메뉴 건너뛰기




Volumn 10, Issue 1, 2013, Pages

Genetic mouse models to study blood-brain barrier development and function

Author keywords

Astrocytes; Blood brain barrier; Central Nervous system; Endothelial cells; Mouse models; Neuro vascular unit; Pericytes

Indexed keywords

ABC TRANSPORTER; ADAPTOR PROTEIN; ANGIOPOIETIN RECEPTOR; BETA ACTIN; BETA GALACTOSIDASE; BREAST CANCER RESISTANCE PROTEIN; CAVEOLIN; CAVEOLIN 1; CD11 ANTIGEN; CD18 ANTIGEN; CINGULIN; CLAUDIN 1; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLUCOSE TRANSPORTER 1; GREEN FLUORESCENT PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 1; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NOTCH RECEPTOR; OCCLUDIN; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN; PROTEIN ZO1; PROTEIN ZO2; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 5;

EID: 84875576366     PISSN: None     EISSN: 20458118     Source Type: Journal    
DOI: 10.1186/2045-8118-10-3     Document Type: Review
Times cited : (27)

References (183)
  • 1
    • 0031589555 scopus 로고    scopus 로고
    • Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains
    • 10.1006/bbrc.1997.7124, 9299439
    • Feil R, Wagner J, Metzger D, Chambon P. Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem Biophys Res Commun 1997, 237:752-757. 10.1006/bbrc.1997.7124, 9299439.
    • (1997) Biochem Biophys Res Commun , vol.237 , pp. 752-757
    • Feil, R.1    Wagner, J.2    Metzger, D.3    Chambon, P.4
  • 2
    • 21444454735 scopus 로고    scopus 로고
    • A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration
    • 10.1038/nmeth762, 15908920
    • Buch T, Heppner FL, Tertilt C, Heinen TJ, Kremer M, Wunderlich FT, Jung S, Waisman A. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods 2005, 2:419-426. 10.1038/nmeth762, 15908920.
    • (2005) Nat Methods , vol.2 , pp. 419-426
    • Buch, T.1    Heppner, F.L.2    Tertilt, C.3    Heinen, T.J.4    Kremer, M.5    Wunderlich, F.T.6    Jung, S.7    Waisman, A.8
  • 3
    • 0030990991 scopus 로고    scopus 로고
    • Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells
    • 10.1073/pnas.94.8.3789, 20519, 9108056
    • Zambrowicz BP, Imamoto A, Fiering S, Herzenberg LA, Kerr WG, Soriano P. Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci U S A 1997, 94:3789-3794. 10.1073/pnas.94.8.3789, 20519, 9108056.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 3789-3794
    • Zambrowicz, B.P.1    Imamoto, A.2    Fiering, S.3    Herzenberg, L.A.4    Kerr, W.G.5    Soriano, P.6
  • 4
    • 0032547833 scopus 로고    scopus 로고
    • A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts
    • 10.1083/jcb.143.2.391, 2132845, 9786950
    • Furuse M, Sasaki H, Fujimoto K, Tsukita S. A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J Cell Biol 1998, 143:391-401. 10.1083/jcb.143.2.391, 2132845, 9786950.
    • (1998) J Cell Biol , vol.143 , pp. 391-401
    • Furuse, M.1    Sasaki, H.2    Fujimoto, K.3    Tsukita, S.4
  • 5
    • 0033582334 scopus 로고    scopus 로고
    • Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands
    • 10.1073/pnas.96.2.511, 15167, 9892664
    • Morita K, Furuse M, Fujimoto K, Tsukita S. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A 1999, 96:511-516. 10.1073/pnas.96.2.511, 15167, 9892664.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 511-516
    • Morita, K.1    Furuse, M.2    Fujimoto, K.3    Tsukita, S.4
  • 6
    • 0027744129 scopus 로고
    • Occludin: a novel integral membrane protein localizing at tight junctions
    • 10.1083/jcb.123.6.1777, 2290891, 8276896
    • Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S. Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 1993, 123:1777-1788. 10.1083/jcb.123.6.1777, 2290891, 8276896.
    • (1993) J Cell Biol , vol.123 , pp. 1777-1788
    • Furuse, M.1    Hirase, T.2    Itoh, M.3    Nagafuchi, A.4    Yonemura, S.5    Tsukita, S.6    Tsukita, S.7
  • 7
    • 2642614521 scopus 로고    scopus 로고
    • Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration
    • 10.1083/jcb.142.1.117, 2133024, 9660867
    • Martin-Padura I, Lostaglio S, Schneemann M, Williams L, Romano M, Fruscella P, Panzeri C, Stoppacciaro A, Ruco L, Villa A, et al. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol 1998, 142:117-127. 10.1083/jcb.142.1.117, 2133024, 9660867.
    • (1998) J Cell Biol , vol.142 , pp. 117-127
    • Martin-Padura, I.1    Lostaglio, S.2    Schneemann, M.3    Williams, L.4    Romano, M.5    Fruscella, P.6    Panzeri, C.7    Stoppacciaro, A.8    Ruco, L.9    Villa, A.10
  • 8
    • 77952756845 scopus 로고    scopus 로고
    • Molecular basis of the core structure of tight junctions
    • 10.1101/cshperspect.a002907, 2827901, 20182608
    • Furuse M. Molecular basis of the core structure of tight junctions. Cold Spring Harb Perspect Biol 2010, 2:a002907. 10.1101/cshperspect.a002907, 2827901, 20182608.
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Furuse, M.1
  • 9
    • 0037648580 scopus 로고    scopus 로고
    • Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
    • 10.1083/jcb.200302070, 2172943, 12743111
    • Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 2003, 161:653-660. 10.1083/jcb.200302070, 2172943, 12743111.
    • (2003) J Cell Biol , vol.161 , pp. 653-660
    • Nitta, T.1    Hata, M.2    Gotoh, S.3    Seo, Y.4    Sasaki, H.5    Hashimoto, N.6    Furuse, M.7    Tsukita, S.8
  • 10
    • 0038819415 scopus 로고    scopus 로고
    • Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme
    • Wolburg H, Wolburg-Buchholz K, Kraus J, Rascher-Eggstein G, Liebner S, Hamm S, Duffner F, Grote EH, Risau W, Engelhardt B. Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme. Acta Neuropathol 2003, 105:586-592.
    • (2003) Acta Neuropathol , vol.105 , pp. 586-592
    • Wolburg, H.1    Wolburg-Buchholz, K.2    Kraus, J.3    Rascher-Eggstein, G.4    Liebner, S.5    Hamm, S.6    Duffner, F.7    Grote, E.H.8    Risau, W.9    Engelhardt, B.10
  • 11
    • 33845302602 scopus 로고    scopus 로고
    • Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro
    • 10.1016/j.neuint.2006.07.005, 16956696
    • Belanger M, Asashima T, Ohtsuki S, Yamaguchi H, Ito S, Terasaki T. Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro. Neurochem Int 2007, 50:95-101. 10.1016/j.neuint.2006.07.005, 16956696.
    • (2007) Neurochem Int , vol.50 , pp. 95-101
    • Belanger, M.1    Asashima, T.2    Ohtsuki, S.3    Yamaguchi, H.4    Ito, S.5    Terasaki, T.6
  • 12
    • 82355190262 scopus 로고    scopus 로고
    • Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis
    • 10.1007/s00401-011-0883-2, 3207130, 21983942
    • Pfeiffer F, Schafer J, Lyck R, Makrides V, Brunner S, Schaeren-Wiemers N, Deutsch U, Engelhardt B. Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta Neuropathol 2011, 122:601-614. 10.1007/s00401-011-0883-2, 3207130, 21983942.
    • (2011) Acta Neuropathol , vol.122 , pp. 601-614
    • Pfeiffer, F.1    Schafer, J.2    Lyck, R.3    Makrides, V.4    Brunner, S.5    Schaeren-Wiemers, N.6    Deutsch, U.7    Engelhardt, B.8
  • 13
    • 84864446952 scopus 로고    scopus 로고
    • Animal models of multiple sclerosis: the good, the bad and the bottom line
    • 10.1038/nn.3168, 22837037
    • Ransohoff RM. Animal models of multiple sclerosis: the good, the bad and the bottom line. Nat Neurosci 2012, 15:1074-1077. 10.1038/nn.3168, 22837037.
    • (2012) Nat Neurosci , vol.15 , pp. 1074-1077
    • Ransohoff, R.M.1
  • 17
    • 0024826077 scopus 로고
    • Increased vesicular transport and decreased mitochondrial content in blood-brain barrier endothelial cells during experimental autoimmune encephalomyelitis
    • 1880501, 2596575
    • Claudio L, Kress Y, Norton WT, Brosnan CF. Increased vesicular transport and decreased mitochondrial content in blood-brain barrier endothelial cells during experimental autoimmune encephalomyelitis. Am J Pathol 1989, 135:1157-1168. 1880501, 2596575.
    • (1989) Am J Pathol , vol.135 , pp. 1157-1168
    • Claudio, L.1    Kress, Y.2    Norton, W.T.3    Brosnan, C.F.4
  • 18
    • 41049099175 scopus 로고    scopus 로고
    • Plasmalemmal vesicle associated protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models
    • 10.1186/1471-2202-9-29, 2270280, 18302779
    • Shue EH, Carson-Walter EB, Liu Y, Winans BN, Ali ZS, Chen J, Walter KA. Plasmalemmal vesicle associated protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models. BMC Neurosci 2008, 9:29. 10.1186/1471-2202-9-29, 2270280, 18302779.
