Lung Inflammation and Epithelial Changes in a Murine Model of Atopic Asthma

American Journal of Respiratory Cell and Molecular Biology

Volumn 14, Issue 5, 1996, Pages 425-438

  Blyth, David I ^a   Pedrick, Michael S ^b   Savage, Tony J ^b   Hessel, Edith M ^b   Fattah, Dilniya ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; DEXAMETHASONE; OVALBUMIN;

ANIMAL; ARTICLE; ASTHMA; BAGG ALBINO MOUSE; BRONCHUS; DISEASE MODEL; DRUG EFFECT; EOSINOPHIL; EPITHELIUM; HUMAN; HYPERPLASIA; IMMUNOLOGY; INFLAMMATION; LEUKOCYTE COUNT; LUNG; LYMPHOCYTE; MALE; MONOCYTE; MOUSE; NEUTROPHIL; PATHOLOGY; PATHOPHYSIOLOGY; PERITONEUM MACROPHAGE; TIME;

ALLERGENS; ANIMALS; ASTHMA; BRONCHI; DEXAMETHASONE; DISEASE MODELS, ANIMAL; EOSINOPHILS; EPITHELIUM; HUMANS; HYPERPLASIA; INFLAMMATION; LEUKOCYTE COUNT; LUNG; LYMPHOCYTES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED BALB C; MONOCYTES; NEUTROPHILS; OVALBUMIN; TIME FACTORS;

EID: 0030139443     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.14.5.8624247     Document Type: Article

References (73)

