell toll-like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production Immunology 128 2009 573 579
135. K.M. Kelly-Scumpia, P.O. Scumpia, J.S. Weinstein, M.J. Delano, A.G. Cuenca, and D.C. Nacionales B cells enhance early innate immune responses during bacterial sepsis J Exp Med 208 2011 1673 1682
136. R. Baccala, K. Hoebe, D.H. Kono, B. Beutler, and A.N. Theofilopoulos TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity Nat Med 13 2007 543 551 (Pubitemid 46828489)
137. E.A. Leadbetter, I.R. Rifkin, A.M. Hohlbaum, B.C. Beaudette, M.J. Shlomchik, and A. Marshak-Rothstein Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors Nature 416 2002 603 607 (Pubitemid 34406754)
138. C.M. Lau, C. Broughton, A.S. Tabor, S. Akira, R.A. Flavell, and M.J. Mamula RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement J Exp Med 202 2005 1171 1177 (Pubitemid 41586947)
139. A. Marshak-Rothstein, and I.R. Rifkin Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease Annu Rev Immunol 25 2007 419 441 (Pubitemid 46697913)
140. J.J. Swigris, A. Fischer, J. Gillis, R.T. Meehan, and K.K. Brown Pulmonary and thrombotic manifestations of systemic lupus erythematosus Chest 133 2008 271 280
141. H. Gao, T. Neff, and P.A. Ward Regulation of lung inflammation in the model of IgG immune-complex injury Annu Rev Pathol 1 2006 215 242
142. J. Stavnezer, J.E. Guikema, and C.E. Schrader Mechanism and regulation of class switch recombination Annu Rev Immunol 26 2008 261 292 (Pubitemid 351600377)
143. L.M. Fawaz, E. Sharif-Askari, O. Hajoui, A. Soussi-Gounni, Q. Hamid, and B.D. Mazer Expression of IL-9 receptor alpha chain on human germinal center B cells modulates IgE secretion J Allergy Clin Immunol 120 2007 1208 1215 (Pubitemid 350029906)
144. D.T. Avery, V.L. Bryant, C.S. Ma, R. de Waal Malefyt, and S.G. Tangye IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4 J Immunol 181 2008 1767 1779
145. D.T. Avery, C.S. Ma, V.L. Bryant, B. Santner-Nanan, R. Nanan, and M. Wong STAT3 is required for IL-21-induced secretion of IgE from human naive B cells Blood 112 2008 1784 1793
146. T. Kishimoto Interleukin-6: from basic science to medicine - 40 years in immunology Annu Rev Immunol 23 2005 1 21 (Pubitemid 40563163)
147. A.T. Peters, A. Kato, N. Zhang, D.B. Conley, L. Suh, and B. Tancowny Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polyps J Allergy Clin Immunol 125 2010 397 403.e10
148. S. Malin, S. McManus, and M. Busslinger STAT5 in B cell development and leukemia Curr Opin Immunol 22 2010 168 176
149. D. Konforte, N. Simard, and C.J. Paige IL-21: an executor of B cell fate J Immunol 182 2009 1781 1787
150. T. Cupedo, N.K. Crellin, N. Papazian, E.J. Rombouts, K. Weijer, and J.L. Grogan Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells Nat Immunol 10 2009 66 74
151. M. Mitsdoerffer, Y. Lee, A. Jager, H.J. Kim, T. Korn, and J.K. Kolls Proinflammatory T helper type 17 cells are effective B-cell helpers Proc Natl Acad Sci U S A 107 2010 14292 14297
152. G. Maarof, L. Bouchet-Delbos, H. Gary-Gouy, I. Durand-Gasselin, R. Krzysiek, and A. Dalloul Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells Blood 115 2010 1718 1726
153. Z. Liu, Y. Zou, and A. Davidson Plasma cells in systemic lupus erythematosus: the long and short of it all Eur J Immunol 41 2011 588 591
