Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity

Nature Medicine

Volumn 10, Issue 9, 2004, Pages 927-934

  Moyron Quiroz, Juan E ^a   Rangel Moreno, Javier ^a   Kusser, Kim ^a   Hartson, Louise ^a   Sprague, Frank ^a   Goodrich, Stephen ^a   Woodland, David L ^a   Lund, Frances E ^a   Randall, Troy D ^a  

^a TRUDEAU INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; CXCL13 CHEMOKINE; LYMPHOTOXIN; SECONDARY LYMPHOID TISSUE CHEMOKINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE ACTIVATION; BRONCHUS MUCOSA; CONTROLLED STUDY; CYTOKINE RELEASE; HOST RESISTANCE; IMMUNOREACTIVITY; INFLUENZA; LYMPHOCYTE PROLIFERATION; LYMPHOID TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; BLOTTING, NORTHERN; BROMODEOXYURIDINE; BRONCHI; CHEMOKINES, CC; CHEMOKINES, CXC; CHROMIUM RADIOISOTOPES; DNA, COMPLEMENTARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNITY, CELLULAR; IMMUNOHISTOCHEMISTRY; LYMPHOCYTES; LYMPHOID TISSUE; MICE; MICE, INBRED C57BL; ORTHOMYXOVIRIDAE; ORTHOMYXOVIRIDAE INFECTIONS; SEQUENCE ANALYSIS, DNA;

ANIMALIA; BRONCHUS;

EID: 4644330206     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1091     Document Type: Article

References (41)

