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Volumn 126, Issue 5, 2010, Pages 898-907

The germinal center reaction

Author keywords

Affinity maturation; Antibody response; B cell differentiation; B cell migration; Germinal center; Somatic hypermutation

Indexed keywords

ANTIGEN; AUTOANTIBODY; CD40 ANTIGEN; CD40 LIGAND; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR5; CXCL13 CHEMOKINE; INTERLEUKIN 21; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; STROMAL CELL DERIVED FACTOR 1;

EID: 78049456523     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.09.007     Document Type: Review
Times cited : (141)

References (104)
  • 1
    • 84951605128 scopus 로고
    • Studien über Regeneration der Gewebe
    • W. Flemming Studien über Regeneration der Gewebe Arch Mikrosk Anat 24 1885 50 91
    • (1885) Arch Mikrosk Anat , vol.24 , pp. 50-91
    • Flemming, W.1
  • 2
    • 78049485046 scopus 로고
    • Schlussbemerkungen über die Zellvermehrung in den lymphoiden Drüsen
    • W. Flemming Schlussbemerkungen über die Zellvermehrung in den lymphoiden Drüsen Arch Mikrosk Anat 24 1885 355 361
    • (1885) Arch Mikrosk Anat , vol.24 , pp. 355-361
    • Flemming, W.1
  • 3
    • 0021246815 scopus 로고
    • Functional anatomy of germinal centers
    • P. Nieuwenhuis, and D. Opstelten Functional anatomy of germinal centers Am J Anat 170 1984 421 435
    • (1984) Am J Anat , vol.170 , pp. 421-435
    • Nieuwenhuis, P.1    Opstelten, D.2
  • 5
    • 0037034880 scopus 로고    scopus 로고
    • Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position
    • K. Reif, E.H. Ekland, L. Ohl, H. Nakano, M. Lipp, and R. Forster Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position Nature 416 2002 94 99
    • (2002) Nature , vol.416 , pp. 94-99
    • Reif, K.1    Ekland, E.H.2    Ohl, L.3    Nakano, H.4    Lipp, M.5    Forster, R.6
  • 6
    • 0028298229 scopus 로고
    • Gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory
    • T.M. Foy, J.D. Laman, J.A. Ledbetter, A. Aruffo, E. Claassen, and R.J. Noelle gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory J Exp Med 180 1994 157 163
    • (1994) J Exp Med , vol.180 , pp. 157-163
    • Foy, T.M.1    Laman, J.D.2    Ledbetter, J.A.3    Aruffo, A.4    Claassen, E.5    Noelle, R.J.6
  • 7
    • 0029052398 scopus 로고
    • Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers
    • S. Han, K. Hathcock, B. Zheng, T.B. Kepler, R. Hodes, and G. Kelsoe Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers J Immunol 155 1995 556 567
    • (1995) J Immunol , vol.155 , pp. 556-567
    • Han, S.1    Hathcock, K.2    Zheng, B.3    Kepler, T.B.4    Hodes, R.5    Kelsoe, G.6
  • 9
    • 42649123314 scopus 로고    scopus 로고
    • Mechanism and regulation of class switch recombination
    • J. Stavnezer, J.E. Guikema, and C.E. Schrader Mechanism and regulation of class switch recombination Annu Rev Immunol 26 2008 261 292
    • (2008) Annu Rev Immunol , vol.26 , pp. 261-292
    • Stavnezer, J.1    Guikema, J.E.2    Schrader, C.E.3
  • 10
    • 70349249529 scopus 로고    scopus 로고
    • Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts
    • T.D. Chan, D. Gatto, K. Wood, T. Camidge, A. Basten, and R. Brink Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts J Immunol 183 2009 3139 3149
    • (2009) J Immunol , vol.183 , pp. 3139-3149
    • Chan, T.D.1    Gatto, D.2    Wood, K.3    Camidge, T.4    Basten, A.5    Brink, R.6
  • 11
    • 0037867080 scopus 로고    scopus 로고
    • Visualization of the genesis and fate of isotype-switched B cells during a primary immune response
    • K.A. Pape, V. Kouskoff, D. Nemazee, H.L. Tang, J.G. Cyster, and L.E. Tze Visualization of the genesis and fate of isotype-switched B cells during a primary immune response J Exp Med 197 2003 1677 1687
    • (2003) J Exp Med , vol.197 , pp. 1677-1687
    • Pape, K.A.1    Kouskoff, V.2    Nemazee, D.3    Tang, H.L.4    Cyster, J.G.5    Tze, L.E.6
  • 12
    • 0025951891 scopus 로고
    • Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens
    • Y.J. Liu, J. Zhang, P.J. Lane, E.Y. Chan, and I.C. MacLennan Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens Eur J Immunol 21 1991 2951 2962