154. A. Amoroso, S. Hafsi, L. Militello, A.E. Russo, Z. Soua, and M.C. Mazzarino Understanding rituximab function and resistance: implications for tailored therapy Front Biosci 16 2011 770 782
155. K.K. Donvik, and R. Omdal Churg-Strauss syndrome successfully treated with rituximab Rheumatol Int 31 2011 89 91
156. A.S. Debertin, T. Tschernig, H. Tonjes, W.J. Kleemann, H.D. Troger, and R. Pabst Nasal-associated lymphoid tissue (NALT): frequency and localization in young children Clin Exp Immunol 134 2003 503 507 (Pubitemid 37542092)
157. J. Bienenstock, and M.R. McDermott Bronchus- and nasal-associated lymphoid tissues Immunol Rev 206 2005 22 31 (Pubitemid 41105161)
158. H.S. Park, K.P. Francis, J. Yu, and P.P. Cleary Membranous cells in nasal-associated lymphoid tissue: a portal of entry for the respiratory mucosal pathogen group A streptococcus J Immunol 171 2003 2532 2537 (Pubitemid 37025563)
159. N. Ogasawara, T. Kojima, M. Go, K. Takano, R. Kamekura, and T. Ohkuni Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids Acta Otolaryngol 131 2011 116 123
160. P. Verbrugghe, P. Kujala, W. Waelput, P.J. Peters, and C.A. Cuvelier Clusterin in human gut-associated lymphoid tissue, tonsils, and adenoids: localization to M cells and follicular dendritic cells Histochem Cell Biol 129 2008 311 320
161. D.Y. Kim, A. Sato, S. Fukuyama, H. Sagara, T. Nagatake, and I.G. Kong The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens J Immunol 186 2011 4253 4262
162. R. Koshi, Y. Mustafa, and M.E. Perry Vimentin, cytokeratin 8 and cytokeratin 18 are not specific markers for M-cells in human palatine tonsils J Anat 199 2001 663 674 (Pubitemid 34023816)
163. A.S. Hiller, T. Tschernig, W.J. Kleemann, and R. Pabst Bronchus-associated lymphoid tissue (BALT) and larynx-associated lymphoid tissue (LALT) are found at different frequencies in children, adolescents and adults Scand J Immunol 47 1998 159 162 (Pubitemid 28122798)
164. S.J. Gould, and P.G. Isaacson Bronchus-associated lymphoid tissue (BALT) in human fetal and infant lung J Pathol 169 1993 229 234 (Pubitemid 23063461)
165. I. Heier, K. Malmstrom, A. Sajantila, J. Lohi, M. Makela, and F.L. Jahnsen Characterisation of bronchus-associated lymphoid tissue and antigen-presenting cells in central airway mucosa of children Thorax 66 2010 151 156
166. I. Richmond, G.E. Pritchard, T. Ashcroft, A. Avery, P.A. Corris, and E.H. Walters Bronchus associated lymphoid tissue (BALT) in human lung: its distribution in smokers and non-smokers Thorax 48 1993 1130 1134 (Pubitemid 23336831)
167. T. Tschernig, and R. Pabst Bronchus-associated lymphoid tissue (BALT) is not present in the normal adult lung but in different diseases Pathobiology 68 2000 1 8 (Pubitemid 30434161)
168. T. Tschernig, W.J. Kleemann, and R. Pabst Bronchus-associated lymphoid tissue (BALT) in the lungs of children who had died from sudden infant death syndrome and other causes Thorax 50 1995 658 660
169. S. Delventhal, A. Brandis, H. Ostertag, and R. Pabst Low incidence of bronchus-associated lymphoid tissue (BALT) in chronically inflamed human lungs Virchows Arch B Cell Pathol Incl Mol Pathol 62 1992 271 274
