Plasma cells in systemic lupus erythematosus: The long and short of it all

European Journal of Immunology

Volumn 41, Issue 3, 2011, Pages 588-591

  Liu, Zheng ^a   Zou, YongRui ^a   Davidson, Anne ^a  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Interferon a; Plasma cells; Systemic lupus erythematosus

Indexed keywords

ABATACEPT; ALPHA INTERFERON; APRIL PROTEIN; B CELL ACTIVATING FACTOR; B LYMPHOCYTE RECEPTOR; BELIMUMAB; CHEMOKINE RECEPTOR CXCR4; CYCLOPHOSPHAMIDE; CYTOKINE; DOUBLE STRANDED DNA ANTIBODY; IMMUNOSUPPRESSIVE AGENT; INTERFERON; INTERFERON ANTIBODY; INTERLEUKIN 6; PROTEASOME INHIBITOR; RITUXIMAB; STEROID; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL DIFFERENTIATION; CELL FATE; CELL PROLIFERATION; CELL SURVIVAL; CELL THERAPY; CONTROLLED CLINICAL TRIAL (TOPIC); DRUG MECHANISM; DRUG MEGADOSE; DRUG TARGETING; HEMATOPOIESIS; HISTOPATHOLOGY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MEMORY CELL; NONHUMAN; PHASE 3 CLINICAL TRIAL (TOPIC); PLASMA CELL; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RELAPSE; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODY SPECIFICITY; AUTOANTIBODIES; CELL DIFFERENTIATION; CELL SURVIVAL; DISEASE MODELS, ANIMAL; HUMANS; INTERFERON TYPE I, RECOMBINANT; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED BALB C; MICE, INBRED NZB; PLASMA CELLS;

EID: 79951784900     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201041354     Document Type: Article

References (28)