    • (2008) BMC Neurosci , vol.9 , pp. 29
    • Shue, E.H.1    Carson-Walter, E.B.2    Liu, Y.3    Winans, B.N.4    Ali, Z.S.5    Chen, J.6    Walter, K.A.7
  • 19
    • 57749186709 scopus 로고    scopus 로고
    • Endothelial transcytosis in health and disease
    • 10.1007/s00441-008-0688-3, 18836747
    • Simionescu M, Popov D, Sima A. Endothelial transcytosis in health and disease. Cell Tissue Res 2009, 335:27-40. 10.1007/s00441-008-0688-3, 18836747.
    • (2009) Cell Tissue Res , vol.335 , pp. 27-40
    • Simionescu, M.1    Popov, D.2    Sima, A.3
  • 20
    • 0037378555 scopus 로고    scopus 로고
    • Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis
    • 10.1016/S0002-9440(10)63920-X, 1851223, 12651616
    • Cao G, Yang G, Timme TL, Saika T, Truong LD, Satoh T, Goltsov A, Park SH, Men T, Kusaka N, et al. Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. Am J Pathol 2003, 162:1241-1248. 10.1016/S0002-9440(10)63920-X, 1851223, 12651616.
    • (2003) Am J Pathol , vol.162 , pp. 1241-1248
    • Cao, G.1    Yang, G.2    Timme, T.L.3    Saika, T.4    Truong, L.D.5    Satoh, T.6    Goltsov, A.7    Park, S.H.8    Men, T.9    Kusaka, N.10
  • 21
    • 0035964954 scopus 로고    scopus 로고
    • Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
    • 10.1126/science.1062688, 11498544
    • Drab M, Verkade P, Elger M, Kasper M, Lohn M, Lauterbach B, Menne J, Lindschau C, Mende F, Luft FC, et al. Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science 2001, 293:2449-2452. 10.1126/science.1062688, 11498544.
    • (2001) Science , vol.293 , pp. 2449-2452
    • Drab, M.1    Verkade, P.2    Elger, M.3    Kasper, M.4    Lohn, M.5    Lauterbach, B.6    Menne, J.7    Lindschau, C.8    Mende, F.9    Luft, F.C.10
  • 23
    • 0035965995 scopus 로고    scopus 로고
    • Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo
    • 10.1074/jbc.C100613200, 11689550
    • Schubert W, Frank PG, Razani B, Park DS, Chow CW, Lisanti MP. Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo. J Biol Chem 2001, 276:48619-48622. 10.1074/jbc.C100613200, 11689550.
    • (2001) J Biol Chem , vol.276 , pp. 48619-48622
    • Schubert, W.1    Frank, P.G.2    Razani, B.3    Park, D.S.4    Chow, C.W.5    Lisanti, M.P.6
  • 24
    • 0037131313 scopus 로고    scopus 로고
    • Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice
    • 10.1074/jbc.M205948200, 12167625
    • Schubert W, Frank PG, Woodman SE, Hyogo H, Cohen DE, Chow CW, Lisanti MP. Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice. J Biol Chem 2002, 277:40091-40098. 10.1074/jbc.M205948200, 12167625.
    • (2002) J Biol Chem , vol.277 , pp. 40091-40098
    • Schubert, W.1    Frank, P.G.2    Woodman, S.E.3    Hyogo, H.4    Cohen, D.E.5    Chow, C.W.6    Lisanti, M.P.7
  • 25
    • 0036096748 scopus 로고    scopus 로고
    • Intracellular retention of glycosylphosphatidyl inositol-linked proteins in caveolin-deficient cells
    • 10.1128/MCB.22.11.3905-3926.2002, 133834, 11997523
    • Sotgia F, Razani B, Bonuccelli G, Schubert W, Battista M, Lee H, Capozza F, Schubert AL, Minetti C, Buckley JT, et al. Intracellular retention of glycosylphosphatidyl inositol-linked proteins in caveolin-deficient cells. Mol Cell Biol 2002, 22:3905-3926. 10.1128/MCB.22.11.3905-3926.2002, 133834, 11997523.
    • (2002) Mol Cell Biol , vol.22 , pp. 3905-3926
    • Sotgia, F.1    Razani, B.2    Bonuccelli, G.3    Schubert, W.4    Battista, M.5    Lee, H.6    Capozza, F.7    Schubert, A.L.8    Minetti, C.9    Buckley, J.T.10
  • 26
    • 78149456928 scopus 로고    scopus 로고
    • The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells
    • 10.1371/journal.pone.0013741, 2966423, 21060791
    • Daneman R, Zhou L, Agalliu D, Cahoy JD, Kaushal A, Barres BA. The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells. PLoS One 2010, 5:e13741. 10.1371/journal.pone.0013741, 2966423, 21060791.
    • (2010) PLoS One , vol.5
    • Daneman, R.1    Zhou, L.2    Agalliu, D.3    Cahoy, J.D.4    Kaushal, A.5    Barres, B.A.6
  • 27
    • 22244470426 scopus 로고    scopus 로고
    • Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice
    • 10.1073/pnas.0504391102, 1175015, 15994223
    • Carlson TR, Yan Y, Wu X, Lam MT, Tang GL, Beverly LJ, Messina LM, Capobianco AJ, Werb Z, Wang R. Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proc Natl Acad Sci U S A 2005, 102:9884-9889. 10.1073/pnas.0504391102, 1175015, 15994223.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9884-9889
    • Carlson, T.R.1    Yan, Y.2    Wu, X.3    Lam, M.T.4    Tang, G.L.5    Beverly, L.J.6    Messina, L.M.7    Capobianco, A.J.8    Werb, Z.9    Wang, R.10
  • 28
    • 0032968435 scopus 로고    scopus 로고
    • Increased expression of endothelial antigen PAL-E in human diabetic retinopathy correlates with microvascular leakage
    • 10.1007/s001250051200, 10333053
    • Schlingemann RO, Hofman P, Vrensen GF, Blaauwgeers HG. Increased expression of endothelial antigen PAL-E in human diabetic retinopathy correlates with microvascular leakage. Diabetologia 1999, 42:596-602. 10.1007/s001250051200, 10333053.
    • (1999) Diabetologia , vol.42 , pp. 596-602
    • Schlingemann, R.O.1    Hofman, P.2    Vrensen, G.F.3    Blaauwgeers, H.G.4
  • 29
    • 0030823912 scopus 로고    scopus 로고
    • P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain
    • 1218702, 9291129
    • Beaulieu E, Demeule M, Ghitescu L, Beliveau R. P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain. Biochem J 1997, 326(Pt 2):539-544. 1218702, 9291129.
    • (1997) Biochem J , vol.326 , Issue.PART 2 , pp. 539-544
    • Beaulieu, E.1    Demeule, M.2    Ghitescu, L.3    Beliveau, R.4
  • 30
    • 0024544045 scopus 로고
    • The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues
    • 362730, 2471060
    • Croop JM, Raymond M, Haber D, Devault A, Arceci RJ, Gros P, Housman DE. The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol Cell Biol 1989, 9:1346-1350. 362730, 2471060.
    • (1989) Mol Cell Biol , vol.9 , pp. 1346-1350
    • Croop, J.M.1    Raymond, M.2    Haber, D.3    Devault, A.4    Arceci, R.J.5    Gros, P.6    Housman, D.E.7
  • 31
    • 84858002750 scopus 로고    scopus 로고
    • Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance
    • 10.1016/j.bcp.2012.01.002, 22248732
    • Natarajan K, Xie Y, Baer MR, Ross DD. Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance. Biochem Pharmacol 2012, 83:1084-1103. 10.1016/j.bcp.2012.01.002, 22248732.
    • (2012) Biochem Pharmacol , vol.83 , pp. 1084-1103
    • Natarajan, K.1    Xie, Y.2    Baer, M.R.3    Ross, D.D.4
  • 33
    • 65249142243 scopus 로고    scopus 로고
    • A new model for studying tissue-specific mdr1a gene expression in vivo by live imaging
    • 10.1073/pnas.0807343106, 2654810, 19282474
    • Gu L, Tsark WM, Brown DA, Blanchard S, Synold TW, Kane SE. A new model for studying tissue-specific mdr1a gene expression in vivo by live imaging. Proc Natl Acad Sci U S A 2009, 106:5394-5399. 10.1073/pnas.0807343106, 2654810, 19282474.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 5394-5399
    • Gu, L.1    Tsark, W.M.2    Brown, D.A.3    Blanchard, S.4    Synold, T.W.5    Kane, S.E.6
  • 34
    • 0030972417 scopus 로고    scopus 로고
    • P-glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity
    • 10.1006/taap.1996.8086, 9144452
    • Lankas GR, Cartwright ME, Umbenhauer D. P-glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity. Toxicol Appl Pharmacol 1997, 143:357-365. 10.1006/taap.1996.8086, 9144452.
    • (1997) Toxicol Appl Pharmacol , vol.143 , pp. 357-365
    • Lankas, G.R.1    Cartwright, M.E.2    Umbenhauer, D.3
  • 35
    • 19944425121 scopus 로고    scopus 로고
    • The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model
    • Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E, Chen C, Chen X, Choo E, Cianfrogna J, et al. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos 2005, 33:165-174.
    • (2005) Drug Metab Dispos , vol.33 , pp. 165-174
    • Doran, A.1    Obach, R.S.2    Smith, B.J.3    Hosea, N.A.4    Becker, S.5    Callegari, E.6    Chen, C.7    Chen, X.8    Choo, E.9    Cianfrogna, J.10
  • 36
    • 25444485195 scopus 로고    scopus 로고
    • Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice
    • 10.1634/stemcells.2005-0150, 16002779
    • Jonker JW, Freeman J, Bolscher E, Musters S, Alvi AJ, Titley I, Schinkel AH, Dale TC. Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice. Stem Cells 2005, 23:1059-1065. 10.1634/stemcells.2005-0150, 16002779.
