Lymphotoxin-α-deficient mice can clear a productive infection with murine gammaherpesvirus 68 but fail to develop splenomegaly or lymphocytosis

Journal of Virology

Volumn 74, Issue 6, 2000, Pages 2786-2792

  Lee, Bong Joo ^a   Santee, Sybil ^a   Von Gesjen, Sigrid ^a   Ware, Carl F ^a   Sarawar, Sally R ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; HERPES VIRUS; IMMUNE RESPONSE; LUNG INFECTION; LYMPHOCYTOSIS; LYMPHOID TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLENOMEGALY; T LYMPHOCYTE; VIRUS INFECTION; VIRUS PATHOGENESIS;

3T3 CELLS; ANIMALS; ANTIBODIES, VIRAL; FEMALE; GAMMAHERPESVIRINAE; HERPESVIRIDAE INFECTIONS; IMMUNOGLOBULIN CLASS SWITCHING; INTERFERON TYPE II; LUNG; LYMPHOCYTOSIS; LYMPHOTOXIN-ALPHA; MALE; MICE; MICE, KNOCKOUT; PNEUMONIA; SPLENOMEGALY; T-LYMPHOCYTES, CYTOTOXIC; VIRUS REPLICATION;

EID: 0342905086     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.6.2786-2792.2000     Document Type: Article

References (32)

