Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex

Current Opinion in Immunology

Volumn 17, Issue 3, 2005, Pages 237-243

  Rickert, Robert C ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD19 ANTIGEN; CD81 ANTIGEN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT COMPONENT C3D; COMPLEMENT COMPONENT C3D RECEPTOR; COMPLEMENT RECEPTOR;

ANTIBODY RESPONSE; ANTIGEN RECOGNITION; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE ACTIVATION; CELL DIFFERENTIATION; COMPLEMENT ACTIVATION; COMPLEMENT FIXATION; COMPLEMENT SYSTEM; HUMAN; IMMUNE RESPONSE; NONHUMAN; RECEPTOR BINDING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD19; B-LYMPHOCYTES; COMPLEMENT C3; GENE EXPRESSION REGULATION; HUMANS; LYMPHOCYTE ACTIVATION; MICE; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, COMPLEMENT 3D; SIGNAL TRANSDUCTION;

EID: 18844395578     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2005.03.001     Document Type: Review

References (57)

1. P.W. Dempsey, M.E. Allison, S. Akkaraju, C.C. Goodnow, and D.T. Fearon C3d of complement as a molecular adjuvant: bridging innate and acquired immunity Science 271 1996 348 350
2. K.M. Haas, F.R. Toapanta, J.A. Oliver, J.C. Poe, J.H. Weis, D.R. Karp, J.F. Bower, T.M. Ross, and T.F. Tedder Cutting edge: C3d functions as a molecular adjuvant in the absence of CD21/35 expression J Immunol 172 2004 5833 5837 The authors extend findings reported in [ 1,3 ] to show a CD21-CD35-independent adjuvant activity for C3dg.
3. T.M. Ross, Y. Xu, R.A. Bright, and H.L. Robinson C3d enhancement of antibodies to hemagglutinin accelerates protection against influenza virus challenge Nat Immunol 1 2000 127 131
4. B.P. Morgan, and C.L. Harris Complement Regulatory Proteins 1999 Academic Press San Diego
5. J. Rossbacher, and M.J. Shlomchik The B cell receptor itself can activate complement to provide the complement receptor 1/2 ligand required to enhance B cell immune responses in vivo J Exp Med 198 2003 591 602 The authors utilize a BCR transgenic mouse expressing a membrane IgM molecule unable to bind C1q to demonstrate an associated failure to produce membrane-associated C3. These data suggest an additional mechanism for recruiting CD21-CD35 to the BCR.
6. R.H. Carter, and R.A. Barrington Signaling by the CD19/CD21 complex on B cells Curr Dir Autoimmun 7 2004 4 32
7. T. Shoham, R. Rajapaksa, C. Boucheix, E. Rubinstein, J.C. Poe, T.F. Tedder, and S. Levy The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment J Immunol 171 2003 4062 4072
8. A. Cherukuri, P.C. Cheng, H.W. Sohn, and S.K. Pierce The CD19/CD21 complex functions to prolong B cell antigen receptor signaling from lipid rafts Immunity 14 2001 169 179
9. A. Cherukuri, T. Shoham, H.W. Sohn, S. Levy, S. Brooks, R. Carter, and S.K. Pierce The tetraspanin CD81 is necessary for partitioning of coligated CD19/CD21-B cell antigen receptor complexes into signaling-active lipid rafts J Immunol 172 2004 370 380
10. A. Cherukuri, R.H. Carter, S. Brooks, W. Bornmann, R. Finn, C.S. Dowd, and S.K. Pierce B cell signaling is regulated by induced palmitoylation of CD81 J Biol Chem 279 2004 31973 31982
11. M. Hasegawa, M. Fujimoto, J.C. Poe, D.A. Steeber, and T.F. Tedder CD19 can regulate B lymphocyte signal transduction independent of complement activation J Immunol 167 2001 3190 3200
12. D.C. Otero, A.N. Anzelon, and R.C. Rickert CD19 Function in Early and Late B Cell Development: I. Maintenance of Follicular and Marginal Zone B Cells Requires CD19-Dependent Survival Signals J Immunol 170 2003 73 83
13. R.H. Carter, and D.T. Fearon CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes Science 256 1992 105 107
14. R.H. Carter, and D.T. Fearon Polymeric C3dg primes human B lymphocytes for proliferation induced by anti-IgM J Immunol 143 1989 1755 1760
