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Volumn 16, Issue 4, 2006, Pages 176-180

Hedgehog signalling: how to get from Smo to Ci and Gli

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI1;

EID: 33645734474     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2006.02.004     Document Type: Article
Times cited : (103)

References (38)
  • 1
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nüsslein-Volhard C., and Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 287 (1980) 795-801
    • (1980) Nature , vol.287 , pp. 795-801
    • Nüsslein-Volhard, C.1    Wieschaus, E.2
  • 3
    • 13344261322 scopus 로고    scopus 로고
    • Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus
    • Zhang W., et al. Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev. Cell 8 (2005) 267-278
    • (2005) Dev. Cell , vol.8 , pp. 267-278
    • Zhang, W.1
  • 4
    • 10744233219 scopus 로고    scopus 로고
    • Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
    • Lum L., et al. Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol. Cell 12 (2003) 1261-1274
    • (2003) Mol. Cell , vol.12 , pp. 1261-1274
    • Lum, L.1
  • 5
    • 0242361620 scopus 로고    scopus 로고
    • Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
    • Jia J., et al. Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev. 17 (2003) 2709-2720
    • (2003) Genes Dev. , vol.17 , pp. 2709-2720
    • Jia, J.1
  • 6
    • 0141728540 scopus 로고    scopus 로고
    • Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
    • Ruel L., et al. Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. Nat. Cell Biol. 5 (2003) 907-913
    • (2003) Nat. Cell Biol. , vol.5 , pp. 907-913
    • Ruel, L.1
  • 7
    • 0242625184 scopus 로고    scopus 로고
    • Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2
    • Ogden S.K., et al. Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Curr. Biol. 13 (2003) 1998-2003
    • (2003) Curr. Biol. , vol.13 , pp. 1998-2003
    • Ogden, S.K.1
  • 8
    • 1342282946 scopus 로고    scopus 로고
    • The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner
    • Stegman M.A., et al. The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner. J. Biol. Chem. 279 (2004) 7064-7071
    • (2004) J. Biol. Chem. , vol.279 , pp. 7064-7071
    • Stegman, M.A.1
  • 9
    • 12344305145 scopus 로고    scopus 로고
    • Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
    • Apionishev S., et al. Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat. Cell Biol. 7 (2005) 86-92
    • (2005) Nat. Cell Biol. , vol.7 , pp. 86-92
    • Apionishev, S.1
  • 10
    • 11144237279 scopus 로고    scopus 로고
    • Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
    • Jia J., et al. Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature 432 (2004) 1045-1050
    • (2004) Nature , vol.432 , pp. 1045-1050
    • Jia, J.1
  • 11
    • 11144248964 scopus 로고    scopus 로고
    • Extensive phosphorylation of Smoothened in Hedgehog pathway activation
    • Zhang C., et al. Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 17900-17907
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 17900-17907
    • Zhang, C.1
  • 12
    • 11144256194 scopus 로고    scopus 로고
    • Activity-dependent internalization of smoothened mediated by β-arrestin 2 and GRK2
    • Chen W., et al. Activity-dependent internalization of smoothened mediated by β-arrestin 2 and GRK2. Science 306 (2004) 2257-2260
    • (2004) Science , vol.306 , pp. 2257-2260
    • Chen, W.1
  • 13
    • 11144285406 scopus 로고    scopus 로고
    • β-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway
    • Wilbanks A.M., et al. β-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. Science 306 (2004) 2264-2267
    • (2004) Science , vol.306 , pp. 2264-2267
    • Wilbanks, A.M.1
  • 14
    • 17644402459 scopus 로고    scopus 로고
    • Transduction of receptor signals by β-arrestins
    • Lefkowitz R.J., and Shenoy S.K. Transduction of receptor signals by β-arrestins. Science 308 (2005) 512-517