    • (1991) Eur J Immunol , vol.21 , pp. 2951-2962
    • Liu, Y.J.1    Zhang, J.2    Lane, P.J.3    Chan, E.Y.4    MacLennan, I.C.5
  • 13
    • 0025726702 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations
    • J. Jacob, R. Kassir, and G. Kelsoe In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations J Exp Med 173 1991 1165 1175
    • (1991) J Exp Med , vol.173 , pp. 1165-1175
    • Jacob, J.1    Kassir, R.2    Kelsoe, G.3
  • 15
    • 0026670190 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers
    • J. Jacob, and G. Kelsoe In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers J Exp Med 176 1992 679 687
    • (1992) J Exp Med , vol.176 , pp. 679-687
    • Jacob, J.1    Kelsoe, G.2
  • 16
    • 0027491651 scopus 로고
    • Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections
    • R. Kuppers, M. Zhao, M.L. Hansmann, and K. Rajewsky Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections EMBO J 12 1993 4955 4967
    • (1993) EMBO J , vol.12 , pp. 4955-4967
    • Kuppers, R.1    Zhao, M.2    Hansmann, M.L.3    Rajewsky, K.4
  • 18
    • 0030582773 scopus 로고    scopus 로고
    • A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    • R. Forster, A.E. Mattis, E. Kremmer, E. Wolf, G. Brem, and M. Lipp A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen Cell 87 1996 1037 1047
    • (1996) Cell , vol.87 , pp. 1037-1047
    • Forster, R.1    Mattis, A.E.2    Kremmer, E.3    Wolf, E.4    Brem, G.5    Lipp, M.6
  • 19
    • 0035796411 scopus 로고    scopus 로고
    • A coordinated change in chemokine responsiveness guides plasma cell movements
    • D.C. Hargreaves, P.L. Hyman, T.T. Lu, V.N. Ngo, A. Bidgol, and G. Suzuki A coordinated change in chemokine responsiveness guides plasma cell movements J Exp Med 194 2001 45 56
    • (2001) J Exp Med , vol.194 , pp. 45-56
    • Hargreaves, D.C.1    Hyman, P.L.2    Lu, T.T.3    Ngo, V.N.4    Bidgol, A.5    Suzuki, G.6
  • 20
    • 68649108084 scopus 로고    scopus 로고
    • Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses
    • D. Gatto, D. Paus, A. Basten, C.R. Mackay, and R. Brink Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses Immunity 31 2009 259 269
    • (2009) Immunity , vol.31 , pp. 259-269
    • Gatto, D.1    Paus, D.2    Basten, A.3    MacKay, C.R.4    Brink, R.5
  • 21
    • 69349087555 scopus 로고    scopus 로고
    • EBI2 mediates B cell segregation between the outer and centre follicle
    • J.P. Pereira, L.M. Kelly, Y. Xu, and J.G. Cyster EBI2 mediates B cell segregation between the outer and centre follicle Nature 460 2009 1122 1126
    • (2009) Nature , vol.460 , pp. 1122-1126
    • Pereira, J.P.1    Kelly, L.M.2    Xu, Y.3    Cyster, J.G.4
  • 22
    • 4644219817 scopus 로고    scopus 로고
    • Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
    • C.D. Allen, K.M. Ansel, C. Low, R. Lesley, H. Tamamura, and N. Fujii Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5 Nat Immunol 5 2004 943 952
    • (2004) Nat Immunol , vol.5 , pp. 943-952
    • Allen, C.D.1    Ansel, K.M.2    Low, C.3    Lesley, R.4    Tamamura, H.5    Fujii, N.6
  • 23
    • 33751574420 scopus 로고    scopus 로고
    • Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor
    • B.P. O'Connor, L.A. Vogel, W. Zhang, W. Loo, D. Shnider, and E.F. Lind Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor J Immunol 177 2006 7723 7732
    • (2006) J Immunol , vol.177 , pp. 7723-7732
    • O'Connor, B.P.1    Vogel, L.A.2    Zhang, W.3    Loo, W.4    Shnider, D.5    Lind, E.F.6
  • 24
    • 33645856486 scopus 로고    scopus 로고
    • Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation
    • D. Paus, T.G. Phan, T.D. Chan, S. Gardam, A. Basten, and R. Brink Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation J Exp Med 203 2006 1081 1091
    • (2006) J Exp Med , vol.203 , pp. 1081-1091
    • Paus, D.1    Phan, T.G.2    Chan, T.D.3    Gardam, S.4    Basten, A.5    Brink, R.6
  • 26
    • 0022405823 scopus 로고
    • Human follicular dendritic cells express CR1, CR2, and CR3 complement receptor antigens
    • M. Reynes, J.P. Aubert, J.H. Cohen, J. Audouin, V. Tricottet, and J. Diebold Human follicular dendritic cells express CR1, CR2, and CR3 complement receptor antigens J Immunol 135 1985 2687 2694