15. Y. Wang, S.R. Brooks, X. Li, A.N. Anzelon, R.C. Rickert, and R.H. Carter The physiologic role of CD19 cytoplasmic tyrosines Immunity 17 2002 501 514
16. M. Fujimoto, Y. Fujimoto, J.C. Poe, P.J. Jansen, C.A. Lowell, A.L. DeFranco, and T.F. Tedder CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification Immunity 13 2000 47 57
17. A.M. Buhl, and J.C. Cambier Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase J Immunol 162 1999 4438 4446
18. C.J. van Noesel, A.C. Lankester, G.M. van Schijndel, and R.A. van Lier The CR2/CD19 complex on human B cells contains the src-family kinase Lyn Int Immunol 5 1993 699 705
19. A.N. Anzelon, H. Wu, and R.C. Rickert Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function Nat Immunol 4 2003 287 294 This report, together with [15] demonstrates the importance of PI3-kinase recruitment and activation for CD19 function in vivo.
20. M.B. Fischer, M. Ma, N.C. Hsu, and M.C. Carroll Local synthesis of C3 within the splenic lymphoid compartment can reconstitute the impaired immune response in C3-deficient mice J Immunol 160 1998 2619 2625
21. A. Verschoor, M.A. Brockman, M. Gadjeva, D.M. Knipe, and M.C. Carroll Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection J Immunol 171 2003 5363 5371
22. A. Verschoor, M.A. Brockman, D.M. Knipe, and M.C. Carroll Cutting edge: myeloid complement C3 enhances the humoral response to peripheral viral infection J Immunol 167 2001 2446 2451
23. P.R. Taylor, M.C. Pickering, M.H. Kosco-Vilbois, M.J. Walport, M. Botto, S. Gordon, and L. Martinez-Pomares The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues Eur J Immunol 32 2002 1888 1896
24. R. Guinamard, M. Okigaki, J. Schlessinger, and J.V. Ravetch Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response Nat Immunol 1 2000 31 36
25. K.M. Haas, M. Hasegawa, D.A. Steeber, J.C. Poe, M.D. Zabel, C.B. Bock, D.R. Karp, D.E. Briles, J.H. Weis, and T.F. Tedder Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses Immunity 17 2002 713 723
26. •,28 ], these references address the role of C3 and CD21-CD35 in the capture of antigen/immune complexes by MZ B cells and their delivery to FDCs.
27. •].
28. H. Song, and J. Cerny Functional heterogeneity of marginal zone B cells revealed by their ability to generate both early antibody-forming cells and germinal centers with hypermutation and memory in response to a T-dependent antigen J Exp Med 198 2003 1923 1935
29. A.M. Oliver, F. Martin, G.L. Gartland, R.H. Carter, and J.F. Kearney Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses Eur J Immunol 27 1997 2366 2374
30. J.M. Ahearn, M.B. Fischer, D. Croix, S. Goerg, M. Ma, J. Xia, X. Zhou, R.G. Howard, T.L. Rothstein, and M.C. Carroll Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen Immunity 4 1996 251 262
31. H. Molina, V.M. Holers, B. Li, Y. Fung, S. Mariathasan, J. Goellner, J. Strauss-Schoenberger, R.W. Karr, and D.D. Chaplin Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2 Proc Natl Acad Sci USA 93 1996 3357 3361
32. F. Martin, A.M. Oliver, and J.F. Kearney Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens Immunity 14 2001 617 629
33. S.D. Fleming, T. Shea-Donohue, J.M. Guthridge, L. Kulik, T.J. Waldschmidt, M.G. Gipson, G.C. Tsokos, and V.M. Holers Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire J Immunol 169 2002 2126 2133
34. R.R. Reid, S. Woodcock, A. Shimabukuro-Vornhagen, W.G. Austen Jr., L. Kobzik, M. Zhang, H.B. Hechtman, F.D. Moore Jr., and M.C. Carroll Functional activity of natural antibody is altered in Cr2-deficient mice J Immunol 169 2002 5433 5440