170. P. Brandtzaeg, I.N. Farstad, F.E. Johansen, H.C. Morton, I.N. Norderhaug, and T. Yamanaka The B-cell system of human mucosae and exocrine glands Immunol Rev 171 1999 45 87 (Pubitemid 29504711)
171. N.Y. Zheng, K. Wilson, X. Wang, A. Boston, G. Kolar, and S.M. Jackson Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells J Clin Invest 113 2004 1188 1201 (Pubitemid 38544104)
172. C. Cunningham-Rundles, and P.P. Ponda Molecular defects in T- and B-cell primary immunodeficiency diseases Nat Rev Immunol 5 2005 880 892 (Pubitemid 41581669)
173. C. Cunningham-Rundles Lung disease, antibodies and other unresolved issues in immune globulin therapy for antibody deficiency Clin Exp Immunol 157 suppl 1 2009 12 16
174. R.H. Buckley Pulmonary complications of primary immunodeficiencies Paediatr Respir Rev 5 suppl A 2004 S225 S233
175. A.A. Jesus, A.J. Duarte, and J.B. Oliveira Autoimmunity in hyper-IgM syndrome J Clin Immunol 28 suppl 1 2008 S62 S66
176. S.M. Holland, F.R. DeLeo, H.Z. Elloumi, A.P. Hsu, G. Uzel, and N. Brodsky STAT3 mutations in the hyper-IgE syndrome N Engl J Med 357 2007 1608 1619 (Pubitemid 47598403)
177. A. Meyer-Bahlburg, E.D. Renner, S. Rylaarsdam, J. Reichenbach, L.F. Schimke, and A. Marks Heterozygous signal transducer and activator of transcription 3 mutations in hyper-IgE syndrome result in altered B-cell maturation J Allergy Clin Immunol 129 2012 559 562 e1-2
178. A.M. Siegel, J. Heimall, A.F. Freeman, A.P. Hsu, E. Brittain, and J.M. Brenchley A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory Immunity 35 2011 806 818
179. C. Speckmann, A. Enders, C. Woellner, D. Thiel, A. Rensing-Ehl, and M. Schlesier Reduced memory B cells in patients with hyper IgE syndrome Clin Immunol 129 2008 448 454
180. C. Cunningham-Rundles Autoimmune manifestations in common variable immunodeficiency J Clin Immunol 28 suppl 1 2008 S42 S45
181. E.O. Luger, V. Fokuhl, M. Wegmann, M. Abram, K. Tillack, and G. Achatz Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge J Allergy Clin Immunol 124 2009 819 826.e4
182. P. Takhar, C.J. Corrigan, L. Smurthwaite, B.J. O'Connor, S.R. Durham, and T.H. Lee Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma J Allergy Clin Immunol 119 2007 213 218 (Pubitemid 46037820)
183. J. Rangel-Moreno, L. Hartson, C. Navarro, M. Gaxiola, M. Selman, and T.D. Randall Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis J Clin Invest 116 2006 3183 3194 (Pubitemid 44878632)
184. T. Suda, K. Chida, H. Hayakawa, S. Imokawa, M. Iwata, and H. Nakamura Development of bronchus-associated lymphoid tissue in chronic hypersensitivity pneumonitis Chest 115 1999 357 363 (Pubitemid 29083041)
185. D.E. Aguilar Leon, V. Novelo Retana, and E. Martinez-Cordero Anti-avian antibodies and rheumatoid factor in pigeon hypersensitivity pneumonitis Clin Exp Allergy 33 2003 226 232 (Pubitemid 36241381)
186. M.T. Araiza, D.E. Aguilar Leon, V.N. Retana, and E. Martinez-Cordero IgM, IgG, and IgA rheumatoid factors in pigeon hypersensitivity pneumonitis J Clin Lab Anal 21 2007 315 321 (Pubitemid 47556811)
187. J.C. Hogg, F. Chu, S. Utokaparch, R. Woods, W.M. Elliott, and L. Buzatu The nature of small-airway obstruction in chronic obstructive pulmonary disease N Engl J Med 350 2004 2645 2653 (Pubitemid 38787999)