1. Cucak, H., Yrlid, U., Reizis, B., Kalinke, U. and Johansson-Lindbom, B., Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity 2009. 31: 491-501.
2. Boule, M. W., Broughton, C., Mackay, F., Akira, S., Marshak-Rothstein, A. and Rifkin, I. R., Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J. Exp. Med. 2004. 199: 1631-1640.
3. Banchereau, J. and Pascual, V., Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 2006. 25: 383-392.
4. Mathian, A., Weinberg, A., Gallegos, M., Banchereau, J. and Koutouzov, S., IFN-alpha induces early lethal lupus in preautoimmune (New Zealand Black x New Zealand White) F1 but not in BALB/c mice. J. Immunol. 2005. 174: 2499-2506.
5. Ramanujam, M., Kahn, P., Huang, W., Tao, H., Madaio, M. P., Factor, S. M. and Davidson, A., Interferon-alpha treatment of female (NZW x BXSB)F(1) mice mimics some but not all features associated with the Yaa mutation. Arthritis Rheum. 2009. 60: 1096-1101.
6. Fairhurst, A. M., Mathian, A., Connolly, J. E., Wang, A., Gray, H. F., George, T. A., Boudreaux, C. D. et al., Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice. Eur. J. Immunol. 2008. 38: 1948-1960.
7. Baccala, R., Hoebe, K., Kono, D. H., Beutler, B. and Theofilopoulos, A. N., TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat. Med. 2007. 13: 543-551.
8. Mathian, A., Gallegos, M., Pascual, V., Banchereau, J. and Koutouzov, S., Interferon alpha induces unabated production of short-lived plasma cells in pre-autoimmune lupus-prone (NZB×NZW)F1 mice but not in BALB/c mice. Eur. J. Immunol. 2011. 41: 863-872
9. Liu, Z., Bethunaickan, R., Huang, W., Lodhi, U., Solano, I., Madaio, M. P. and Davidson, A., Interferon alpha accelerates murine SLE in a T cell dependent manner. Arthritis Rheum. 2011. 63: 219-229.
10. Paus, D., Phan, T. G., Chan, T. D., Gardam, S., Basten, A. and Brink, R., Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. J. Exp. Med. 2006. 203: 1081-1091.
11. Oracki, S. A., Walker, J. A., Hibbs, M. L., Corcoran, L. M. and Tarlinton, D. M., Plasma cell development and survival. Immunol Rev. 2010. 237: 140-159.
12. Herlands, R. A., William, J., Hershberg, U. and Shlomchik, M. J., Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites. Eur. J. Immunol. 2007. 37: 3339-3351.
13. Kim, S. J., Caton, M., Wang, C., Khalil, M., Zhou, Z. L., Hardin, J. A. and Diamond, B., Increased IL-12 inhibits B cell differentiation to germinal center plasma cells and promotes differentiation to short-lived plasmablasts. J. Exp. Med. 2008. 205: 2437-2448.
14. Gatto, D., Paus, D., Basten, A., Mackay, C. R. and Brink, R., Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity 2009. 31: 259-269.
15. Erickson, L. D., Durell, B. G., Vogel, L. A., O'Connor, B. P., Cascalho, M., Yasui, T., Kikutani, H. and Noelle, R. J., Short-circuiting long-lived humoral immunity by the heightened engagement of CD40. J. Clin. Invest. 2002. 109: 613-620.
16. Sze, D. M., Toellner, K. M., Garcia de Vinuesa, C., Taylor, D. R. and MacLennan, I. C., Intrinsic constraint on plasmablast growth and extrinsic limits of plasma cell survival. J. Exp. Med. 2000. 192: 813-821.
17. Phan, T. G., Paus, D., Chan, T. D., Turner, M. L., Nutt, S. L., Basten, A. and Brink, R., High affinity germinal center B cells are actively selected into the plasma cell compartment. J. Exp. Med. 2006. 203: 2419-2424.
18. Gatto, D., Pfister, T., Jegerlehner, A., Martin, S. W., Kopf, M. and Bachmann, M. F., Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1. J. Exp. Med. 2005. 201: 993-1005.
19. Cassese, G., Lindenau, S., de Boer, B., Arce, S., Hauser, A., Riemekasten, G., Berek, C. et al., Inflamed kidneys of NZB/W mice are a major site for the homeostasis of plasma cells. Eur. J. Immunol. 2001. 31: 2726-2732.
20. Mohr, E., Serre, K., Manz, R. A., Cunningham, A. F., Khan, M., Hardie, D. L., Bird, R. and MacLennan, I. C., Dendritic cells and monocyte/macrophages that create the IL-6/APRIL-rich lymph node microenvironments where plasmablasts mature. J. Immunol. 2009. 182: 2113-2123.
21. Tokoyoda, K., Zehentmeier, S., Chang, H. D. and Radbruch, A., Organization and maintenance of immunological memory by stroma niches. Eur. J. Immunol. 2009. 39: 2095-2099.
22. Ueda, Y., Yang, K., Foster, S. J., Kondo, M. and Kelsoe, G., Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. J. Exp. Med. 2004. 199: 47-58.
23. Adalid-Peralta, L., Mathian, A., Tran, T., Delbos, L., Durand-Gasselin, I., Berrebi, D., Peuchmaur, M. et al., Leukocytes and the kidney contribute to interstitial inflammation in lupus nephritis. Kidney Int. 2008. 73: 172-180.
24. Grammer, A. C. and Lipsky, P. E., B cell abnormalities in systemic lupus erythematosus. Arthritis Res. Ther. 2003. 5: S22-S27.
25. Odendahl, M., Jacobi, A., Hansen, A., Feist, E., Hiepe, F., Burmester, G. R., Lipsky, P. E. et al., Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. J. Immunol. 2000. 165: 5970-5979.
26. Huang, W., Sinha, J., Newman, J., Reddy, B., Budhai, L., Furie, R., Vaishnaw, A. and Davidson, A., The effect of anti-CD40 ligand antibody on B cells in human SLE. Arthritis Rheum. 2002. 46: 1554-1562.
27. Looney, R. J., Anolik, J. and Sanz, I., B cells as therapeutic targets for rheumatic diseases. Curr. Opin. Rheumatol. 2004. 16: 180-185.
28. Merrill, J. T., Neuwelt, C. M., Wallace, D. J., Shanahan, J. C., Latinis, K. M., Oates, J. C., Utset, T. O. et al., Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial. Arthritis Rheum. 2010. 62: 222-233.