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Volumn 24, Issue 9, 2004, Pages 2143-2155

Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury

Author keywords

Blood brain barrier; Glial fibrillary acid protein; Inflammation; Motor function; Neural degeneration; Reactive astrocytes; Spinal cord injury; Transgenic mice

Indexed keywords

GANCICLOVIR; GLIAL FIBRILLARY ACIDIC PROTEIN; THYMIDINE KINASE;

EID: 1542317072     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3547-03.2004     Document Type: Article
Times cited : (1317)

References (49)
  • 1
    • 0031020308 scopus 로고    scopus 로고
    • Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury
    • Agrawal SK, Fehlings MG (1997) Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury. J Neurosci 17:1055-1063.
    • (1997) J Neurosci , vol.17 , pp. 1055-1063
    • Agrawal, S.K.1    Fehlings, M.G.2
  • 2
    • 0026505309 scopus 로고
    • The acute inflammatory response to lipopolysaccharide in CNS parenchyma differs from that in other body tissues
    • Andersson P-B, Perry VH, Gordon S (1992) The acute inflammatory response to lipopolysaccharide in CNS parenchyma differs from that in other body tissues. Neuroscience 48:169-186.
    • (1992) Neuroscience , vol.48 , pp. 169-186
    • Andersson, P.-B.1    Perry, V.H.2    Gordon, S.3
  • 3
    • 0028919411 scopus 로고
    • A sensitive and reliable locomotor rating scale for open field testing in rats
    • Basso DM, Beattie MS, Bresnahan JC (1995) A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21.
    • (1995) J Neurotrauma , vol.12 , pp. 1-21
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 4
    • 0028293108 scopus 로고
    • Modeling of acute spinal cord injury in the rat: Neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673
    • Behrmann DL, Bresnahan JC, Beattie MS (1994) Modeling of acute spinal cord injury in the rat: neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673. Exp Neurol 126:61-75.
    • (1994) Exp Neurol , vol.126 , pp. 61-75
    • Behrmann, D.L.1    Bresnahan, J.C.2    Beattie, M.S.3
  • 7
    • 0013567808 scopus 로고
    • Serum proteins by-pass the blood brain barrier for extracellular entry to the CNS
    • Broadwell RD, Sofroniew MV (1993) Serum proteins by-pass the blood brain barrier for extracellular entry to the CNS. Exp Neurol 120:246-263.
    • (1993) Exp Neurol , vol.120 , pp. 246-263
    • Broadwell, R.D.1    Sofroniew, M.V.2
  • 9
  • 10
    • 0029865499 scopus 로고    scopus 로고
    • Genetic ablation of parietal cells in transgenic mice: A new model for analyzing cell lineage relationships in the gastric mucosa
    • Canfield V, West AB, Goldenring JR, Levenson R (1996) Genetic ablation of parietal cells in transgenic mice: a new model for analyzing cell lineage relationships in the gastric mucosa. Proc Natl Acad Sci USA 93:2431-2435.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2431-2435
    • Canfield, V.1    West, A.B.2    Goldenring, J.R.3    Levenson, R.4
  • 12
    • 0000899756 scopus 로고
    • Regeneration of severed nerve fibers in the spinal cord of the adult cat
    • Clemente CD, Windle WF (1954) Regeneration of severed nerve fibers in the spinal cord of the adult cat. J Comp Neurol 101:691-731.
    • (1954) J Comp Neurol , vol.101 , pp. 691-731
    • Clemente, C.D.1    Windle, W.F.2
  • 13
    • 0027954265 scopus 로고
    • The effects of methylprednisolone and ganglioside GM1 on acute spinal cord injury in rats
    • Constantini S, Young W (1994) The effects of methylprednisolone and ganglioside GM1 on acute spinal cord injury in rats. J Neurosurg 80:97-111.
    • (1994) J Neurosurg , vol.80 , pp. 97-111
    • Constantini, S.1    Young, W.2