    • (1985) J Immunol , vol.135 , pp. 2687-2694
    • Reynes, M.1    Aubert, J.P.2    Cohen, J.H.3    Audouin, J.4    Tricottet, V.5    Diebold, J.6
  • 27
    • 0019231835 scopus 로고
    • The follicular dendritic cell: Long term antigen retention during immunity
    • T.E. Mandel, R.P. Phipps, A. Abbot, and J.G. Tew The follicular dendritic cell: long term antigen retention during immunity Immunol Rev 53 1980 29 59
    • (1980) Immunol Rev , vol.53 , pp. 29-59
    • Mandel, T.E.1    Phipps, R.P.2    Abbot, A.3    Tew, J.G.4
  • 28
    • 0025853549 scopus 로고
    • Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways
    • G. Koopman, H.K. Parmentier, H.J. Schuurman, W. Newman, C.J. Meijer, and S.T. Pals Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways J Exp Med 173 1991 1297 1304
    • (1991) J Exp Med , vol.173 , pp. 1297-1304
    • Koopman, G.1    Parmentier, H.K.2    Schuurman, H.J.3    Newman, W.4    Meijer, C.J.5    Pals, S.T.6
  • 29
    • 38049144850 scopus 로고    scopus 로고
    • Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    • N.M. Haynes, C.D. Allen, R. Lesley, K.M. Ansel, N. Killeen, and J.G. Cyster Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation J Immunol 179 2007 5099 5108
    • (2007) J Immunol , vol.179 , pp. 5099-5108
    • Haynes, N.M.1    Allen, C.D.2    Lesley, R.3    Ansel, K.M.4    Killeen, N.5    Cyster, J.G.6
  • 30
    • 33846400415 scopus 로고    scopus 로고
    • The germinal center response is impaired in the absence of T cell-expressed CXCR5
    • C.N. Arnold, D.J. Campbell, M. Lipp, and E.C. Butcher The germinal center response is impaired in the absence of T cell-expressed CXCR5 Eur J Immunol 37 2007 100 109
    • (2007) Eur J Immunol , vol.37 , pp. 100-109
    • Arnold, C.N.1    Campbell, D.J.2    Lipp, M.3    Butcher, E.C.4
  • 31
    • 0029872907 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes
    • S.D. Wagner, and M.S. Neuberger Somatic hypermutation of immunoglobulin genes Annu Rev Immunol 14 1996 441 457
    • (1996) Annu Rev Immunol , vol.14 , pp. 441-457
    • Wagner, S.D.1    Neuberger, M.S.2
  • 32
    • 4944257670 scopus 로고    scopus 로고
    • The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies
    • Z. Luo, D. Ronai, and M.D. Scharff The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies J Allergy Clin Immunol 114 2004 726 736
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 726-736
    • Luo, Z.1    Ronai, D.2    Scharff, M.D.3
  • 33
    • 0035753523 scopus 로고    scopus 로고
    • Emerging links between hypermutation of antibody genes and DNA polymerases
    • P.J. Gearhart, and R.D. Wood Emerging links between hypermutation of antibody genes and DNA polymerases Nat Rev Immunol 1 2001 187 192
    • (2001) Nat Rev Immunol , vol.1 , pp. 187-192
    • Gearhart, P.J.1    Wood, R.D.2
  • 34
    • 0026331458 scopus 로고
    • Maturation of the immune response in germinal centers
    • C. Berek, A. Berger, and M. Apel Maturation of the immune response in germinal centers Cell 67 1991 1121 1129
    • (1991) Cell , vol.67 , pp. 1121-1129
    • Berek, C.1    Berger, A.2    Apel, M.3
  • 35
    • 0026060620 scopus 로고
    • Intraclonal generation of antibody mutants in germinal centres
    • J. Jacob, G. Kelsoe, K. Rajewsky, and U. Weiss Intraclonal generation of antibody mutants in germinal centres Nature 354 1991 389 392
    • (1991) Nature , vol.354 , pp. 389-392
    • Jacob, J.1    Kelsoe, G.2    Rajewsky, K.3    Weiss, U.4
  • 37
    • 33846635838 scopus 로고    scopus 로고
    • Imaging of germinal center selection events during affinity maturation
    • C.D. Allen, T. Okada, H.L. Tang, and J.G. Cyster Imaging of germinal center selection events during affinity maturation Science 315 2007 528 531
    • (2007) Science , vol.315 , pp. 528-531
    • Allen, C.D.1    Okada, T.2    Tang, H.L.3    Cyster, J.G.4
  • 38
    • 34248585765 scopus 로고    scopus 로고
    • Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns
    • A.E. Hauser, T. Junt, T.R. Mempel, M.W. Sneddon, S.H. Kleinstein, and S.E. Henrickson Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns Immunity 26 2007 655 667