35. S.D. Fleming, R.P. Egan, C. Chai, G. Girardi, V.M. Holers, J. Salmon, M. Monestier, G.C. Tsokos, R.R. Reid, and S. Woodcock Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor 2/complement receptor 1-deficient mice Functional activity of natural antibody is altered in Cr2-deficient mice Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire J Immunol 173 2004 7055 7061
36. A. Cariappa, M. Tang, C. Parng, E. Nebelitskiy, M. Carroll, K. Georgopoulos, and S. Pillai The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21 Immunity 14 2001 603 615
37. Y. Fang, C. Xu, Y.X. Fu, V.M. Holers, and H. Molina Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG J Immunol 160 1998
38. M.B. Fischer, S. Goerg, L. Shen, A.P. Prodeus, C.C. Goodnow, G. Kelsoe, and M.C. Carroll Dependence of germinal center B cells on expression of CD21/CD35 for survival Science 280 1998 582 585
39. R.A. Barrington, O. Pozdnyakova, M.R. Zafari, C.D. Benjamin, and M.C. Carroll B lymphocyte memory: role of stromal cell complement and FcgammaRIIB receptors J Exp Med 196 2002 1189 1199
40. P. Engel, L.J. Zhou, D.C. Ord, S. Sato, B. Koller, and T.F. Tedder Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule Immunity 3 1995 39 50
41. R.C. Rickert, K. Rajewsky, and J. Roes Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice Nature 376 1995 352 355
42. F. Martin, and J.F. Kearney Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk Immunity 12 2000 39 49
43. M. Inaoki, S. Sato, B.C. Weintraub, C.C. Goodnow, and T.F. Tedder CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes J Exp Med 186 1997 1923 1931
44. F. Martin, and J.F. Kearney Marginal-zone B cells Nat Rev Immunol 2 2002 323 335
45. M.C. Carroll The complement system in regulation of adaptive immunity Nat Immunol 5 2004 981 986
46. B.P. Thornton, V. Vetvicka, and G.D. Ross Natural antibody and complement-mediated antigen processing and presentation by B lymphocytes J Immunol 152 1994 1727 1737
47. S.A. Boackle, V.M. Holers, and D.R. Karp CD21 augments antigen presentation in immune individuals Eur J Immunol 27 1997 122 129
48. D.V. Barrault, and A.M. Knight Distinct sequences in the cytoplasmic domain of complement receptor 2 are involved in antigen internalization and presentation J Immunol 172 2004 3509 3517
49. A. Cherukuri, P.C. Cheng, and S.K. Pierce The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens J Immunol 167 2001 163 172
50. A.P. Prodeus, S. Goerg, L.M. Shen, O.O. Pozdnyakova, L. Chu, E.M. Alicot, C.C. Goodnow, and M.C. Carroll A critical role for complement in maintenance of self-tolerance Immunity 9 1998 721 731
51. K. Takahashi, Y. Kozono, T.J. Waldschmidt, D. Berthiaume, R.J. Quigg, A. Baron, and V.M. Holers Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice J Immunol 159 1997 1557 1569
52. X. Wu, N. Jiang, C. Deppong, J. Singh, G. Dolecki, D. Mao, L. Morel, and H.D. Molina A role for the Cr2 gene in modifying autoantibody production in systemic lupus erythematosus J Immunol 169 2002 1587 1592
53. S.A. Boackle, V.M. Holers, X. Chen, G. Szakonyi, D.R. Karp, E.K. Wakeland, and L. Morel Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein Immunity 15 2001 775 785
54. M.C. Carroll A protective role for innate immunity in systemic lupus erythematosus Nat Rev Immunol 4 2004 825 831
55. M.A. Hietala, I.M. Jonsson, A. Tarkowski, S. Kleinau, and M. Pekna Complement deficiency ameliorates collagen-induced arthritis in mice J Immunol 169 2002 454 459
56. L. Chakravarty, M.D. Zabel, J.J. Weis, and J.H. Weis Depletion of Lyn kinase from the BCR complex and inhibition of B cell activation by excess CD21 ligation Int Immunol 14 2002 139 146
57. R.J. Benschop, E. Brandl, A.C. Chan, and J.C. Cambier Unique signaling properties of B cell antigen receptor in mature and immature B cells: implications for tolerance and activation J Immunol 167 2001 4172 4179