1. Hessel, E. M., A. J. M. Van Oosterhout, J. Garsen, H. Van Loveren, H. F. J. Savelkoul, and F. P. Nijkamp. 1993. Immediate asthmatic reactions and changes in airway responsiveness after single versus chronic ovalbumin inhalation in sensitized mice. Eur. J. Allergy Clin. Immunol. 48:101.
2. Johnston, S. L., and S. T. Holgate. 1991. The inflammatory response in asthma. Br. J. Hosp. Med. 46:84-90.
3. Arm, J. P., and T. H. Lee. 1992. Pathobiology of bronchial asthma. Adv. Immunol. 51:323-382.
4. Busse, W. W., W. F. Calhoun, and J. D. Sedgewick. 1993. Mechanism of airway inflammation in asthma. Am. Rev. Respir. Dis. 147:S20-S24.
5. Hogg, J. C. 1984. The pathology of asthma. Clin. Chest Med. 5:567-571.
6. Roche, W. R., R. Beasley, J. H. Williams, and S. T. Holgate. 1989. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1:520-524.
7. Jeffery, P. K. 1992. Histological features of the airways in asthma and COPD. Respiration 59(Suppl. 1):13-16.
8. Beasley, R., W. R. Roche, J. A. Roberts, and S. T. Holgate. 1989. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am. Rev. Respir. Dis. 139:806-817.
9. Wardlaw, A. J., S. Dunnette, G. J. Gleich, J. V. Collins and A. B. Kay. 1988. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am. Rev. Respir. Dis. 137:62-69.
10. Ehrlich, P. E. 1879. Über die specifischen granulationen des blutes. Arch. Anat. Physiol. 3:571-579.
11. Gollasch. 1889. Zur kenntnis des asthmatischen sputums. Fortschr. Med. 7:28.
12. Ehrlich, P. E., and A. Lazarus. 1900. In Histology of the Blood. W. Myers, editor. Cambridge University Press, Cambridge, UK. 157-158.
13. Corrigan, C. J., and A. B. Kay. 1992. T-cells and eosinophils in the pathogenesis of asthma. Immunol. Today 13:501-506.
14. Kroegel, C., J. A. Warner, J. C. Virchow, and H. Matthys. 1994. Pulmonary immune cells in health and disease. II. The eosinophil leucocyte. Eur. Respir. J. 7:743-760.
15. Frigas, E., S. Motojima, and G. J. Gleich. 1991. The eosinophilic injury to the mucosa of the airways in the pathogenesis of bronchial asthma. Eur. Respir. J. 4(Suppl. 13): 123S-135S.
16. Filley, W. V., K. E. Holley, G. M. Kephart, and G. J. Gleich. 1982. Identification by immunofluorescence of eosinophil granule major basic-protein in lung tissue of patients with bronchial asthma. Lancet 2:11-16.
17. Chapman, I. D., A. Foster, and J. Morley. 1993. The relationship between inflammation and hyperreactivity of the airways in asthma. Clin. Exp. Allergy 23:168-171.
18. Bomford, R. 1980. The comparative selectivity of adjuvants for humoral and cell-mediated immunity. I. Effect on the antibody response to bovine sheep red blood cells of Freund's incomplete adjuvants, alhydrogel: Corynebacterium parvum, Bordetella pertussis, muramyl dipeptide, and saponin. Clin. Exp. Immunol. 39:426-434.
19. Bomford, R. 1980. The comparative selectivity of adjuvants for humoral and cell-mediated immunity. II. Effect on delayed-type hypersensitivity, and cell-mediated immunity to tumour antigens in the mouse of Freund's incomplete and complete adjuvants, alhydrogel: Corynebacterium parvum, Bordetella pertussis, muramyl dipeptide, and saponin. Clin. Exp. Immunol. 39:435-441.
20. Veenendahl, G. H., D. J. Kool, D. J. De Wildt, and F. P. Nijkamp. 1986. Disturbance of mice tracheal β-adrenoceptor and cholinergic receptor function by Bordetella pertussis and its cell wall components. Agents Actions 19:366-367.
21. Holt, P. G., A. H. Rose, J. E. Batty, and K. J. Turner. 1981. Induction of adjuvant-independent IgE responses in inbred mice: primary, secondary and persistent IgE responses to ovalbumin and ovomucoid. Int. Arch. Allergy Appl. Immunol. 65:42-50.
22. Hessel, E. M., A. Zwart, E. Oostveen, A. J. M. Van Oosterhout, D. I. Blyth, and F. P. Nijkamp. Repeated measurement of respiratory function and bronchoconstriction in unanaesthetized mice. J. Appl. Physiol. 79:1711-1716.
23. Clément, J., F. J. Làndsér, and K. P. Van de Woestijne. 1983. Total resistance and reactance in patients with respiratory complaints with and without airways obstruction. Chest 83:215-220.
24. Hessel, E. M., A. J. M. Van Oosterhout, C. L. Hofstra, J. Garssen, H. van Loveren, H. F. J. Savelkoul, and F. P. Nijkamp. 1994. Repeated ovalbumin inhalation causes bronchial hyperresponsiveness and eosinophil infiltration in sensitized mice. Am. J. Respir. Crit. Care Med. 149:A754. (Abstr.)