  • 14
    • 0031015075 scopus 로고    scopus 로고
    • Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys
    • Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Beattie MS (1997) Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med 3:73-76.
    • (1997) Nat Med , vol.3 , pp. 73-76
    • Crowe, M.J.1    Bresnahan, J.C.2    Shuman, S.L.3    Masters, J.N.4    Beattie, M.S.5
  • 15
    • 0033565865 scopus 로고    scopus 로고
    • Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord
    • Davies SJA, Goucher DR, Doller C, Silver J (1999) Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord. J Neurosci 19:5810-5822.
    • (1999) J Neurosci , vol.19 , pp. 5810-5822
    • Davies, S.J.A.1    Goucher, D.R.2    Doller, C.3    Silver, J.4
  • 16
    • 18144453796 scopus 로고    scopus 로고
    • Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease
    • DeWitt DA, Perry G, Cohen M, Doller C, Silver J (1998) Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease. Exp Brain Res 149:329-340.
    • (1998) Exp Brain Res , vol.149 , pp. 329-340
    • DeWitt, D.A.1    Perry, G.2    Cohen, M.3    Doller, C.4    Silver, J.5
  • 17
    • 0027314268 scopus 로고
    • Molecular profile of reactive astrocytes: Implications for their role in neurological disease
    • Eddleston M, Mucke L (1993) Molecular profile of reactive astrocytes: implications for their role in neurological disease. Neuroscience 54:15-36.
    • (1993) Neuroscience , vol.54 , pp. 15-36
    • Eddleston, M.1    Mucke, L.2
  • 19
    • 0029012783 scopus 로고
    • The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury
    • Fehlings MG, Tator CH (1995) The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury. Exp Neurol 132:220-228.
    • (1995) Exp Neurol , vol.132 , pp. 220-228
    • Fehlings, M.G.1    Tator, C.H.2
  • 21
    • 0033216123 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of glial scarring and progressive cavitation: In vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma
    • Fitch MT, Doller C, Combs CK, Landreth GE, Silver J (1999) Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma. J Neurosci 19:8182-8198.
    • (1999) J Neurosci , vol.19 , pp. 8182-8198
    • Fitch, M.T.1    Doller, C.2    Combs, C.K.3    Landreth, G.E.4    Silver, J.5
  • 22
    • 0029820185 scopus 로고    scopus 로고
    • Genetic influences on cellular reactions to spinal cord injury: Activation of macrophages/microglia and astrocytes is delayed in mice carrying a mutation (WldS) that causes delayed Wallerian degeneration
    • Fujiki M, Zhang Z, Guth L, Steward O (1996) Genetic influences on cellular reactions to spinal cord injury: activation of macrophages/microglia and astrocytes is delayed in mice carrying a mutation (WldS) that causes delayed Wallerian degeneration. J Comp Neurol 371:469-484.
    • (1996) J Comp Neurol , vol.371 , pp. 469-484
    • Fujiki, M.1    Zhang, Z.2    Guth, L.3    Steward, O.4
  • 24
    • 0344559101 scopus 로고    scopus 로고
    • The predominant neural stem cell isolated from postnatal and adult forebrain but not from early embryonic forebrain expresses GFAP
    • Imura T, Kornblum HI, Sofroniew MV (2003) The predominant neural stem cell isolated from postnatal and adult forebrain but not from early embryonic forebrain expresses GFAP. J Neurosci 23:2824-2832.
    • (2003) J Neurosci , vol.23 , pp. 2824-2832
    • Imura, T.1    Kornblum, H.I.2    Sofroniew, M.V.3
  • 25
    • 0037271439 scopus 로고    scopus 로고
    • Physical size does not determine the unique histopathological response seen in the injured mouse spinal cord
    • Inman DM, Steward O (2003) Physical size does not determine the unique histopathological response seen in the injured mouse spinal cord. J Neurotrauma 20:33-42.
