Death Receptors DR6 and TROY Regulate Brain Vascular Development

Developmental Cell

Volumn 22, Issue 2, 2012, Pages 403-417

  Tam, Stephen J ^a   Richmond, David L ^a   Kaminker, Joshua S ^a   Modrusan, Zora ^a   Martin McNulty, Baby ^a   Cao, Tim C ^a   Weimer, Robby M ^a   Carano, Richard A D ^a   vanBruggen, Nick ^a   Watts, Ryan J ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; DEATH RECEPTOR; DEATH RECEPTOR 6; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN DEVELOPMENT; BRAIN TISSUE; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; MOUSE; NERVE SPROUTING; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VASCULARIZATION; ZEBRA FISH;

ANIMALS; BETA CATENIN; BIOLOGICAL MARKERS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; CELL COMMUNICATION; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; EMBRYO, MAMMALIAN; ENDOTHELIUM, VASCULAR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IMMUNOPRECIPITATION; MAP KINASE KINASE 4; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, TUMOR NECROSIS FACTOR; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; ZEBRAFISH;

DANIO RERIO; MUS;

EID: 84856978029     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2011.11.018     Document Type: Article

References (52)

1. Adams R.H., Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell Biol. 2007, 8:464-478.
2. Ashkenazi A., Dixit V.M. Death receptors: signaling and modulation. Science 1998, 281:1305-1308.
3. Beg A.A., Baltimore D. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 1996, 274:782-784.
4. Caporali A., Pani E., Horrevoets A.J., Kraenkel N., Oikawa A., Sala-Newby G.B., Meloni M., Cristofaro B., Graiani G., Leroyer A.S., et al. Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles. Circ. Res. 2008, 103:e15-e26.
5. Chan F.K., Chun H.J., Zheng L., Siegel R.M., Bui K.L., Lenardo M.J. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 2000, 288:2351-2354.
6. Chen J., Somanath P.R., Razorenova O., Chen W.S., Hay N., Bornstein P., Byzova T.V. Akt1 regulates pathological angiogenesis, vascular maturation and permeability invivo. Nat. Med. 2005, 11:1188-1196.
7. Chen L., Park S.M., Tumanov A.V., Hau A., Sawada K., Feig C., Turner J.R., Fu Y.X., Romero I.L., Lengyel E., Peter M.E. CD95 promotes tumour growth. Nature 2010, 465:492-496.
8. Daneman R., Agalliu D., Zhou L., Kuhnert F., Kuo C.J., Barres B.A. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc. Natl. Acad. Sci. USA 2009, 106:641-646.
9. Daneman R., Zhou L., Agalliu D., Cahoy J.D., Kaushal A., Barres B.A. The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells. PLoS ONE 2010, 5:e13741.
10. DeAlmeida V.I., Miao L., Ernst J.A., Koeppen H., Polakis P., Rubinfeld B. The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas invivo. Cancer Res. 2007, 67:5371-5379.
11. Eby M.T., Jasmin A., Kumar A., Sharma K., Chaudhary P.M. TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death. J.Biol. Chem. 2000, 275:15336-15342.
12. Ek C.J., Dziegielewska K.M., Stolp H., Saunders N.R. Functional effectiveness of the blood-brain barrier to small water-soluble molecules in developing and adult opossum (Monodelphis domestica). J.Comp. Neurol. 2006, 496:13-26.
13. Eliceiri B.P., Paul R., Schwartzberg P.L., Hood J.D., Leng J., Cheresh D.A. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol. Cell 1999, 4:915-924.
14. Gaillard P., Jeanclaude-Etter I., Ardissone V., Arkinstall S., Cambet Y., Camps M., Chabert C., Church D., Cirillo R., Gretener D., et al. Design and synthesis of the first generation of novel potent, selective, and invivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase. J.Med. Chem. 2005, 48:4596-4607.
15. Gerber H.P., Dixit V., Ferrara N. Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J.Biol. Chem. 1998, 273:13313-13316.
16. Gong Y., Bourhis E., Chiu C., Stawicki S., DeAlmeida V.I., Liu B.Y., Phamluong K., Cao T.C., Carano R.A., Ernst J.A., et al. Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies. PLoS ONE 2010, 5:e12682.
17. Gu C., Rodriguez E.R., Reimert D.V., Shu T., Fritzsch B., Richards L.J., Kolodkin A.L., Ginty D.D. Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev. Cell 2003, 5:45-57.
18. Hallmann R., Mayer D.N., Berg E.L., Broermann R., Butcher E.C. Novel mouse endothelial cell surface marker is suppressed during differentiation of the blood brain barrier. Dev. Dyn. 1995, 202:325-332.
19. Hödar C., Assar R., Colombres M., Aravena A., Pavez L., González M., Martínez S., Inestrosa N.C., Maass A. Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method. BMC Genomics 2010, 11:348.
20. Horie R., Watanabe T., Morishita Y., Ito K., Ishida T., Kanegae Y., Saito I., Higashihara M., Mori S., Kadin M.E., Watanabe T. Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells. Oncogene 2002, 21:2493-2503.
21. Jeong J.Y., Kwon H.B., Ahn J.C., Kang D., Kwon S.H., Park J.A., Kim K.W. Functional and developmental analysis of the blood-brain barrier in zebrafish. Brain Res. Bull. 2008, 75:619-628.
22. Jin S.W., Beis D., Mitchell T., Chen J.N., Stainier D.Y. Cellular and molecular analyses of vascular tube and lumen formation in zebrafish. Development 2005, 132:5199-5209.