25. Hessel, E. M., A. J. M. Van Oosterhout, J. Garsen, H. van Loveren, H. F. J. Savelkoul, and F. P. Nijkamp. 1994. Effect of anti-IL-4 and anti-IFNγ on bronchial hyperresponsiveness induced after single ovalbumin inhalation in sensitized mice. Am. J. Respir. Crit. Care Med. 149: A754. (Abstr.)
26. Hessel, E. M., A. J. M. Van Oosterhout, J. J. de Bie, G. Hofman, H. van Loveren, and F. P. Nijkamp. 1995. Opposite effects of dexamethasone and metyrapone on airway hyperresponsiveness and inflammation in a murine model for allergic asthma. Am. J. Respir. Crit. Care Med. 151:A390. (Abstr.)
27. Ho, W., and A. Furst. 1973. Intratracheal instillation method for mouse lungs. Oncology 27:385-393.
28. Discombe, G. 1946. Criteria of eosinophilia. Lancet 1:195-196.
29. Mowry, R. W. 1956. Alcian blue techniques for the histochemical study of acidic carbohydrates. J. Histochem. Cytochem. 4:407.
30. Gordon, H., and H. H. Sweets. 1936. A simple method for the silver impregnation of reticulum. Am. J. Pathol. 12:545-552.
31. Lilly, R. D., and J. Greco. 1947. Malt diastase and ptyalin in place of saliva in the identification of glycogen. Stain Technol. 22:67-70.
32. Bolender, R. P., D. M. Hyde, and R. T. Dehoff. 1993. Lung morphometry: a new generation of tools and experiments for organ, tissue, cell and molecular biology. Am. J. Physiol. 265:L521-L548.
33. Dunnett, C. W. 1964. New tables for multiple comparisons with a control. Biometrics 20:482-491.
34. Miller, R. G. 1981. Simultaneous Statistical Inference. 2nd Ed. Springer-Verlag, New York. 81-90.
35. Hollander, M., and D. A. Wolfe. 1973. Nonparametric Statistical Methods. 1st Ed. Wiley, New York. 124-132.
36. Hollander, M., and D. A. Wolfe. 1973. Nonparametric Statistical Methods. 1st Ed. Wiley, New York. 120-123.
37. Laitinen, L. A., M. Heino, A. Laitinen, T. Kava, and T. Haahtela. 1985. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am. Rev. Respir. Dis. 131:599-606.
38. Metzger, W. J., D. Zavala, H. B. Richerson, P. Moseley, P. Iwamoto, M. Monick, K. Sjoerdsma, and G. W. Hunninghake. 1987. Local antigen challenge and bronchoalveolar lavage of allergic asthmatic lungs. Am. Rev. Respir. Dis. 135:433-440.
39. van Oosterhout, A. J. M., and F. J. Nijkamp. 1993. Role of cytokines in bronchial hyperresponsiveness. Pulm. Pharmacol. 6:225-236.
40. Anderson, G. P., and Coyle, A. J. 1994. Th2 and "Th2-like" cells in allergy and asthma: Pharmacological perspectives. Trends Pharmacol. Sci. 15: 324-332.
41. Rogers, D. F. 1994. Airway goblet cells. Responsive and adaptable front-line defenders. Eur. Respir. J. 7:1690-1706.
42. Thomson, N. C. 1992. Management of asthma in adults. Part 1. Hospital Update April 1992:288-293.
43. Jeffery, P. K., A. J. Wardlaw, F. C. Nelson, J. V. Collins, and A. B. Kay. 1989. Bronchial biopsies in asthma: an ultrastructural, quantitative study and correlation with hyperreactivity. Am. Rev. Respir. Dis. 140:1745-1753.
44. Bousquet, J., P. Chanez, J. Y. Lacoste, G. Barneon, N. Ghavanian, I. Enander, P. Venge, S. Ahlstedt, J. Simony-Lafontaine, P. Godard, and F. B. Michel. 1990. Eosinophilic inflammation in asthma. N. Engl. J. Med. 323:1033-1039.
45. Laitinen, L. A., A. Laitinen, and T. Haahtela. 1993. Airway mucosal inflammation even in patients with newly diagnosed asthma. Am. Rev. Respir. Dis. 147:697-704.
46. Sur, S., T. B. Crothy, G. M. Kephart, B. A. Hyma, T. V. Colby, C. E. Reed, L. W. Hunt, and G. J. Gleich. 1993. Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa? Am. Rev. Respir. Dis. 148:713-719.
47. Lozewicz, S., C. Wells, E. Gomez, H. Ferguson, P. Richman, and J. Devalia. 1990. Morphological integrity of the bronchial epithelium in mild asthma. Thorax 45:12-15.
48. Laitinen, A., and L. A. Laitinen. 1992. Structural changes and cell findings in airway epithelium in asthmatic patients. Res. Clin. Forums 14:59-64.
49. McDowell, E. M., L. A. Berret, F. Gavin, C. Harris, and B. F. Trump. 1978. The respiratory epithelium. I. Human bronchus. J. Natl. Cancer Inst. 61:539-559.
50. Rhodin, J. A. 1966. The ciliated cell. Ultrastructure and function of the human tracheal mucosa. Am. Rev. Respir. Dis. 93:1-15.