    • (2003) J Neurotrauma , vol.20 , pp. 33-42
    • Inman, D.M.1    Steward, O.2
  • 26
    • 0037163431 scopus 로고    scopus 로고
    • Genetic influences on secondary degeneration and wound healing following spinal cord injury in various strains of mice
    • Inman DM, Guth L, Steward O (2002) Genetic influences on secondary degeneration and wound healing following spinal cord injury in various strains of mice. J Comp Neurol 451:225-235.
    • (2002) J Comp Neurol , vol.451 , pp. 225-235
    • Inman, D.M.1    Guth, L.2    Steward, O.3
  • 27
    • 0029257309 scopus 로고
    • Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: In vitro comparison of distinct GFAP-lacZ transgenes
    • Johnson WB, Ruppe MD, Rockenstein EM, Price J, Sarthy VP, Vederber LC, Mucke L (1995) Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vitro comparison of distinct GFAP-lacZ transgenes. Glia 13:174-184.
    • (1995) Glia , vol.13 , pp. 174-184
    • Johnson, W.B.1    Ruppe, M.D.2    Rockenstein, E.M.3    Price, J.4    Sarthy, V.P.5    Vederber, L.C.6    Mucke, L.7
  • 29
    • 0028866210 scopus 로고
    • Regeneration in the vertebrate central nervous system: Phylogeny, ontogeny, and mechanisms
    • Larner AJ, Johnson AR, Keynes RJ (1995) Regeneration in the vertebrate central nervous system: phylogeny, ontogeny, and mechanisms. Biol Rev 70:597-619.
    • (1995) Biol Rev , vol.70 , pp. 597-619
    • Larner, A.J.1    Johnson, A.R.2    Keynes, R.J.3
  • 31
    • 0023647298 scopus 로고
    • Astrocytes block axonal regeneration in mammals by activating the physiological stop pathway
    • Liuzzi FJ, Lasek RJ (1987) Astrocytes block axonal regeneration in mammals by activating the physiological stop pathway. Science 237:642-645.
    • (1987) Science , vol.237 , pp. 642-645
    • Liuzzi, F.J.1    Lasek, R.J.2
  • 32
    • 0034982490 scopus 로고    scopus 로고
    • Behavioral and histological outcomes following graded spinal cord contusion injury in C57/Bl/6 mouse
    • Ma M, Walters P, Stokes BT, Jakeman LB (2001) Behavioral and histological outcomes following graded spinal cord contusion injury in C57/Bl/6 mouse. Exp Neurol 169:239-254.
    • (2001) Exp Neurol , vol.169 , pp. 239-254
    • Ma, M.1    Walters, P.2    Stokes, B.T.3    Jakeman, L.B.4
  • 33
    • 0033061941 scopus 로고    scopus 로고
    • Comparing deficits following excitotoxic and contusion injuries in the thoracic and lumbar spinal cord of the adult rat
    • Magnuson DS, Trinder TC, Zhang YP, Burke D, Morassutti DJ, Shields CB (1999) Comparing deficits following excitotoxic and contusion injuries in the thoracic and lumbar spinal cord of the adult rat. Exp Neurol 156:191-204.
    • (1999) Exp Neurol , vol.156 , pp. 191-204
    • Magnuson, D.S.1    Trinder, T.C.2    Zhang, Y.P.3    Burke, D.4    Morassutti, D.J.5    Shields, C.B.6
  • 34
    • 2642640420 scopus 로고    scopus 로고
    • Lysophsphatidic acid stimulates actomyosin contraction in astrocytes
    • Manning Jr TJ, Rosenfeld SS, Sontheimer H (1998) Lysophsphatidic acid stimulates actomyosin contraction in astrocytes. J Neurosci Res 53:343-352.
    • (1998) J Neurosci Res , vol.53 , pp. 343-352
    • Manning Jr., T.J.1    Rosenfeld, S.S.2    Sontheimer, H.3
  • 35
    • 0034667678 scopus 로고    scopus 로고
    • A transgenic mouse model for inducible and reversible dysmyelination
    • Mathis C, Hindelang C, LeMeur M, Borrelli E (2000) A transgenic mouse model for inducible and reversible dysmyelination. J Neurosci 20:7698-7705.
    • (2000) J Neurosci , vol.20 , pp. 7698-7705
    • Mathis, C.1    Hindelang, C.2    LeMeur, M.3    Borrelli, E.4
  • 36