    • (2007) Immunity , vol.26 , pp. 655-667
    • Hauser, A.E.1    Junt, T.2    Mempel, T.R.3    Sneddon, M.W.4    Kleinstein, S.H.5    Henrickson, S.E.6
  • 41
    • 67649221652 scopus 로고    scopus 로고
    • Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation
    • T.G. Phan, J.A. Green, E.E. Gray, Y. Xu, and J.G. Cyster Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation Nat Immunol 10 2009 786 793
    • (2009) Nat Immunol , vol.10 , pp. 786-793
    • Phan, T.G.1    Green, J.A.2    Gray, E.E.3    Xu, Y.4    Cyster, J.G.5
  • 42
    • 0024989657 scopus 로고
    • Maintenance of B-cell memory by long-lived cells generated from proliferating precursors
    • B. Schittek, and K. Rajewsky Maintenance of B-cell memory by long-lived cells generated from proliferating precursors Nature 346 1990 749 751
    • (1990) Nature , vol.346 , pp. 749-751
    • Schittek, B.1    Rajewsky, K.2
  • 43
    • 0025783070 scopus 로고
    • Molecular characterization of single memory B cells
    • M.G. McHeyzer-Williams, G.J. Nossal, and P.A. Lalor Molecular characterization of single memory B cells Nature 350 1991 502 505
    • (1991) Nature , vol.350 , pp. 502-505
    • McHeyzer-Williams, M.G.1    Nossal, G.J.2    Lalor, P.A.3
  • 44
    • 1842405362 scopus 로고    scopus 로고
    • Lifetime of plasma cells in the bone marrow
    • R.A. Manz, A. Thiel, and A. Radbruch Lifetime of plasma cells in the bone marrow Nature 388 1997 133 134
    • (1997) Nature , vol.388 , pp. 133-134
    • Manz, R.A.1    Thiel, A.2    Radbruch, A.3
  • 45
    • 33750502877 scopus 로고    scopus 로고
    • High affinity germinal center B cells are actively selected into the plasma cell compartment
    • T.G. Phan, D. Paus, T.D. Chan, M.L. Turner, S.L. Nutt, and A. Basten High affinity germinal center B cells are actively selected into the plasma cell compartment J Exp Med 203 2006 2419 2424
    • (2006) J Exp Med , vol.203 , pp. 2419-2424
    • Phan, T.G.1    Paus, D.2    Chan, T.D.3    Turner, M.L.4    Nutt, S.L.5    Basten, A.6
  • 46
    • 0034614896 scopus 로고    scopus 로고
    • Bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells
    • K.G. Smith, A. Light, L.A. O'Reilly, S.M. Ang, A. Strasser, and D. Tarlinton bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells J Exp Med 191 2000 475 484
    • (2000) J Exp Med , vol.191 , pp. 475-484
    • Smith, K.G.1    Light, A.2    O'Reilly, L.A.3    Ang, S.M.4    Strasser, A.5    Tarlinton, D.6
  • 47
    • 17144418984 scopus 로고    scopus 로고
    • Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1
    • D. Gatto, T. Pfister, A. Jegerlehner, S.W. Martin, M. Kopf, and M.F. Bachmann Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1 J Exp Med 201 2005 993 1005
    • (2005) J Exp Med , vol.201 , pp. 993-1005
    • Gatto, D.1    Pfister, T.2    Jegerlehner, A.3    Martin, S.W.4    Kopf, M.5    Bachmann, M.F.6
  • 49
    • 0037998827 scopus 로고    scopus 로고
    • Transcriptional regulatory cascades controlling plasma cell differentiation
    • K.I. Lin, C. Tunyaplin, and K. Calame Transcriptional regulatory cascades controlling plasma cell differentiation Immunol Rev 194 2003 19 28
    • (2003) Immunol Rev , vol.194 , pp. 19-28
    • Lin, K.I.1    Tunyaplin, C.2    Calame, K.3
  • 51
    • 0030901289 scopus 로고    scopus 로고
    • Control of inflammation, cytokine expression, and germinal center formation by BCL-6
    • A.L. Dent, A.L. Shaffer, X. Yu, D. Allman, and L.M. Staudt Control of inflammation, cytokine expression, and germinal center formation by BCL-6 Science 276 1997 589 592
    • (1997) Science , vol.276 , pp. 589-592
    • Dent, A.L.1    Shaffer, A.L.2    Yu, X.3    Allman, D.4    Staudt, L.M.5
  • 52
    • 0030763072 scopus 로고    scopus 로고
    • Disruption of the Bcl6 gene results in an impaired germinal center formation
    • T. Fukuda, T. Yoshida, S. Okada, M. Hatano, T. Miki, and K. Ishibashi Disruption of the Bcl6 gene results in an impaired germinal center formation J Exp Med 186 1997 439 448
    • (1997) J Exp Med , vol.186 , pp. 439-448
    • Fukuda, T.1    Yoshida, T.2    Okada, S.3    Hatano, M.4    Miki, T.5    Ishibashi, K.6
  • 55
    • 0033680860 scopus 로고    scopus 로고
    • BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control
    • A.L. Shaffer, X. Yu, Y. He, J. Boldrick, E.P. Chan, and L.M. Staudt BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control Immunity 13 2000 199 212
    • (2000) Immunity , vol.13 , pp. 199-212
    • Shaffer, A.L.1    Yu, X.2    He, Y.3    Boldrick, J.4    Chan, E.P.5    Staudt, L.M.6
  • 56
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • R.J. Johnston, A.C. Poholek, D. DiToro, I. Yusuf, D. Eto, and B. Barnett Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation Science 325 2009 1006 1010
    • (2009) Science , vol.325 , pp. 1006-1010
    • Johnston, R.J.1    Poholek, A.C.2    Ditoro, D.3    Yusuf, I.4    Eto, D.5    Barnett, B.6
  • 58
    • 0029936947 scopus 로고    scopus 로고
    • Induction of long-lived germinal centers associated with persisting antigen after viral infection
    • M.F. Bachmann, B. Odermatt, H. Hengartner, and R.M. Zinkernagel Induction of long-lived germinal centers associated with persisting antigen after viral infection J Exp Med 183 1996 2259 2269
    • (1996) J Exp Med , vol.183 , pp. 2259-2269
    • Bachmann, M.F.1    Odermatt, B.2    Hengartner, H.3    Zinkernagel, R.M.4
  • 59
    • 33845949142 scopus 로고    scopus 로고
    • Regulation of memory antibody levels: The role of persisting antigen versus plasma cell life span
    • D. Gatto, S.W. Martin, J. Bessa, E. Pellicioli, P. Saudan, and H.J. Hinton Regulation of memory antibody levels: the role of persisting antigen versus plasma cell life span J Immunol 178 2007 67 76
    • (2007) J Immunol , vol.178 , pp. 67-76
    • Gatto, D.1    Martin, S.W.2    Bessa, J.3    Pellicioli, E.4    Saudan, P.5    Hinton, H.J.6
  • 61
    • 0025873842 scopus 로고
    • Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis
    • Y.J. Liu, D.Y. Mason, G.D. Johnson, S. Abbot, C.D. Gregory, and D.L. Hardie Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis Eur J Immunol 21 1991 1905 1910
    • (1991) Eur J Immunol , vol.21 , pp. 1905-1910
    • Liu, Y.J.1    Mason, D.Y.2    Johnson, G.D.3    Abbot, S.4    Gregory, C.D.5    Hardie, D.L.6
  • 62
    • 77952557954 scopus 로고    scopus 로고
    • PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
    • K.L. Good-Jacobson, C.G. Szumilas, L. Chen, A.H. Sharpe, M.M. Tomayko, and M.J. Shlomchik PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells Nat Immunol 11 2010 535 542
    • (2010) Nat Immunol , vol.11 , pp. 535-542
    • Good-Jacobson, K.L.1    Szumilas, C.G.2    Chen, L.3    Sharpe, A.H.4    Tomayko, M.M.5    Shlomchik, M.J.6
  • 65
    • 77149122105 scopus 로고    scopus 로고
    • IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
    • M.A. Linterman, L. Beaton, D. Yu, R.R. Ramiscal, M. Srivastava, and J.J. Hogan IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses J Exp Med 207 2010 353 363
    • (2010) J Exp Med , vol.207 , pp. 353-363
    • Linterman, M.A.1    Beaton, L.2    Yu, D.3    Ramiscal, R.R.4    Srivastava, M.5    Hogan, J.J.6
  • 66
    • 77149142640 scopus 로고    scopus 로고
    • IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    • D. Zotos, J.M. Coquet, Y. Zhang, A. Light, K. D'Costa, and A. Kallies IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism J Exp Med 207 2010 365 378
    • (2010) J Exp Med , vol.207 , pp. 365-378
    • Zotos, D.1    Coquet, J.M.2    Zhang, Y.3    Light, A.4    D'Costa, K.5    Kallies, A.6
  • 67
    • 76149139419 scopus 로고    scopus 로고
    • B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
    • D.T. Avery, E.K. Deenick, C.S. Ma, S. Suryani, N. Simpson, and G.Y. Chew B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans J Exp Med 207 2010 155 171
    • (2010) J Exp Med , vol.207 , pp. 155-171
    • Avery, D.T.1    Deenick, E.K.2    Ma, C.S.3    Suryani, S.4    Simpson, N.5    Chew, G.Y.6
  • 68
    • 27744447066 scopus 로고    scopus 로고
    • Molecular defects in T- and B-cell primary immunodeficiency diseases
    • C. Cunningham-Rundles, and P.P. Ponda Molecular defects in T- and B-cell primary immunodeficiency diseases Nat Rev Immunol 5 2005 880 892
    • (2005) Nat Rev Immunol , vol.5 , pp. 880-892
    • Cunningham-Rundles, C.1    Ponda, P.P.2
  • 70