51. Söderberg, M., S. Hellström, T. Sandström, R. Lundgren, and A. Bergh. 1990. Structural characterization of bronchial mucosal biopsies from healthy volunteers: a light and electron microscopical study. Eur. Respir. J. 3:261-266.
52. Aikawa, T., S. Shimura, H. Sasaki, M. Ebina, and T. Takashima. 1992. Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthmatic attacks. Chest 101:916-921.
53. Marini, M., and Vittori, E. 1992. Expression of potent inflammatory cytokines, GM-CSF, IL-6 and IL-8, in bronchial epithelial cells of patients with asthma. J. Allergy Clin. Immunol. 89:1001-1009.
54. Weill, P. 1919. Über die leukocytären elemente der darmschleimhaut der saugetiere. Ein beitrag zur beurteilung der granulationen in leukocyten. Arch. Mikr. Anat. 93:1-81.
55. Akpavie, S. O., and Pirie, H. M. 1989. The globule leucocyte: morphology, origin, function and fate. A review. Anat. Histol. Embryol. 18: 87-95.
56. Jarrett, W. F. M., H. R. P. Miller, and M. Murray. 1967. The relationship between mast cell and globule leucocytes in parasitic infections. Vet. Rec. 80:503-506.
57. Murray, M., H. R. P. Miller, and W. F. H. Jarrett. 1968. The globule leucocyte and its derivation from the subepithelial mast cell. Lab. Invest. 2:222-234.
58. Baldwin, F., and A. B. Becker. 1993. Bronchoalveolar eosinophilic cells in a canine model of asthma. Two distinctive populations. Vet. Pathol. 30:97-103.
59. Gibson, P. G., A. Gingis-Gabardo, M. M. Morris, S. Mattoli, J. M. Kay, J. Dolovich, J. Denburg, and F. E. Hargreave. 1989. Cellular characteristics of sputum from patients with asthma and chronic bronchitis. Thorax 44:693-699.
60. Dunnill, M. S. 1960. The pathology of asthma with special reference to changes in the bronchial mucosa. J. Clin. Pathol. 13:27-33.
61. Glynn, A. A., and L. Michaels. 1960. Bronchial biopsy in chronic bronchitis and asthma. Thorax 15:142-153.
62. Renz, H., H. R. Smith, J. E. Henson, B. S. Ray, C. G. Irvin, and E. W. Gelfand. 1992. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse. J. Allergy Clin. Immunol. 89:1127-1138.
63. Renz, H., J. Saloga, K. L. Bradley, J. E. Loader, J. K. Greenstein, G. Larsen and E. W. Gelfand. 1993. Specific Vβ T-cell subsets mediate the immediate hypersensitivity response to ragweed allergen. J. Immunol. 151:1907-1917.
64. Renz, H., G. Lack, J. Saloga, R. Schwinzer, K. Bradley, J. Loader, A. Kupfer, G. L. Larsen, and E. W. Gelfand. 1994. Inhibition of IgE production and normalization of airways responsiveness by sensitized CD8 T cells in a mouse model of allergen-induced sensitization. J. Immunol. 152:351-360.
65. Lack, G., H. Renz, J. Saloga, K. L. Bradley, J. Loader, D. Y. M. Leung, G. Larson, and E. W. Gelfand. 1994. Nebulized but not parenteral interferon-gamma decreases IgE production and normalizes airways function in a murine model of allergen sensitization. J. Immunol. 152:2546-2554.
66. Nakajima, H., H. Sano, T. Nishimura, S. Yoshida and I. Iwamoto. 1994. Role of VCAM-1, VLA-4 and ICAM-1, LFA-1 interactions in antigen-induced eosinophil and T-cell recruitment into the tissue. J. Exp. Med. 179:1145-1154.
67. Nakajima, H., I. Iwamoto, and S. Yoshida. 1993. Aerosolized recombinant interferon-gamma prevents antigen-induced eosinophil recruitment in mouse trachea. Am. Rev. Respir. Dis. 148:1102-1104.
68. + T-cell recruitment into tissue. J. Immunol. 153:1264-1270.
69. Lukacs, N. W., R. M. Streiter, S. W. Chensue, and S. L. Kunkel. 1994. Interleukin-4-dependent pulmonary eosinophil infiltration in a murine model of asthma. Am. J. Respir. Cell Mol. Biol. 10:526-532.
70. + T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am. J. Respir. Cell Mol. Biol. 10:587-593.
71. Yamaguchi, S., H. Nagai, H. Tanaka, M. Tsujimoto, and N. Tsuruoka. 1994. Time-course study for antigen-induced airway hyperreactivity and the effect of soluble IL-5 receptor. Life Sci. 54:PL471-PL475.
72. Brusselle, G. G., J. C. Kips, J. H. Tavernier, J. G. van der Heyden, C. A. Cuvelier, R. A. Pauwels, and H. Bluethmann. 1994. Attenuation of allergic airway inflammation in IL-4- deficient mice. Clin. Exp. Allergy 24: 73-80.
73. Kung, T. T., H. Jones, G. K. Adams, S. P. Umland, W. Kreutner, R. W. Egan, R. W. Chapman, and A. S. Watnick. 1994. Characterization of a murine model of allergic pulmonary inflammation. Int. Arch. Allergy Immunol. 105:83-90.