1. Alexopoulou, L., M. Pasparakis, and G. Kollias. 1998. Complementation of lymphotoxin alpha knockout mice with tumor necrosis factor-expressing transgenes rectifies defective splenic structure and function. J. Exp. Med. 188:745-754.
2. Alimzhanov, M. B., D. V. Kuprash, M. H. Kosco-Vilbois, A. Luz, R. L. Turetskaya, A. Tarakhovsky, K. Rajewsky, S. A. Nedospasov, and K. Pfeffer. 1997. Abnormal development of secondary lymphoid tissues in lymphotoxin b-deficient mice. Proc. Natl. Acad. Sci. USA 94:9302-9307.
3. Allan, W., Z. Tabi, A. Cleary, and P. C. Doherty. 1990. Cellular events in the lymph node and lung of mice with influenza. Consequences of depleting CD4+ T cells. J. Immunol. 144:3980-3986.
4. Banks, T. A., B. T. Rouse, M. K. Kerley, P. J. Blair, V. L. Godfrey, N. A. Kuklin, D. M. Bouley, J. Thomas, S. Kanangat, and M. L. Mucenski. 1995. Lymphotoxin-a-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J. Immunol. 155:1685-1693.
5. Berger, D. P., D. Naniche, M. T. Crowley, P. A. Koni, R. A. Flavell, and M. B. Oldstone. 1999. Lymphotoxin-beta-deficient mice show defective antiviral immunity. Virology 260:136-147.
6. Blaskovic, D., M. Stancekova, J. Svobodova, and J. Mistrikova. 1980. Isolation of five strains of herpesviruses from two species of free living small rodents. Acta Virol. 24:468. (Letter.)
7. Cardin, R. D., J. W. Brooks, S. R. Sarawar, and P. C. Doherty. 1996. Progressive loss of CD8+ T cell-mediated control of a g-herpesvirus in the absence of CD4+ T cells. J. Exp. Med. 184:863-871.
8. Davis, I. A., K. A. Knight, and B. T. Rouse. 1998. The spleen and organized lymph nodes are not essential for the development of gut-induced mucosal immune responses in lymphotoxin-alpha deficient mice. Clin. Immunol. Immunopathol. 89:150-159.
9. Efstathiou, S., Y. M. Ho, and A. C. Minson. 1990. Cloning and molecular characterization of the murine herpesvirus 68 genome. J. Gen. Virol. 71: 1355-1364.
10. Ehtisham, S., N. P. Sunil Chandra, and A. A. Nash. 1993. Pathogenesis of murine gammaherpesvirus infection in mice deficient in CD4 and CD8 T cells. J. Virol. 67:5247-5252.
11. Eugster, H.-P., M. Müller, U. Karrer, B. D. Car, B. Schnyder, V. M. Eng, G. Woerly, M. Le Hir, F. di Padova, M. Aguet, R. Zinkernagel, H. Bluethmann, and B. Ryffel. 1996. Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-a double-deficient mice. Int. Immunol. 8:23-36.
12. Fu, Y.-X., H. Molina, M. Matsumoto, G. Huang, J. Min, and D. D. Chaplin. 1997. Lymphotoxin-α (LTα) supports development of splenic follicular structure that is required for IgG responses. J. Exp. Med. 185:2111-2120.
13. Futterer, A., K. Mink, A. Luz, M. H. Kosco-Vilbois, and K. Pfeffer. 1998. The lymphotoxin beta receptor controls organigenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9:59-70.
14. Iizuka, K., D. D. Chaplin, Y. Wang, Q. Wu, L. E. Pegg, W. M. Yokohama, and Y. X. Fu. 1999. Requirement for membrane lymphotoxin in natural killer cell development. Proc. Natl. Acad. Sci. USA 96:6336-6340.
15. Ito, D., T. C. Back, A. N. Shakhov, R. H. Wiltrout, and S. A. Nedospasov. 1999. Mice with a targeted mutation in lymphotoxin-alpha exhibit enhanced tumor growth and metastasis: impaired NK cell development and recruitment. J. Immunol. 163:2809-2815.
16. Karrer, U., A. Althage, B. Odermatt, C. W. Roberts, S. J. Korsmeyer, S. Miyawaki, H. Hengartner, and R. M. Zinkernagel. 1997. On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly/aly) and spleenless (Hox11(-)/-) mutant mice. J. Exp. Med. 185:2157-2170.
17. Koni, P. A., and R. A. Flavell. 1998. A role for tumor necrosis factor receptor type 1 in gut-associated lymphoid tissue development: genetic evidence of synergism with lymphotoxin beta. J. Exp. Med. 187:1977-1983.
18. Koni, P. A., R. Sacca, P. Lawton, J. L. Browning, N. H. Ruddle, and R. A. Flavell. 1997. Distinct roles in lymphoid organogenesis for lymphotoxins a and β revealed in lymphotoxin β-deficient mice. Immunity 6:491-500.
19. Matsumoto, M., S. F. Lo, C. J. L. Carruthers, J. Min, S. Mariathasan, G. Huang, D. R. Plas, S. M. Martin, R. S. Geha, M. H. Nahm, and D. D. Chaplin. 1996. Affinity maturation without germinal centers in lymphotoxin-α-deficient mice. Nature 382:462-466.
20. Nash, A. A., and N. P. Sunil Chandra. 1994. Interactions of the murine gammaherpesvirus with the immune system. Curr. Opin. Immunol. 6:560-563.
21. Rennert, P. D., D. James, F. Mackay, J. L. Browning, and P. S. Hochman. 1998. Lymph node genesis is induced by signaling through the lymphotoxin beta receptor. Immunity 9:71-79.
22. Sarawar, S. R., and P. C. Doherty. 1994. Concurrent production of interleukin-2, interleukin-10, and gamma interferon in the regional lymph nodes of mice with influenza pneumonia. J. Virol. 68:3112-3119.
23. Sarin, A., M. Conan-Cibotti, and P. A. Henkart. 1995. Cytotoxic effect of TNF and lymphotoxin on T lymphoblasts. J. Immunol. 155:3716-3718.
24. Shinkura, R., K. Kitada, F. Matsuda, K. Tashiro, K. Ikuta, M. Suzuki, K. Kogishi, T. Serikawa, and T. Honjo. 1999. Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase. Nat. Genet. 22:74-77.
25. Stevenson, P. G., and P. C. Doherty. 1998. Kinetic analysis of the specific host response to a murine gammaherpesvirus. J. Virol. 72:943-949.
26. Stewart, J. P., E. J. Usherwood, A. Ross, H. Dyson, and T. Nash. 1998. Lung epithelial cells are a major site of murine gammaherpesvirus persistence. J. Exp. Med. 187:1941-1951.
27. Tripp, R. A., A. M. Hamilton Easton, R. D. Cardin, P. Nguyen, F. G. Behm, D. L. Woodland, P. C. Doherty, and M. A. Blackman. 1997. Pathogenesis of an infectious mononucleosis-like disease induced by a murine gamma-herpesvirus: role for a viral superantigen? J. Exp. Med. 185:1641-1650.
28. Virgin, H. W., IV, P. Latreille, P. Wamsley, K. Hallsworth, K. E. Weck, A. J. Dal Canto, and S. H. Speck. 1997. Complete sequence and genomic analysis of murine gammaherpesvirus 68. J. Virol. 71:5894-5904.
29. Ware, C. F., S. Santee, and A. Glass. 1998. Tumor necrosis factor-related ligands and receptors, p. 549-592. In A. Thompson (ed.), The cytokine handbook. Academic Press, San Diego, Calif.
30. Watanabe-Fukunaga, R., C. I. Brannan, N. G. Copeland, N. A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314-317.
31. Week, K. E., S. S. Kim, H. W. Virgin, IV, and S. H. Speck. 1999. Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells. J. Virol. 73:3273-3283.
32. Wu, Q., Y. Wang, J. Wang, E. O. Hedgeman, J. L. Browning, and Y. X. Fu. 1999. The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues. J. Exp. Med. 190:629-638.