188. M.M. Gosman, B.W. Willemse, D.F. Jansen, T.S. Lapperre, A. van Schadewijk, and P.S. Hiemstra Increased number of B-cells in bronchial biopsies in COPD Eur Respir J 27 2006 60 64 (Pubitemid 43092667)
189. S.H. Lee, S. Goswami, A. Grudo, L.Z. Song, V. Bandi, and S. Goodnight-White Antielastin autoimmunity in tobacco smoking-induced emphysema Nat Med 13 2007 567 569 (Pubitemid 46828488)
190. C.A. Feghali-Bostwick, A.S. Gadgil, L.E. Otterbein, J.M. Pilewski, M.W. Stoner, and E. Csizmadia Autoantibodies in patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 177 2008 156 163
191. A. Berra, L. Sterin-Borda, S. Bacman, and E. Borda Role of salivary IgA in the pathogenesis of Sjogren syndrome Clin Immunol 104 2002 49 57 (Pubitemid 34856508)
192. A.T. Borchers, C. Chang, C.L. Keen, and M.E. Gershwin Idiopathic pulmonary fibrosis - an epidemiological and pathological review Clin Rev Allergy Immunol 40 2011 117 134
193. W.A. Wallace, S.E. Howie, A.S. Krajewski, and D. Lamb The immunological architecture of B-lymphocyte aggregates in cryptogenic fibrosing alveolitis J Pathol 178 1996 323 329 (Pubitemid 26122361)
194. A. Seetharam, V. Tiriveedhi, and T. Mohanakumar Alloimmunity and autoimmunity in chronic rejection Curr Opin Organ Transplant 15 2010 531 536
195. A. KleinJan, J.G. Vinke, L.W. Severijnen, and W.J. Fokkens Local production and detection of (specific) IgE in nasal B-cells and plasma cells of allergic rhinitis patients Eur Respir J 15 2000 491 497 (Pubitemid 30158186)
196. T. Van Zele, P. Gevaert, G. Holtappels, P. van Cauwenberge, and C. Bachert Local immunoglobulin production in nasal polyposis is modulated by superantigens Clin Exp Allergy 37 2007 1840 1847
197. A. Sabirov, R.G. Hamilton, J.B. Jacobs, D.E. Hillman, R.A. Lebowitz, and J.D. Watts Role of local immunoglobulin E specific for Alternaria alternata in the pathogenesis of nasal polyposis Laryngoscope 118 2008 4 9
198. B.K. Tan, Q.Z. Li, L. Suh, A. Kato, D.B. Conley, and R.K. Chandra Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps J Allergy Clin Immunol 128 2011 1198 1206.e1
199. M. Liu, V. Subramanian, C. Christie, M. Castro, and T. Mohanakumar Immune responses to self-antigens in asthma patients: clinical and immunopathological implications Hum Immunol 73 2012 511 516
200. B.M. Simpson, A. Custovic, A. Simpson, C.L. Hallam, D. Walsh, and H. Marolia NAC Manchester Asthma and Allergy Study (NACMAAS): risk factors for asthma and allergic disorders in adults Clin Exp Allergy 31 2001 391 399 (Pubitemid 34204159)
201. B. Nunez, J. Sauleda, J.M. Anto, M.R. Julia, M. Orozco, and E. Monso Anti-tissue antibodies are related to lung function in chronic obstructive pulmonary disease Am J Respir Crit Care Med 183 2011 1025 1031
202. T. Iwata, A. Philipovskiy, A.J. Fisher, R.G. Presson Jr., M. Chiyo, and J. Lee Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction J Immunol 181 2008 5738 5747
203. M. Sato, S. Hirayama, D.M. Hwang, H. Lara-Guerra, D. Wagnetz, and T.K. Waddell The role of intrapulmonary de novo lymphoid tissue in obliterative bronchiolitis after lung transplantation J Immunol 182 2009 7307 7316
204. K. Kurosu, Y. Takiguchi, O. Okada, N. Yumoto, S. Sakao, and Y. Tada Identification of annexin 1 as a novel autoantigen in acute exacerbation of idiopathic pulmonary fibrosis J Immunol 181 2008 756 767