    • (2005) Science , vol.308 , pp. 512-517
    • Lefkowitz, R.J.1    Shenoy, S.K.2
  • 15
    • 0347623882 scopus 로고    scopus 로고
    • The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling
    • Kasai K., et al. The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling. Genes Cells 9 (2004) 49-58
    • (2004) Genes Cells , vol.9 , pp. 49-58
    • Kasai, K.1
  • 16
    • 13344283332 scopus 로고    scopus 로고
    • Hedgehog signaling: from the Drosophila cuticle to anti-cancer drugs
    • Briscoe J., and Thérond P. Hedgehog signaling: from the Drosophila cuticle to anti-cancer drugs. Dev. Cell 8 (2005) 143-151
    • (2005) Dev. Cell , vol.8 , pp. 143-151
    • Briscoe, J.1    Thérond, P.2
  • 17
    • 14744268335 scopus 로고    scopus 로고
    • A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo
    • Tay S.Y., et al. A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo. Development 132 (2005) 625-634
    • (2005) Development , vol.132 , pp. 625-634
    • Tay, S.Y.1
  • 18
    • 20944433211 scopus 로고    scopus 로고
    • Analysis of mouse embryonic patterning and morphogenesis by forward genetics
    • Garcia-Garcia M.J., et al. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 5910-5912
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 5910-5912
    • Garcia-Garcia, M.J.1
  • 19
    • 23144466931 scopus 로고    scopus 로고
    • Mouse intraflagellar transport proteins regulate both the activation and repressor function of Gli transcription factors
    • Liu A., et al. Mouse intraflagellar transport proteins regulate both the activation and repressor function of Gli transcription factors. Development 132 (2005) 3103-3111
    • (2005) Development , vol.132 , pp. 3103-3111
    • Liu, A.1
  • 20
    • 23844485210 scopus 로고    scopus 로고
    • Cilia and Hedgehog responsiveness in the mouse
    • Huangfu D., and Anderson K.V. Cilia and Hedgehog responsiveness in the mouse. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 11325-11330
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 11325-11330
    • Huangfu, D.1    Anderson, K.V.2
  • 21
    • 26644460824 scopus 로고    scopus 로고
    • Vertebrate Smoothened functions at the primary cilium
    • Corbit K.C., et al. Vertebrate Smoothened functions at the primary cilium. Nature 437 (2005) 1018-1021
    • (2005) Nature , vol.437 , pp. 1018-1021
    • Corbit, K.C.1
  • 22
    • 40749144679 scopus 로고    scopus 로고
    • Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein Polaris for processing and function
    • Haycraft C.J., et al. Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein Polaris for processing and function. PLoS Genet. 1 (2005) e53
    • (2005) PLoS Genet. , vol.1
    • Haycraft, C.J.1
  • 23
    • 27744484694 scopus 로고    scopus 로고
    • Loss of the retrograde motor for ITF disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
    • May S.R., et al. Loss of the retrograde motor for ITF disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev. Biol. 287 (2005) 378-389
    • (2005) Dev. Biol. , vol.287 , pp. 378-389
    • May, S.R.1
  • 24
    • 30544448979 scopus 로고    scopus 로고
    • Mouse Rab23 regulates Hedgehog signalling from Smoothened to Gli proteins
    • Eggenschwiler J.T., et al. Mouse Rab23 regulates Hedgehog signalling from Smoothened to Gli proteins. Dev. Biol. 290 (2006) 1-12
    • (2006) Dev. Biol. , vol.290 , pp. 1-12
    • Eggenschwiler, J.T.1
  • 25
    • 0033781026 scopus 로고    scopus 로고
    • Gli regulation by the opposing activities of fused and suppressor of fused
    • Murone M., et al. Gli regulation by the opposing activities of fused and suppressor of fused. Nat. Cell Biol. 2 (2000) 310-313
    • (2000) Nat. Cell Biol. , vol.2 , pp. 310-313
    • Murone, M.1
  • 26
    • 9144243807 scopus 로고    scopus 로고
    • The FU gene and its possible protein isoforms
    • Østerlund T., et al. The FU gene and its possible protein isoforms. BMC Genomics 5 (2004) 49
    • (2004) BMC Genomics , vol.5 , pp. 49
    • Østerlund, T.1