    • (2005) Stem Cells , vol.23 , pp. 1059-1065
    • Jonker, J.W.1    Freeman, J.2    Bolscher, E.3    Musters, S.4    Alvi, A.J.5    Titley, I.6    Schinkel, A.H.7    Dale, T.C.8
  • 37
    • 34548278289 scopus 로고    scopus 로고
    • Influence of breast cancer resistance protein (Abcg2) and p-glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec) across the mouse blood-brain barrier
    • 10.1111/j.1471-4159.2007.04808.x, 17696988
    • Bihorel S, Camenisch G, Lemaire M, Scherrmann JM. Influence of breast cancer resistance protein (Abcg2) and p-glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec) across the mouse blood-brain barrier. J Neurochem 2007, 102:1749-1757. 10.1111/j.1471-4159.2007.04808.x, 17696988.
    • (2007) J Neurochem , vol.102 , pp. 1749-1757
    • Bihorel, S.1    Camenisch, G.2    Lemaire, M.3    Scherrmann, J.M.4
  • 38
  • 42
    • 33746715057 scopus 로고    scopus 로고
    • Modulation and compensation of the mRNA expression of energy related transporters in the brain of glucose transporter 1-deficient mice
    • 10.1248/bpb.29.1587, 16880609
    • Ohtsuki S, Kikkawa T, Hori S, Terasaki T. Modulation and compensation of the mRNA expression of energy related transporters in the brain of glucose transporter 1-deficient mice. Biol Pharm Bull 2006, 29:1587-1591. 10.1248/bpb.29.1587, 16880609.
    • (2006) Biol Pharm Bull , vol.29 , pp. 1587-1591
    • Ohtsuki, S.1    Kikkawa, T.2    Hori, S.3    Terasaki, T.4
  • 43
    • 79961069521 scopus 로고    scopus 로고
    • Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo
    • 10.1371/journal.pone.0023205, 3149640, 21826239
    • Young CD, Lewis AS, Rudolph MC, Ruehle MD, Jackman MR, Yun UJ, Ilkun O, Pereira R, Abel ED, Anderson SM. Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo. PLoS One 2011, 6:e23205. 10.1371/journal.pone.0023205, 3149640, 21826239.
    • (2011) PLoS One , vol.6
    • Young, C.D.1    Lewis, A.S.2    Rudolph, M.C.3    Ruehle, M.D.4    Jackman, M.R.5    Yun, U.J.6    Ilkun, O.7    Pereira, R.8    Abel, E.D.9    Anderson, S.M.10
  • 44
    • 0347994902 scopus 로고    scopus 로고
    • Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy
    • 10.1073/pnas.2536196100, 307616, 14673082
    • Heilig CW, Saunders T, Brosius FC, Moley K, Heilig K, Baggs R, Guo L, Conner D. Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy. Proc Natl Acad Sci U S A 2003, 100:15613-15618. 10.1073/pnas.2536196100, 307616, 14673082.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15613-15618
    • Heilig, C.W.1    Saunders, T.2    Brosius, F.C.3    Moley, K.4    Heilig, K.5    Baggs, R.6    Guo, L.7    Conner, D.8
  • 45
    • 79953701030 scopus 로고    scopus 로고
    • Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte-endothelial interactions
    • 10.1189/jlb.0710432, 21169520
    • Rossi B, Angiari S, Zenaro E, Budui SL, Constantin G. Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte-endothelial interactions. J Leukoc Biol 2011, 89:539-556. 10.1189/jlb.0710432, 21169520.
    • (2011) J Leukoc Biol , vol.89 , pp. 539-556
    • Rossi, B.1    Angiari, S.2    Zenaro, E.3    Budui, S.L.4    Constantin, G.5
  • 46
    • 77649097668 scopus 로고    scopus 로고
    • Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of stroke
    • 10.1186/1471-2202-11-12, 2829030, 20122276
    • Jin AY, Tuor UI, Rushforth D, Kaur J, Muller RN, Petterson JL, Boutry S, Barber PA. Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of stroke. BMC Neurosci 2010, 11:12. 10.1186/1471-2202-11-12, 2829030, 20122276.
    • (2010) BMC Neurosci , vol.11 , pp. 12
    • Jin, A.Y.1    Tuor, U.I.2    Rushforth, D.3    Kaur, J.4    Muller, R.N.5    Petterson, J.L.6    Boutry, S.7    Barber, P.A.8
  • 48
    • 23244449103 scopus 로고    scopus 로고
    • P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice
    • Engelhardt B, Kempe B, Merfeld-Clauss S, Laschinger M, Furie B, Wild MK, Vestweber D. P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice. J Immunol 2005, 175:1267-1275.
    • (2005) J Immunol , vol.175 , pp. 1267-1275
    • Engelhardt, B.1    Kempe, B.2    Merfeld-Clauss, S.3    Laschinger, M.4    Furie, B.5    Wild, M.K.6    Vestweber, D.7
  • 49
    • 23044481655 scopus 로고    scopus 로고
    • PSGL-1 is not required for development of experimental autoimmune encephalomyelitis
    • 10.1016/j.jneuroim.2005.06.001, 16005524
    • Osmers I, Bullard DC, Barnum SR. PSGL-1 is not required for development of experimental autoimmune encephalomyelitis. J Neuroimmunol 2005, 166:193-196. 10.1016/j.jneuroim.2005.06.001, 16005524.
    • (2005) J Neuroimmunol , vol.166 , pp. 193-196
    • Osmers, I.1    Bullard, D.C.2    Barnum, S.R.3
  • 50
    • 40049095589 scopus 로고    scopus 로고
    • E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice
    • Doring A, Wild M, Vestweber D, Deutsch U, Engelhardt B. E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice. J Immunol 2007, 179:8470-8479.
    • (2007) J Immunol , vol.179 , pp. 8470-8479
    • Doring, A.1    Wild, M.2    Vestweber, D.3    Deutsch, U.4    Engelhardt, B.5
  • 51
    • 0029825455 scopus 로고    scopus 로고
    • Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivo
    • 10.1161/01.RES.79.6.1196, 8943958
    • Kunkel EJ, Ley K. Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivo. Circ Res 1996, 79:1196-1204. 10.1161/01.RES.79.6.1196, 8943958.
    • (1996) Circ Res , vol.79 , pp. 1196-1204
    • Kunkel, E.J.1    Ley, K.2
  • 53
    • 0027326544 scopus 로고
    • Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1
    • 10.1073/pnas.90.18.8529, 47390, 8104338
    • Sligh JE, Ballantyne CM, Rich SS, Hawkins HK, Smith CW, Bradley A, Beaudet AL. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci U S A 1993, 90:8529-8533. 10.1073/pnas.90.18.8529, 47390, 8104338.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 8529-8533
    • Sligh, J.E.1    Ballantyne, C.M.2    Rich, S.S.3    Hawkins, H.K.4    Smith, C.W.5    Bradley, A.6    Beaudet, A.L.7
  • 54
    • 0345447594 scopus 로고    scopus 로고
    • Mac-1, but not LFA-1, uses intercellular adhesion molecule-1 to mediate slow leukocyte rolling in TNF-alpha-induced inflammation
    • Dunne JL, Collins RG, Beaudet AL, Ballantyne CM, Ley K. Mac-1, but not LFA-1, uses intercellular adhesion molecule-1 to mediate slow leukocyte rolling in TNF-alpha-induced inflammation. J Immunol 2003, 171:6105-6111.
    • (2003) J Immunol , vol.171 , pp. 6105-6111
    • Dunne, J.L.1    Collins, R.G.2    Beaudet, A.L.3    Ballantyne, C.M.4    Ley, K.5
  • 55
    • 77952323359 scopus 로고    scopus 로고
    • Differential ICAM-1 isoform expression regulates the development and progression of experimental autoimmune encephalomyelitis
    • 10.1016/j.molimm.2010.03.005, 20371120
    • Hu X, Barnum SR, Wohler JE, Schoeb TR, Bullard DC. Differential ICAM-1 isoform expression regulates the development and progression of experimental autoimmune encephalomyelitis. Mol Immunol 2010, 47:1692-1700. 10.1016/j.molimm.2010.03.005, 20371120.
    • (2010) Mol Immunol , vol.47 , pp. 1692-1700
    • Hu, X.1    Barnum, S.R.2    Wohler, J.E.3    Schoeb, T.R.4    Bullard, D.C.5
  • 56
    • 0032567006 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis in intercellular adhesion molecule-1-deficient mice
    • 10.1006/cimm.1998.1395, 9826450
    • Samoilova EB, Horton JL, Chen Y. Experimental autoimmune encephalomyelitis in intercellular adhesion molecule-1-deficient mice. Cell Immunol 1998, 190:83-89. 10.1006/cimm.1998.1395, 9826450.
    • (1998) Cell Immunol , vol.190 , pp. 83-89
    • Samoilova, E.B.1    Horton, J.L.2    Chen, Y.3
  • 57
    • 0028855419 scopus 로고
    • Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation
    • 10.1101/gad.9.1.1, 7530222
    • Gurtner GC, Davis V, Li H, McCoy MJ, Sharpe A, Cybulsky MI. Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation. Genes Dev 1995, 9:1-14. 10.1101/gad.9.1.1, 7530222.
    • (1995) Genes Dev , vol.9 , pp. 1-14
    • Gurtner, G.C.1    Davis, V.2    Li, H.3    McCoy, M.J.4    Sharpe, A.5    Cybulsky, M.I.6
  • 59
    • 0035911253 scopus 로고    scopus 로고
    • Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow
    • 10.1084/jem.193.6.741, 2193418, 11257140
    • Koni PA, Joshi SK, Temann UA, Olson D, Burkly L, Flavell RA. Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J Exp Med 2001, 193:741-754. 10.1084/jem.193.6.741, 2193418, 11257140.
