Hedgehog signalling in vascular development

Angiogenesis

Volumn 11, Issue 1, 2008, Pages 71-77

  Nagase, Takashi ^a   Nagase, Miki ^b   Machida, Masafumi ^a   Fujita, Toshiro ^b  

^a NATIONAL HOSPITAL ORGANIZATION MURAYAMA MEDICAL CENTER   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Angiogenesis; Hedgehog signalling; Indian hedgehog; Motor neuron; Sonic Hedgehog; Whole embryo culture; Yolk sac

Indexed keywords

CYCLOPAMINE; SONIC HEDGEHOG PROTEIN;

ANGIOGENESIS; CONGENITAL BLOOD VESSEL MALFORMATION; EMBRYO CULTURE; EMBRYO DEVELOPMENT; HUMAN; NEURAL TUBE; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BLOOD VESSELS; HEDGEHOG PROTEINS; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 41049083500     PISSN: 09696970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10456-008-9105-5     Document Type: Review

References (45)

1. Cohen MM Jr (2003) The hedgehog signalling network. Am J Med Genet A 123:5-28
2. Nagase T, Nagase M (2007) Time windows of hedgehog signalling in craniofacial and vascular development: Analyses using a mouse whole embryo culture system. In: Grachevsky N (ed) Signal transduction research trends. NOVA Science Publishers, Hauppauge, pp 131-170
3. Pola R, Ling LE et al (2001) The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat Med 7:706-711
4. Byrd N, Grabel L (2004) Hedgehog signalling in murine vasculogenesis and angiogenesis. Trends Cardiovasc Med 14:308-313
5. Lavine KJ, Ornitz DM (2007) Rebuilding the coronary vasculature: hedgehog as a new candidate for pharmacologic revascularization. Trends Cardiovasc Med 17:77-83
6. Donahue JK (2006) Gene therapy, angiogenesis, Sonic Hedgehog: Sonic the Hedgehog to the rescue? Gene Ther 13:998-999
7. Nagase T, Nagase M et al (2007) Hedgehog signalling: a biophysical or biomechanical modulator in embryonic development? Ann N Y Acad Sci 1101:412-438
8. Mann RK, Beachy PA (2004) Novel lipid modifications of secreted protein signals. Annu Rev Biochem 73:891-923
9. Burke R Nellen D et al (1999) Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signalling cells. Cell 99:803-815
10. Kalderon D (2005) The mechanism of hedgehog signal transduction. Biochem Soc Trans 33:1509-1512
11. Aza-Blanc P, Ramirez-Weber FA et al (1997) Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89:1043-1053
12. Lum L, Zhang C et al (2003) Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell 12:1261-1274
13. Chen JK, Taipale J et al (2002) Inhibition of Hedgehog signalling by direct binding of cyclopamine to Smoothened. Genes Dev 16:2743-2748
14. Roelink H, Porter JA et al (1995) Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell 81:445-455
15. Jessell TM (2000) Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat Rev Genet 1:20-29
16. Panman L, Zeller R (2003) Patterning the limb before and after SHH signalling. J Anat 202:3-12
17. Chiang C, Litingtung Y et al (1996) Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383:407-413
18. Athar M, tang X et al (2006) Hedgehog signalling in skin development and cancer. Exp Dematol 15:667-677
19. Dellovade T, Romer JT et al (2006) The hedgehog pathway and neurological disorders. Annu Rev Neuroci 29:539-563
20. Lawson ND, Vogel AM et al (2002) Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell 3:127-136
21. Vokes SA, Yatskievych TA et al (2004) Hedgehog signalling is essential for endothelial tube formation during vasculogenesis. Development 131:4371-4380
22. Lavine KJ, White AC et al (2006) Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev 20:1651-1666
23. Van Tuyl M, Groenman F et al (2007) Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs. Dev Biol 303:514-526
24. White AC, Lavine KJ et al (2007) FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network. Development 134:3743-3752
25. Kanda S, Mochizuki Y et al (2003) Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase. J Biol Chem 278:8244-8249
26. Hochman E, Castiel A et al (2006) Molecular pathways regulating pro-migratory effects of Hedgehog signalling. J Biol Chem 281:33860-33870
27. Asai J, Takenaka H et al (2006) Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodelling. Circulation 113:2413-2424
28. Lee SW, Moskowitz MA et al (2007) Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts. Int J Mol Med 19:445-451
29. Byrd N, Becker S et al (2002) Hedgehog is required for murine yolk sac angiogenesis. Development 129:361-372
30. Chung Ul, Schipani E et al (2001) Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest 107:295-304
31. Colnot C, de la Fuente L et al (2005) Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development. Development 132:1057-1067
32. Kusano KF, Allendoerfer KL et al (2004) Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy. Arterioscler Thromb Vasc Biol 24:2102-2107
33. Pola R, Ling LE et al (2003) Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia. Circulation 108:479-485
34. Surace EM, Balaggan KS et al (2006) Inhibition of ocular neovascularisation by hedgehog blockade. Mol Ther 13:573-579
35. Kusano KF, Pola R et al (2005) Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signalling. Nat Med 11:1197-1204
36. Velcheti V (2007) Hedgehog signalling is a potent regulator of angiogenesis in small cell lung cancer. Med Hypotheses 69:948-949
37. Olsen CL, Hsu PP et al (2004) Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. BMC Cancer 4:43
38. Nagase T, Nagase M et al (2005) Angiogenesis within the developing mouse neural tube is dependent on sonic hedgehog signalling: possible roles of motor neurons. Genes Cells 10:595-604
39. Nagase T, Nagase M et al (2006) Defects in aortic fusion and craniofacial vasculature in the holoprosencephalic mouse embryo under inhibition of Sonic hedgehog signalling. J Craniofac Surg 17:736-744
40. Nagase M, Nagase T et al (2006) Critical time window of hedgehog-dependent angiogenesis in murine yolk sac. Microvasc Res 71:85-90
41. Osumi N, Inoue T (2001) Gene transfer into cultured mammalian embryos by electroporation. Methods 24:35-42
42. Nagase T, Nagase M et al (2005) Craniofacial anomalies of the cultured mouse embryo induced by inhibition of sonic hedgehog signalling: an animal model of holoprosencephaly. J Craniofax Surg 16:80-88
43. Dyer MA, Farrington SM et al (2001) Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo. Development 128:1717-1730
44. Nakao T, Ishizawa A et al (1988) Observations of vascularisation in the spinal cord of mouse embryos, with special reference to development of boundary membranes and perivascular spaces. Anat Rec 221:663-677
45. Sato TN, Tozawa Y et al (1995) Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376:70-74