    • 72949104221 scopus 로고    scopus 로고
    • Dysregulation of germinal centres in autoimmune disease
    • C.G. Vinuesa, I. Sanz, and M.C. Cook Dysregulation of germinal centres in autoimmune disease Nat Rev Immunol 9 2009 845 857
    • (2009) Nat Rev Immunol , vol.9 , pp. 845-857
    • Vinuesa, C.G.1    Sanz, I.2    Cook, M.C.3
  • 71
    • 0029949635 scopus 로고    scopus 로고
    • Cloning and analysis of IgG kappa and IgG lambda anti-thyroglobulin autoantibodies from a patient with Hashimoto's thyroiditis: Evidence for in vivo antigen-driven repertoire selection
    • R.S. McIntosh, M.S. Asghar, P.F. Watson, E.H. Kemp, and A.P. Weetman Cloning and analysis of IgG kappa and IgG lambda anti-thyroglobulin autoantibodies from a patient with Hashimoto's thyroiditis: evidence for in vivo antigen-driven repertoire selection J Immunol 157 1996 927 935
    • (1996) J Immunol , vol.157 , pp. 927-935
    • McIntosh, R.S.1    Asghar, M.S.2    Watson, P.F.3    Kemp, E.H.4    Weetman, A.P.5
  • 72
    • 0026535985 scopus 로고
    • Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response
    • T. Olee, E.W. Lu, D.F. Huang, R.W. Soto-Gil, M. Deftos, and F. Kozin Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response J Exp Med 175 1992 831 842
    • (1992) J Exp Med , vol.175 , pp. 831-842
    • Olee, T.1    Lu, E.W.2    Huang, D.F.3    Soto-Gil, R.W.4    Deftos, M.5    Kozin, F.6
  • 74
    • 53349167095 scopus 로고    scopus 로고
    • Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis
    • Z. Hao, G.S. Duncan, J. Seagal, Y.W. Su, C. Hong, and J. Haight Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis Immunity 29 2008 615 627
    • (2008) Immunity , vol.29 , pp. 615-627
    • Hao, Z.1    Duncan, G.S.2    Seagal, J.3    Su, Y.W.4    Hong, C.5    Haight, J.6
  • 75
    • 0028274042 scopus 로고
    • Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule
    • J. Cheng, T. Zhou, C. Liu, J.P. Shapiro, M.J. Brauer, and M.C. Kiefer Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule Science 263 1994 1759 1762
    • (1994) Science , vol.263 , pp. 1759-1762
    • Cheng, J.1    Zhou, T.2    Liu, C.3    Shapiro, J.P.4    Brauer, M.J.5    Kiefer, M.C.6
  • 76
    • 0029006893 scopus 로고
    • Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity
    • F. Rieux-Laucat, F. Le Deist, C. Hivroz, I.A. Roberts, K.M. Debatin, and A. Fischer Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity Science 268 1995 1347 1349
    • (1995) Science , vol.268 , pp. 1347-1349
    • Rieux-Laucat, F.1    Le Deist, F.2    Hivroz, C.3    Roberts, I.A.4    Debatin, K.M.5    Fischer, A.6
  • 78
    • 21144438325 scopus 로고    scopus 로고
    • A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
    • C.G. Vinuesa, M.C. Cook, C. Angelucci, V. Athanasopoulos, L. Rui, and K.M. Hill A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity Nature 435 2005 452 458
    • (2005) Nature , vol.435 , pp. 452-458
    • Vinuesa, C.G.1    Cook, M.C.2    Angelucci, C.3    Athanasopoulos, V.4    Rui, L.5    Hill, K.M.6
  • 79
    • 0037643418 scopus 로고    scopus 로고
    • Expression and function of the co-stimulator H4/ICOS on activated T cells of patients with rheumatoid arthritis
    • T. Okamoto, S. Saito, H. Yamanaka, T. Tomatsu, N. Kamatani, and H. Ogiuchi Expression and function of the co-stimulator H4/ICOS on activated T cells of patients with rheumatoid arthritis J Rheumatol 30 2003 1157 1163
    • (2003) J Rheumatol , vol.30 , pp. 1157-1163
    • Okamoto, T.1    Saito, S.2    Yamanaka, H.3    Tomatsu, T.4    Kamatani, N.5    Ogiuchi, H.6
  • 80
    • 74849138095 scopus 로고    scopus 로고
    • Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    • N. Simpson, P.A. Gatenby, A. Wilson, S. Malik, D.A. Fulcher, and S.G. Tangye Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus Arthritis Rheum 62 2010 234 244
    • (2010) Arthritis Rheum , vol.62 , pp. 234-244
    • Simpson, N.1    Gatenby, P.A.2    Wilson, A.3    Malik, S.4    Fulcher, D.A.5    Tangye, S.G.6
  • 81
    • 0029059370 scopus 로고
    • Soluble antigen can cause enhanced apoptosis of germinal-centre B cells
    • B. Pulendran, G. Kannourakis, S. Nouri, K.G. Smith, and G.J. Nossal Soluble antigen can cause enhanced apoptosis of germinal-centre B cells Nature 375 1995 331 334