    • (2001) J Exp Med , vol.193 , pp. 741-754
    • Koni, P.A.1    Joshi, S.K.2    Temann, U.A.3    Olson, D.4    Burkly, L.5    Flavell, R.A.6
  • 60
    • 0028952534 scopus 로고
    • Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice
    • Kwee L, Baldwin HS, Shen HM, Stewart CL, Buck C, Buck CA, Labow MA. Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development 1995, 121:489-503.
    • (1995) Development , vol.121 , pp. 489-503
    • Kwee, L.1    Baldwin, H.S.2    Shen, H.M.3    Stewart, C.L.4    Buck, C.5    Buck, C.A.6    Labow, M.A.7
  • 61
    • 0031239469 scopus 로고    scopus 로고
    • Cre-mediated generation of a VCAM-1 null allele in transgenic mice
    • 10.1023/A:1018475031852, 9322371
    • Terry RW, Kwee L, Baldwin HS, Labow MA. Cre-mediated generation of a VCAM-1 null allele in transgenic mice. Transgenic Res 1997, 6:349-356. 10.1023/A:1018475031852, 9322371.
    • (1997) Transgenic Res , vol.6 , pp. 349-356
    • Terry, R.W.1    Kwee, L.2    Baldwin, H.S.3    Labow, M.A.4
  • 65
    • 4444292859 scopus 로고    scopus 로고
    • Axon fasciculation defects and retinal dysplasias in mice lacking the immunoglobulin superfamily adhesion molecule BEN/ALCAM/SC1
    • 10.1016/j.mcn.2004.06.005, 15345243
    • Weiner JA, Koo SJ, Nicolas S, Fraboulet S, Pfaff SL, Pourquie O, Sanes JR. Axon fasciculation defects and retinal dysplasias in mice lacking the immunoglobulin superfamily adhesion molecule BEN/ALCAM/SC1. Mol Cell Neurosci 2004, 27:59-69. 10.1016/j.mcn.2004.06.005, 15345243.
    • (2004) Mol Cell Neurosci , vol.27 , pp. 59-69
    • Weiner, J.A.1    Koo, S.J.2    Nicolas, S.3    Fraboulet, S.4    Pfaff, S.L.5    Pourquie, O.6    Sanes, J.R.7
  • 66
    • 0033638508 scopus 로고    scopus 로고
    • Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94
    • Asahi M, Asahi K, Jung JC, del Zoppo GJ, Fini ME, Lo EH. Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94. J Cereb Blood Flow Metab 2000, 20:1681-1689.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 1681-1689
    • Asahi, M.1    Asahi, K.2    Jung, J.C.3    del Zoppo, G.J.4    Fini, M.E.5    Lo, E.H.6
  • 67
    • 84861665494 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 or -9 deletions protect against hemorrhagic transformation during early stage of cerebral ischemia and reperfusion
    • Suofu Y, Clark JF, Broderick JP, Kurosawa Y, Wagner KR, Lu A. Matrix metalloproteinase-2 or -9 deletions protect against hemorrhagic transformation during early stage of cerebral ischemia and reperfusion. Neuroscience 2012, 212:180-189.
    • (2012) Neuroscience , vol.212 , pp. 180-189
    • Suofu, Y.1    Clark, J.F.2    Broderick, J.P.3    Kurosawa, Y.4    Wagner, K.R.5    Lu, A.6
  • 68
    • 33847092562 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia
    • 10.1523/JNEUROSCI.4391-06.2007, 17301159
    • Svedin P, Hagberg H, Savman K, Zhu C, Mallard C. Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia. J Neurosci 2007, 27:1511-1518. 10.1523/JNEUROSCI.4391-06.2007, 17301159.
    • (2007) J Neurosci , vol.27 , pp. 1511-1518
    • Svedin, P.1    Hagberg, H.2    Savman, K.3    Zhu, C.4    Mallard, C.5
  • 69
    • 84862732009 scopus 로고    scopus 로고
    • Matrix metalloproteinase-12 deficiency ameliorates the clinical course and demyelination in Theiler's murine encephalomyelitis
    • 10.1007/s00401-012-0942-3, 22271152
    • Hansmann F, Herder V, Kalkuhl A, Haist V, Zhang N, Schaudien D, Deschl U, Baumgartner W, Ulrich R. Matrix metalloproteinase-12 deficiency ameliorates the clinical course and demyelination in Theiler's murine encephalomyelitis. Acta Neuropathol 2012, 124:127-142. 10.1007/s00401-012-0942-3, 22271152.
    • (2012) Acta Neuropathol , vol.124 , pp. 127-142
    • Hansmann, F.1    Herder, V.2    Kalkuhl, A.3    Haist, V.4    Zhang, N.5    Schaudien, D.6    Deschl, U.7    Baumgartner, W.8    Ulrich, R.9
  • 70
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • 10.1016/0006-291X(89)92678-8, 2735925
    • Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989, 161:851-858. 10.1016/0006-291X(89)92678-8, 2735925.
    • (1989) Biochem Biophys Res Commun , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 71
    • 0033135876 scopus 로고    scopus 로고
    • Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development
    • 10.1101/gad.13.9.1055, 10323857
    • Gale NW, Yancopoulos GD. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev 1999, 13:1055-1066. 10.1101/gad.13.9.1055, 10323857.
    • (1999) Genes Dev , vol.13 , pp. 1055-1066
    • Gale, N.W.1    Yancopoulos, G.D.2
  • 74
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • 10.1038/376066a0, 7596436
    • Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995, 376:66-70. 10.1038/376066a0, 7596436.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 76
    • 0141503519 scopus 로고    scopus 로고
    • Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling
    • 10.1016/S0012-1606(03)00356-7, 14550787
    • Haigh JJ, Morelli PI, Gerhardt H, Haigh K, Tsien J, Damert A, Miquerol L, Muhlner U, Klein R, Ferrara N, et al. Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol 2003, 262:225-241. 10.1016/S0012-1606(03)00356-7, 14550787.
    • (2003) Dev Biol , vol.262 , pp. 225-241
    • Haigh, J.J.1    Morelli, P.I.2    Gerhardt, H.3    Haigh, K.4    Tsien, J.5    Damert, A.6    Miquerol, L.7    Muhlner, U.8    Klein, R.9    Ferrara, N.10
  • 77
    • 1642418268 scopus 로고    scopus 로고
    • Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor
    • Raab S, Beck H, Gaumann A, Yuce A, Gerber HP, Plate K, Hammes HP, Ferrara N, Breier G. Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor. Thromb Haemost 2004, 91:595-605.
    • (2004) Thromb Haemost , vol.91 , pp. 595-605
    • Raab, S.1    Beck, H.2    Gaumann, A.3    Yuce, A.4    Gerber, H.P.5    Plate, K.6    Hammes, H.P.7    Ferrara, N.8    Breier, G.9
  • 78
    • 33749455560 scopus 로고    scopus 로고
    • Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia
    • 10.1093/brain/awl207, 2605397, 16901914
    • Liu H, Honmou O, Harada K, Nakamura K, Houkin K, Hamada H, Kocsis JD. Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia. Brain 2006, 129:2734-2745. 10.1093/brain/awl207, 2605397, 16901914.
    • (2006) Brain , vol.129 , pp. 2734-2745
    • Liu, H.1    Honmou, O.2    Harada, K.3    Nakamura, K.4    Houkin, K.5    Hamada, H.6    Kocsis, J.D.7
  • 79
    • 84859427107 scopus 로고    scopus 로고
    • PlGF knockout delays brain vessel growth and maturation upon systemic hypoxic challenge
    • 10.1038/jcbfm.2011.167, 22126916
    • Freitas-Andrade M, Carmeliet P, Charlebois C, Stanimirovic DB, Moreno MJ. PlGF knockout delays brain vessel growth and maturation upon systemic hypoxic challenge. J Cereb Blood Flow Metab 2012, 32:663-675. 10.1038/jcbfm.2011.167, 22126916.
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 663-675
    • Freitas-Andrade, M.1    Carmeliet, P.2    Charlebois, C.3    Stanimirovic, D.B.4    Moreno, M.J.5
  • 80
    • 21744442626 scopus 로고    scopus 로고
    • Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles
    • 10.1016/j.modgep.2005.04.004, 15923152
    • Benedito R, Duarte A. Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles. Gene Expr Patterns 2005, 5:750-755. 10.1016/j.modgep.2005.04.004, 15923152.
    • (2005) Gene Expr Patterns , vol.5 , pp. 750-755
    • Benedito, R.1    Duarte, A.2
  • 81
    • 84859516498 scopus 로고    scopus 로고
    • Ligand-dependent notch signaling in vascular formation
    • 10.1007/978-1-4614-0899-4_16, 22399350
    • Kume T. Ligand-dependent notch signaling in vascular formation. Adv Exp Med Biol 2012, 727:210-222. 10.1007/978-1-4614-0899-4_16, 22399350.
    • (2012) Adv Exp Med Biol , vol.727 , pp. 210-222
    • Kume, T.1
  • 82
    • 17144403287 scopus 로고    scopus 로고
    • Essential role of endothelial Notch1 in angiogenesis
    • 10.1161/01.CIR.0000160870.93058.DD, 2633594, 15809373
    • Limbourg FP, Takeshita K, Radtke F, Bronson RT, Chin MT, Liao JK. Essential role of endothelial Notch1 in angiogenesis. Circulation 2005, 111:1826-1832. 10.1161/01.CIR.0000160870.93058.DD, 2633594, 15809373.