  • 27
    • 18644383201 scopus 로고    scopus 로고
    • Expression of the human FUSED protein in Drosophila
    • Daoud F., and Blanchet-Tournier M.-F. Expression of the human FUSED protein in Drosophila. Dev. Genes Evol. 215 (2005) 230-237
    • (2005) Dev. Genes Evol. , vol.215 , pp. 230-237
    • Daoud, F.1    Blanchet-Tournier, M.-F.2
  • 28
    • 23344453462 scopus 로고    scopus 로고
    • Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed Hedgehog signalling during embryonic development
    • Chen M.-H., et al. Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed Hedgehog signalling during embryonic development. Mol. Cell. Biol. 25 (2005) 7042-7053
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 7042-7053
    • Chen, M.-H.1
  • 29
    • 23344442477 scopus 로고    scopus 로고
    • Loss of serine/threonine kinase Fused results in postnatal growth defects and lethality due to progressive hydrocephalus
    • Merchant M., et al. Loss of serine/threonine kinase Fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Mol. Cell. Biol. 25 (2005) 7054-7068
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 7054-7068
    • Merchant, M.1
  • 30
    • 27644584608 scopus 로고    scopus 로고
    • Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused
    • Cooper A.F., et al. Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development 132 (2005) 4407-4417
    • (2005) Development , vol.132 , pp. 4407-4417
    • Cooper, A.F.1
  • 31
    • 0033194243 scopus 로고    scopus 로고
    • Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1
    • Kogerman P., et al. Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. Nat. Cell Biol. 1 (1999) 312-319
    • (1999) Nat. Cell Biol. , vol.1 , pp. 312-319
    • Kogerman, P.1
  • 32
    • 0037117611 scopus 로고    scopus 로고
    • Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex
    • Cheng S.Y., and Bishop J.M. Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 5442-5447
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 5442-5447
    • Cheng, S.Y.1    Bishop, J.M.2
  • 33
    • 39049146684 scopus 로고    scopus 로고
    • The Zebrafish mutants dre, uki, and lep encode negative regulators of Hedgehog signalling pathway
    • Koudijs M.J., et al. The Zebrafish mutants dre, uki, and lep encode negative regulators of Hedgehog signalling pathway. PLoS Genet. 1 (2005) e19
    • (2005) PLoS Genet. , vol.1
    • Koudijs, M.J.1
  • 34
    • 0032848136 scopus 로고    scopus 로고
    • Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
    • Sasaki H., et al. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 126 (1999) 3915-3924
    • (1999) Development , vol.126 , pp. 3915-3924
    • Sasaki, H.1
  • 35
    • 0347764480 scopus 로고    scopus 로고
    • All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    • Bai C.B., et al. All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev. Cell 6 (2004) 103-115
    • (2004) Dev. Cell , vol.6 , pp. 103-115
    • Bai, C.B.1
  • 36
    • 0036801765 scopus 로고    scopus 로고
    • Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
    • Bai C.B., et al. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development 129 (2002) 4753-4761
    • (2002) Development , vol.129 , pp. 4753-4761
    • Bai, C.B.1
  • 37
    • 31744451535 scopus 로고    scopus 로고
    • Genetic elimination of Suppressor of Fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
    • Svärd J., et al. Genetic elimination of Suppressor of Fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev. Cell 10 (2006) 187-197
    • (2006) Dev. Cell , vol.10 , pp. 187-197
    • Svärd, J.1
  • 38
    • 31744436876 scopus 로고    scopus 로고
    • Divergence of Hedgehog signal transduction mechanism between Drosophila and mammals
    • Varjosalo M., et al. Divergence of Hedgehog signal transduction mechanism between Drosophila and mammals. Dev. Cell 10 (2006) 177-186
    • (2006) Dev. Cell , vol.10 , pp. 177-186
    • Varjosalo, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.