    • (1995) Nature , vol.375 , pp. 331-334
    • Pulendran, B.1    Kannourakis, G.2    Nouri, S.3    Smith, K.G.4    Nossal, G.J.5
  • 82
    • 0029014435 scopus 로고
    • Antigen-induced B-cell death and elimination during germinal-centre immune responses
    • K.M. Shokat, and C.C. Goodnow Antigen-induced B-cell death and elimination during germinal-centre immune responses Nature 375 1995 334 338
    • (1995) Nature , vol.375 , pp. 334-338
    • Shokat, K.M.1    Goodnow, C.C.2
  • 84
    • 0031942845 scopus 로고    scopus 로고
    • Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes
    • F. Stevenson, S. Sahota, D. Zhu, C. Ottensmeier, C. Chapman, and D. Oscier Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes Immunol Rev 162 1998 247 259
    • (1998) Immunol Rev , vol.162 , pp. 247-259
    • Stevenson, F.1    Sahota, S.2    Zhu, D.3    Ottensmeier, C.4    Chapman, C.5    Oscier, D.6
  • 85
    • 0038243177 scopus 로고    scopus 로고
    • Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma
    • L. Pasqualucci, A. Migliazza, K. Basso, J. Houldsworth, R.S. Chaganti, and R. Dalla-Favera Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma Blood 101 2003 2914 2923
    • (2003) Blood , vol.101 , pp. 2914-2923
    • Pasqualucci, L.1    Migliazza, A.2    Basso, K.3    Houldsworth, J.4    Chaganti, R.S.5    Dalla-Favera, R.6
  • 87
    • 37549015263 scopus 로고    scopus 로고
    • Germinal centres: Role in B-cell physiology and malignancy
    • U. Klein, and R. Dalla-Favera Germinal centres: role in B-cell physiology and malignancy Nat Rev Immunol 8 2008 22 33
    • (2008) Nat Rev Immunol , vol.8 , pp. 22-33
    • Klein, U.1    Dalla-Favera, R.2
  • 88
    • 16844381831 scopus 로고    scopus 로고
    • Mechanisms of B-cell lymphoma pathogenesis
    • R. Kuppers Mechanisms of B-cell lymphoma pathogenesis Nat Rev Cancer 5 2005 251 262
    • (2005) Nat Rev Cancer , vol.5 , pp. 251-262
    • Kuppers, R.1
  • 89
    • 33344475672 scopus 로고    scopus 로고
    • Lymphoid neogenesis in chronic inflammatory diseases
    • F. Aloisi, and R. Pujol-Borrell Lymphoid neogenesis in chronic inflammatory diseases Nat Rev Immunol 6 2006 205 217
    • (2006) Nat Rev Immunol , vol.6 , pp. 205-217
    • Aloisi, F.1    Pujol-Borrell, R.2
  • 91
    • 0034842962 scopus 로고    scopus 로고
    • Thyroid autoimmune disease: Demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers
    • M.P. Armengol, M. Juan, A. Lucas-Martin, M.T. Fernandez-Figueras, D. Jaraquemada, and T. Gallart Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers Am J Pathol 159 2001 861 873
    • (2001) Am J Pathol , vol.159 , pp. 861-873
    • Armengol, M.P.1    Juan, M.2    Lucas-Martin, A.3    Fernandez-Figueras, M.T.4    Jaraquemada, D.5    Gallart, T.6
  • 92
    • 0242663585 scopus 로고    scopus 로고
    • Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjogren's syndrome
    • S. Salomonsson, M.V. Jonsson, K. Skarstein, K.A. Brokstad, P. Hjelmstrom, and M. Wahren-Herlenius Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjogren's syndrome Arthritis Rheum 48 2003 3187 3201
    • (2003) Arthritis Rheum , vol.48 , pp. 3187-3201
    • Salomonsson, S.1    Jonsson, M.V.2    Skarstein, K.3    Brokstad, K.A.4    Hjelmstrom, P.5    Wahren-Herlenius, M.6
  • 93
    • 0033563249 scopus 로고    scopus 로고
    • Fibroblast-like synoviocytes from rheumatoid arthritis patients have intrinsic properties of follicular dendritic cells
    • E. Lindhout, M. van Eijk, M. van Pel, J. Lindeman, H.J. Dinant, and C. de Groot Fibroblast-like synoviocytes from rheumatoid arthritis patients have intrinsic properties of follicular dendritic cells J Immunol 162 1999 5949 5956
    • (1999) J Immunol , vol.162 , pp. 5949-5956
    • Lindhout, E.1    Van Eijk, M.2    Van Pel, M.3    Lindeman, J.4    Dinant, H.J.5    De Groot, C.6
  • 94
    • 0033105654 scopus 로고    scopus 로고
    • Plasma cell development in synovial germinal centers in patients with rheumatoid and reactive arthritis
    • H.J. Kim, V. Krenn, G. Steinhauser, and C. Berek Plasma cell development in synovial germinal centers in patients with rheumatoid and reactive arthritis J Immunol 162 1999 3053 3062