    • 0031952612 scopus 로고    scopus 로고
    • Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity
    • McDonald JW, Althomsons SP, Hyrc KL, Choi DW, Goldberg MP (1998) Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity. Nat Med 4:291-297.
    • (1998) Nat Med , vol.4 , pp. 291-297
    • McDonald, J.W.1    Althomsons, S.P.2    Hyrc, K.L.3    Choi, D.W.4    Goldberg, M.P.5
  • 37
    • 0041806517 scopus 로고    scopus 로고
    • Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin
    • Menet V, Prieto M, Privat A, Gimenez y Ribotta M (2003) Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin. Proc Natl Acad Sci USA 100:8999-9004.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8999-9004
    • Menet, V.1    Prieto, M.2    Privat, A.3    Gimenez Y Ribotta, M.4
  • 38
    • 0032838089 scopus 로고    scopus 로고
    • Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury
    • Popovich PG, Guan Z, Wei P, Huitinga I, van Rooijen N, Stokes BT (1999) Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp Neurol 158:351-365.
    • (1999) Exp Neurol , vol.158 , pp. 351-365
    • Popovich, P.G.1    Guan, Z.2    Wei, P.3    Huitinga, I.4    Van Rooijen, N.5    Stokes, B.T.6
  • 41
    • 0002741112 scopus 로고
    • The astrocytic scar as an impediment to regeneration in the central nervous system
    • (Kao CC, Bunge RP, Reier PJ, eds). New York: Raven
    • Reier PJ, Stensaas LJ, Guth J (1983) The astrocytic scar as an impediment to regeneration in the central nervous system. In: Spinal cord reconstruction (Kao CC, Bunge RP, Reier PJ, eds), pp 163-195. New York: Raven.
    • (1983) Spinal Cord Reconstruction , pp. 163-195
    • Reier, P.J.1    Stensaas, L.J.2    Guth, J.3
  • 42
    • 0030697366 scopus 로고    scopus 로고
    • Reactive astrocytes: Cellular and molecular cues to biological function
    • Ridet JL, Malhotra SK, Privat A, Gage FH (1997) Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci 20:570-577.
    • (1997) Trends Neurosci , vol.20 , pp. 570-577
    • Ridet, J.L.1    Malhotra, S.K.2    Privat, A.3    Gage, F.H.4
  • 43
    • 0032936851 scopus 로고    scopus 로고
    • The cell biology of the blood-brain barrier
    • Rubbin LL, Staddon JM (1999) The cell biology of the blood-brain barrier. Annu Rev Neurosci 22:11-28.
    • (1999) Annu Rev Neurosci , vol.22 , pp. 11-28
    • Rubbin, L.L.1    Staddon, J.M.2
  • 44
    • 0025513601 scopus 로고
    • Inhibition of neurite growth on astroglial scars in vitro
    • Rudge JS, Silver J (1990) Inhibition of neurite growth on astroglial scars in vitro. J Neurosci 10:3594-3603.
    • (1990) J Neurosci , vol.10 , pp. 3594-3603
    • Rudge, J.S.1    Silver, J.2
  • 45
    • 0032790541 scopus 로고    scopus 로고
    • Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury
    • Springer JE, Azbill RD, Knapp PE (1999) Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury. Nat Med 5:943-946.
    • (1999) Nat Med , vol.5 , pp. 943-946
    • Springer, J.E.1    Azbill, R.D.2    Knapp, P.E.3
  • 46
  • 47
    • 0027475987 scopus 로고
    • Secondary injury mechanisms in acute spinal cord injury
    • Young W (1993) Secondary injury mechanisms in acute spinal cord injury. J Emerg Med 11:13-22.
    • (1993) J Emerg Med , vol.11 , pp. 13-22
    • Young, W.1
  • 49
    • 0242291129 scopus 로고    scopus 로고
    • Early loss of astrocytes after experimental traumatic brain injury
    • Zhao X, Ahram A, Berman RF, Muizellar JP, Lyeth BC (2003) Early loss of astrocytes after experimental traumatic brain injury. Glia 44:140-152.
    • (2003) Glia , vol.44 , pp. 140-152
    • Zhao, X.1    Ahram, A.2    Berman, R.F.3    Muizellar, J.P.4    Lyeth, B.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.