    • (2005) Circulation , vol.111 , pp. 1826-1832
    • Limbourg, F.P.1    Takeshita, K.2    Radtke, F.3    Bronson, R.T.4    Chin, M.T.5    Liao, J.K.6
  • 84
    • 0028989016 scopus 로고
    • Notch1 is required for the coordinate segmentation of somites
    • Conlon RA, Reaume AG, Rossant J. Notch1 is required for the coordinate segmentation of somites. Development 1995, 121:1533-1545.
    • (1995) Development , vol.121 , pp. 1533-1545
    • Conlon, R.A.1    Reaume, A.G.2    Rossant, J.3
  • 85
    • 0028216808 scopus 로고
    • Notch1 is essential for postimplantation development in mice
    • 10.1101/gad.8.6.707, 7926761
    • Swiatek PJ, Lindsell CE, del Amo FF, Weinmaster G, Gridley T. Notch1 is essential for postimplantation development in mice. Genes Dev 1994, 8:707-719. 10.1101/gad.8.6.707, 7926761.
    • (1994) Genes Dev , vol.8 , pp. 707-719
    • Swiatek, P.J.1    Lindsell, C.E.2    del Amo, F.F.3    Weinmaster, G.4    Gridley, T.5
  • 86
    • 49449110100 scopus 로고    scopus 로고
    • Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice
    • 10.1073/pnas.0802743105, 2504798, 18667694
    • Murphy PA, Lam MT, Wu X, Kim TN, Vartanian SM, Bollen AW, Carlson TR, Wang RA. Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice. Proc Natl Acad Sci U S A 2008, 105:10901-10906. 10.1073/pnas.0802743105, 2504798, 18667694.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10901-10906
    • Murphy, P.A.1    Lam, M.T.2    Wu, X.3    Kim, T.N.4    Vartanian, S.M.5    Bollen, A.W.6    Carlson, T.R.7    Wang, R.A.8
  • 89
    • 8644290828 scopus 로고    scopus 로고
    • Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development
    • 10.1073/pnas.0407290101, 524697, 15520367
    • Gale NW, Dominguez MG, Noguera I, Pan L, Hughes V, Valenzuela DM, Murphy AJ, Adams NC, Lin HC, Holash J, et al. Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A 2004, 101:15949-15954. 10.1073/pnas.0407290101, 524697, 15520367.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 15949-15954
    • Gale, N.W.1    Dominguez, M.G.2    Noguera, I.3    Pan, L.4    Hughes, V.5    Valenzuela, D.M.6    Murphy, A.J.7    Adams, N.C.8    Lin, H.C.9    Holash, J.10
  • 91
    • 33847607880 scopus 로고    scopus 로고
    • The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
    • 10.1073/pnas.0611177104, 1805603, 17296941
    • Suchting S, Freitas C, le Noble F, Benedito R, Breant C, Duarte A, Eichmann A. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci U S A 2007, 104:3225-3230. 10.1073/pnas.0611177104, 1805603, 17296941.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3225-3230
    • Suchting, S.1    Freitas, C.2    le Noble, F.3    Benedito, R.4    Breant, C.5    Duarte, A.6    Eichmann, A.7
  • 92
    • 33847635620 scopus 로고    scopus 로고
    • Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting
    • 10.1073/pnas.0611206104, 1805530, 17296940
    • Lobov IB, Renard RA, Papadopoulos N, Gale NW, Thurston G, Yancopoulos GD, Wiegand SJ. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A 2007, 104:3219-3224. 10.1073/pnas.0611206104, 1805530, 17296940.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3219-3224
    • Lobov, I.B.1    Renard, R.A.2    Papadopoulos, N.3    Gale, N.W.4    Thurston, G.5    Yancopoulos, G.D.6    Wiegand, S.J.7
  • 93
    • 67049108093 scopus 로고    scopus 로고
    • DLL1-Mediated notch activation regulates endothelial identity in mouse fetal arteries
    • 10.1182/blood-2008-08-174508, 19144989
    • Sorensen I, Adams RH, Gossler A. DLL1-Mediated notch activation regulates endothelial identity in mouse fetal arteries. Blood 2009, 113:5680-5688. 10.1182/blood-2008-08-174508, 19144989.
    • (2009) Blood , vol.113 , pp. 5680-5688
    • Sorensen, I.1    Adams, R.H.2    Gossler, A.3
  • 94
    • 58849119932 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis
    • 10.1073/pnas.0805165106, 2626756, 19129494
    • Daneman R, Agalliu D, Zhou L, Kuhnert F, Kuo CJ, Barres BA. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A 2009, 106:641-646. 10.1073/pnas.0805165106, 2626756, 19129494.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 641-646
    • Daneman, R.1    Agalliu, D.2    Zhou, L.3    Kuhnert, F.4    Kuo, C.J.5    Barres, B.A.6
  • 96
    • 56749104928 scopus 로고    scopus 로고
    • Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature
    • 10.1126/science.1164594, 19023080
    • Stenman JM, Rajagopal J, Carroll TJ, Ishibashi M, McMahon J, McMahon AP. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science 2008, 322:1247-1250. 10.1126/science.1164594, 19023080.
    • (2008) Science , vol.322 , pp. 1247-1250
    • Stenman, J.M.1    Rajagopal, J.2    Carroll, T.J.3    Ishibashi, M.4    McMahon, J.5    McMahon, A.P.6
  • 97
    • 84862207240 scopus 로고    scopus 로고
    • Three decades of Wnts: a personal perspective on how a scientific field developed
    • 10.1038/emboj.2012.146, 22617420
    • Nusse R, Varmus H. Three decades of Wnts: a personal perspective on how a scientific field developed. EMBO J 2012, 31:2670-2684. 10.1038/emboj.2012.146, 22617420.
    • (2012) EMBO J , vol.31 , pp. 2670-2684
    • Nusse, R.1    Varmus, H.2
  • 98
    • 33845351102 scopus 로고    scopus 로고
    • Transgenic Wnt/TCF pathway reporters: all you need is Lef?
    • 10.1038/sj.onc.1210057, 17143294
    • Barolo S. Transgenic Wnt/TCF pathway reporters: all you need is Lef?. Oncogene 2006, 25:7505-7511. 10.1038/sj.onc.1210057, 17143294.
    • (2006) Oncogene , vol.25 , pp. 7505-7511
    • Barolo, S.1
  • 99
    • 0141768242 scopus 로고    scopus 로고
    • The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility
    • 10.1083/jcb.200212157, 2172846, 12975353
    • Cattelino A, Liebner S, Gallini R, Zanetti A, Balconi G, Corsi A, Bianco P, Wolburg H, Moore R, Oreda B, et al. The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol 2003, 162:1111-1122. 10.1083/jcb.200212157, 2172846, 12975353.
    • (2003) J Cell Biol , vol.162 , pp. 1111-1122
    • Cattelino, A.1    Liebner, S.2    Gallini, R.3    Zanetti, A.4    Balconi, G.5    Corsi, A.6    Bianco, P.7    Wolburg, H.8    Moore, R.9    Oreda, B.10
  • 100
    • 0035865048 scopus 로고    scopus 로고
    • Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo
    • 10.1006/dbio.2000.0106, 11161575
    • Kisanuki YY, Hammer RE, Miyazaki J, Williams SC, Richardson JA, Yanagisawa M. Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol 2001, 230:230-242. 10.1006/dbio.2000.0106, 11161575.
    • (2001) Dev Biol , vol.230 , pp. 230-242
    • Kisanuki, Y.Y.1    Hammer, R.E.2    Miyazaki, J.3    Williams, S.C.4    Richardson, J.A.5    Yanagisawa, M.6
  • 102
    • 79955029851 scopus 로고    scopus 로고
    • GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier
    • 10.1073/pnas.1017192108, 3078373, 21421844
    • Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, et al. GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A 2011, 108:5759-5764. 10.1073/pnas.1017192108, 3078373, 21421844.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 5759-5764
    • Cullen, M.1    Elzarrad, M.K.2    Seaman, S.3    Zudaire, E.4    Stevens, J.5    Yang, M.Y.6    Li, X.7    Chaudhary, A.8    Xu, L.9    Hilton, M.B.10
  • 105
    • 0026783674 scopus 로고
    • Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
    • 10.1016/0092-8674(92)90264-D, 1394430
    • Lee JJ, von Kessler DP, Parks S, Beachy PA. Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 1992, 71:33-50. 10.1016/0092-8674(92)90264-D, 1394430.
    • (1992) Cell , vol.71 , pp. 33-50
    • Lee, J.J.1    von Kessler, D.P.2    Parks, S.3    Beachy, P.A.4
  • 106
    • 33645734474 scopus 로고    scopus 로고
    • Hedgehog signalling: how to get from Smo to Ci and Gli
    • 10.1016/j.tcb.2006.02.004, 16516476
    • Osterlund T, Kogerman P. Hedgehog signalling: how to get from Smo to Ci and Gli. Trends Cell Biol 2006, 16:176-180. 10.1016/j.tcb.2006.02.004, 16516476.
    • (2006) Trends Cell Biol , vol.16 , pp. 176-180
    • Osterlund, T.1    Kogerman, P.2
  • 107
    • 33748951151 scopus 로고    scopus 로고
    • Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development
    • 10.1038/nrn1990, 16988653
    • Fuccillo M, Joyner AL, Fishell G. Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development. Nat Rev Neurosci 2006, 7:772-783. 10.1038/nrn1990, 16988653.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 772-783
    • Fuccillo, M.1    Joyner, A.L.2    Fishell, G.3
  • 108
    • 41049083500 scopus 로고    scopus 로고
    • Hedgehog signalling in vascular development
    • 10.1007/s10456-008-9105-5, 18301996
    • Nagase T, Nagase M, Machida M, Fujita T. Hedgehog signalling in vascular development. Angiogenesis 2008, 11:71-77. 10.1007/s10456-008-9105-5, 18301996.
