Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124

Science

Volumn 330, Issue 6006, 2010, Pages 985-989

  Kuhnert, Frank ^a,f   Mancuso, Michael R ^a   Shamloo, Amir ^b   Wang, Hsiao Ting ^a   Choksi, Vir ^b   Florek, Mareike ^c   Su, Hua ^d   Fruttiger, Marcus ^e   Young, William L ^d   Heilshorn, Sarah C ^b   Kuo, Calvin J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Stanford University   (United States)

^c STANFORD UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 124; GLUCOSE TRANSPORTER 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; BLOOD; BRAIN; DISEASE TREATMENT; EMBRYO; PATHOLOGY; PROTEIN; TUMOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; CENTRAL NERVOUS SYSTEM; CEREBROVASCULAR MALFORMATION; CONTROLLED STUDY; EMBRYO; EMBRYOTOXICITY; FOREBRAIN; GENE DELETION; IN VITRO STUDY; MIGRATION; MOUSE; NERVE SPROUTING; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; REGULATORY MECHANISM;

ANIMALS; BLOOD VESSELS; BLOOD-BRAIN BARRIER; CELL MOVEMENT; EMBRYONIC DEVELOPMENT; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GENE DELETION; GLUCOSE TRANSPORTER TYPE 1; MESENCEPHALON; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NEOVASCULARIZATION, PHYSIOLOGIC; NEURAL TUBE; PROSENCEPHALON; RECEPTORS, G-PROTEIN-COUPLED; RHOMBENCEPHALON; TELENCEPHALON;

EID: 78149399666     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1196554     Document Type: Article

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32. We are indebted to R. Daneman, B. Barres, C. Chartier, and the Kuo laboratory for comments; J. Yuan and J. Hampton for animal husbandry and genotyping; and A. Connolly and H. Vogel for neuropathology. F.K. was supported by an American Heart Association (AHA) Postdoctoral Fellowship and M.R.M. by AHA Predoctoral Fellowship AHA09PRE2110036 and the Stanford Medical Scientist Training Program Program (National Institute of General Medical Science, NIH, GM07365). This work was also supported by NIH R21 NS070153 and AHA 10GRNT3130004 (H.S.); NIH R01NS27713 (W.L.Y.); P01NS44155 (W.L.Y. and H.S.); U.K. Medical Research Council G0501711 (M.F.); NIH 1DP2 OD006477, 1R21 NS058600, and National Academies Keck Futures Initiative CS10 grants (S.C.H.); and NIH 1R01NS052830, 1R01NS064517, 1R01HL074267, Brain Tumor Society, Goldhirsh Foundation, and the Stanford Center for Children's Brain Tumors grants (C.J.K.). F.K., H.W., and C.J.K. have a patent pending regarding vascular applications of GPR124.