    • (1999) J Immunol , vol.162 , pp. 3053-3062
    • Kim, H.J.1    Krenn, V.2    Steinhauser, G.3    Berek, C.4
  • 95
    • 0032167731 scopus 로고    scopus 로고
    • Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis
    • Y. Qin, P. Duquette, Y. Zhang, P. Talbot, R. Poole, and J. Antel Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis J Clin Invest 102 1998 1045 1050
    • (1998) J Clin Invest , vol.102 , pp. 1045-1050
    • Qin, Y.1    Duquette, P.2    Zhang, Y.3    Talbot, P.4    Poole, R.5    Antel, J.6
  • 96
    • 0032169223 scopus 로고    scopus 로고
    • Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjogren's syndrome
    • D.I. Stott, F. Hiepe, M. Hummel, G. Steinhauser, and C. Berek Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjogren's syndrome J Clin Invest 102 1998 938 946
    • (1998) J Clin Invest , vol.102 , pp. 938-946
    • Stott, D.I.1    Hiepe, F.2    Hummel, M.3    Steinhauser, G.4    Berek, C.5
  • 97
    • 0035881829 scopus 로고    scopus 로고
    • Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis
    • G.P. Sims, H. Shiono, N. Willcox, and D.I. Stott Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis J Immunol 167 2001 1935 1944
    • (2001) J Immunol , vol.167 , pp. 1935-1944
    • Sims, G.P.1    Shiono, H.2    Willcox, N.3    Stott, D.I.4
  • 98
    • 0030456345 scopus 로고    scopus 로고
    • Germinal center formation and local immunoglobulin e (IgE) production in the lung after an airway antigenic challenge
    • Y. Chvatchko, M.H. Kosco-Vilbois, S. Herren, J. Lefort, and J.Y. Bonnefoy Germinal center formation and local immunoglobulin E (IgE) production in the lung after an airway antigenic challenge J Exp Med 184 1996 2353 2360
    • (1996) J Exp Med , vol.184 , pp. 2353-2360
    • Chvatchko, Y.1    Kosco-Vilbois, M.H.2    Herren, S.3    Lefort, J.4    Bonnefoy, J.Y.5
  • 99
    • 0242494188 scopus 로고    scopus 로고
    • Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients
    • H.A. Coker, S.R. Durham, and H.J. Gould Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients J Immunol 171 2003 5602 5610
    • (2003) J Immunol , vol.171 , pp. 5602-5610
    • Coker, H.A.1    Durham, S.R.2    Gould, H.J.3
  • 100
    • 0037114638 scopus 로고    scopus 로고
    • Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells
    • A. Suto, H. Nakajima, K. Hirose, K. Suzuki, S. Kagami, and Y. Seto Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells Blood 100 2002 4565 4573
    • (2002) Blood , vol.100 , pp. 4565-4573
    • Suto, A.1    Nakajima, H.2    Hirose, K.3    Suzuki, K.4    Kagami, S.5    Seto, Y.6
  • 101
    • 0037159687 scopus 로고    scopus 로고
    • A critical role for IL-21 in regulating immunoglobulin production
    • K. Ozaki, R. Spolski, C.G. Feng, C.F. Qi, J. Cheng, and A. Sher A critical role for IL-21 in regulating immunoglobulin production Science 298 2002 1630 1634
    • (2002) Science , vol.298 , pp. 1630-1634
    • Ozaki, K.1    Spolski, R.2    Feng, C.G.3    Qi, C.F.4    Cheng, J.5    Sher, A.6
  • 102
    • 33750460981 scopus 로고    scopus 로고
    • IgE isotype switch and IgE production are enhanced in IL-21-deficient but not IFN-gamma-deficient mice in a Th2-biased response
    • X.Z. Shang, K.Y. Ma, J. Radewonuk, J. Li, X.Y. Song, and D.E. Griswold IgE isotype switch and IgE production are enhanced in IL-21-deficient but not IFN-gamma-deficient mice in a Th2-biased response Cell Immunol 241 2006 66 74
    • (2006) Cell Immunol , vol.241 , pp. 66-74
    • Shang, X.Z.1    Ma, K.Y.2    Radewonuk, J.3    Li, J.4    Song, X.Y.5    Griswold, D.E.6
  • 103
    • 0032827421 scopus 로고    scopus 로고
    • Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: Specific regulation of iepsilon transcription and immunoglobulin e switching
    • M.B. Harris, C.C. Chang, M.T. Berton, N.N. Danial, J. Zhang, and D. Kuehner Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching Mol Cell Biol 19 1999 7264 7275
    • (1999) Mol Cell Biol , vol.19 , pp. 7264-7275
    • Harris, M.B.1    Chang, C.C.2    Berton, M.T.3    Danial, N.N.4    Zhang, J.5    Kuehner, D.6


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