    • (2008) Angiogenesis , vol.11 , pp. 71-77
    • Nagase, T.1    Nagase, M.2    Machida, M.3    Fujita, T.4
  • 109
    • 0029777408 scopus 로고    scopus 로고
    • Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function
    • 10.1038/383407a0, 8837770
    • Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA. Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function. Nature 1996, 383:407-413. 10.1038/383407a0, 8837770.
    • (1996) Nature , vol.383 , pp. 407-413
    • Chiang, C.1    Litingtung, Y.2    Lee, E.3    Young, K.E.4    Corden, J.L.5    Westphal, H.6    Beachy, P.A.7
  • 110
    • 0033570359 scopus 로고    scopus 로고
    • Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells
    • Rowitch DH BSJ, Lee SM, Flax JD, Snyder EY, McMahon AP. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci 1999, 19:8954-8965.
    • (1999) J Neurosci , vol.19 , pp. 8954-8965
    • Rowitch DH, B.S.J.1    Lee, S.M.2    Flax, J.D.3    Snyder, E.Y.4    McMahon, A.P.5
  • 112
    • 84873056128 scopus 로고    scopus 로고
    • The brain renin-angiotensin system: a diversity of functions and implications for CNS diseases
    • epub ahead of print
    • Wright JW, Harding JW. The brain renin-angiotensin system: a diversity of functions and implications for CNS diseases. Pflugers Arch 2012, epub ahead of print.
    • (2012) Pflugers Arch
    • Wright, J.W.1    Harding, J.W.2
  • 113
    • 0031720384 scopus 로고    scopus 로고
    • Impaired blood-brain barrier function in angiotensinogen-deficient mice
    • 10.1038/2070, 9734405
    • Kakinuma Y, Hama H, Sugiyama F, Yagami K, Goto K, Murakami K, Fukamizu A. Impaired blood-brain barrier function in angiotensinogen-deficient mice. Nat Med 1998, 4:1078-1080. 10.1038/2070, 9734405.
    • (1998) Nat Med , vol.4 , pp. 1078-1080
    • Kakinuma, Y.1    Hama, H.2    Sugiyama, F.3    Yagami, K.4    Goto, K.5    Murakami, K.6    Fukamizu, A.7
  • 114
    • 34548145190 scopus 로고    scopus 로고
    • Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis
    • 10.1523/JNEUROSCI.2088-07.2007, 17715340
    • Wosik K, Cayrol R, Dodelet-Devillers A, Berthelet F, Bernard M, Moumdjian R, Bouthillier A, Reudelhuber TL, Prat A. Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis. J Neurosci 2007, 27:9032-9042. 10.1523/JNEUROSCI.2088-07.2007, 17715340.
    • (2007) J Neurosci , vol.27 , pp. 9032-9042
    • Wosik, K.1    Cayrol, R.2    Dodelet-Devillers, A.3    Berthelet, F.4    Bernard, M.5    Moumdjian, R.6    Bouthillier, A.7    Reudelhuber, T.L.8    Prat, A.9
  • 117
    • 0022350033 scopus 로고
    • Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system
    • 10.1172/JCI112130, 424114, 3932467
    • Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM. Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 1985, 76:1501-1513. 10.1172/JCI112130, 424114, 3932467.
    • (1985) J Clin Invest , vol.76 , pp. 1501-1513
    • Boyles, J.K.1    Pitas, R.E.2    Wilson, E.3    Mahley, R.W.4    Taylor, J.M.5
  • 118
    • 34247325468 scopus 로고    scopus 로고
    • ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage
    • Hafezi-Moghadam A, Thomas KL, Wagner DD. ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage. Am J Physiol Cell Physiol 2007, 292:C1256-C1262.
    • (2007) Am J Physiol Cell Physiol , vol.292
    • Hafezi-Moghadam, A.1    Thomas, K.L.2    Wagner, D.D.3
  • 120
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes are required for blood-brain barrier integrity during embryogenesis
    • 10.1038/nature09513, 3241506, 20944625
    • Daneman R, Zhou L, Kebede AA, Barres BA. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 2010, 468:562-566. 10.1038/nature09513, 3241506, 20944625.
    • (2010) Nature , vol.468 , pp. 562-566
    • Daneman, R.1    Zhou, L.2    Kebede, A.A.3    Barres, B.A.4
  • 121
    • 80055014830 scopus 로고    scopus 로고
    • Central nervous system pericytes in health and disease
    • 10.1038/nn.2946, 22030551
    • Winkler EA, Bell RD, Zlokovic BV. Central nervous system pericytes in health and disease. Nat Neurosci 2011, 14:1398-1405. 10.1038/nn.2946, 22030551.
    • (2011) Nat Neurosci , vol.14 , pp. 1398-1405
    • Winkler, E.A.1    Bell, R.D.2    Zlokovic, B.V.3
  • 122
    • 0035972251 scopus 로고    scopus 로고
    • Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    • 10.1083/jcb.153.3.543, 2190573, 11331305
    • Hellstrom M, Gerhardt H, Kalen M, Li X, Eriksson U, Wolburg H, Betsholtz C. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol 2001, 153:543-553. 10.1083/jcb.153.3.543, 2190573, 11331305.
    • (2001) J Cell Biol , vol.153 , pp. 543-553
    • Hellstrom, M.1    Gerhardt, H.2    Kalen, M.3    Li, X.4    Eriksson, U.5    Wolburg, H.6    Betsholtz, C.7
  • 123
    • 0030756325 scopus 로고    scopus 로고
    • Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    • 10.1126/science.277.5323.242, 9211853
    • Lindahl P, Johansson BR, Leveen P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 1997, 277:242-245. 10.1126/science.277.5323.242, 9211853.
    • (1997) Science , vol.277 , pp. 242-245
    • Lindahl, P.1    Johansson, B.R.2    Leveen, P.3    Betsholtz, C.4
  • 124
    • 2342419356 scopus 로고    scopus 로고
    • Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development
    • 261889, 14624252
    • Tallquist MD, French WJ, Soriano P. Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development. PLoS Biol 2003, 1:E52. 261889, 14624252.
    • (2003) PLoS Biol , vol.1
    • Tallquist, M.D.1    French, W.J.2    Soriano, P.3
  • 125
    • 78049279739 scopus 로고    scopus 로고
    • Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
    • 10.1016/j.neuron.2010.09.043, 3056408, 21040844
    • Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 2010, 68:409-427. 10.1016/j.neuron.2010.09.043, 3056408, 21040844.
    • (2010) Neuron , vol.68 , pp. 409-427
    • Bell, R.D.1    Winkler, E.A.2    Sagare, A.P.3    Singh, I.4    LaRue, B.5    Deane, R.6    Zlokovic, B.V.7
  • 127
    • 79960099283 scopus 로고    scopus 로고
    • A pericyte origin of spinal cord scar tissue
    • 10.1126/science.1203165, 21737741
    • Goritz C, Dias DO, Tomilin N, Barbacid M, Shupliakov O, Frisen J. A pericyte origin of spinal cord scar tissue. Science 2011, 333:238-242. 10.1126/science.1203165, 21737741.
    • (2011) Science , vol.333 , pp. 238-242
    • Goritz, C.1    Dias, D.O.2    Tomilin, N.3    Barbacid, M.4    Shupliakov, O.5    Frisen, J.6
  • 128
    • 79952525332 scopus 로고    scopus 로고
    • Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with notch
    • 10.1016/j.devcel.2011.01.011, 21397841
    • Li F, Lan Y, Wang Y, Wang J, Yang G, Meng F, Han H, Meng A, Wang Y, Yang X. Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with notch. Dev Cell 2011, 20:291-302. 10.1016/j.devcel.2011.01.011, 21397841.
    • (2011) Dev Cell , vol.20 , pp. 291-302
    • Li, F.1    Lan, Y.2    Wang, Y.3    Wang, J.4    Yang, G.5    Meng, F.6    Han, H.7    Meng, A.8    Wang, Y.9    Yang, X.10
  • 129
    • 78149314205 scopus 로고    scopus 로고
    • Specification and morphogenesis of astrocytes
    • 10.1126/science.1190928, 21051628
    • Freeman MR. Specification and morphogenesis of astrocytes. Science 2010, 330:774-778. 10.1126/science.1190928, 21051628.
    • (2010) Science , vol.330 , pp. 774-778
    • Freeman, M.R.1
  • 130
    • 77952410964 scopus 로고    scopus 로고
    • Morphology and dynamics of perisynaptic glia
    • 10.1016/j.brainresrev.2010.02.003, 20176054
    • Reichenbach A, Derouiche A, Kirchhoff F. Morphology and dynamics of perisynaptic glia. Brain Res Rev 2010, 63:11-25. 10.1016/j.brainresrev.2010.02.003, 20176054.
    • (2010) Brain Res Rev , vol.63 , pp. 11-25
    • Reichenbach, A.1    Derouiche, A.2    Kirchhoff, F.3
  • 131
    • 57749193067 scopus 로고    scopus 로고
    • Brain endothelial cells and the glio-vascular complex
    • 10.1007/s00441-008-0658-9, 18633647
    • Wolburg H, Noell S, Mack A, Wolburg-Buchholz K, Fallier-Becker P. Brain endothelial cells and the glio-vascular complex. Cell Tissue Res 2009, 335:75-96. 10.1007/s00441-008-0658-9, 18633647.
