Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice

American Journal of Respiratory Cell and Molecular Biology

Volumn 27, Issue 3, 2002, Pages 368-374

  Churg, Andrew ^a   Zay, Katalin ^a   Shay, Selena ^a   Xie, Changshi ^a   Shapiro, Steven D ^a   Hendricks, Robert ^a   Wright, Joanne L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; MYCOBACTERIUM AVIUM COMPLEX (MAC); NICOTIANA TABACUM;

EID: 0036727064     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.4791     Document Type: Article

References (37)

1. The definition of emphysema
2. Chronic obstructive pulmonary disease (COPD)
3. Evolving concepts in the pathogenesis of chronic obstructive pulmonary disease
4. Pitfalls in antiprotease therapy of emphysema
5. Cigarette smoking, emphysema, and damage to α1-proteinase inhibitor
6. Risk factors for emphysema: Cigarette smoking is associated with a reduction in the association rate constant of lung α1-antitrypsin for neutrophil elastase
7. Acute cigarette smoke-induced connective tissue breakdown is mediated by neutrophils and prevented by α-1-antitrypsin
8. Cigarette smoking and lung destruction
9. Alveolar inflammation and its relation to emphysema in smokers
10. Cigarette smoking causes accumulation of polymorphonuclear leukocytes in the alveolar septum
11. Elastases and Emphysema: Current assessment of the protease-antiprotease hypothesis
12. Cellularity of the alveolar walls in smokers and its relation to alveolar destruction
13. Neutrophil recruitment into the lungs is associated with increased lung elastase burden, decreased lung elastin, and emphysema in alpha-1-proteinase inhibitor-deficient mice
14. Elastin degradation by human alveolar macrophages
15. Elastolytic metalloproteinases produced by human mononuclear phagocytes
16. Human 92- and 72-kilodalton type IV collagenases are elastases
17. Collagen and elastin in human pulmonary emphysema
18. Smoke-induced emphysema in the guinea pig is associated with morphometric evidence of collagen breakdown and repair
19. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
20. Effect of exposure of guinea pigs to cigarette smoke on elastolytic activity of pulmonary macrophages
21. Matrix metalloproteinase expression and production by alveolar macrophages in emphysema
22. Tobacco smoke-induced lung emphysema in guinea pigs is associated with increased interstitial collagenase
23. Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema
24. Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects
25. Reduced tumor necrosis factor-alpha and transforming factor betal expression in the lungs of inbred mice that fail to develop fibroproliferative lesions consequent to asbestos exposure
26. Matrix metalloproteinase inhibition limits arterial enlargement in a rodent arteriovenous fistula model
27. Cigarette smoke causes rapid cell proliferation in small airways and associated pulmonary arteries
28. Mineral dusts cause collagen and elastin breakdown in the rat lung: A potential mechanism of dust-induced emphysema
29. Chemotactic activity of elastin-derived peptides
30. Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes
31. Elastin fragments attract macrophage precursors to diseased sites in pulmonary emphysema
32. Neutrophil response following intratracheal instillation of collagen peptides into rat lungs
33. Smoke extract stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activity
34. The serpin α1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo
35. The role of metalloelastase in immune complex induced acute lung injury
36. Role of stromelysin 1 and gelatinase B in experimental acute lung injury
37. Amplification of inflammation in emphysema and its association with latent adenoviral infection