23. Klapholz-Brown Z., Walmsley G.G., Nusse Y.M., Nusse R., Brown P.O. Transcriptional program induced by Wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments. PLoS ONE 2007, 2:e945.
24. Laukeviciene A., Brecht S., Kevelaitis E., Herdegen T. Enhanced contractility of small blood vessels in JNK knockout mice. Eur. J. Pharm. Sci. 2006, 29:335-339.
25. Lavrik I.N., Golks A., Riess D., Bentele M., Eils R., Krammer P.H. Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling. J.Biol. Chem. 2007, 282:13664-13671.
26. Lawson N.D., Weinstein B.M. Invivo imaging of embryonic vascular development using transgenic zebrafish. Dev. Biol. 2002, 248:307-318.
27. Liebner S., Corada M., Bangsow T., Babbage J., Taddei A., Czupalla C.J., Reis M., Felici A., Wolburg H., Fruttiger M., et al. Wnt/beta-catenin signaling controls development of the blood-brain barrier. J.Cell Biol. 2008, 183:409-417.
28. Logan C.Y., Nusse R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 2004, 20:781-810.
29. Nakatsu M.N., Sainson R.C., Aoto J.N., Taylor K.L., Aitkenhead M., Pérez-del-Pulgar S., Carpenter P.M., Hughes C.C. Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1. Microvasc. Res. 2003, 66:102-112.
30. Nikolaev A., McLaughlin T., O'Leary D.D., Tessier-Lavigne M. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 2009, 457:981-989.
31. Pan G., Bauer J.H., Haridas V., Wang S., Liu D., Yu G., Vincenz C., Aggarwal B.B., Ni J., Dixit V.M. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 1998, 431:351-356.
32. Pan Q., Chanthery Y., Liang W.C., Stawicki S., Mak J., Rathore N., Tong R.K., Kowalski J., Yee S.F., Pacheco G., et al. Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell 2007, 11:53-67.
33. Pardridge W.M., Boado R.J., Farrell C.R. Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and insitu hybridization. J.Biol. Chem. 1990, 265:18035-18040.
34. Park J.B., Yiu G., Kaneko S., Wang J., Chang J., He X.L., Garcia K.C., He Z. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron 2005, 45:345-351.
35. Pedram A., Razandi M., Levin E.R. Extracellular signal-regulated protein kinase/Jun kinase cross-talk underlies vascular endothelial cell growth factor-induced endothelial cell proliferation. J.Biol. Chem. 1998, 273:26722-26728.
36. Qiu W., Hu Y., Andersen T.E., Jafari A., Li N., Chen W., Kassem M. Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical Wnt signaling and C/EBP. J.Biol. Chem. 2010, 285:14438-14449.
37. Rousseau S., Houle F., Landry J., Huot J. p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells. Oncogene 1997, 15:2169-2177.
38. Rubin L.L., Staddon J.M. The cell biology of the blood-brain barrier. Annu. Rev. Neurosci. 1999, 22:11-28.
39. Schnepp A., Komp Lindgren P., Hülsmann H., Kröger S., Paulsson M., Hartmann U. Mouse testican-2. Expression, glycosylation, and effects on neurite outgrowth. J.Biol. Chem. 2005, 280:11274-11280.
40. Shao Z., Browning J.L., Lee X., Scott M.L., Shulga-Morskaya S., Allaire N., Thill G., Levesque M., Sah D., McCoy J.M., et al. TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. Neuron 2005, 45:353-359.
41. Shin H., Kwack M.H., Shin S.H., Oh J.W., Kang B.M., Kim A.A., Kim J., Kim M.K., Kim J.C., Sung Y.K. Identification of transcriptional targets of Wnt/beta-catenin signaling in dermal papilla cells of human scalp hair follicles: EP2 is a novel transcriptional target of Wnt3a. J.Dermatol. Sci. 2010, 58:91-96.
42. Six I., Kureishi Y., Luo Z., Walsh K. Akt signaling mediates VEGF/VPF vascular permeability invivo. FEBS Lett. 2002, 532:67-69.
43. Stenman J.M., Rajagopal J., Carroll T.J., Ishibashi M., McMahon J., McMahon A.P. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science 2008, 322:1247-1250.
44. Szczepankiewicz B.G., Kosogof C., Nelson L.T., Liu G., Liu B., Zhao H., Serby M.D., Xin Z., Liu M., Gum R.J., et al. Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J.Med. Chem. 2006, 49:3563-3580.
45. Takahashi T., Ueno H., Shibuya M. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 1999, 18:2221-2230.
46. Tam S.J., Watts R.J. Connecting vascular and nervous system development: angiogenesis and the blood-brain barrier. Annu. Rev. Neurosci. 2010, 33:379-408.
47. Tong A.H., Evangelista M., Parsons A.B., Xu H., Bader G.D., Pagé N., Robinson M., Raghibizadeh S., Hogue C.W., Bussey H., et al. Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 2001, 294:2364-2368.
48. Uchida C., Gee E., Ispanovic E., Haas T.L. JNK as a positive regulator of angiogenic potential in endothelial cells. Cell Biol. Int. 2008, 32:769-776.
49. Vasudevan A., Long J.E., Crandall J.E., Rubenstein J.L., Bhide P.G. Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain. Nat. Neurosci. 2008, 11:429-439.
50. Virgintino D., Girolamo F., Errede M., Capobianco C., Robertson D., Stallcup W.B., Perris R., Roncali L. An intimate interplay between precocious, migrating pericytes and endothelial cells governs human fetal brain angiogenesis. Angiogenesis 2007, 10:35-45.
51. Wang K.C., Kim J.A., Sivasankaran R., Segal R., He Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature 2002, 420:74-78.
52. Wu G., Luo J., Rana J.S., Laham R., Sellke F.W., Li J. Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells. Cardiovasc. Res. 2006, 69:512-519.