    • (2009) Cell Tissue Res , vol.335 , pp. 75-96
    • Wolburg, H.1    Noell, S.2    Mack, A.3    Wolburg-Buchholz, K.4    Fallier-Becker, P.5
  • 133
    • 0021245990 scopus 로고
    • Glial cells influence polarity of the blood-brain barrier
    • 10.1097/00005072-198405000-00001, 6726282
    • Beck DW, Vinters HV, Hart MN, Cancilla PA. Glial cells influence polarity of the blood-brain barrier. J Neuropathol Exp Neurol 1984, 43:219-224. 10.1097/00005072-198405000-00001, 6726282.
    • (1984) J Neuropathol Exp Neurol , vol.43 , pp. 219-224
    • Beck, D.W.1    Vinters, H.V.2    Hart, M.N.3    Cancilla, P.A.4
  • 134
    • 84858076374 scopus 로고    scopus 로고
    • Genetic approaches to study glial cells in the rodent brain
    • 10.1002/glia.22283, 22162024
    • Pfrieger FW, Slezak M. Genetic approaches to study glial cells in the rodent brain. Glia 2012, 60:681-701. 10.1002/glia.22283, 22162024.
    • (2012) Glia , vol.60 , pp. 681-701
    • Pfrieger, F.W.1    Slezak, M.2
  • 135
    • 0029956806 scopus 로고    scopus 로고
    • Conditional ablation of cerebellar astrocytes in postnatal transgenic mice
    • Delaney CL, Brenner M, Messing A. Conditional ablation of cerebellar astrocytes in postnatal transgenic mice. J Neurosci 1996, 16:6908-6918.
    • (1996) J Neurosci , vol.16 , pp. 6908-6918
    • Delaney, C.L.1    Brenner, M.2    Messing, A.3
  • 136
    • 7044233126 scopus 로고    scopus 로고
    • GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain
    • 10.1038/nn1340, 15494728
    • Garcia AD, Doan NB, Imura T, Bush TG, Sofroniew MV. GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat Neurosci 2004, 7:1233-1241. 10.1038/nn1340, 15494728.
    • (2004) Nat Neurosci , vol.7 , pp. 1233-1241
    • Garcia, A.D.1    Doan, N.B.2    Imura, T.3    Bush, T.G.4    Sofroniew, M.V.5
  • 137
    • 0034954304 scopus 로고    scopus 로고
    • Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain
    • 10.1002/glia.1061, 11360300
    • Cui W, Allen ND, Skynner M, Gusterson B, Clark AJ. Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain. Glia 2001, 34:272-282. 10.1002/glia.1061, 11360300.
    • (2001) Glia , vol.34 , pp. 272-282
    • Cui, W.1    Allen, N.D.2    Skynner, M.3    Gusterson, B.4    Clark, A.J.5
  • 138
    • 84855918291 scopus 로고    scopus 로고
    • Transgenic techniques for cell ablation or molecular deletion to investigate functions of astrocytes and other GFAP-expressing cell types
    • 10.1007/978-1-61779-452-0_35, 22144330
    • Sofroniew MV. Transgenic techniques for cell ablation or molecular deletion to investigate functions of astrocytes and other GFAP-expressing cell types. Methods Mol Biol 2012, 814:531-544. 10.1007/978-1-61779-452-0_35, 22144330.
    • (2012) Methods Mol Biol , vol.814 , pp. 531-544
    • Sofroniew, M.V.1
  • 140
    • 1542317072 scopus 로고    scopus 로고
    • Reactive astrocytes protect tissue and preserve function after spinal cord injury
    • 10.1523/JNEUROSCI.3547-03.2004, 14999065
    • Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB, Sofroniew MV. Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci 2004, 24:2143-2155. 10.1523/JNEUROSCI.3547-03.2004, 14999065.
    • (2004) J Neurosci , vol.24 , pp. 2143-2155
    • Faulkner, J.R.1    Herrmann, J.E.2    Woo, M.J.3    Tansey, K.E.4    Doan, N.B.5    Sofroniew, M.V.6
  • 141
    • 70349103383 scopus 로고    scopus 로고
    • Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS
    • 10.1523/JNEUROSCI.1514-09.2009, 2768309, 19759299
    • Voskuhl RR, Peterson RS, Song B, Ao Y, Morales LB, Tiwari-Woodruff S, Sofroniew MV. Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. J Neurosci 2009, 29:11511-11522. 10.1523/JNEUROSCI.1514-09.2009, 2768309, 19759299.
    • (2009) J Neurosci , vol.29 , pp. 11511-11522
    • Voskuhl, R.R.1    Peterson, R.S.2    Song, B.3    Ao, Y.4    Morales, L.B.5    Tiwari-Woodruff, S.6    Sofroniew, M.V.7
  • 142
    • 38049054706 scopus 로고    scopus 로고
    • Water movements in the brain: role of aquaporins
    • 10.1016/j.tins.2007.11.003, 18054802
    • Tait MJ, Saadoun S, Bell BA, Papadopoulos MC. Water movements in the brain: role of aquaporins. Trends Neurosci 2008, 31:37-43. 10.1016/j.tins.2007.11.003, 18054802.
    • (2008) Trends Neurosci , vol.31 , pp. 37-43
    • Tait, M.J.1    Saadoun, S.2    Bell, B.A.3    Papadopoulos, M.C.4
  • 143
    • 0033966090 scopus 로고    scopus 로고
    • Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke
    • 10.1038/72256, 10655103
    • Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 2000, 6:159-163. 10.1038/72256, 10655103.
    • (2000) Nat Med , vol.6 , pp. 159-163
    • Manley, G.T.1    Fujimura, M.2    Ma, T.3    Noshita, N.4    Filiz, F.5    Bollen, A.W.6    Chan, P.7    Verkman, A.S.8
  • 144
    • 67349162678 scopus 로고    scopus 로고
    • AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology
    • 10.1016/j.neuroscience.2009.03.069, 19345723
    • Saadoun S, Tait MJ, Reza A, Davies DC, Bell BA, Verkman AS, Papadopoulos MC. AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology. Neuroscience 2009, 161:764-772. 10.1016/j.neuroscience.2009.03.069, 19345723.
    • (2009) Neuroscience , vol.161 , pp. 764-772
    • Saadoun, S.1    Tait, M.J.2    Reza, A.3    Davies, D.C.4    Bell, B.A.5    Verkman, A.S.6    Papadopoulos, M.C.7
  • 146
    • 33750240193 scopus 로고    scopus 로고
    • Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome
    • 10.1371/journal.pbio.0040315, 1563491, 16968134
    • Davy A, Bush JO, Soriano P. Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol 2006, 4:e315. 10.1371/journal.pbio.0040315, 1563491, 16968134.
    • (2006) PLoS Biol , vol.4
    • Davy, A.1    Bush, J.O.2    Soriano, P.3
  • 147
    • 39749169771 scopus 로고    scopus 로고
    • Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy
    • 10.1016/j.jneumeth.2007.11.011, 2647134, 18192022
    • Davalos D, Lee JK, Smith WB, Brinkman B, Ellisman MH, Zheng B, Akassoglou K. Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy. J Neurosci Methods 2008, 169:1-7. 10.1016/j.jneumeth.2007.11.011, 2647134, 18192022.
    • (2008) J Neurosci Methods , vol.169 , pp. 1-7
    • Davalos, D.1    Lee, J.K.2    Smith, W.B.3    Brinkman, B.4    Ellisman, M.H.5    Zheng, B.6    Akassoglou, K.7
  • 148
    • 0034028817 scopus 로고    scopus 로고
    • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • 10.1128/MCB.20.11.4106-4114.2000, 85780, 10805752
    • Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, Sher A, Littman DR. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 2000, 20:4106-4114. 10.1128/MCB.20.11.4106-4114.2000, 85780, 10805752.
    • (2000) Mol Cell Biol , vol.20 , pp. 4106-4114
    • Jung, S.1    Aliberti, J.2    Graemmel, P.3    Sunshine, M.J.4    Kreutzberg, G.W.5    Sher, A.6    Littman, D.R.7
  • 151
    • 84855384345 scopus 로고    scopus 로고
    • The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood
    • 10.4049/jimmunol.1100421, 3244524, 22079990
    • Mizutani M, Pino PA, Saederup N, Charo IF, Ransohoff RM, Cardona AE. The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood. J Immunol 2012, 188:29-36. 10.4049/jimmunol.1100421, 3244524, 22079990.
    • (2012) J Immunol , vol.188 , pp. 29-36
    • Mizutani, M.1    Pino, P.A.2    Saederup, N.3    Charo, I.F.4    Ransohoff, R.M.5    Cardona, A.E.6
  • 152
    • 78149438403 scopus 로고    scopus 로고
    • Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice
    • 10.1371/journal.pone.0013693, 2965160, 21060874
    • Saederup N, Cardona AE, Croft K, Mizutani M, Cotleur AC, Tsou CL, Ransohoff RM, Charo IF. Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice. PLoS One 2010, 5:e13693. 10.1371/journal.pone.0013693, 2965160, 21060874.
    • (2010) PLoS One , vol.5
    • Saederup, N.1    Cardona, A.E.2    Croft, K.3    Mizutani, M.4    Cotleur, A.C.5    Tsou, C.L.6    Ransohoff, R.M.7    Charo, I.F.8
  • 156
    • 0035077333 scopus 로고    scopus 로고
    • Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice
    • Gustafsson E, Brakebusch C, Hietanen K, Fassler R. Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice. J Cell Sci 2001, 114:671-676.
    • (2001) J Cell Sci , vol.114 , pp. 671-676
    • Gustafsson, E.1    Brakebusch, C.2    Hietanen, K.3    Fassler, R.4
  • 157
    • 29944436856 scopus 로고    scopus 로고
    • Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation
    • 10.1083/jcb.200506184, 2063542, 16391003
    • Braren R, Hu H, Kim YH, Beggs HE, Reichardt LF, Wang R. Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol 2006, 172:151-162. 10.1083/jcb.200506184, 2063542, 16391003.
