Immune responses to self-antigens in asthma patients: Clinical and immunopathological implications

Human Immunology

Volumn 73, Issue 5, 2012, Pages 511-516

  Liu, Michael ^a   Subramanian, Vijay ^a   Christie, Chandrika ^b   Castro, Mario ^b   Mohanakumar, Thallachallour ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

Catenin; Activin A type 1 receptor; Asthma; Autoimmunity; Collagen V; Epidermal growth factor receptor

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; ALPHA CATENIN; COLLAGEN TYPE 5; CORTICOSTEROID; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; BLOOD; CONTROLLED STUDY; CORRELATION ANALYSIS; CORTICOSTEROID THERAPY; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOPATHOLOGY; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MILD INTERMITTENT ASTHMA; MILD PERSISTENT ASTHMA; MODERATE PERSISTENT ASTHMA; PATHOGENESIS; PNEUMONIA; PREVALENCE; PRIORITY JOURNAL; PROTEIN MICROARRAY; TISSUE INJURY;

ACTIVIN RECEPTORS, TYPE I; ADRENAL CORTEX HORMONES; ADULT; ALPHA CATENIN; ASTHMA; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; CASE-CONTROL STUDIES; COLLAGEN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; PROTEIN ARRAY ANALYSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RESPIRATORY SYSTEM; SEVERITY OF ILLNESS INDEX;

EID: 84860229954     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2012.02.010     Document Type: Article

References (38)

1. Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J Allergy Clin Immunol 2007, 120:S94-S138. National Asthma Education and Prevention Program.
2. Rackemann F.M. A working classification of asthma. Am J Med 1947, 3:601-606.
3. Romanet-Manent S., Charpin D., Magnan A., Lanteaume A., Vervloet D. Allergic vs nonallergic asthma: what makes the difference?. Allergy 2002, 57:607-613. EGEA Cooperative Group.
4. Humbert M., Menz G., Ying S., Corrigan C.J., Robinson D.S., Durham S.R., et al. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences. Immunol Today 1999, 20:528-533.
5. Stene L.C., Nafstad P. Relation between occurrence of type 1 diabetes and asthma. Lancet 2001, 357:607-608.
6. Kero J., Gissler M., Hemminki E., Isolauri E. Could TH1 and TH2 diseases coexist?. Evaluation of asthma incidence in children with coeliac disease, type 1 diabetes, or rheumatoid arthritis: a register study. J Allergy Clin Immunol 2001, 108:781-783.
7. Leopold H.C., Rynes S., Stoloff I.L. Fluorescent antibody study for antinuclear antibodies in bronchial asthma. J Allergy Clin Immunol 1965, 36:175.
8. Szczeklik A., Nizankowska E., Serafin A., Dyczek A., Duplaga M., Musial J. Autoimmune phenomena in bronchial asthma with special reference to aspirin intolerance. Am J Respir Crit Care Med 1995, 152:1753-1756.
9. Comi A.L., Tedeschi A., Lorini M., Miadonna A. Novel clinical and serological aspects in non-allergic asthma. Respir Med 2007, 101:2526-2533.
10. Lidor Y., Topilsky M., Spitzer S.A., Yehoshua H. Autoimmune antibodies in intrinsic (non-atopic) asthma. Ann Allergy 1980, 44:296-298.
11. Harrison L.C., Callaghan J., Venter J.C., Fraser C.M., Kaliner M.L. Atopy, autonomic function and beta-adrenergic receptor autoantibodies. Ciba Found Symp 1982, 90:248-262.
12. Nahm D.H., Lee Y.E., Yim E.J., Park H.S., Yim H., Kang Y., et al. Identification of cytokeratin 18 as a bronchial epithelial autoantigen associated with nonallergic asthma. Am J Respir Crit Care Med 2002, 165:1536-1539.
13. Nahm D.H., Lee K.H., Shin J.Y., Ye Y.M., Kang Y., Park H.S. Identification of alpha-enolase as an autoantigen associated with severe asthma. J Allergy Clin Immunol 2006, 118:376-381.
14. Lee H.A., Kwon B., Hur G.Y., Choi S.J., Nahm D.H., Park H.S. Isotype and IgG subclass distribution of autoantibody response to alpha-enolase protein in adult patients with severe asthma. Yonsei Med J 2008, 49:923-930.
15. Sun R.S., Chen X.H., Sui J.F., Liu R.Q., Cheng T.M., Ran X.Z., et al. Detecting anti-FcepsilonRI autoantibodies in patients with asthma by flow cytometry. J Int Med Res 2008, 36:1214-1219.
16. Haque M.A., Mizobuchi T., Yasufuku K., Fujisawa T., Brutkiewicz R.R., Zheng Y., et al. Evidence for immune responses to a self-antigen in lung transplantation: role of type V collagen-specific T cells in the pathogenesis of lung allograft rejection. J Immunol 2002, 169:1542-1549.
17. Wilkes D.S., Heidler K.M., Yasufuku K., Devito-Haynes L., Jankowska-Gan E., Meyer K.C., et al. Cell-mediated immunity to collagen V in lung transplant recipients: correlation with collagen V release into BAL fluid. J Heart Lung Transplant 2001, 20:167.
18. Bharat A., Fields R.C., Steward N., Trulock E.P., Patterson G.A., Mohanakumar T. CD4+25+ regulatory T cells limit Th1-autoimmunity by inducing IL-10 producing T cells following human lung transplantation. Am J Transplant 2006, 6:1799-1808.
19. Goers T.A., Ramachandran S., Aloush A., Trulock E., Patterson G.A., Mohanakumar T. De novo production of K-alpha1 tubulin-specific antibodies: role in chronic lung allograft rejection. J Immunol 2008, 180:4487-4494.
20. Mares D.C., Heidler K.M., Smith G.N., Cummings O.W., Harris E.R., Foresman B., et al. Type V collagen modulates alloantigen-induced pathology and immunology in the lung. Am J Respir Cell Mol Biol 2000, 23:62-70.
21. Yasufuku K., Heidler K.M., Woods K.A., Smith G.N., Cummings O.W., Fujisawa T., et al. Prevention of bronchiolitis obliterans in rat lung allografts by type V collagen-induced oral tolerance. Transplantation 2002, 73:500-505.
22. Madri J.A., Furthmayr H. Collagen polymorphism in the lung. An immunochemical study of pulmonary fibrosis. Hum Pathol 1980, 11:353-366.
23. Bharat A., Fields R.C., Trulock E.P., Patterson G.A., Mohanakumar T. Induction of IL-10 suppressors in lung transplant patients by CD4+25+ regulatory T cells through CTLA-4 signaling. J Immunol 2006, 177:5631-5638.
24. Burlingham W.J., Love R.B., Jankowska-Gan E., Haynes L.D., Xu Q., Bobadilla J.L., et al. IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. J Clin Invest 2007, 117:3498-3506. CrossRef].
25. Expert panel report 2: guidelines for the diagnosis and management of asthma 2006, National Asthma Education and Prevention Program, National Institutes of Health, Bethesda, MD.
26. Bharat A., Saini D., Steward N., Hachem R., Trulock E.P., Patterson G.A., et al. Antibodies to self-antigens predispose to primary lung allograft dysfunction and chronic rejection. Ann Thorac Surg 2010, 90:1094-1101.
27. Maffey A.F., Barrero P.R., Venialgo C., Fernández F., Fuse V.A., Saia M., et al. Viruses and atypical bacteria associated with asthma exacerbations in hospitalized children. Pediatr Pulmonol 2010, 45:619-625.
28. Horvat J.C., Starkey M.R., Kim R.Y., Phipps S., Gibson P.G., Beagley K.W., et al. Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology. J Allergy Clin Immunol 2010, 125:617-625. 625.e1.
29. Kloepfer K.M., Gern J.E. Virus/allergen interactions and exacerbations of asthma. Immunol Allergy Clin North Am 2010, 30:553-563. vii.
30. Pleass R.J., Lang M.L., Kerr M.A., Woof J.M. IgA is a more potent inducer of NADPH oxidase activation and degranulation in blood eosinophils than IgE. Mol Immunol 2007, 44:1401-1408.
31. Amishima M., Munakata M., Nasuhara Y., Sato A., Takahashi T., Homma Y., et al. Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway. Am J Respir Crit Care Med 1998, 157:1907-1912.
32. Puddicombe S.M., Polosa R., Richter A., Krishna M.T., Howarth P.H., Holgate S.T., et al. Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J 2000, 14:1362-1374.
33. Burgel P.R., Escudier E., Coste A., Dao-Pick T., Ueki I.F., Takeyama K., et al. Relation of epidermal growth factor receptor expression to goblet cell hyperplasia in nasal polyps. J Allergy Clin Immunol 2000, 106:705-712.
34. Takeyama K., Fahy J.V., Nadel J.A. Relationship of epidermal growth factor receptors to goblet cell production in human bronchi. Am J Respir Crit Care Med 2001, 163:511-516.
35. Hamilton L.M., Torres-Lozano C., Puddicombe S.M., Richter A., Kimber I., Dearman R.J., et al. The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma. Clin Exp Allergy 2003, 33:233-240.
36. Karagiannidis C., Hense G., Martin C., Epstein M., Rückert B., Mantel P.Y., et al. Activin A is an acute allergen-responsive cytokine and provides a link to TGF-beta-mediated airway remodeling in asthma. J Allergy Clin Immunol 2006, 117:111-118.
37. Kariyawasam H.H., Semitekolou M., Robinson D.S., Xanthou G. Activin-A: a novel critical regulator of allergic asthma. Clin Exp Allergy 2011, 41:1505-1514.
38. de Boer W.I., Sharma H.S., Baelemans S.M., Hoogsteden H.C., Lambrecht B.N., Braunstahl G.J. Altered expression of epithelial junctional proteins in atopic asthma: possible role in inflammation. Can J Physiol Pharmacol 2008, 86:105-112.