1. Goodnow, C.C. Chance encounters and organized rendezvous. Immunol. Rev. 156, 5-10 (1997).
2. Barker, C.F. & Billingham, R.E. The role of afferent lymphatics in the rejection of skin homografts. J. Exp. Med. 128, 197-221 (1968).
3. Zinkernagel, R.M. et al. Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity. Immunol. Rev. 156, 199-209 (1997).
4. + T cells. J. Exp. Med. 194, 953-966 (2001).
5. Roman, E. et al. CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function. J. Exp. Med. 196, 957-968 (2002).
6. Banks, T.A. et al. Lymphotoxin-α-deficient mice: effects on secondary lymphoid organ development and humoral immune responsiveness. J. Immunol. 155, 1685-1693 (1995).
7. de Togni, P. et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264, 703-707 (1994).
8. Miyawaki, S. et al. A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur. J. Immunol. 24, 429-434 (1994).
9. Shinkura, R. et al. Alymphoplasia is caused by a point mutation in the mouse gene encoding NFκB-inducing kinase. Nat. Genet. 22, 74-77 (1999).
10. -/-) mutant mice. J. Exp. Med. 185, 2157-2170 (1997).
11. Rennert, P.D. et al. Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-α-deficient mice. J. Exp. Med. 193, 1227-1238 (2001).
12. Lakkis, F.G., Arakelov, A., Konieczny, B.T. & Inoue, Y. Immunological 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue. Nat. Med. 6, 686-688 (2000).
13. Lund, F.E. et al. Lymphotoxin-α-deficient mice make delayed, but effective, T and B cell responses to influenza. J. Immunol. 169, 5236-5243 (2002).
14. Lee, B.J., Santee, S., Von Gesjen, S., Ware, C.F. & Sarawar, S.R. Lymphotoxin-α-deficient mice can clear a productive infection with murine gammaherpesvirus 68 but fail to develop splenomegaly or lymphocytosis. J. Virol. 74, 2786-2792 (2000).
15. Feuerer, M. et al. Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nat. Med. 9, 1151-1157 (2003).
16. Tripp, R.A., Topham, D.J., Watson, S.R. & Doherty, P.C. Bone marrow can function as a lymphoid organ during a primary immune response under conditions of disrupted lymphocyte trafficking. J. Immunol. 158, 3716-3720 (1997).
17. Bienenstock, J., Rudzik, O., Clancy, R.L. & Perey, D.Y. Bronchial lymphoid tissue. Adv. Exp. Med. Biol. 45, 47-56 (1974).
18. Delventhal, S., Hensel, A., Petzoldt, K. & Pabst, R. Effects of microbial stimulation on the number, size and activity of bronchus-associated lymphoid tissue (BALT) structures in the pig. Int. J. Exp. Path. 73, 351-357 (1992).
19. Tshering, T. & Pabst, R. Bronchus associated lymphoid tissue (BALT) is not present in normal adult lung but in different diseases. Pathobiol. 68, 1-8 (2000).
20. Chvatchko, Y., Kosco-Vilbois, M.H., Herren, S., Lefort, J. & Bonnefoy, J.-Y. Germinal center formation and local immunoglobulin E (IgE) production in the lung after an airway antigenic challenge. J. Exp. Med. 184, 2353-2360 (1996).
21. Chin, R.K. et al. Lymphotoxin pathway directs thymic Aire expression. Nat. Immunol. 4, 1121-1127 (2003).
22. Bienenstock, J. & Johnston, N. A morphologic study of rabbit bronchial lymphoid aggregates and lymphoepithelium. Lab. Invest. 35, 343-348 (1976).
23. Plesch, B.E.C., van der Brugge-Garnelkoorn, G.J. & van de Ende, M.B. Development of bronchus associated lymphoid tissue (BALT) in the rat, with special reference to T and B cells. Dev. Comp. Immunol. 7, 79-84 (1983).
24. Harmsen, A. et al. Organogenesis of nasal associated lymphoid tissue (NALT) occurs independently of lymphotoxin-α (LTα) and retinoic acid receptor-related orphan receptor-g, but the organization of NALT is LTα-dependent. J. Immunol. 168, 986-990 (2002).
25. Sun, Z. et al. Requirement for RORγ in thymocyte survival and lymphoid organ development. Science 288, 2369-2373 (2000).
26. Matsumoto, M. et al. Role of lymphotoxin and the type 1 TNF receptor in the formation of germinal centers. Science 271, 1289-1291 (1996).
27. Fu, Y.-X., Huang, G., Matsumoto, M., Molina, H. & Chaplin, D.D. Independent signals regulate development of primary and secondary follicular structure in spleen and mesenteric lymph node. Proc. Natl. Acad. Sci. 94, 5739-5743 (1997).
28. Ngo, V.N. et al. Lymphotoxin α/β and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J. Exp. Med. 189, 403-412 (1999).
29. Gunn, M.D. et al. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189, 451-460 (1999).
30. Nakano, H. & Gunn, M.D. Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. J. Immunol. 166, 361-369 (2001).
31. Hussell, T., Pennycook, A. & Openshaw, P.J. Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology. Eur. J. Immunol. 31, 2566-2573 (2001).
32. Constant, S.L. et al. Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ. J. Clin. Invest. 110, 1441-1448 (2002).
33. + T cells in heterologous antiviral immunity and immunopathology in the lung. Nat. Immunol. 2, 1067-1076 (2001).
34. Brimnes, M.K., Bonifaz, L., Steinman, R.M. & Moran, T.M. Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein. J. Exp. Med. 198, 133-144 (2003).
35. Hogg, J.C. et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 350, 2645-2653 (2004).
36. Xu, B. et al. Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, α4β1 integrin/VCAM-1, and LFA-1 adhesion pathways. J. Exp. Med. 197, 1255-1267 (2003).
37. Ansel, K.M. et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 406, 309-314 (2000).
38. Futterer, A., Mink, K., Luz, A., Kosco-Vilbois, M.H. & Pfeffer, K. The lymphotoxin b receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9, 59-70 (1998).
39. Kang, H.S. et al. Lymphotoxin is required for maintaining physiological levels of serum IgE that minimizes Th1-mediated airway inflammation. J. Exp. Med. 198, 1643-1652 (2003).
40. Lo, J.C. et al. Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues. J. Clin. Invest. 112, 1495-1505 (2003).
41. + T cell-mediated intestinal allograft rejection. J. Immunol. 167, 4796-4800 (2001).