Matrix metalloproteinase-12 deficiency ameliorates the clinical course and demyelination in Theiler's murine encephalomyelitis

Acta Neuropathologica

Volumn 124, Issue 1, 2012, Pages 127-142

  Hansmann, Florian ^a,b   Herder, Vanessa ^a,b   Kalkuhl, Arno ^c   Haist, Verena ^a   Zhang, Ning ^a,b   Schaudien, Dirk ^a   Deschl, Ulrich ^c   Baumgärtner, Wolfgang ^a,b   Ulrich, Reiner ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Knockout mice; Matrix metalloproteinases; Microarray analysis; MMP 12; Multiple sclerosis; Theiler's murine encephalomyelitis

Indexed keywords

GELATINASE B; MACROPHAGE ELASTASE; STROMELYSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL INFILTRATION; CONTROLLED STUDY; DEMYELINATION; DISEASE COURSE; ENZYME ACTIVITY; FEMALE; GENE; INFLAMMATORY INFILTRATE; MACROPHAGE ELASTASE GENE; MEMBRANE DAMAGE; MICROARRAY ANALYSIS; MOLECULAR PATHOLOGY; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; STROMELYSIN GENE; TRANSCRIPTION REGULATION; WILD TYPE;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN STEM; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; ELECTRON MICROSCOPE TOMOGRAPHY; ENCEPHALOMYELITIS; GLIAL FIBRILLARY ACIDIC PROTEIN; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; MATRIX METALLOPROTEINASE 12; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; MICE; MICE, KNOCKOUT; MICROARRAY ANALYSIS; MYELIN PROTEINS; TEGMENTUM MESENCEPHALI; THEILOVIRUS; TIME FACTORS;

EID: 84862732009     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-012-0942-3     Document Type: Article

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