205. S. Salomonsson, and M. Wahren-Herlenius Local production of Ro/SSA and La/SSB autoantibodies in the target organ coincides with high levels of circulating antibodies in sera of patients with Sjogren's syndrome Scand J Rheumatol 32 2003 79 82 (Pubitemid 36428344)
206. L. Smurthwaite, and S.R. Durham Local IgE synthesis in allergic rhinitis and asthma Curr Allergy Asthma Rep 2 2002 231 238
207. D.I. Blyth, M.S. Pedrick, T.J. Savage, E.M. Hessel, and D. Fattah Lung inflammation and epithelial changes in a murine model of atopic asthma Am J Respir Cell Mol Biol 14 1996 425 438 (Pubitemid 126440511)
208. T.D. Randall Bronchus-associated lymphoid tissue (BALT) structure and function Adv Immunol 107 2010 187 241
209. C. McSharry B lymphocytes in allergic alveolitis Clin Exp Allergy 33 2003 159 162 (Pubitemid 36241370)
210. M. Drent, H. van Velzen-Blad, M. Diamant, S.S. Wagenaar, M. Donckerwolck-Bogaert, and J.M. van den Bosch Differential diagnostic value of plasma cells in bronchoalveolar lavage fluid Chest 103 1993 1720 1724 (Pubitemid 23174304)
211. E. Martinez-Cordero, M.C. Negrete-Garcia, and A. Mendoza Rheumatoid factor activity in serum and bronchoalveolar lavage fluid from patients with acute hypersensitivity pneumonitis J Investig Allergol Clin Immunol 2 1992 254 257
212. A. Churg, K. Zay, S. Shay, C. Xie, S.D. Shapiro, and R. Hendricks Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice Am J Respir Cell Mol Biol 27 2002 368 374 (Pubitemid 34979296)
213. M. Saetta, G. Turato, F.M. Facchini, L. Corbino, R.E. Lucchini, and G. Casoni Inflammatory cells in the bronchial glands of smokers with chronic bronchitis Am J Respir Crit Care Med 156 1997 1633 1639 (Pubitemid 27505536)
214. C.H. Bosken, J. Hards, K. Gatter, and J.C. Hogg Characterization of the inflammatory reaction in the peripheral airways of cigarette smokers using immunocytochemistry Am Rev Respir Dis 145 1992 911 917
215. S.G. Kelsen, M.O. Aksoy, M. Georgy, R. Hershman, R. Ji, and X. Li Lymphoid follicle cells in chronic obstructive pulmonary disease overexpress the chemokine receptor CXCR3 Am J Respir Crit Care Med 179 2009 799 805
216. B.W. van der Strate, D.S. Postma, C.A. Brandsma, B.N. Melgert, M.A. Luinge, and M. Geerlings Cigarette smoke-induced emphysema: s role for the B cell? Am J Respir Crit Care Med 173 2006 751 758
217. J. Zhu, Y. Qiu, M. Valobra, S. Qiu, S. Majumdar, and D. Matin Plasma cells and IL-4 in chronic bronchitis and chronic obstructive pulmonary disease Am J Respir Crit Care Med 175 2007 1125 1133 (Pubitemid 46855453)
218. V.V. Polosukhin, J.M. Cates, W.E. Lawson, R. Zaynagetdinov, A.P. Milstone, and P.P. Massion Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease Am J Respir Crit Care Med 184 2011 317 327
219. B. Crestani The respiratory system in connective tissue disorders Allergy 60 2005 715 734 (Pubitemid 40769873)
220. R. Lafyatis, C. O'Hara, C.A. Feghali-Bostwick, and E. Matteson B cell infiltration in systemic sclerosis-associated interstitial lung disease Arthritis Rheum 56 2007 3167 3168 (Pubitemid 47502765)
221. S. Salomonsson, M.V. Jonsson, K. Skarstein, K.A. Brokstad, P. Hjelmstrom, and M. Wahren-Herlenius Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjogren's syndrome Arthritis Rheum 48 2003 3187 3201 (Pubitemid 37409331)