    • (2006) J Cell Biol , vol.172 , pp. 151-162
    • Braren, R.1    Hu, H.2    Kim, Y.H.3    Beggs, H.E.4    Reichardt, L.F.5    Wang, R.6
  • 158
    • 47649119224 scopus 로고    scopus 로고
    • Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice
    • 10.1242/dev.016378, 2582018, 18480158
    • Carlson TR, Hu H, Braren R, Kim YH, Wang RA. Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice. Development 2008, 135:2193-2202. 10.1242/dev.016378, 2582018, 18480158.
    • (2008) Development , vol.135 , pp. 2193-2202
    • Carlson, T.R.1    Hu, H.2    Braren, R.3    Kim, Y.H.4    Wang, R.A.5
  • 159
    • 0037353035 scopus 로고    scopus 로고
    • Evidence for novel fate of Flk1+ progenitor: contribution to muscle lineage
    • 10.1002/gene.10175, 12640619
    • Motoike T, Markham DW, Rossant J, Sato TN. Evidence for novel fate of Flk1+ progenitor: contribution to muscle lineage. Genesis 2003, 35:153-159. 10.1002/gene.10175, 12640619.
    • (2003) Genesis , vol.35 , pp. 153-159
    • Motoike, T.1    Markham, D.W.2    Rossant, J.3    Sato, T.N.4
  • 160
    • 0942276447 scopus 로고    scopus 로고
    • Endothelium-specific Cre recombinase activity in flk-1-Cre transgenic mice
    • 10.1002/dvdy.10416, 14745955
    • Licht AH, Raab S, Hofmann U, Breier G. Endothelium-specific Cre recombinase activity in flk-1-Cre transgenic mice. Dev Dyn 2004, 229:312-318. 10.1002/dvdy.10416, 14745955.
    • (2004) Dev Dyn , vol.229 , pp. 312-318
    • Licht, A.H.1    Raab, S.2    Hofmann, U.3    Breier, G.4
  • 161
    • 33644925814 scopus 로고    scopus 로고
    • VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells
    • 10.1002/dvdy.20643, 16450386
    • Alva JA, Zovein AC, Monvoisin A, Murphy T, Salazar A, Harvey NL, Carmeliet P, Iruela-Arispe ML. VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn 2006, 235:759-767. 10.1002/dvdy.20643, 16450386.
    • (2006) Dev Dyn , vol.235 , pp. 759-767
    • Alva, J.A.1    Zovein, A.C.2    Monvoisin, A.3    Murphy, T.4    Salazar, A.5    Harvey, N.L.6    Carmeliet, P.7    Iruela-Arispe, M.L.8
  • 162
    • 84856230669 scopus 로고    scopus 로고
    • Development and characterization of transgenic mouse models for conditional gene knockout in the blood-brain and blood-CSF barriers
    • 10.1007/s11248-011-9512-z, 3192922, 21538071
    • Crouthamel MH, Kelly EJ, Ho RJ. Development and characterization of transgenic mouse models for conditional gene knockout in the blood-brain and blood-CSF barriers. Transgenic Res 2012, 21:113-130. 10.1007/s11248-011-9512-z, 3192922, 21538071.
    • (2012) Transgenic Res , vol.21 , pp. 113-130
    • Crouthamel, M.H.1    Kelly, E.J.2    Ho, R.J.3
  • 163
    • 0036687898 scopus 로고    scopus 로고
    • Temporal Cre-mediated recombination exclusively in endothelial cells using Tie2 regulatory elements
    • 10.1002/gene.10117, 12203917
    • Forde A, Constien R, Grone HJ, Hammerling G, Arnold B. Temporal Cre-mediated recombination exclusively in endothelial cells using Tie2 regulatory elements. Genesis 2002, 33:191-197. 10.1002/gene.10117, 12203917.
    • (2002) Genesis , vol.33 , pp. 191-197
    • Forde, A.1    Constien, R.2    Grone, H.J.3    Hammerling, G.4    Arnold, B.5
  • 164
    • 39549098360 scopus 로고    scopus 로고
    • Efficient, inducible Cre-recombinase activation in vascular endothelium
    • 10.1002/dvg.20367, 18257043
    • Claxton S, Kostourou V, Jadeja S, Chambon P, Hodivala-Dilke K, Fruttiger M. Efficient, inducible Cre-recombinase activation in vascular endothelium. Genesis 2008, 46:74-80. 10.1002/dvg.20367, 18257043.
    • (2008) Genesis , vol.46 , pp. 74-80
    • Claxton, S.1    Kostourou, V.2    Jadeja, S.3    Chambon, P.4    Hodivala-Dilke, K.5    Fruttiger, M.6
  • 165
  • 166
    • 33845357881 scopus 로고    scopus 로고
    • VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium
    • 10.1002/dvdy.20982, 17072878
    • Monvoisin A, Alva JA, Hofmann JJ, Zovein AC, Lane TF, Iruela-Arispe ML. VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium. Dev Dyn 2006, 235:3413-3422. 10.1002/dvdy.20982, 17072878.
    • (2006) Dev Dyn , vol.235 , pp. 3413-3422
    • Monvoisin, A.1    Alva, J.A.2    Hofmann, J.J.3    Zovein, A.C.4    Lane, T.F.5    Iruela-Arispe, M.L.6
  • 171
    • 79955624288 scopus 로고    scopus 로고
    • Dual origin of mesenchymal stem cells contributing to organ growth and repair
    • 10.1073/pnas.1015449108, 3081015, 21464310
    • Feng J, Mantesso A, De Bari C, Nishiyama A, Sharpe PT. Dual origin of mesenchymal stem cells contributing to organ growth and repair. Proc Natl Acad Sci U S A 2011, 108:6503-6508. 10.1073/pnas.1015449108, 3081015, 21464310.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 6503-6508
    • Feng, J.1    Mantesso, A.2    De Bari, C.3    Nishiyama, A.4    Sharpe, P.T.5
  • 176
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
    • 10.1038/nbt.1807, 21423189
    • Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 2011, 29:341-345. 10.1038/nbt.1807, 21423189.
    • (2011) Nat Biotechnol , vol.29 , pp. 341-345
    • Alvarez-Erviti, L.1    Seow, Y.2    Yin, H.3    Betts, C.4    Lakhal, S.5    Wood, M.J.6
  • 177
    • 81755172852 scopus 로고    scopus 로고
    • Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging
    • 10.1073/pnas.1111405108, 3219113, 22065785
    • Koffie RM, Farrar CT, Saidi LJ, William CM, Hyman BT, Spires-Jones TL. Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging. Proc Natl Acad Sci U S A 2011, 108:18837-18842. 10.1073/pnas.1111405108, 3219113, 22065785.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 18837-18842
    • Koffie, R.M.1    Farrar, C.T.2    Saidi, L.J.3    William, C.M.4    Hyman, B.T.5    Spires-Jones, T.L.6
  • 178
    • 79959349811 scopus 로고    scopus 로고
    • Minimally invasive molecular delivery into the brain using optical modulation of vascular permeability
    • 10.1073/pnas.1018790108, 3107279, 21576460
    • Choi M, Ku T, Chong K, Yoon J, Choi C. Minimally invasive molecular delivery into the brain using optical modulation of vascular permeability. Proc Natl Acad Sci U S A 2011, 108:9256-9261. 10.1073/pnas.1018790108, 3107279, 21576460.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 9256-9261
    • Choi, M.1    Ku, T.2    Chong, K.3    Yoon, J.4    Choi, C.5
  • 180
    • 79951830550 scopus 로고    scopus 로고
    • LSR defines cell corners for tricellular tight junction formation in epithelial cells
    • 10.1242/jcs.072058, 21245199
    • Masuda S, Oda Y, Sasaki H, Ikenouchi J, Higashi T, Akashi M, Nishi E, Furuse M. LSR defines cell corners for tricellular tight junction formation in epithelial cells. J Cell Sci 2011, 124:548-555. 10.1242/jcs.072058, 21245199.
    • (2011) J Cell Sci , vol.124 , pp. 548-555
    • Masuda, S.1    Oda, Y.2    Sasaki, H.3    Ikenouchi, J.4    Higashi, T.5    Akashi, M.6    Nishi, E.7    Furuse, M.8
  • 181
    • 29144533473 scopus 로고    scopus 로고
    • Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
    • 10.1083/jcb.200510043, 2171318, 16365161
    • Ikenouchi J, Furuse M, Furuse K, Sasaki H, Tsukita S, Tsukita S. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J Cell Biol 2005, 171:939-945. 10.1083/jcb.200510043, 2171318, 16365161.
    • (2005) J Cell Biol , vol.171 , pp. 939-945
    • Ikenouchi, J.1    Furuse, M.2    Furuse, K.3    Sasaki, H.4    Tsukita, S.5    Tsukita, S.6
  • 182
    • 77949532370 scopus 로고    scopus 로고
    • Split-CreERT2: temporal control of DNA recombination mediated by split-Cre protein fragment complementation
    • 10.1371/journal.pone.0008354, 2791205, 20016782
    • Hirrlinger J, Requardt RP, Winkler U, Wilhelm F, Schulze C, Hirrlinger PG. Split-CreERT2: temporal control of DNA recombination mediated by split-Cre protein fragment complementation. PLoS One 2009, 4:e8354. 10.1371/journal.pone.0008354, 2791205, 20016782.
    • (2009) PLoS One , vol.4
    • Hirrlinger, J.1    Requardt, R.P.2    Winkler, U.3    Wilhelm, F.4    Schulze, C.5    Hirrlinger, P.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.