222. V. Pulkkinen, K. Salmenkivi, V.L. Kinnula, E. Sutinen, M. Halme, and U. Hodgson A novel screening method detects herpesviral DNA in the idiopathic pulmonary fibrosis lung Ann Med 44 2012 178 186
223. D.A. Campbell, L.W. Poulter, G. Janossy, and R.M. du Bois Immunohistological analysis of lung tissue from patients with cryptogenic fibrosing alveolitis suggesting local expression of immune hypersensitivity Thorax 40 1985 405 411 (Pubitemid 15055529)
224. J. Marchal-Somme, Y. Uzunhan, S. Marchand-Adam, D. Valeyre, V. Soumelis, and B. Crestani Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis J Immunol 176 2006 5735 5739
225. W.A. Wallace, and S.E. Howie Upregulation of tenascin and TGFbeta production in a type II alveolar epithelial cell line by antibody against a pulmonary auto-antigen J Pathol 195 2001 251 256 (Pubitemid 32899036)
226. A. Sato, K. Chida, M. Iwata, and H. Hayakawa Study of bronchus-associated lymphoid tissue in patients with diffuse panbronchiolitis Am Rev Respir Dis 146 1992 473 478
227. K.G. Huggins, and J. Brostoff Local production of specific IgE antibodies in allergic-rhinitis patients with negative skin tests Lancet 2 1975 148 150
228. S. Nakajima, D.N. Gillespie, and G.J. Gleich Differences between IgA and IgE as secretory proteins Clin Exp Immunol 21 1975 306 317
229. T.G. Merrett, M. Houri, A.L. Mayer, and J. Merrett Measurement of specific IgE antibodies in nasal secretion - evidence for local production Clin Allergy 6 1976 69 73
230. H. Deuschl, and S.G. Johansson Specific IgE antibodies in nasal secretion from patients with allergic rhinitis and with negative or weakly positive RAST on the serum Clin Allergy 7 1977 195 202 (Pubitemid 8095813)
231. T.A. Platts-Mills Local production of IgG, IgA and IgE antibodies in grass pollen hay fever J Immunol 122 1979 2218 2225 (Pubitemid 9185780)
232. P. Small, D. Barrett, S. Frenkiel, L. Rochon, C. Cohen, and M. Black Local specific IgE production in nasal polyps associated with negative skin tests and serum RAST Ann Allergy 55 1985 736 739 (Pubitemid 16219336)
233. E. Jones, S. Frenkiel, P. Small, and L. Rochon Immunopathological characteristics of nasal polyps J Otolaryngol 16 1987 19 22 (Pubitemid 17012471)
234. K. Hoffmann-Sommergruber, E.D. Ferreira, C. Ebner, T. Barisani, L. Korninger, and D. Kraft Detection of allergen-specific IgE in tears of grass pollen-allergic patients with allergic rhinoconjunctivitis Clin Exp Allergy 26 1996 79 87 (Pubitemid 26037265)
235. J.S. Shatkin, K.G. Delsupehe, R.A. Thisted, and J.P. Corey Mucosal allergy in the absence of systemic allergy in nasal polyposis and rhinitis: a meta-analysis Otolaryngol Head Neck Surg 111 1994 553 556 (Pubitemid 24376641)
236. T. Yoshida, A. Usui, T. Kusumi, S. Inafuku, T. Sugiyama, and N. Koide A quantitative analysis of cedar pollen-specific immunoglobulins in nasal lavage supported the local production of specific IgE, not of specific IgG Microbiol Immunol 49 2005 529 534 (Pubitemid 40943832)
237. J.A. Bellanti, R.L. Sanga, B. Klutinis, B. Brandt, and M.S. Artenstein Antibody responses in serum and nasal secretions of children immunized with inactivated and attenuated measles-virus vaccines N Engl J Med 280 1969 628 633
238. L.A. Cameron, S.R. Durham, M.R. Jacobson, K. Masuyama, S. Juliusson, and H.J. Gould Expression of IL-4, Cepsilon RNA, and Iepsilon RNA in the nasal mucosa of patients with seasonal rhinitis: effect of topical corticosteroids J Allergy Clin Immunol 101 1998 330 336
239. V.T. Chu, A. Frohlich, G. Steinhauser, T. Scheel, T. Roch, and S. Fillatreau Eosinophils are required for the maintenance of plasma cells in the bone marrow Nat Immunol 12 2011 151 159
240. B.K. Tan, R.P. Schleimer, and R.C. Kern Perspectives on the etiology of chronic rhinosinusitis Curr Opin Otolaryngol Head Neck Surg 18 2010 21 26
241. D.D. Tieu, R.C. Kern, and R.P. Schleimer Alterations in epithelial barrier function and host defense responses in chronic rhinosinusitis J Allergy Clin Immunol 124 2009 37 42
242. B.K. Tan, W. Zirkle, R.K. Chandra, D. Lin, D.B. Conley, and A.T. Peters Atopic profile of patients failing medical therapy for chronic rhinosinusitis Int Forum Allergy Rhinol 1 2011 88 94
243. G.A. Settipane, and F.H. Chafee Nasal polyps in asthma and rhinitis. A review of 6,037 patients J Allergy Clin Immunol 59 1977 17 21 (Pubitemid 8023064)
244. M. Patadia, J. Dixon, D. Conley, R. Chandra, A. Peters, and L.A. Suh Evaluation of the presence of B-cell attractant chemokines in chronic rhinosinusitis Am J Rhinol Allergy 24 2010 11 16
245. A. Kato, A.Q. Truong-Tran, A.L. Scott, K. Matsumoto, and R.P. Schleimer Airway epithelial cells produce B cell-activating factor of TNF family by an IFN-beta-dependent mechanism J Immunol 177 2006 7164 7172 (Pubitemid 44715085)
246. M.B. Litinskiy, B. Nardelli, D.M. Hilbert, B. He, A. Schaffer, and P. Casali DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL Nat Immunol 3 2002 822 829
247. O. Ghaffar, F. Lavigne, A. Kamil, P. Renzi, and Q. Hamid Interleukin-6 expression in chronic sinusitis: colocalization of gene transcripts to eosinophils, macrophages, T lymphocytes, and mast cells Otolaryngol Head Neck Surg 118 1998 504 511 (Pubitemid 28177982)
248. K.E. Hulse, J. Norton, L. Suh, Q. Zhong, M. Mahdavinia, and P. Simon Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression J Allergy Clin Immunol 131 2013 1075 1083
249. A. Sanchez-Segura, J.A. Brieva, and C. Rodriguez Regulation of immunoglobulin secretion by plasma cells infiltrating nasal polyps Laryngoscope 110 2000 1183 1188 (Pubitemid 30439779)
250. T. Van Zele, P. Gevaert, J.B. Watelet, G. Claeys, G. Holtappels, and C. Claeys Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis J Allergy Clin Immunol 114 2004 981 983 (Pubitemid 39330280)
251. E. Castigli, S.A. Wilson, S. Scott, F. Dedeoglu, S. Xu, and K.P. Lam TACI and BAFF-R mediate isotype switching in B cells J Exp Med 201 2005 35 39 (Pubitemid 40130081)
252. F. Mackay, S.A. Woodcock, P. Lawton, C. Ambrose, M. Baetscher, and P. Schneider Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations J Exp Med 190 1999 1697 1710 (Pubitemid 30002351)
253. R. Kumar, L.K. Williams, A. Kato, E.L. Peterson, S. Favoreto Jr., and K. Hulse Genetic variation in B cell-activating factor of the TNF family (BAFF) and asthma exacerbations among African American subjects J Allergy Clin Immunol 130 2012 996 999.e6
254. K.R. Carson, A.M. Evens, E.A. Richey, T.M. Habermann, D. Focosi, and J.F. Seymour Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project Blood 113 2009 4834 4840